Italians' public opinion on road roundabouts: A web based survey

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Factors with the greatest influence on drivers' judgment of roundabouts safety. An analysis based on web survey in Italy

The aim of this paper is to identify the roundabout geometric characteristics affecting the safety perception while the typical maneuvers (entry, circulation, exit) are being carried out. The tool used was an on-line questionnaire, filled out by about 1.650 respondents. Four different dimensionality reduction methods (Cluster Analysis, Correspondence Analysis, Exploratory Factor Analysis and Confirmatory Factor Analysis) were used to analyze the data collected from the survey, in order to examine the key factors affecting the safety perception during the typical roundabout maneuvers. The considerations arising from the final model are the following: 1) the respondents' opinions regarding the safety perception of maneuvers are not preconceived ideas, but they originate from specific safety perceptions due to roundabout geometric configurations; 2) the users prefer definitely single lane roundabouts; this is an important confirmation of most results in the literature; 3) it was quantified the extent of the relationship between the safety perception of the typical roundabout maneuvers and the following aspects: a) maneuver type, b) geometric characteristics of the roundabouts design elements. This is the innovative aspect of the present research whose results have implications regarding theory, infrastructure and the application of new safety technologies. Keywords: Road safety, Statistical analysis, Dimensionality reduction methods, Roundabout design, Driving behavio

Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification

Motivation: Prediction of phenotypes from high-dimensional data is a crucial task in precision biology and medicine. Many technologies employ genomic biomarkers to characterize phenotypes. However, such elements are not sufficient to explain the underlying biology. To improve this, pathway analysis techniques have been proposed. Nevertheless, such methods have shown lack of accuracy in phenotypes classification. Results: Here we propose a novel methodology called MITHrIL (Mirna enrIched paTHway Impact anaLysis) for the analysis of signaling pathways, which has built on top of the work of Tarca et al., 2009. MITHrIL extends pathways by adding missing regulatory elements, such as microRNAs, and their interactions with genes. The method takes as input the expression values of genes and/or microRNAs and returns a list of pathways sorted according to their deregulation degree, together with the corresponding statistical significance (p-values). Our analysis shows that MITHrIL outperforms its competitors even in the worst case. In addition, our method is able to correctly classify sets of tumor samples drawn from TCGA. Availability: MITHrIL is freely available at the following URL: http://alpha.dmi.unict.it/mithril

Del Noce legge Rousseau. La simmetria con Rosmini

- Prefazione #10- Introduzione #12- Prima parte Premessa #70- La funzione mediatrice delle Istituzioni #72- Prove di dialogo: Ugo Spirito e Augusto Del Noce #78- La democrazia e il rapporto Rousseau-Rosmini #90- Contrattualismo, platonismo, protestantesimo #98- Simmetrie tra Rousseau e Gentile nel modello filosofico di Del Noce #106- Del Noce e l’elemento platonico di Rousseau #124- Rousseau: il male nel corpo sociale #130- Considerazioni conclusive #134- Seconda parte Il Rousseau di Augusto del Noce #138- Status naturae purae e secolarizzazione: Cartesio e Rousseau #162- L’ambivalenza filosofica di Rousseau #196- Il pensiero politico di Antonio Rosmini Serbati una bibliografia Sara Capelli #274- Bibliografia del volume #284- Indice dei nomi #30

Karyomorphology, heterochromatin patterns and evolution in the genus Ophrys (Orchidaceae)

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Candidate Acetic Acid Bacteria Strains for Levan Production

In this study, twelve strains of acetic acid bacteria (AAB) belonging to five different genera were tested for their ability to produce levan, at 70 and 250 g/L of sucrose concentration, respectively. The fructan produced by the bacterial strains was characterized as levan by NMR spectroscopy. Most of the strains produced levan, highlighting intra- and inter-species variability. High yield was observed for Neoasaia chiangmaiensis NBRC 101099 T, Kozakia baliensis DSM 14400 T and Gluconobacter cerinus DSM 9533 T at 70 g/L of sucrose. A 12-fold increase was observed for N. chiangmaiensis NBRC 101099 T at 250 g/L of sucrose concentration. Levan production was found to be affected by glucose accumulation and pH reduction, especially in Ko. baliensis DSM 14400 T. All the Gluconobacter strains showed a negative correlation with the increase in sucrose concentration. Among strains of Komagataeibacter genus, no clear effect of sucrose on levan yield was found. Results obtained in this study highlighted the differences in levan yield among AAB strains and showed interdependence between culture conditions, carbon source utilization, and time of incubation. On the contrary, the levan yield was not always related to the sucrose concentration

NETME: on-the-fly knowledge network construction from biomedical literature

Background: The rapidly increasing biological literature is a key resource to automatically extract and gain knowledge concerning biological elements and their relations. Knowledge Networks are helpful tools in the context of biological knowledge discovery and modeling. Results: We introduce a novel system called NETME, which, starting from a set of full-texts obtained from PubMed, through an easy-to-use web interface, interactively extracts biological elements from ontological databases and then synthesizes a network inferring relations among such elements. The results clearly show that our tool is capable of inferring comprehensive and reliable biological networks

Cosesimic liquefaction phenomena from DInSAR after the May 20, 2012 Emilia earthquake

In this paper, we have investigated the capability of Differential Interferometry Synthetic Aperture Radar (DInSAR) technique to detect the ground effects induced by liquefaction phenomena occurred during the May 20, 2012 Emilia earthquake. To this aim, a set of COSMO-SkyMed (CSK) SAR images covering the coseismic phase has been used. The detected surface effects have been related to liquefaction of deep sandy layers. Thanks to the geological/geotechnical data in the area and a liquefaction susceptibility analysis of the subsoil, it has been identified a sandy layer between 9 and 13 m in deep, which probably liquefied during the earthquake. The estimated vertical displacements due to liquefaction are comparable with the values measured by DInSAR.Published5-95T. Sismologia, geofisica e geologia per l'ingegneria sismicaN/A or not JC

"Diagnosis on the Dock" project: A proactive screening program for diagnosing pulmonary tuberculosis in disembarking refugees and new SEI model.

Abstract Objective From 2011 to 2017, the total number of refugees arriving in Europe, particularly in Italy, climbed dramatically. Our aim was to diagnose pulmonary TB in migrants coming from the African coast using a clinical-based port of arrival (PoA) screening program. Methods From 2016 to 2018, migrants coming via the Mediterranean Route were screened for body temperature and the presence of cough directly on the dock: if they were feverish with productive cough, their sputum was examined with NAAT; with a dry cough, they underwent Chest-X-ray (CXR). Those migrants with positive NAAT or CXR suggestive for TB were admitted to our ward. In addition, we plotted an SEI simulation of our project to evaluate the epidemiological impact of our screening. Results Out of 33.676 disembarking migrants, 314 (0.9%) had fever and cough: 80 (25.47%) with productive cough underwent NAAT in sputum, and 16 were positive for TB; 234 (74.52%) with dry cough had a CXR examination, and 39 were suggestive of TB, later confirmed by mycobacterial culture. The SEI-new model analysis demonstrated that our screening program significantly reduced TB spreading all over the country. Conclusions For possible future high migrant flows, PoA screening for TB has to be considered feasible and effective in decreasing TB spreading