YOLOv5s-MC: Lightweight road target detection network

For the problem of large number of target detection algorithm parameters, a lightweight real-time detection algorithm YOLOv5s-MC based on improved YOLOv5s road scenes is proposed. firstly, CA attention is added to the model to improve the sensitivity of the network to detect targets; secondly, in the feature fusion network, add adaptive weight parameters using AS-Concat structure are added to better fuse the feature information of different layers and improve the detection accuracy of the algorithm ; adding a small target detection layer to improve the detection accuracy of tiny targets; finally introducing Mobilnetv2, a lightweight network, as the overall backbone layer to realize the lightweight requirement of the network; to verify the advantages of the proposed algorithm, experiments were conducted on the kitti dataset. The experimental results show that the proposed algorithm, compared with the original network, improves the average accuracy by 0.2% with 55.8% less parameters and 33.7% less computation, and the detection speed reaches 35 FPS, which meets the requirements of real-time detection and improves the ability of algorithm deployment in weak hardware computing power scenarios to a certain extent

The north–south shift of the ridge location of the western Pacific subtropical high and its influence on the July precipitation in the Jianghuai region from 1978 to 2021

The Jianghuai region is the area between the Yangtze River and the Huai River in China and is a densely populated agriculture region therefore, the economics and human activity there are significantly affected by the precipitation changes, particularly during the summer when extreme storms and droughts normally occur. It will be helpful if the summer precipitation changes can be predicted. The monthly ERA5 atmospheric reanalysis data from 1978 to 2021 are used in this study to investigate the relationship between the ridge latitudinal location of the western Pacific subtropical high (WPSH) and the precipitation in July over the Jianghuai region. The results show that the WPSH ridge location has an important impact on the amount and spatial distribution of the precipitation in this region. When the ridge was northward, an anomalous anticyclonic circulation will appear over the western Pacific, leading to the weakening of the summer monsoon and the reduction of moisture transport from the Indian Ocean, therefore decreasing precipitation in the Jianghuai region, while the situation is opposite when the ridge was southward. The Niño 3.4 index in March and the India–Burma trough intensity index in June have significant correlations with the July WPSH ridge location, and both can be used as precursors to predict the WPSH ridge location and, therefore, the precipitation in this region

Flood Inundation Extraction and its Impact on Ground Subsidence Using Sentinel-1 Data: A Case Study of the “7.20” Rainstorm Event in Henan Province, China

On July 20, 2021, the northern Henan Province was hit by a historically rare, exceptionally heavy rainstorm (“7.20” Rainstorm Event), accompanied by severe urban flooding, flash floods, landslides, and other multiple disasters, resulting in significant casualties and property losses. On the other hand, the long-term overexploitation of groundwater since the last century has led to severe ground subsidence in the same area. We apply the intensity information of Sentinel-1 SAR images to extract the large-scale flood inundation area and their phase information to measure the ground deformation. Since heavy precipitations can recharge groundwater, the relationship between flood inundation, groundwater level change, and ground deformation is analyzed. The results show that the flood inundation areas are mainly distributed along the major rivers due to river overflowing, while heavy precipitation led to the rise of groundwater levels, and there was a significant amount of subsidence mitigation and surface uplift across the region due to the groundwater recovery. This study demonstrates the contribution of radar remote sensing to analyze the mechanism of groundwater recharge and subsidence mitigation benefited by rainstorm events and provides a technical reference to similar circumstances

Donkey milk inhibits tumor growth by inducing apoptosis, pyroptosis and modulation of Th1/Th2 responses in a 4T1 murine breast cancer model

Studies have demonstrated that donkey milk (DM) displays anti-tumor activity. In this study, we investigated the role and underlying mechanism of DM in the progression of 4T1 breast tumors in mice. We found that DM significantly reduced tumor volumes and tumor weights in 4T1-treated mice. Simultaneously, DM ameliorated the pathological changes in spleen, liver and lung tissues of 4T1 tumor-bearing mice. WB results showed that DM inducing the expression of Bax and pyroptosis-related proteins, and inhibiting the expression of Bcl-2 in tumors. Besides, DM up-regulation of Th1 cytokines and down-regulation of Th2/Treg cytokines in the tumors and spleen. Moreover, DM significantly decreased the ratios of p-JAK2/JAK2, p-STAT3/STAT3, p-STAT5/STAT5, as well as up-regulation the ratio of p-STAT4/STAT4 in tumors and spleen. Our data suggest that DM inhibit the growth of mouse 4T1 tumors by inducing apoptosis and pyroptosis, as well as promoting Th1 cell activation and quelling immunosuppression from Tregs

Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population

<div><p>Objectives</p><p>Individual variations in the capacity of DNA repair machinery to relieve benzene-induced DNA damage may be the key to developing chronic benzene poisoning (CBP), an increasingly prevalent occupational disease in China. ERCC1 (Excision repair cross complementation group 1) is located on chromosome 19q13.2–3 and participates in the crucial steps of Nucleotide Excision Repair (NER); moreover, we determined that one of its polymorphisms, ERCC1 rs11615, is a biomarker for CBP susceptibility in our previous report. Our aim is to further explore the deeper association between some genetic variations related to ERCC1 polymorphisms and CBP risk.</p><p>Methods</p><p>Nine single nucleotide polymorphisms (SNPs) of XRCC1 (X-ray repair cross-complementing 1), CD3EAP (CD3e molecule, epsilon associated protein), PPP1R13L (protein phosphatase 1, regulatory subunit 13 like), XPB (Xeroderma pigmentosum group B), XPC (Xeroderma pigmentosum group C) and XPF (Xeroderma pigmentosum group F) were genotyped by the Snapshot and TaqMan-MGB^® probe techniques, in a study involving 102 CBP patients and 204 controls. The potential interactions between these SNPs and lifestyle factors, such as smoking and drinking, were assessed using a stratified analysis.</p><p>Results</p><p>An XRCC1 allele, rs25487, was related to a higher risk of CBP (<i>P</i><0.001) even after stratifying for potential confounders. Carriers of the TT genotype of XRCC1 rs1799782 who were alcohol drinkers (OR = 8.000; 95% CI: 1.316–48.645; <i>P</i> = 0.022), male (OR = 9.333; 95% CI: 1.593–54.672; <i>P</i> = 0.019), and had an exposure of ≤12 years (OR = 2.612; 95% CI: 1.048–6.510; <i>P</i> = 0.035) had an increased risk of CBP. However, the T allele in PPP1R13L rs1005165 (P<0.05) and the GA allele in CD3EAP rs967591 (OR = 0.162; 95% CI: 0039~0.666; <i>P</i> = 0.037) decreased the risk of CBP in men. The haplotype analysis of XRCC1 indicated that XRCC1 rs25487^A, rs25489^G and rs1799782^T (OR = 15.469; 95% CI: 5.536–43.225; <i>P</i><0.001) were associated with a high risk of CBP.</p><p>Conclusions</p><p>The findings showed that the rs25487 and rs1799782 polymorphisms of XRCC1 may contribute to an individual’s susceptibility to CBP and may be used as valid biomarkers. Overall, the genes on chromosome 19q13.2–3 may have a special significance in the development of CBP in occupationally exposed Chinese populations.</p></div