Gotyckie wnętrza : zagadnienia stylu i perspektywy

"Niniejszy artykuł powstał w oparciu o szerokie spektrum tekstów źródłowych. Wydaje się to być jedyne słuszne podejście, skoro emblematyczny gotycki potwór, ten któremu już zawsze przypisywać się będzie imię - Frankenstein, również powstał ze zszytych ze sobą, znalezionych w kostnicy fragmentów ciał [...]"

Uncommon causes of ischaemic stroke: how to approach the diagnosis

Stroke is a common neurological emergency and although most cases are associated with traditional vascular risk factors leading to cerebral ischaemia by well-recognised pathophysiological mechanisms, around 4% of ischaemic strokes are due to rare conditions. These are important to recognise due to their different management, which is often specific and effective, and due to their different prognosis from otherwise cryptogenic ischaemic strokes. We outline a practical approach to identifying uncommon causes of ischaemic stroke by highlighting diagnostic 'red flags' and propose a structured approach to investigating them

Women and Haunted Houses in the Films of Jaume Balagueró: The Nightmares of Presence

Jaume Balagueró has developed a successful resumé of horror films that show a decided preference for the classic Gothic motif of the haunted house and the Gothic heroine who investigates its interior. This paper touches first on the Derridean concept of ‘dreams of presence’ (as theorized by cultural geographer Mitch Rose), in order to propose the ‘nightmares of presence’ in which the relationship, the call to care or commitment, between the subject and the space in which the subject dwells or moves is Gothicised but nonetheless remains to tie the subject to the space concerned. It then focuses on Balagueró’s Los sin nombre, Fragile and [REC] to consider three very different Gothic heroines: the mother of a dead daughter, a nurse in a children’s hospital, and a television reporter. The antagonistic call to care of the ‘nightmare of presence’ will be used to interrogate spatial aspects of the Gothic heroine. Keywords: Jaume Balagueró; haunted house; Spanish Gothic; Spanish horror; Spanish film Jaume Balagueró ha desarrollado un grupo de películas exitosas que demuestra una preferencia hacia el escenario clásico de lo gótico, la casa encantada tanto como la heroína gótica que la investiga. Este ensayo estudia en primer lugar el concepto derrideano de ‘los sueños de presencia’ (según la teoría de geógrafo cultural Mitch Rose), para proponer las ‘pesadillas de presencia’ en que el vínculo, la llamada a compromiso, entre el sujeto y el espacio en que se mueve o que habita, llega a ser gotizado; pero que fija al sujeto en el espacio relevante. El argumento se enfoca en Los sin nombre, Fragile y [REC] para considerar tres heroínas distintas: la madre de una hija muerta, una enfermera en un hospital para niños, y una locutora para un programa televisivo. La llamada antagonista de la pesadilla de presencia se usa para interrogar los aspectos espaciales de la heroína gótica

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Pleasure and historical memory in Spanish Gothic film

This essay argues that scholars of Spanish culture are too ready to assume a reading of Gothic texts in terms of historical memory, or the rectification of injustices that occurred during the Franco era. It suggests that there has been a neglect of the question of the pleasures of reading or viewing the Gothic, even though these pleasures may well undermine the desire to do retrospective justice to the victims of Franco. Using as a case study the film Insensibles (Juan Carlos Medina 2012) this essay proposes some examples of pleasures that serve to disrupt the recuperation of historical memory, and calls for better awareness of the pleasures of genre in analysing relevant texts

Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids

The relationship between nutrient starvation and mitochondrial dynamics is poorly understood. We find that cells facing amino acid starvation display clear mitochondrial fusion as a means to evade mitophagy. Surprisingly, further supplementation of glutamine (Q), leucine (L), and arginine (R) did not reverse, but produced stronger mitochondrial hyperfusion. Interestingly, the hyperfusion response to Q + L + R was dependent upon mitochondrial fusion proteins Mfn1 and Opa1 but was independent of MTORC1. Metabolite profiling indicates that Q + L + R addback replenishes amino acid and nucleotide pools. Inhibition of fumarate hydratase, glutaminolysis, or inosine monophosphate dehydrogenase all block Q + L + R-dependent mitochondrial hyperfusion, which suggests critical roles for the tricarboxylic acid (TCA) cycle and purine biosynthesis in this response. Metabolic tracer analyses further support the idea that supplemented Q promotes purine biosynthesis by serving as a donor of amine groups. We thus describe a metabolic mechanism for direct sensing of cellular amino acids to control mitochondrial fusion and cell fate