8 research outputs found
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
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- Anderson R
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- Andersson H
- Andersson L
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- Andres C
- Andresen D
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- Zhou Yingyuan
- Zhu Wangqin
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- Ziefle S
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- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: A tolerability, safety, and preliminary efficacy study
- Author
- Batty
- Brioni Moore
- Bustos
- Chen
- Cook
- Dondorp
- Dulci Lautu
- Genton
- Gorman
- Hassan Alin
- Hombhanje
- Hombhanje
- Ivo Mueller
- John Benjamin
- Karunajeewa
- Krudsood
- Kunming Pharmaceutical Corporation
- Mackinnon
- Manning
- McIntosh
- Michon
- Michèle Senn
- Mytton
- Nosten
- Papua New Guinea Department of Health
- Peter Siba
- Pirozzo
- Price
- Qu
- Sam Salman
- Sook Ting Lee
- Susan Griffin
- Svensson
- Timothy M. E. Davis
- Tun
- Van Dorn
- Wang
- White
- World Health Organization
- World Health Organization
- Publication venue
- 'American Society for Microbiology'
- Publication date
- 01/01/2012
- Field of study
Artemisinin-naphthoquine (ART-NQ) is a fixed-dose coformulated antimalarial therapy recommended as a single-dose treatment and marketed in Papua New Guinea among other tropical countries. We conducted a tolerability, safety, and efficacy study of ART-NQ for Papua New Guinean children aged 5 to 12 years with uncomplicated malaria, comparing single-dose ART-NQ (15 and 6 mg/kg of body weight) given with water (group 1; n = 15), single-dose ART-NQ (22 and 9 mg/kg) given with milk (group 2; n = 17), or two daily doses of 22 and 9 mg/kg given with water (group 3; n = 16). Of the 48 children (45 with Plasmodium falciparum malaria, 2 with Plasmodium vivax malaria, and 1 with mixed-species malaria), 2 in group 2 did not attend all follow-up assessments. All regimens were well tolerated, with no serious adverse events. There were no clinically significant changes in pulse, blood pressure, rate-corrected electrocardiographic QT, routine biochemistry/hematology, or hearing after treatment. Fever clearance was prompt. Mean 50% parasite clearance times were 4, 4, and 5 h for groups 1, 2, and 3, respectively. One group 1 patient had PCR-confirmed P. falciparum recrudescence at day 23; four had PCR-confirmed P. falciparum reinfections on day 28 or 42; and three had P. vivax infections detected on day 42. The only recurrent parasitemia in groups 2 and 3 occurred in a group 2 child who developed a P. vivax infection on day 42. Day 14 gametocyte positivity levels were 20%, 27%, and 9% in groups 1, 2, and 3, respectively. The lower single ART-NQ dose was associated with relatively frequent recurrence of parasitemia, but the prolonged gametocytemia in all three groups has implications for the transmission of malaria. Copyright © 2012, American Society for Microbiology. All Rights Reserved
Improved Delivery of CRISPR/Cas9 System Using Magnetic Nanoparticles into Porcine Fibroblast
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Extracellular vesicles: their role in cancer biology and epithelial–mesenchymal transition
- Author
- Aatonen
- Adnan Shafiq
- Aga
- Al-Nedawi
- Alexander
- Alin Rai
- Ambros
- Anderson
- Antonyak
- Atkin-Smith
- Balaj
- Bartel
- Bebawy
- Boelens
- Bushati
- Byon
- Carrasco-Ramirez
- Chen
- Clancy
- Colombo
- Conigliaro
- Corrado
- Costa-Silva
- David W. Greening
- Davidson
- Demory Beckler
- Derynck
- Dewji
- Espinosa-Neira
- Fedele
- Franzen
- Galindo-Hernandez
- Garnier
- Garnier
- Gopal
- Gopal
- Grange
- Greening
- Greening
- Greening
- Grotegut
- Guarino
- Hanahan
- Hanson
- Heerboth
- Higginbotham
- Hoeben
- Hong-Jian Zhu
- Hood
- Hoshino
- Hsu
- Huber
- Hurley
- Jeppesen
- Ji
- Jung
- Kahlert
- Kalluri
- Kessenbrock
- Kim
- Kloosterman
- Kong
- Kosaka
- Kourembanas
- Kowal
- Lamouille
- Le
- Leong
- Li
- Liu
- Lo Cicero
- Lu
- Luga
- Ma
- Maoshan Chen
- Martello
- Mathias
- Mathias
- Mathias
- Mehlen
- Menck
- Menck
- Mercer
- Mincheva-Nilsson
- Muralidharan-Chari
- Muralidharan-Chari
- Oliveras-Ferraros
- Ostrowski
- Pasquier
- Peinado
- Peinado
- Pitt
- Pokharel
- Prensner
- Putz
- Qin
- Qu
- Quail
- Ratajczak
- Record
- Richard J. Simpson
- Ridder
- Roberts
- Roccaro
- Rommel A. Mathias
- Rong Xu
- Saleem
- Savagner
- Sharghi-Namini
- Shashi K. Gopal
- Shimoda
- Shurtleff
- Skog
- Sleeman
- Song
- Syn
- Takahashi
- Takahashi
- Tauro
- Tauro
- Tauro
- Thakur
- Thiery
- Thiery
- Thiery
- Thompson
- Tominaga
- Tsai
- Valadi
- Velasco-Loyden
- Vicente-Duenas
- Voulgari
- Webber
- Webber
- Willms
- Xiao
- Xin
- Xu
- Xu
- Yamada
- Yang
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- Yonezawa
- Yoon
- You
- Zaborowski
- Zhang
- Zhang
- Zomer
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
The Genetic Architecture of Depression in Individuals of East Asian Ancestry
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- Abdellaoui Abdel
- Adams Mark J.
- Agee Michelle
- Agerbo Esben
- Air Tracy M.
- Andlauer Till F. M.
- Arolt Volker
- Aslibekyan Stella
- Auton Adam
- Avery Daniel
- Awasthi Swapnil
- Babalola Elizabeth
- Bacanu Silviu-Alin
- Bass Nick
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- Beekman Aartjan T. F.
- Bell Robert K.
- Bennett Derrick
- Berger Klaus
- Bian Zheng
- Bielenberg Jessica
- Bigdeli Tim B.
- Binder Elisabeth B.
- Boomsma Dorret I.
- Boxall Ruth
- Bragg Fiona
- Breen Gerome
- Bryc Katarzyna
- Bryois Julien
- Bullis Emily
- Burmeister Margit
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Byrne Enda M.
- Bækvad-Hansen Marie
- Børglum Anders D.
- Cai Na
- Cameron Briana
- Castelao Enrique
- Chan Ka Hung
- Chang Liang
- Chang Yumei
- Chen Biyun
- Chen Chun-Hsin
- Chen Hsi-Chung
- Chen Jinyan
- Chen Junshi
- Chen Naying
- Chen Ningyu
- Chen Xiaofang
- Chen Yiping
- Chen Yiping
- Chen Zhengming
- Chen Zhengming
- Cheng Liang
- Christensen Jane Hvarregaard
- Cichon Sven
- Clarke Johnathan
- Clarke Robert
- Clarke Toni-Kim
- Coker Daniella
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Collins Rory
- Colodro-Conde Lucía
- Coon Hilary
- Couvy-Duchesne Baptiste
- Craddock Nick
- Crawford Gregory E.
- Cuellar Partida Gabriel
- Dannlowski Udo
- Das Sayantan
- Davies Gail
- de Geus EJC
- Deary Ian J.
- Degenhardt Franziska
- DePaulo J. Raymond
- Derks Eske M.
- Dhamija Devika
- Direk Nese
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Dong Caixia
- Du Huaidong
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- Dunn Erin C.
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- Escott-Price Valentina
- Esko Tõnu
- Fairhurst-Hunter Zammy
- Fan Lei
- Fang Yu
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- Fletez-Brant Kipper
- Fontanillas Pierre
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- Frank Josef
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- Fu Zhongxi
- Gan Wei
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- Gao Ruqin
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- Gu Qijun
- Guo Yu
- Guo Zhendong
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- Han Xiao
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- Su Jian
- Su Mei-Hsin
- Sullivan Patrick F.
- Sun Huarong
- Sun Qiang
- Sun Xiaohui
- Tang Aiyu
- Tang Zhenzhu
- Tansey Katherine E.
- Tao Ran
- Teismann Henning
- Teumer Alexander
- Thompson Pippa A.
- Thompson Wesley
- Thorgeirsson Thorgeir E.
- Tian Chao
- Tian Chao
- Tian Xiaocao
- Tiemeier Henning
- Tran Vinh
- Traylor Matthew
- Treutlein Jens
- Trubetskoy Vassily
- Trzaskowski Maciej
- Tung Joyce Y.
- Turnbull Iain
- Tyrrell Jess
- Uher Rudolf
- Uitterlinden André G.
- Umbricht Daniel
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- Van der Auwera Sandra
- van Hemert Albert M.
- Viktorin Alexander
- Visscher Peter M.
- Völzke Henry
- Walters Robin
- Walters Robin G.
- Wan Meng
- Wang Chen
- Wang Chunmei
- Wang Hao
- Wang Junzheng
- Wang Lin
- Wang Ping
- Wang Shaojie
- Wang Sisi
- Wang Tao
- Wang Wei
- Wang Xiaohuan
- Wang Xin
- Wang Yunpeng
- Webb Bradley T.
- Wei Liuping
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Weldon Catherine H.
- Wellmann Jürgen
- Weng Min
- Werge Thomas
- Willemsen Gonneke
- Wilton Peter
- Witt Stephanie H.
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- Wright Neil
- Wu Ming
- Wu Shukuan
- Wu Xianping
- Wu Yang
- Xi Hualin S.
- Xie Kaixu
- Xu Qiaohua
- Xu Qinai
- Xu Xin
- Yan Shichun
- Yang Jian
- Yang Jie
- Yang Ling
- Yang Xiaoming
- Yao Pang
- Yin Li
- Yu Bo
- Yu Canqing
- Yu Min
- Zhai Yaoming
- Zhang Futao
- Zhang Hao
- Zhang Hui
- Zhang Jun
- Zhang Libo
- Zhang Ningmei
- Zhang Xi
- Zhang Xiaoyi
- Zhang Xukui
- Zhong Xunfu
- Zhou Ding Zhang
- Zhou Gang
- Zhou Jinyi
- Zhou Liyuan
- Zhou Weiwei
- Zhou Xue
- Zhou Yonglin
- Zou Mingyuan
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2021
- Field of study
Extracellular vesicles in cancer — implications for future improvements in cancer care
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- A Andea
- A Bobrie
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- MD Mitchell
- MF Baietti
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- MJ Bissell
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- S Dai
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- S Viaud
- S Viaud
- S Yang
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- Silvia H. De Paoli
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- Publication date
- Field of study
Recent Advances in Biophysical stimulation of MSC for bone regeneration
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- Adamo L Garcia-Carde-AG.
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- Zhong W Tian K, Zheng X, Li L, Zhang W, Wang S.
- Publication venue
- 'Indian Society for Education and Environment'
- Publication date
- Field of study