17 research outputs found
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome
Inhaled mucoactive drugs for treating non-cystic fibrosis bronchiectasis in children
Abstract
Non-cystic fibrosis bronchiectasis (nCFb) is an acquired condition of variable etiology. Medical treatment basically involves antibiotics and chest physiotherapy. An impaired mucociliary clearance seems to be one of the mechanisms behind nCFb, and inhaled therapy with mucoactive agents has frequently been used to try to correct it. The most often used mucoactive agents in this setting are N-acetylcysteine, hypertonic saline solution (HS), mannitol powder and recombinant human DNase (rhDNase). Reviewing the international medical literature on the use of these drugs for patients with nCFb from 1992 to the present day, we retrieved 88 articles, only 12 of which met our selection criteria for this analysis. We found only 2 papers and 2 reviews on the use of rhDNase in children, and in adults 3 trials on HS, 5 on mannitol powder and 2 on rhDNase. In conclusion, no observational or randomized controlled trials (RCT) have been published on the use of these drugs in children with nCFb, while the few conducted on adult patients report some evidence of their effects. Further studies are needed on inhaled mucoactive drugs for the treatment of children with nCFb
Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women
Psychosocial functioning in consultation-liaison psychiatry patients. Influence of psychosomatic syndromes, psychopathology, and somatization.
Background: This study investigated whether the Diagnostic
Criteria for Psychosomatic Research (DCPR) were able to
predict psychosocial functioning in addition to psychiatric
diagnoses and somatization in consultation-liaison psychiatry
(CLP) patients. Method: A consecutive sample of 208 CLP
patients were recruited and assessed for sociodemographic
and medical data, psychopathology (SCID), psychosomatic
syndromes (DCPR structured interview) and somatization
(SCL-90-R SOM scale and multisomatoform disorder, MSD).
The main endpoints were the mental and physical components
of psychosocial functioning (SF-36). Results: A total of
185 (89%) patients had any psychiatric diagnosis, 51 (25%)
had MSD positive criteria, 176 (85%) had any DCPR syndrome,
and 105 (51%) had multiple DCPR syndromes. Although psychiatric
and psychosomatic syndromes were variously associated
with psychosocial functioning, hierarchical regression
and effect size analyses showed that only DCPR
syndromes, particularly demoralization and health anxiety,
with somatization but not DSM-IV psychopathology independently
predicted poor psychosocial functioning. Conclusions: The presence of psychosomatic syndromes, assessed
with DCPR criteria, and high levels of somatization
had larger effect size and were independent predictors
of the mental and physical components of psychosocial
dysfunction, over and above psychopathology. The DCPR
classification can provide CLP professionals with a set of
sensitive diagnostic criteria for a comprehensive clinical
evaluation of psychosomatic syndromes that might play a
significant mediating role in the course and the outcome of
medical patients referred for psychiatric consultation
Psychopathology of first-episode psychosis in HIV-positive persons in comparison to first-episode schizophrenia: a neglected issue.
The aggressor at the mirror: Psychiatric correlates of deliberate self-harm in male prison inmates
International audienc
Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus: prospective evaluation in a large cohort of Italian patients.
OBJECTIVE:
To verify the association of ribosomal anti-P antibodies (anti-P), as detected by a sensitive ELISA, with serological findings and clinical manifestations, including neuropsychiatric involvement evaluated according to the American College of Rheumatology (ACR) nomenclature, in a large cohort of patients with systemic lupus erythematosus (SLE).
METHODS:
Anti-P were evaluated in the serum of 149 consecutive Italian SLE patients by an ELISA using a multiple antigen peptide carrying four copies of a common P0, P1 and P2 epitope. A complete laboratory evaluation and clinical examination were performed in each patient. In addition, all patients underwent an accurate neuropsychiatric and neuropsychological assessment performed by trained specialists according to the 1999 ACR suggestions.
RESULTS:
Serum anti-P were detected in 18/149 patients (12.1%). The anti-P prevalence was similar (11.7%) when the analysis was performed in a larger series of sera including 82 additional SLE patients, who were not included in the clinical study. The age of anti-P-positive patients at disease onset was less than 33 yr and, in comparison with the anti-P-negative patients, these patients showed more active disease activity and a higher prevalence of photosensitivity and malar and discoid rash. A strong association between IgG anticardiolipin antibodies and anti-P was also found. However, anti-P were associated with neither neuropsychiatric syndromes nor cognitive impairment.
CONCLUSION:
This study does not seem to confirm the described association of anti-P with SLE neuropsychiatric manifestations. However, it supports the anti-P association with different skin manifestations as well as the presence of anticardiolipin in a subset of patients with SLE characterized by early disease onset
Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus : prospective evaluation in a large cohort of Italian patients
OBJECTIVE: To verify the association of ribosomal anti-P antibodies (anti-P), as detected by a sensitive ELISA, with serological findings and clinical manifestations, including neuropsychiatric involvement evaluated according to the American College of Rheumatology (ACR) nomenclature, in a large cohort of patients with systemic lupus erythematosus (SLE). METHODS: Anti-P were evaluated in the serum of 149 consecutive Italian SLE patients by an ELISA using a multiple antigen peptide carrying four copies of a common P0, P1 and P2 epitope. A complete laboratory evaluation and clinical examination were performed in each patient. In addition, all patients underwent an accurate neuropsychiatric and neuropsychological assessment performed by trained specialists according to the 1999 ACR suggestions. RESULTS: Serum anti-P were detected in 18/149 patients (12.1%). The anti-P prevalence was similar (11.7%) when the analysis was performed in a larger series of sera including 82 additional SLE patients, who were not included in the clinical study. The age of anti-P-positive patients at disease onset was less than 33 yr and, in comparison with the anti-P-negative patients, these patients showed more active disease activity and a higher prevalence of photosensitivity and malar and discoid rash. A strong association between IgG anticardiolipin antibodies and anti-P was also found. However, anti-P were associated with neither neuropsychiatric syndromes nor cognitive impairment. CONCLUSION: This study does not seem to confirm the described association of anti-P with SLE neuropsychiatric manifestations. However, it supports the anti-P association with different skin manifestations as well as the presence of anticardiolipin in a subset of patients with SLE characterized by early disease onset