Spinor driven cosmic bounces and their cosmological perturbations

When coupling fermions to gravity, torsion is naturally induced. We consider the possibility that fermion bilinears can act as a source for torsion, altering the dynamics of the early universe such that the big bang gets replaced with a classical non-singular bounce. We extend previous studies in several ways: we allow more general fermion couplings, consider both commuting and anti-commuting spinors, and demonstrate that with an appropriate choice of potential one can easily obtain essentially arbitrary equations of state, including violations of the null energy condition, as required for a bounce. As an example, we construct a model of ekpyrotic contraction followed by a non-singular bounce into an expanding phase. We analyze cosmological fluctuations in these models, and show that the perturbations can be rewritten in real fluid form. We find indications that spinor bounces are stable, and exhibit several solutions for the perturbations. Interestingly, spinor models do not admit a scalar-vector-tensor decomposition, and consequently some types of scalar fluctuations can act as a source for gravitational waves already at linear order. We also find that the first order dynamics are directionally dependent, an effect which might lead to distinguished observational signatures.Comment: 43 pages, 10 figure

Metric learning pairwise kernel for graph inference

Much recent work in bioinformatics has focused on the inference of various types of biological networks, representing gene regulation, metabolic processes, protein-protein interactions, etc. A common setting involves inferring network edges in a supervised fashion from a set of high-confidence edges, possibly characterized by multiple, heterogeneous data sets (protein sequence, gene expression, etc.). Here, we distinguish between two modes of inference in this setting: direct inference based upon similarities between nodes joined by an edge, and indirect inference based upon similarities between one pair of nodes and another pair of nodes. We propose a supervised approach for the direct case by translating it into a distance metric learning problem. A relaxation of the resulting convex optimization problem leads to the support vector machine (SVM) algorithm with a particular kernel for pairs, which we call the metric learning pairwise kernel (MLPK). We demonstrate, using several real biological networks, that this direct approach often improves upon the state-of-the-art SVM for indirect inference with the tensor product pairwise kernel

An Empirical Investigation of the Linkages Between Government Payments and Leasing Arrangements

Replaced with revised version of poster 07/22/10.Agricultural and Food Policy, Industrial Organization, Land Economics/Use,

Daytime temperature is sensed by phytochrome B in Arabidopsis through a transcriptional activator HEMERA.

Ambient temperature sensing by phytochrome B (PHYB) in Arabidopsis is thought to operate mainly at night. Here we show that PHYB plays an equally critical role in temperature sensing during the daytime. In daytime thermosensing, PHYB signals primarily through the temperature-responsive transcriptional regulator PIF4, which requires the transcriptional activator HEMERA (HMR). HMR does not regulate PIF4 transcription, instead, it interacts directly with PIF4, to activate the thermoresponsive growth-relevant genes and promote warm-temperature-dependent PIF4 accumulation. A missense allele hmr-22, which carries a loss-of-function D516N mutation in HMR's transcriptional activation domain, fails to induce the thermoresponsive genes and PIF4 accumulation. Both defects of hmr-22 could be rescued by expressing a HMR22 mutant protein fused with the transcriptional activation domain of VP16, suggesting a causal relationship between HMR-mediated activation of PIF4 target-genes and PIF4 accumulation. Together, this study reveals a daytime PHYB-mediated thermosensing mechanism, in which HMR acts as a necessary activator for PIF4-dependent induction of temperature-responsive genes and PIF4 accumulation

Modélisation de la fissuration à chaud en soudage d'un acier inoxydable austénitique

National audienceCette contribution présente les résultats numériques et expérimentaux d'une étude sur la modélisation de la fissuration à chaud. Les résultats numériques issus de Code_Aster complètent ainsi les essais JWRI permettant d'identifier les critères de fissuration à chaud. Cette étude fait ressortir une chute de ductilité critique de l'ordre de 1,5% (Modèle macroscopique basée sur la mécanique des solides).See http://hal.archives-ouvertes.fr/docs/00/59/27/42/ANNEX/r_ZMQYWQMR.pd

Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction

AbstractObjectivesWe investigated the effects of short-term tezosentan treatment on cardiac function, pulmonary edema and long-term evolution of heart failure (HF) in a rat model of myocardial infarction (MI).BackgroundEndothelin (ET) may play a major role in the progression from MI to HF. Tezosentan is a new dual ETA/ETBreceptor antagonist.MethodsRats were subjected to coronary artery ligation and were treated with either vehicle or tezosentan (10 mg/kg IV bolus) at 1 h and 24 h after MI. Cardiac hemodynamics and lung weight were measured at 48 h after MI. Survival was assessed over a five-month period.ResultsAt 48 h after ligation, vehicle-treated rats developed HF, as evidenced by a marked increase in left ventricular end-diastolic pressure (LVEDP), reduction in dP/dtmaxand mean arterial pressure (MAP), and development of pulmonary edema. Tezosentan treatment attenuated the increase in LVEDP and in lung weight and slightly reduced MAP without affecting dP/dtmax. Infarct size was not modified by tezosentan. Despite the fact that treatment with tezosentan was stopped after 24 h, the initial tezosentan administration significantly reduced cardiac hypertrophy (22%) and decreased mortality by 51% at five months (50% survival vs. 19% survival in vehicle-treated rats, p < 0.001).ConclusionsTezosentan administered during the first day after MI in rats, in addition to improving acutely hemodynamic conditions, markedly increases long-term survival. This increase is associated with a decrease of pulmonary edema and prevention of cardiac hypertrophy. Tezosentan could be a safe and useful therapeutic agent in the prevention and treatment of ischemic HF

Comparison of two hot tearing criteria in numerical modelling of arc welding of stainless steel AISI 321

International audienceTwo hot cracking criteria have been tested: the RDG criterion, based on the prediction of liquid cavitation as a precursor of crack formation, and a strain-based solid mechanics criterion. Both criteria have been implemented in a finite element thermo-mechanical simulation of gas tungsten arc welding. After comparison with experimental results obtained in a test campaign on stainless steel AISI 321, both criteria have shown good ability to predict crack occurrence. Yet, the best response in terms of cracking prediction was obtained with the strain-based solid mechanics criterion

Nano-architecture of gustatory chemosensory bristles and trachea in Drosophila wings

International audienceIn the Drosophila wing anterior margin, the dendrites of gustatory neurons occupy the interior of thin and long bristles that present tiny pores at their extremities. Many attempts to measure ligand-evoked currents in insect wing gustatory neurons have been unsuccessful for technical reasons. The functions of this gustatory activity therefore remain elusive and controversial. To advance our knowledge on this understudied tissue, we investigated the architecture of the wing chemosensory bristles and wing trachea using Raman spectroscopy and fluorescence microscopy. We hypothesized that the wing gustatory hair, an open-ended capillary tube, and the wing trachea constitute biological systems similar to nano-porous materials. We present evidence that argues in favour of the existence of a layer or a bubble of air beneath the pore inside the gustatory hair. We demonstrate that these hollow hairs and wing tracheal tubes fulfil conditions for which the physics of fluids applied to open-ended capillaries and porous materials are relevant. We also document that the wing gustatory hair and tracheal architectures are capable of trapping volatile molecules from the environment, which might increase the efficiency of their spatial detection by way of wing vibrations or during flight

Optical characterization of ultra-short Bragg grating on lithium niobate ridge waveguide

International audienceIn this Letter, we report a technique to etch giant aspect ratio nanostructures in lithium niobate. An 8 μm long Bragg grating on a Ti:LiNbO3 ridge waveguide was fabricated by combining optical-grade dicing and focused ion beam milling. The reflectivity was evaluated using an optical coherence tomography system: it is measured to be 53% for the TM wave and 47% for the TE wave. We study by 2D-FDTD the modeled behavior of the electromagnetic field when an angle exists between two consecutive sidewalls of the grating in order to understand the difference between ideal Bragg grating and experimental samples. These simulations allow us to optimize the parameters in order to increase the reflection of the grating up to 80%