Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-waves

We propose two electrocardiogram (ECG)-derived markers of T-wave morphological variability in the temporal, dw , and amplitude, da , domains. Two additional markers, d(NL)w and d(NL)a , restricted to measure the non-linear information present within dw and da are also proposed. METHODS: We evaluated the accuracy of the proposed markers in capturing T-wave time and amplitude variations in 3 situations: (1) In a simulated set up with presence of additive Laplacian noise, (2) when modifying the spatio-temporal distribution of electrical repolarization with an electro-physiological cardiac model and (3) in ECG records from healthy subjects undergoing a tilt table test. RESULTS: The metrics dw , da , d(NL)w and d(NL)a followed T-wave time and amplitude induced variations under different levels of noise, were strongly associated with changes in the spatiotemporal dispersion of repolarization, and showed to provide additional information to differences in the heart rate, QT and Tpe intervals, and in the T-wave width and amplitude. CONCLUSION: The proposed ECG-derived markers robustly quantify T-wave morphological variability, being strongly associated with changes in the dispersion of repolarization. SIGNIFICANCE: The proposed ECG-derived markers can help to quantify the variability in the dispersion of ventricular repolarization, showing a great potential to be used as arrhythmic risk predictors in clinical situations

The Mid-Infrared Instrument for the James Webb Space Telescope, V: Predicted Performance of the MIRI Coronagraphs

The imaging channel on the Mid-Infrared Instrument (MIRI) is equipped with four coronagraphs that provide high contrast imaging capabilities for studying faint point sources and extended emission that would otherwise be overwhelmed by a bright point-source in its vicinity. Such bright sources might include stars that are orbited by exoplanets and circumstellar material, mass-loss envelopes around post-main-sequence stars, the near-nuclear environments in active galaxies, and the host galaxies of distant quasars. This paper describes the coronagraphic observing modes of MIRI, as well as performance estimates based on measurements of the MIRI flight model during cryo-vacuum testing. A brief outline of coronagraphic operations is also provided. Finally, simulated MIRI coronagraphic observations of a few astronomical targets are presented for illustration

Understanding herbivore-plant-soil feedbacks to improve grazing management on Mediterranean mountain grasslands

The surface of many European mountain grasslands is decreasing due to global change and extensive grazing stands out as a key tool for their conservation. Sound knowledge of grassland ecosystem functioning and its feedback processes is required to implement sustainable grazing management. This study aimed to understand the effect of different grazing intensities on herbivore-plant-soil feedbacks in Mediterranean mountain grasslands. We estimated spatial distribution of sheep grazing intensity using GPS technology in order to assess the effect of grazing pressure on vegetation and soil properties measured throughout the study area. Our results showed that grazing intensity ranged from 0.06 to 2.85 livestock units / ha, corresponding to a gradient of pasture utilisation rates varying from 2.38% to 45.60% of annual productivity from pasture. Increasing grazing pressure was associated with smaller relative cover and species richness of non-leguminous forbs, while the opposite trends were observed for graminoids. Forage had a greater concentration of N and smaller C:N ratio in more heavily grazed areas. Increasing grazing intensity was also associated with higher values of total soil N, NO3-, NH4+, soil organic carbon, microbial biomass C and activity of ß-glucosidase. Higher litter quality was the main factor explaining greater content of soil organic matter, which favoured both soil microbes and plant productivity. Grazing induced changes in the plant community triggered positive hervibore-plant-soil feedbacks, as they ultimately improved forage quality and productivity, which significantly influenced the pasture preference of free-ranging domestic grazers. Our work showed that grazing management aiming pasture utilisation rates of around 45% is critical in sustaining positive herbivore-plant-soil feedbacks and preserving or enhancing the whole ecosystem functioning in the Mediterranean mountain grasslands studied. © 2021 The Author

New constraints on the dust surrounding HR 4796A

Context. HR 4796A is surrounded by a well-structured and very bright circumstellar disc shaped like an annulus with many interesting features: very sharp inner and outer edges, brightness asymmetries, centre offset, and suspected distortions in the ring. Aims. We aim to constrain the properties of the dust surrounding the star HR 4796A, in particular the grain size and composition. We also want to confirm and refine the morphological parameters derived from previous scattered light observations, and reveal the dust spatial extent in regions unexplored so far due to their proximity to the star. Methods. We have obtained new images in polarised light of the binary system HR 4796A and B in the Ks and L′ band with the NaCo instrument at the Very Large Telescope (VLT). In addition, we revisit two archival data sets obtained in the L′ band with that same instrument and at 2.2 μm with the NICMOS instrument on the Hubble Space Telescope. We analyse these observations with simulations using the radiative transfer code MCFOST to investigate the dust properties. We explore a grid of models with various dust compositions and sizes in a Bayesian approach. Results. We detect the disc in polarised light in the Ks band and reveal for the first time the innermost regions down to 0.3″ along the semi-minor axis. We measure a polarised fraction of 29% ± 8% in the two disc ansae, with a maximum occurring more than 13° westwards from the ansae. A very pronounced brightness asymmetry between the north-west and south-east side is detected. This contradicts the asymmetry previously reported in all images of the disc in unpolarised light at wavelengths smaller than or equal to 2.2 μm and is inconsistent with the predicted scattered light from spherical grains using the Mie theory. Our modelling suggests the north-west side is most likely inclined towards the Earth, contrary to previous conclusions. It shows that the dust is composed of porous aggregates larger than 1 μm

Full Connectivity: Corners, edges and faces

We develop a cluster expansion for the probability of full connectivity of high density random networks in confined geometries. In contrast to percolation phenomena at lower densities, boundary effects, which have previously been largely neglected, are not only relevant but dominant. We derive general analytical formulas that show a persistence of universality in a different form to percolation theory, and provide numerical confirmation. We also demonstrate the simplicity of our approach in three simple but instructive examples and discuss the practical benefits of its application to different models.Comment: 28 pages, 8 figure

Review of high-contrast imaging systems for current and future ground- and space-based telescopes I. Coronagraph design methods and optical performance metrics

The Optimal Optical Coronagraph (OOC) Workshop at the Lorentz Center in September 2017 in Leiden, the Netherlands gathered a diverse group of 25 researchers working on exoplanet instrumentation to stimulate the emergence and sharing of new ideas. In this first installment of a series of three papers summarizing the outcomes of the OOC workshop, we present an overview of design methods and optical performance metrics developed for coronagraph instruments. The design and optimization of coronagraphs for future telescopes has progressed rapidly over the past several years in the context of space mission studies for Exo-C, WFIRST, HabEx, and LUVOIR as well as ground-based telescopes. Design tools have been developed at several institutions to optimize a variety of coronagraph mask types. We aim to give a broad overview of the approaches used, examples of their utility, and provide the optimization tools to the community. Though it is clear that the basic function of coronagraphs is to suppress starlight while maintaining light from off-axis sources, our community lacks a general set of standard performance metrics that apply to both detecting and characterizing exoplanets. The attendees of the OOC workshop agreed that it would benefit our community to clearly define quantities for comparing the performance of coronagraph designs and systems. Therefore, we also present a set of metrics that may be applied to theoretical designs, testbeds, and deployed instruments. We show how these quantities may be used to easily relate the basic properties of the optical instrument to the detection significance of the given point source in the presence of realistic noise.Comment: To appear in Proceedings of the SPIE, vol. 1069

L'-band AGPM vector vortex coronagraph's first light on LBTI/LMIRCam

We present the first observations obtained with the L'-band AGPM vortex coronagraph recently installed on LBTI/LMIRCam. The AGPM (Annular Groove Phase Mask) is a vector vortex coronagraph made from diamond subwavelength gratings. It is designed to improve the sensitivity and dynamic range of high-resolution imaging at very small inner working angles, down to 0.09 arcseconds in the case of LBTI/LMIRCam in the L' band. During the first hours on sky, we observed the young A5V star HR\,8799 with the goal to demonstrate the AGPM performance and assess its relevance for the ongoing LBTI planet survey (LEECH). Preliminary analyses of the data reveal the four known planets clearly at high SNR and provide unprecedented sensitivity limits in the inner planetary system (down to the diffraction limit of 0.09 arcseconds).Comment: 9 pages, 4 figures, SPIE proceeding

Age norms for grating acuity and contrast sensitivity in children using eye tracking technology

Key messages: Visual acuity is the most used method to assess visual function in children. Contrast sensitivity complements the information provided for visual acuity, but it is not commonly used in clinical practice. Digital devices are increasingly used as a method to evaluate visual function, due to multiple advantages. Testing with these devices can improve the evaluation of visual development in children from a few months of age. Visual acuity and contrast sensitivity tests, using eye tracking technology, are able to measure visual function in children across a wide range of ages, objectively, quickly and without need of an experienced examiner. Purpose: To report age-normative values for grating visual acuity and contrast sensitivity in healthy children using a digital device with eye tracking technology and to validate the grating acuity test. Methods: In the first project of the study, we examined healthy children aged between 6 months and 7 years with normal ophthalmological assessment. Grating visual acuity (VA) and contrast sensitivity (CS) were assessed using a preferential gaze paradigm with a DIVE (Device for an Integral Visual Examination) assisted with eye tracking technology to provide age norms. For the validation project, we compared LEA grating test (LGT) with DIVE VA in a group of children aged between 6 months and 4 years with normal and abnormal visual development. Results: Fifty-seven children (2.86 ± 1.55 years) were examined with DIVE VA test and 44 successfully completed DIVE CS test (3.06 ± 1.41 years). Both, VA and CS values increased with age, mainly along the first two years of life. Sixty-nine patients (1.34 ± 0.61 years) were included in the DIVE VA test validation. The mean difference between LGT and DIVE VA was − 1.05 ± 4.54 cpd with 95% limits of agreement (LoA) of − 9.95–7.84 cpd. Agreement between the two tests was higher in children younger than 1 year with a mean difference of − 0.19 ± 4.02 cpd. Conclusions: DIVE is an automatic, objective and reliable tool to assess several visual function parameters in children, and it has good agreement with classical VA tests, especially for the first stage of life