16 research outputs found
Echocardiographic Changes with Positive Airway Pressure Therapy in Obesity Hypoventilation Syndrome. Long-Term Pickwick Randomized Controlled Clinical Trial
Spanish Sleep Network.[Rationale] Obesity hypoventilation syndrome (OHS) has been associated with cardiac dysfunction. However, randomized trials assessing the impact of long-term noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP) on cardiac structure and function assessed by echocardiography are lacking. Rationale: Obesity hypoventilation syndrome (OHS) has been associated with cardiac dysfunction. However, randomized trials assessing the impact of long-term noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP) on cardiac structure and function assessed by echocardiography are lacking.[Objectives] In a prespecified secondary analysis of the largest multicenter randomized controlled trial of OHS (Pickwick Project; Nâ=â221 patients with OHS and coexistent severe obstructive sleep apnea), we compared the effectiveness of three years of NIV and CPAP on structural and functional echocardiographic changes.[Methods] At baseline and annually during three sequential years, patients underwent transthoracic two-dimensional and Doppler echocardiography. Echocardiographers at each site were blinded to the treatment allocation. Statistical analysis was performed using a linear mixed-effects model with a treatment group and repeated measures interaction to determine the differential effect between CPAP and NIV.
Measurements and Main Results: A total of 196 patients were analyzed: 102 were treated with CPAP and 94 were treated with NIV. Systolic pulmonary artery pressure decreased from 40.5â±â1.47 mm Hg at baseline to 35.3â±â1.33 mm Hg at three years with CPAP, and from 41.5â±â1.56 mm Hg to 35.5â±â1.42 with NIV (Pâ<â0.0001 for longitudinal intragroup changes for both treatment arms). However, there were no significant differences between groups. NIV and CPAP therapies similarly improved left ventricular diastolic dysfunction and reduced left atrial diameter. Both NIV and CPAP improved respiratory function and dyspnea.[Conclusions] In patients with OHS who have concomitant severe obstructive sleep apnea, long-term treatment with NIV and CPAP led to similar degrees of improvement in pulmonary hypertension and left ventricular diastolic dysfunction
La renovaciĂłn de la palabra en el bicentenario de la Argentina : los colores de la mirada lingĂŒĂstica
El libro reĂșne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de LingĂŒĂstica (SAL), Bicentenario: la renovaciĂłn de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temĂĄticas abordadas en los 167 capĂtulos muestran las grandes lĂneas de investigaciĂłn que se desarrollan fundamentalmente en nuestro paĂs, pero tambiĂ©n en los otros paĂses mencionados arriba, y señalan ademĂĄs las ĂĄreas que reciĂ©n se inician, con poca tradiciĂłn en nuestro paĂs y que deberĂan fomentarse. Los trabajos aquĂ publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigaciĂłn: FonologĂa, Sintaxis, SemĂĄntica y PragmĂĄtica, LingĂŒĂstica Cognitiva, AnĂĄlisis del Discurso, PsicolingĂŒĂstica, AdquisiciĂłn de la Lengua, SociolingĂŒĂstica y DialectologĂa, DidĂĄctica de la lengua, LingĂŒĂstica Aplicada, LingĂŒĂstica Computacional, Historia de la Lengua y la LingĂŒĂstica, Lenguas AborĂgenes, FilosofĂa del Lenguaje, LexicologĂa y TerminologĂa
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
The original version of this article unfortunately contained a mistake
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Hacia innovadoras comunidades de aprendizaje: un proyecto de Aprendizaje-Servicio basado en el desarrollo del STEAM en centros educativos en situaciĂłn de vulnerabilidad de la Comunidad de Madrid
Este proyecto se dirige al desarrollo del STEAM (Science, Technology, Engineering, Arts and Mathematics) con infancia vulnerable de la Comunidad de Madrid, mediante las metodologĂas innovadoras del Aprendizaje-Servicio y los Grupos Interactivos
A georeferenced rRNA amplicon database of aquatic microbiomes from South America
The biogeography of bacterial communities is a key topic in Microbial Ecology. Regarding continental water, most studies are carried out in the northern hemisphere, leaving a gap on microorganismâs diversity patterns on a global scale. South America harbours approximately one third of the worldâs total freshwater resources, and is one of these understudied regions. To fill this gap, we compiled 16S rRNA amplicon sequencing data of microbial communities across South America continental water ecosystems, presenting the first database ”SudAqua[db]. The database contains over 866 georeferenced samples from 9 different ecoregions with contextual environmental information. For its integration and validation we constructed a curated database (”SudAqua[db.sp]) using samples sequenced by Illumina MiSeq platform with commonly used prokaryote universal primers. This comprised ~60% of the total georeferenced samples of the ”SudAqua[db]. This compilation was carried out in the scope of the ”SudAqua collaborative network and represents one of the most complete databases of continental water microbial communities from South America.Fil: Metz, SebastiĂĄn DarĂo. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; ArgentinaFil: Huber, Maria Paula. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Santa Fe. Instituto Nacional de LimnologĂa. Universidad Nacional del Litoral. Instituto Nacional de LimnologĂa; ArgentinaFil: Mateus Barros, Erick. Universidade Federal do SĂŁo Carlos; BrasilFil: Junger, Pedro C.. Universidade Federal do SĂŁo Carlos; BrasilFil: de Melo, Michaela. Universidade Federal do SĂŁo Carlos; BrasilFil: Bagatini, Inessa Lacativa. Universidade Federal do SĂŁo Carlos; BrasilFil: Izaguirre, Irina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Instituto de EcologĂa, GenĂ©tica y EvoluciĂłn de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de EcologĂa, GenĂ©tica y EvoluciĂłn de Buenos Aires; ArgentinaFil: CĂąmara dos Reis, Mariana. Universidade Federal do SĂŁo Carlos; BrasilFil: Llames, Maria Eugenia del Rosario. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; ArgentinaFil: Accattatis, Victoria. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Santa Fe. Instituto Nacional de LimnologĂa. Universidad Nacional del Litoral. Instituto Nacional de LimnologĂa; ArgentinaFil: Quiroga, MarĂa Victoria. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; ArgentinaFil: Devercelli, Melina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Santa Fe. Instituto Nacional de LimnologĂa. Universidad Nacional del Litoral. Instituto Nacional de LimnologĂa; ArgentinaFil: Schiaffino, MarĂa Romina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Niño GarcĂa, Juan Pablo. Universidad de Antioquia; ColombiaFil: Bastidas Navarro, Marcela Alejandra. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Modenutti, Beatriz Estela. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Vieira, Helena. Universidade Federal do SĂŁo Carlos; BrasilFil: Saraceno, MartĂn. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Instituto de EcologĂa, GenĂ©tica y EvoluciĂłn de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de EcologĂa, GenĂ©tica y EvoluciĂłn de Buenos Aires; ArgentinaFil: Sabio y GarcĂa, Carmen Alejandra. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Instituto de EcologĂa, GenĂ©tica y EvoluciĂłn de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de EcologĂa, GenĂ©tica y EvoluciĂłn de Buenos Aires; ArgentinaFil: Pereira, Emiliano. Universidad de la Republica. Centro Universitario Regional del Este.; UruguayFil: GonzĂĄlez Revello, Alvaro. Instituto de Investigaciones BiolĂłgicas "Clemente Estable"; UruguayFil: Piccini, Claudia. Instituto de Investigaciones BiolĂłgicas "Clemente Estable"; UruguayFil: Unrein, Fernando. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; ArgentinaFil: Alonso, Cecilia. Universidad de la Republica. Centro Universitario Regional del Este.; UruguayFil: Sarmento, Hugo. Universidade Federal do SĂŁo Carlos; Brasi
CĂĄncer de cĂ©rvix : proceso asistencial integrado 2ÂȘ ed
Publicado en la pĂĄgina web de la ConsejerĂa de Salud: www.juntadeandalucia.es/salud (ConsejerĂa de Salud / Profesionales / Nuestro Compromiso por la Calidad / Procesos Asistenciales Integrados)YesEl cĂĄncer de cuello uterino se da principalmente en mujeres sexualmente activas, existiendo evidencia consistente de que estĂĄ relacionado con la
infecciĂłn del virus del papiloma humano (VPH). Se conocen mĂĄs de 150 tipos de VPH, de los cuales alrededor de 40 infectan el ĂĄrea genital y anal,
atribuyéndose capacidad oncogénica a los tipos 16,18, 33, 35, 39, 45, 52, 56, 58 y 59, siendo el paradigma de los de alto riesgo los tipos 16 y
18. Se detecta en mĂĄs del 99 % de los cĂĄnceres, tanto epiteliales como adenocarcinomas. Con esta segunda ediciĂłn del PAI CĂĄncer de CĂ©rvix, se ha realizado una revisiĂłn y actualizaciĂłn del documento anterior (año 2002), incorporando nuevos aspectos relacionados con dimensiones especĂficas de calidad, tales como la evidencia cientĂfica, la persona, el uso adecuado del medicamento, los cuidados enfermeros y la seguridad del paciente
Echocardiographic changes with non-invasive ventilation and CPAP in obesity hypoventilation syndrome.
Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. We performed a secondary analysis of the data from the largest multicentre randomised controlled trial of OHS (Pickwick project, n=221) to determine the comparative efficacy of 2 months of NIV (n=71), CPAP (n=80) and lifestyle modification (control group, n=70) on structural and functional echocardiographic changes. Conventional transthoracic two-dimensional and Doppler echocardiograms were obtained at baseline and after 2 months. Echocardiographers at each site were blinded to the treatment arms. Statistical analysis was performed using intention-to-treat analysis. At baseline, 55% of patients had pulmonary hypertension and 51% had evidence of left ventricular hypertrophy. Treatment with NIV, but not CPAP, lowered systolic pulmonary artery pressure (-3.4âmm Hg, 95%âCI -5.3 to -1.5; adjusted P=0.025âvs control and P=0.033âvs CPAP). The degree of improvement in systolic pulmonary artery pressure was greater in patients treated with NIV who had pulmonary hypertension at baseline (-6.4âmm Hg, 95%âCI -9 to -3.8). Only NIV therapy decreased left ventricular hypertrophy with a significant reduction in left ventricular mass index (-5.7âg/m2; 95%âCI -11.0 to -4.4). After adjusted analysis, NIV was superior to control group in improving left ventricular mass index (P=0.015). Only treatment with NIV led to a significant improvement in 6âmin walk distance (32âm; 95%âCI 19 to 46). In patients with OHS, medium-term treatment with NIV is more effective than CPAP and lifestyle modification in improving pulmonary hypertension, left ventricular hypertrophy and functional outcomes. Long-term studies are needed to confirm these results. Pre-results, NCT01405976 (https://clinicaltrials.gov/)
Integrate and learn. Building a farm-to-table blockchain
DecanatoFac. de VeterinariaFALSEsubmitte