Nakanishi Inosuke and Chungsŏ Ijijo: Realism and Authenticity in Early Proletarian Literature

This article discusses the reception in Japan and Korea of the works of Nakanishi Inosuke, a leftist writer in the 1920s whose experiences in Korea formed the basis for much of his work. Two novels in particular, Sprouts from Red Earth and Behind You, were widely praised for their realistic representation of life on the peninsula, especially their depiction of Japanese imperialist activities and the anti-colonial pushback from Koreans. How exactly these novels were to be interpreted varied according to audience, however, giving rise to competing images of Nakanishi. Some critics considered him to be an advocate of a newly emerging international proletarian consciousness while other readers, including many Koreans, looked on Nakanishi (whom they called Chungsŏ Ijijo, the Korean reading of his name) as a supporter of colonial nationalism. Still others contested his claim to authenticity altogether. In tracing the development of these interpretations of Nakanishi from these early works up until his participation in the founding of the Korean Artist Proletarian Federation (KAPF) in August 1925 and after, the article argues that his works’ ability to successfully navigate the period of a dawning proletarian cultural movement through to its collapse lay (and continues to lie) in their ambiguity, an ambiguity that has facilitated a continual reinterpretation of him from the 1920s to the present day. Keywords: Nakanishi Inosuke, Japan, Korea, proletarian literature, KAP

The Clarté Movement in Japan and Korea, 1919-1925.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017

Integrated Environmental Modelling – What is the Vision? Is it Achievable?

Keynote Lecture

Sulfadimethoxine residues in rabbit muscle after extended oral treatment at therapeutic dosage

[EN] Sulfadimethoxine is extensively used in rabbit breeding for preventive and curative purpose and residues are sometimes observed in carcasses at slaughter. It has been suggested this is due to dosage and/or duration of treatment not being in compliance with the manufacturer's recommendations, which probably induces residue levels in the meat above the maximum residue limit (MRL) value of 100 ¿g/kg. In order to test this hypothesis, a study was carried out on gravid rabbits and their progeny. The animals were subjected to an extended treatment with sulfadimethoxine at therapeutic level in the feed. The feed was supplemented before pelleting with a commercial veterinary product containing 20 g of trimethoprim and 93 g of sulfadimethoxine per kg. On the basis of the dosage indicated for this commercial veterinary product, the incorporation level in the feed was 5 kg/ton (i.e. 465 g of sulfadimethoxine/ton), providing oral daily therapeutic treatment of the animals of ca. 12.5 to 50 mg of sulfadimethoxine per kg bodyweight. The mothers were treated during the last 21 d of pregnancy and during the whole period of lactation (35 d). The animals were sacrificed after a wash-out period of 12 d with blank feed. The young rabbits received the supplemented feed after weaning during the first 40 d of the fattening period. These animals were also sacrifi ced after a wash-out period of 8, 12, 15 or 20 d, respectively, with a blank feed. A sample of the leg muscle was taken for analysis. An HPLC analytical method was used to determine the sulfadimethoxine concentrations in tissue, with a LLOQ (Lower Limit Of Quantification) of 50 ¿g/kg of muscle (trimethoprim was not considered in this study). Sulfadimethoxine concentrations above the MRL value of 100 ¿g/kg were registered only in muscle from 1 out of 8 mothers and in 2 out of 8 young rabbits sacrificed 12 d after cessation of the treatment. For other young rabbits sacrificed on the 8th, 15th or 20th d after cessation of treatment, Sulphonamide concentrations in muscle always remained below the MRL value (8 animals per slaughtering time). These results show that oral treatment of rabbits with veterinary products containing sulfadimethoxine administered for a long period at the daily therapeutic level of 12.5 to 50 mg/kg does not seem to induce the accumulation of this molecule in muscle.Barthe, C.; Guicherd, A.; Quillon, J. (2009). Sulfadimethoxine residues in rabbit muscle after extended oral treatment at therapeutic dosage. World Rabbit Science. 17(3):137-144. doi:10.4995/wrs.2009.65313714417

In silico segmentations of lentivirus envelope sequences

BACKGROUND: The gene encoding the envelope of lentiviruses exhibits a considerable plasticity, particularly the region which encodes the surface (SU) glycoprotein. Interestingly, mutations do not appear uniformly along the sequence of SU, but they are clustered in restricted areas, called variable (V) regions, which are interspersed with relatively more stable regions, called constant (C) regions. We look for specific signatures of C/V regions, using hidden Markov models constructed with SU sequences of the equine, human, small ruminant and simian lentiviruses. RESULTS: Our models yield clear and accurate delimitations of the C/V regions, when the test set and the training set were made up of sequences of the same lentivirus, but also when they were made up of sequences of different lentiviruses. Interestingly, the models predicted the different regions of lentiviruses such as the bovine and feline lentiviruses, not used in the training set. Models based on composite training sets produce accurate segmentations of sequences of all these lentiviruses. CONCLUSION: Our results suggest that each C/V region has a specific statistical oligonucleotide composition, and that the C (respectively V) regions of one of these lentiviruses are statistically more similar to the C (respectively V) regions of the other lentiviruses, than to the V (respectively C) regions of the same lentivirus

Modulation of human valve interstitial cell phenotype and function using a fibroblast growth factor 2 formulation

Valve interstitial cells (VICs) are fibroblastic in nature however in culture it is widely accepted that they differentiate into a myofibroblastic phenotype. This study assessed a fibroblast culture media formulation for its ability to maintain the phenotype and function of VICs as in the intact healthy valve. Normal human VICs were cultured separately in standard DMEM and in fibroblast media consisting of FGF2 (10 ng/ml), insulin (50 ng/ml) and 2% FCS for at least a week. Cell morphology, aspect ratio, size, levels and distribution of protein expression, proliferation, cell cycle, contraction and migration were assessed. Some VICs and some valve endothelial cells expressed FGF2 in valve tissue and this expression was increased in calcified valves. VICs in DMEM exhibited large, spread cells whereas VICs in fibroblast media were smaller, elongated and spindly. Aspect ratio and size were both significantly higher in DMEM (p<0.01). The level of expression of α-SMA was significantly reduced in fibroblast media at day 2 after isolation (p<0.01) and the expression of α-SMA, SM22 and EDA-fibronectin was significantly reduced in fibroblast media at days 7 and 12 post-isolation (p<0.01). Expression of cytoskeletal proteins, bone marker proteins and extracellular matrix proteins was reduced in fibroblast media. Proliferation of VICs in fibroblast media was significantly reduced at weeks 1 (p<0.05) and 2 (p<0.01). Collagen gel contraction was significantly reduced in fibroblast media (p<0.05). VICs were found to have significantly fewer and smaller focal adhesions in fibroblast media (p<0.01) with significantly fewer supermature focal adhesions in fibroblast media (p<0.001). Ultrastructurally, VICs in fibroblast media resembled native VICs from intact valves. VICs in fibroblast media demonstrated a slower migratory ability after wounding at 72 hours (p<0.01). Treatment of human VICs with this fibroblast media formulation has the ability to maintain and to dedifferentiate the VICs back to a fibroblastic phenotype with phenotypic and functional characteristics ascribed to cells in the intact valve. This methodology is fundamental in the study of normal valve biology, pathology and in the field of tissue engineering

DRIHM - An Infrastructure To Advance Hydro-Meteorological Research

One of the main challenges in hydro-meteorological research (HMR) is predicting the impact of weather and climate changes on the environment, society and economy, including local severe hazards such as floods and landslides. At the heart of this challenge lies the ability to have easy access to hydro-meteorological data and models, and facilitate the collaboration across discipline boundaries. Within the DRIHM project (Distributed Research Infrastructure for Hydro-Meteorology, www.drihm.eu, EC funded FP7 project 2011-2015) we develop a prototype e-Science environment to facilitate this collaboration and provide end-to-end HMR services (models, datasets, and post-processing tools) at the European level, with the ability to expand to global scale. The objectives of DRIHM are to lead the definition of a common long-term strategy, to foster the development of new HMR models, workflows and observational archives for the study of severe hydro-meteorological events, to promote the execution and analysis of high-end simulations, and to support the dissemination of predictive models as decision analysis tools. For this we implement a service portal to construct heterogeneous simulation workflows that can include deterministic and ensemble runs on a heterogeneous infrastructure consisting of HPC, grid and Windows cloud resources. Via another FP7 project called DRIHM2US (www.drihm2us.eu) we collaborate with the NSF funded SCIHM project (www.scihm.org) to build a wider international collaborative network. This contribution will provide a sketch of the DRIHM architecture and show some use cases such as the November 2011 Genoa flooding