Territorial culture : from information to knowledge and commitment for citizen action : initiative of the chair of Valencian Territorial Culture

El artículo trata de la necesidad de desarrollar una apropiada y necesaria cultura territorial entre la ciudadanía, en un sentido cada vez más comunitario y autónomo, ante el creciente control a la que esta se ve sometida desde diferentes ámbitos. Se presenta como uno de los últimos reductos de politización y compromiso ciudadano para la sostenibilidad del territorio. En este contexto y condiciones se crea la Cátedra de Cultura Territorial Valenciana, que trata de desarrollar este carácter resiliente para con el territorio mediante distintas líneas de actuación que se explican y argumentan a lo largo del texto. Se aborda y defiende la necesidad de consolidar la Ordenación del Territorio como política de primer nivel para poder avanzar en nuevas formas y enfoques de la planificación, tratando de superar de forma efectiva la consolidada tradición que hace prevalecer el enfoque sectorial sobre el integral. Los problemas complejos que tratan de resolverse con métodos y enfoques simples y tecnocráticos, acaban por volverse complicados y de difícil solución. Con ello se pretende conseguir una mayor eficacia, una aplicación más fácil y eficiente de la política de Ordenación del Territorio, más democrática y participada, y tratar de establecer mejores puentes entre teoría y práctica.This paper analyses the need of developing an appropriate territorial culture from an increasingly communitarian and autonomous perspective among citizens, since it faces an increasing control from different areas. It is presented as one of the last strongholds of citizen politicization and commitment for the sustainability of the territory. Under such conditions, the Chair of Valencian Territorial Culture is established with the aim of developing this resilience to the territory, implementing several measures that are developed and supported throughout the work. Also, it is analysed and supported the need to consolidate the land-use planning as a first level policy to make a progress in new forms and approaches to planning, trying to effectively improve the consolidated tradition that makes the sectoral approach prevail over the integral one. Complex problems are difficult to solve when being dealt with simple and technocratic methods and approaches. The purpose of this analysis is to achieve a greater efficiency, an easier and efficient application of the policy of land-use planning in a more democratic and participatory way, and to link theory with practice.Fil: Farinós Dasí, Joaquín. Universidad de ValenciaFil: Peiró Sánchez Manjavacas, Enrique. Universidad de ValenciaFil: Quintanilla Serrano, Pedro. Universidad de Valenci

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T patients and Atm−/− mouse models are particularly predisposed to develop lymphoid cancers derived from deficient repair of RAG-induced DSBs during V(D)J recombination. Here, we unexpectedly find that specifically disturbing the repair of DSBs produced by DNA topoisomerase II (TOP2) by genetically removing the highly specialised repair enzyme TDP2 increases the incidence of thymic tumours in Atm−/− mice. Furthermore, we find that TOP2 strongly colocalizes with RAG, both genome-wide and at V(D)J recombination sites, resulting in an increased endogenous chromosomal fragility of these regions. Thus, our findings demonstrate a strong causal relationship between endogenous TOP2-induced DSBs and cancer development, confirming these lesions as major drivers of ATM-deficient lymphoid malignancies, and potentially other conditions and cancer types.Junta de Andalucía SAF2010-21017, SAF2013-47343-P, SAF2014-55532-R, SAF2017-89619-R, CVI-7948European Research Council ERC-CoG-2014-64735

INGENIERÍAS: “Informe final de trabajos de innovación-implementación de un laboratorio de computo domótico en la Facultad de Ingenierías de la Universidad Evangélica de El Salvador”

En la actualidad, la Facultad de Ingenierías de la Universidad Evangélica de El Salvador cuenta con una herramienta tecnológica que contribuye con la seguridad y el ahorro de recursos, capaz de darle un seguimiento preciso a la seguridad y el ahorro de recursos. La Facultad de Ingeniarías cuenta con el primer sistema automático de control de recursos administrado por un módulo Arduino que permite gestionar recursos, el funcionamiento y control de un circuito cerrado de video vigilancia constituido por cuatro cámaras de visión nocturna; además se incorporó al sistema un control automatizado de encendido y apagado de aires acondicionado y un sistema de sensores de movimiento y temperatura. Para lograr el objetivo del proyecto, se incorporó un sistema de cableado estructurado de datos, así como eléctrico para que diera paso a tener un sistema de redes controlado. Se diseñaron circuitos para permitir el encendido y apagado de luminarias, así como también aires acondicionados, por consiguiente, fueron incorporados en cada interruptor de encendido y apagados. Se diseñó una placa principal para la administración del módulo Arduino. Se diseñó e implemento también un sistema informático integral para la comunicación del sistema y el usuario, el cual permite la programación de las diferentes actividades académicas, así como la manipulación de los recursos de cómputo y la video vigilancia. Este sistema se desarrolló haciendo uso de varios lenguajes de programación convirtiéndolo en un sistema hibrido. Para incorporar este sistema hibrido se instala y configuró un servidor Windows 2008 que sirviera como plataforma

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Background: Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. Methods: In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. Findings: Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p<0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p<0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039). Interpretation: Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation. Funding: None