Dynamical Blueprints for Galaxies

We present an axisymmetric, equilibrium model for late-type galaxies which consists of an exponential disk, a Sersic bulge, and a cuspy dark halo. The model is specified by a phase space distribution function which, in turn, depends on the integrals of motion. Bayesian statistics and the Markov Chain Monte Carlo method are used to tailor the model to satisfy observational data and theoretical constraints. By way of example, we construct a chain of 10^5 models for the Milky Way designed to fit a wide range of photometric and kinematic observations. From this chain, we calculate the probability distribution function of important Galactic parameters such as the Sersic index of the bulge, the disk scale length, and the disk, bulge, and halo masses. We also calculate the probability distribution function of the local dark matter velocity dispersion and density, two quantities of paramount significance for terrestrial dark matter detection experiments. Though the Milky Way models in our chain all satisfy the prescribed observational constraints, they vary considerably in key structural parameters and therefore respond differently to non-axisymmetric perturbations. We simulate the evolution of twenty-five models which have different Toomre Q and Goldreich-Tremaine X parameters. Virtually all of these models form a bar, though some, more quickly than others. The bar pattern speeds are ~ 40 - 50 km/s/kpc at the time when they form and then decrease, presumably due to coupling of the bar with the halo. Since the Galactic bar has a pattern speed ~50 km/s/kpc we conclude that it must have formed recently.Comment: 54 pages, 20 figure

Investigation of ultrafast demagnetization and cubic optical nonlinearity of Ni in the polar geometry

Copyright © 2004 American Institute of PhysicsFemtosecond optical pump-probe experiments were performed upon a Ni(720 Å)/Si(100) sample in the polar geometry with the pump beam close to normal incidence. A signal due to the ultrafast demagnetization effect was observed when the pump pulse was linearly polarized. When the pump was elliptically polarized, additional peaks were observed at zero time delay, resulting from the specular inverse Faraday effect (SIFE) and the specular optical Kerr effect (SOKE). By comparing measurements made with different pump helicities, the SIFE and SOKE peaks and the demagnetization signal were found to superpose in a linear fashion. From the dependence of the peak height upon the pump polarization, values of χxxyy=(1−3i)×10−10 rad cm3 erg−1 and χxyyx=(−9+2i)×10−12 rad cm3 erg−1 were deduced for the nonvanishing components of the local cubic susceptibility tensor. For applied fields less than the saturation value, the sudden reduction of the thin film demagnetizing field leads to an imbalance of the torques acting upon the magnetization, causing it to precess

Portfolio-based appraisal: superficial or useful?

This paper outlines the growing role played by performance appraisal within medical regulation, supported by learning portfolios. It investigates if these are superficial or useful tools. In doing so it argues that caution must be exercised in promoting such tools to help modernise medical regulatory frameworks

Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis

First published online: September 20, 2013BACKGROUND: Improving our understanding of the relationship between the genotype and the drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more accurate molecular diagnostics for drug-resistant tuberculosis. Studies that use direct genetic manipulation to identify the mutations that cause M. tuberculosis drug resistance are superior to associational studies in elucidating an individual mutation's contribution to the drug resistance phenotype. METHODS: We systematically reviewed the literature for publications reporting allelic exchange experiments in any of the resistance-associated M. tuberculosis genes. We included studies that introduced single point mutations using specialized linkage transduction or site-directed/in vitro mutagenesis and documented a change in the resistance phenotype. RESULTS: We summarize evidence supporting the causal relationship of 54 different mutations in eight genes (katG, inhA, kasA, embB, embC, rpoB, gyrA and gyrB) and one intergenic region (furA-katG) with resistance to isoniazid, the rifamycins, ethambutol and fluoroquinolones. We observed a significant role for the strain genomic background in modulating the resistance phenotype of 21 of these mutations and found examples of where the same drug resistance mutations caused varying levels of resistance to different members of the same drug class. CONCLUSIONS: This systematic review highlights those mutations that have been shown to causally change phenotypic resistance in M. tuberculosis and brings attention to a notable lack of allelic exchange data for several of the genes known to be associated with drug resistance.This work was supported by the Portuguese Foundation for Science and Technology (FCT) (SFRH/BD/33902/2009 to H. N.-G.), the National Institutes of Health/Fogarty International Center (1K01 TW009213 to K.R.J.), departmental funds of the pulmonary division of Massachusetts General Hospital to M. R. F. and the National Institutes of Health/NIAID (U19 A1076217 to M.B.M.)

Resource-Bound Quantification for Graph Transformation

Graph transformation has been used to model concurrent systems in software engineering, as well as in biochemistry and life sciences. The application of a transformation rule can be characterised algebraically as construction of a double-pushout (DPO) diagram in the category of graphs. We show how intuitionistic linear logic can be extended with resource-bound quantification, allowing for an implicit handling of the DPO conditions, and how resource logic can be used to reason about graph transformation systems

A dependent nominal type theory

Nominal abstract syntax is an approach to representing names and binding pioneered by Gabbay and Pitts. So far nominal techniques have mostly been studied using classical logic or model theory, not type theory. Nominal extensions to simple, dependent and ML-like polymorphic languages have been studied, but decidability and normalization results have only been established for simple nominal type theories. We present a LF-style dependent type theory extended with name-abstraction types, prove soundness and decidability of beta-eta-equivalence checking, discuss adequacy and canonical forms via an example, and discuss extensions such as dependently-typed recursion and induction principles

Optical excitation of a coherent transverse optical phonon in a polycrystalline Zr metal film

Copyright © 2007 The American Physical SocietyOptical pump-probe measurements of transient reflectivity were made on a sputtered polycrystalline thin film of hcp Zr. On top of a slow multiexponential decay, an oscillatory signal was observed with frequency varying from the initial value of f(0)=2.24 +/- 0.06 THz at zero time delay to a value of 2.56 +/- 0.12 THz after 2 ps, which is similar to that of a transverse optical (TO) phonon near the Gamma point of the Brillouin zone. From the data, the TO phonon relaxation time was determined to be 0.67 ps. The excitation of the coherent phonon was identified as being mediated by resonant coherent Raman scattering

Towards an embedding of Graph Transformation in Intuitionistic Linear Logic

Linear logics have been shown to be able to embed both rewriting-based approaches and process calculi in a single, declarative framework. In this paper we are exploring the embedding of double-pushout graph transformations into quantified linear logic, leading to a Curry-Howard style isomorphism between graphs and transformations on one hand, formulas and proof terms on the other. With linear implication representing rules and reachability of graphs, and the tensor modelling parallel composition of graphs and transformations, we obtain a language able to encode graph transformation systems and their computations as well as reason about their properties

Measurement of hot electron momentum relaxation times in metals by femtosecond ellipsometry

Copyright © 2005 The American Physical SocietyTime-resolved ellipsometric measurements were made upon Au, Cu, Ag, Ni, Pd, Ti, Zr, and Hf thin films. Using an elliptically polarized pump beam, the decay of the optically induced polarization of the sample was observed. Characteristic relaxation times are extracted and interpreted in terms of scattering of linear and angular momentum of hot electrons. A systematic variation is observed between different metals that reflects their underlying band structure

Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of Gambian infants

Background There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective. However, BCG could remain integral to TB control programmes because neonatal BCG protects against disseminated forms of childhood TB and many new vaccines rely on BCG to prime immunity or are recombinant strains of BCG. Interferon-gamma (IFN-) is required for immunity to mycobacteria and used as a marker of immunity when new vaccines are tested. Although BCG is widely given to neonates IFN- responses to BCG in this age group are poorly described. Characterisation of IFN- responses to BCG is required for interpretation of vaccine immunogenicity study data where BCG is part of the vaccination strategy. Methodology/Principal Findings 236 healthy Gambian babies were vaccinated with M. bovis BCG at birth. IFN-, interleukin (IL)-5 and IL-13 responses to purified protein derivative (PPD), killed Mycobacterium tuberculosis (KMTB), M. tuberculosis short term culture filtrate (STCF) and M. bovis BCG antigen 85 complex (Ag85) were measured in a whole blood assay two months after vaccination. Cytokine responses varied up to 10 log-fold within this population. The majority of infants (89-98% depending on the antigen) made IFN- responses and there was significant correlation between IFN- responses to the different mycobacterial antigens (Spearman’s coefficient ranged from 0.340 to 0.675, p=10-6-10-22). IL-13 and IL-5 responses were generally low and there were more non-responders (33-75%) for these cytokines. Nonetheless, significant correlations were observed for IL-13 and IL-5 responses to different mycobacterial antigens Conclusions/Significance Cytokine responses to mycobacterial antigens in BCG-vaccinated infants are heterogeneous and there is significant inter-individual variation. Further studies in large populations of infants are required to identify the factors that determine variation in IFN- responses