10 research outputs found
Dermatomyositis and supraventricular tachycardia
<p>Abstract</p> <p>Background</p> <p>Dermatomyositis is an idiopathic inflammatory myopathy, often associated with an underlying malignancy. Its prevalence rate is approximately one per 100,000 in the general population, and is even rarer without evidence of a cancer. Dermatomyositis rarely involves myocardial muscle fibers, but has shown to be associated with cardiac arrhythmias.</p> <p>Case Presentation</p> <p>We present a case of a young female patient with known history of dermatomyositis who presented to hospital with a flare up of her disease. She also complained of paroxysms of palpitation. Telemetry monitoring revealed several episodes of paroxysmal supraventricular tachycardia with heart rate reaching up to 220 beats per minute.</p> <p>Conclusion</p> <p>Cardiac involvement in dermatomyositis is a very rare, but well known entity. Dermatomyositis patients with palpitations should be monitored on a Holter monitor, and appropriate therapy initiated if found to have a significant arrhythmia.</p
Mediastinal lipomatosis as a cause of low voltage complexes on electrocardiogram and widened mediastinum: A case report
Net ultrafiltration prescription and practice among critically ill patients receiving renal replacement therapy : a multinational survey of critical care practitioners
Objectives: To assess the attitudes of practitioners with respect to net ultrafiltration prescription and practice among critically ill patients with acute kidney injury treated with renal replacement therapy. Design: Multinational internet-assisted survey. Setting: Critical care practitioners involved with 14 societies in 80 countries. Subjects: Intensivists, nephrologists, advanced practice providers, ICU and dialysis nurses. Intervention: A cross-sectional survey. Measurement and Main Results: Of 2,567 practitioners who initiated the survey, 1,569 (61.1%) completed the survey. Most practitioners were intensivists (72.7%) with a median duration of 13.2 years of practice (interquartile range, 7.2-22.0 yr). Two third of practitioners (71.0%; regional range, 55.0-95.5%) reported using continuous renal replacement therapy with a net ultrafiltration rate prescription of median 80.0 mL/hr (interquartile range, 49.0-111.0 mL/hr) for hemodynamically unstable and a maximal rate of 299.0 mL/hr (interquartile range, 200.0-365.0 mL/hr) for hemodynamically stable patients, with regional variation. Only a third of practitioners (31.5%; range, 13.7-47.8%) assessed hourly net fluid balance during continuous renal replacement therapy. Hemodynamic instability was reported in 20% (range, 20-38%) of patients and practitioners decreased the rate of fluid removal (70.3%); started or increased the dose of a vasopressor (51.5%); completely stopped fluid removal (35.8%); and administered a fluid bolus (31.6%), with significant regional variation. Compared with physicians, nurses were most likely to report patient intolerance to net ultrafiltration (73.4% vs 81.3%; p = 0.002), frequent interruptions (40.4% vs 54.5%; p < 0.001), and unavailability of trained staff (11.9% vs 15.6%; p = 0.04), whereas physicians reported unavailability of dialysis machines (14.3% vs 6.1%; p < 0.001) and costs associated with treatment as barriers (12.1% vs 3.0%; p < 0.001) with significant regional variation. Conclusions: Our study provides new knowledge about the presence and extent of international practice variation in net ultrafiltration. We also identified barriers and specific targets for quality improvement initiatives. Our data reflect the need for evidence-based practice guidelines for net ultrafiltration
Kidney Paired Donation for Reducing CMV and EBV Burden in Living Donor Kidney Transplantation
Dermatomiositis y taquicardia supraventricular
La dermatomiositis es una miopatía inflamatoria idiopática, a menudo asociada a una enfermedad oncológica subyacente. En la población general tiene una prevalencia de un caso cada 100.000 habitantes, y es incluso menos frecuente cuando no se acompaña de cáncer. La dermatomiositis raramente afecta a las fibras musculares del miocardio, pero sí que se la ha asociado con arritmias cardíacas. Se presenta el caso de una paciente joven con un historial conocido de dermatomiositis, que acudió a un centro hospitalario con un recrudecimiento de su enfermedad. También se quejaba de palpitaciones paroxísticas. El monitor de telemetría reveló varios episodios de taquicardia paroxística supraventricular y la frecuencia cardíaca llegó a 220 latidos por minuto. La afectación cardíaca en los pacientes con dermatomiositis es muy infrecuente, pero es una entidad bien establecida. Los pacientes con dermatomiositis y palpitaciones deberían supervisarse utilizando un monitor Holter y, si se detectase una arritmia significativa, deberían recibir tratamiento específico
Antibody-Mediated Rejection in Kidney Transplantation: A Review
Antibody mediated rejection (AMR) poses a significant and continued challenge for long term
graft survival in kidney transplantation. However, in the recent years, there has emerged an
increased understanding of the varied manifestations of the antibody mediated processes in
kidney transplantation. In this article, we briefly discuss the various histopathological and clinical
manifestations of AMRs, along with describing the techniques and methods which have made it
easier to define and diagnose these rejections. We also review the emerging issues of C4d
negative AMR, its significance in long term allograft survival and provide a brief summary of the
current management strategies for managing AMRs in kidney transplantation
Outcomes of Adult Intestinal Transplant Recipients Requiring Dialysis and Renal Transplantation
Background: Data on dialysis and renal transplantation (RT) after intestinal transplantation (IT) are sparse. Whether changes in immunosuppression and surgical techniques have modified these outcomes is unknown. Methods: Two hundred eighty-eight adult intestinal transplants performed between 1990 and 2014 at the University of Pittsburgh were analyzed for incidence, risk factors and outcomes after dialysis and RT. Cohort was divided into 3 eras based on immunosuppression and surgical technique (1990-1994, 1995-2001, and 2001-2014). Receiving RT, or dialysis for 90 days or longer was considered as end-stage renal disease (ESRD). Results: During a median follow-up of 5.7 years, 71 (24.7%) patients required dialysis, 38 (13.2%) required long-term dialysis and 17 (6%) received RT after IT. One-, 3-, and 5-year ESRD risk was 2%, 7%, and 14%, respectively. No significant era-based differences were noted. Higher baseline creatinine (hazard ratio [HR], 3.40 per unit increase, P\u3c0.01) and use of liver containing grafts (HR, 2.01; P = 0.04) had an increased ESRD risk. Median patient survival after dialysis initiation was 6 months, with a 3-year survival of 21%. Any dialysis (HR, 12.74; 95% CI 8.46-19.20; P\u3c0.01) and ESRD (HR, 9.53; 95% CI, 5.87-15.49; P\u3c0.01) had higher mortality after adjusting for covariates. For renal after IT, 1- and 3-year kidney and patient survivals were 70% and 49%, respectively. All graft losses were from death with a functioning graft, primarily related to infectious complications (55%). Conclusions: In intestinal transplant recipients, renal failure requiring dialysis or RT is high and is associated with increased mortality. Additionally, the outcomes for kidney after IT are suboptimal due to death with a functioning graft