2,198 research outputs found

    Students Learned Lessons Well

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    Editor’s note: It’s clear that one of the many lessons Charlotte Filer ’54 taught her students was accuracy, accuracy, accuracy. And a number of them caught an error in the last issue of Linfield Magazine. Marvin Henberg wrote that “journalism became a separate major in 1970.” Many readers with journalism degrees prior to that time wrote to protest this date, the result of a typographical error which we regret. The actual date for the journalism major was 1950. As is the case with many Linfield professors, Filer gave her students much more than just class time. She became an integral part of their lives and careers and many remain in touch with her to this day

    Identifying as author: exploring the pedagogical basis for assisting diverse students to discover their identities through creatively defined literacy narratives

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    This thesis explores the current discourse surrounding the redefinition of concepts such as text and authorship in the field of composition studies. Drawing from scholarship on topics ranging from multi-modal composition to feminist historical-appropriation, the author builds a case for redefining these concepts to include a broader range of texts and author-voices from which instructors can draw for course readings. By focusing on the particular instance of selecting readings to teach a literacy narrative unit in a first year college composition course, the author shows how redefining and broadening concepts of text and authorship may allow for students to more easily identify with a literary heritage and identify themselves as authors whose literacy-related experiences have something significant to add to the academic conversation. The chapters present a review of literature, introduce methods and processes for teaching a literacy narrative unit in a freshman composition course, offer the reflections of the instructor on teaching the literacy narrative, and justify a process of selecting texts which aren\u27t necessarily identified as literacy narratives as models for student literacy narratives --Leaf iv

    Novel Photodynamic Therapy Agents: Biochemical Analysis

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    Bioinorganic photochemistry is a rapidly advancing research area in the field of bioinorganic chemistry. This project seeks to build upon the growing field by synthesizing and analyzing new photodynamic therapy (PDT) agents. There are three major generations of PDT agents. The first generation consists of chemically modified natural hematoporphyrins, which are not of great interest in the phototherapeutic field due to their low distinguishability between tumor cells and healthy cells, and extended skin photosensitivity in patients. The second generation consists of organic dyes, aromatic hydrocarbons, polypyrolics complexes, and semi-conductors, but is also not of much interest due to the same issues as the first generation. The third generation of PDT agents, the focus of this project, consists of tetrapyrroles and porphyrins. Porphyrins are essential because they can accept many different metals in their core, which result in changes of its properties for both therapeutic and photodynamic purposes. Porphyrins are also found in other biological molecules such as heme, chlorophyll, and vitamin B12. This project specifically focuses on metalloporphyrins encompassing manganese, and if these porphyrins display a high DNA cleavage rate they could be used in place of the first and second generation PDT agents. MnTDCLPP, MnTTFMPP, and MnTECP are the specific metalloporphyrins being analyzed in this project

    ‘Everything I enjoy doing I just couldn’t do’: Biographical disruption for sport-related injury

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    This article draws on interview data with a population of non-elite sport/exercise participants (n = 20) to illustrate the interrelationship between biographical disruption and sport-related injury. It argues that contrary to the significance implied by their lack of prominence on current public health agendas, sport-related injuries can have a devastating personal impact, comparable to the more extreme variants of biographical disruption depicted in the literature on chronic illness. It seeks to explain the apparent incongruence between biophysical severity and subjective assessment of impact, by invoking notions of community normalisation and imagined futures, and identifying the unavailability of what subjects evaluate as effective medical support. These factors combine to problematise the attainment of biographical repair. It further highlights how biographical contingencies such as youthfulness, distinction through exhibiting responsible citizenship and the sense of failure to exert bodily self-management through exercise, perpetuate and escalate both biographical disruption and chronic illness. The paper thus illustrates the aetiological interdependence of biographical disruption and chronic illness as exercisers exacerbate relatively minor ailments due to their reluctance to modify habitual routines

    Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons

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    AbstractThe use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research. We recently demonstrated that in mouse and human sensory neurons, agonists for metabotropic glutamate receptors 2 and 3 (mGluR2/3) reduce membrane hyperexcitability produced by the inflammatory mediator prostaglandin E2(PGE2). Previous rodent studies indicate that mGluR2/3 can also reduce peripheral sensitization by suppressing inflammation-induced sensitization of TRPV1. Whether this observation similarly translates to human sensory neurons has not yet been tested. We found that activation of mGluR2/3 with the agonist APDC suppressed PGE2-induced sensitization of TRPV1 in mouse, but not human, sensory neurons. We also evaluated sensory neuron expression of the gene transcripts for mGluR2 (Grm2), mGluR3 (Grm3), and TRPV1 (Trpv1). The majority ofTrpv1+mouse and human sensory neurons expressedGrm2and/orGrm3, and in both mice and humans,Grm2was expressed in a greater percentage of sensory neurons thanGrm3. Although we demonstrated a functional difference in the modulation of TRPV1 sensitization by mGluR2/3 activation between mouse and human, there were no species differences in the gene transcript colocalization of mGluR2 or mGluR3 with TRPV1 that might explain this functional difference. Taken together with our previous work, these results suggest that mGluR2/3 activation suppresses only some aspects of human sensory neuron sensitization caused by PGE2. These differences have implications for potential healthy human voluntary studies or clinical trials evaluating the analgesic efficacy of mGluR2/3 agonists or positive allosteric modulators.</jats:p

    Two-way air-sea coupling : A study of the adriatic

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    Abstract High-resolution numerical simulations of the Adriatic Sea using the Navy Coastal Ocean Model (NCOM) and Coupled Ocean–Atmosphere Mesoscale Prediction System (COAMPS) were conducted to examine the impact of the coupling strategy (one versus two way) on the ocean and atmosphere model skill, and to elucidate dynamical aspects of the coupled response. Simulations for 23 September–23 October 2002 utilized 2- and 4-km resolution grids for the ocean and atmosphere, respectively. During a strong wind and sea surface cooling event, cold water fringed the west and north coasts in the two-way coupled simulation (where the atmosphere interacted with SST generated by the ocean model) and attenuated by approximately 20% of the cross-basin extension of bora-driven upward heat fluxes relative to the one-way coupled simulation (where the atmosphere model was not influenced by the ocean model). An assessment of model results using remotely sensed and in situ measurements of ocean temperature along with overwater and coastal wind observations showed enhanced skill in the two-way coupled model. In particular, the two-way coupled model produced spatially complex SSTs after the cooling event that compared more favorably (using mean bias and rms error) with satellite multichannel SST (MCSST) and had a stabilizing effect on the atmosphere. As a consequence, mean mixing was suppressed by over 20% in the atmospheric boundary layer and more realistic mean 10-m wind speeds were produced during the monthlong two-way coupled simulation

    The Virtual Leader

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    INTRODUCTION This chapter provides a critical review and evaluation of the idea and practices of the &#39;virtual leader&#39;. Although the issue of virtuality has been taken up in leadership studies in relation to &#39;virtual teams&#39; (see Martins, Gilson and&nbsp;..
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