683 research outputs found
Lamb Wave Modes in Coal-Tar-Coated Steel Plates
In order to study the feasibility of using ultrasonic Lamb wave modes for detection and sizing of corrosion-related flaws in buried steel pipelines, we have calculated Lamb wave modes and performed numerous experiments on steel plates coated on one side with coal-tar enamel. The purpose of this paper is to discuss these theoretical and experimental results
Luminescent Ruthenium(II) Polypyridyl Functionalized Gold Nanoparticles; Their DNA Binding Abilities and Application As Cellular Imaging Agents
The synthesis and photophysical and biological
investigation of Ru(II)-polypyridyl stabilized watersoluble,
luminescent gold nanoparticles (AuNPs) are described.
These structures bind to DNA and undergo rapid
cellular uptake, being localized within the cell cytoplasm and
nucleus within 4 h
Target and beam-target spin asymmetries in exclusive pion electroproduction for Q2>1GeV2 . I. ep→eπ+n
Beam-target double-spin asymmetries and target single-spin asymmetries were measured for the exclusive
π
+
electroproduction reaction
γ
∗
p
→
n
π
+
. The results were obtained from scattering of 6-GeV longitudinally polarized electrons off longitudinally polarized protons using the CEBAF Large Acceptance Spectrometer at Jefferson Laboratory. The kinematic range covered is
1.1
<
W
<
3
GeV and
1
<
Q
2
<
6
GeV
2
. Results were obtained for about 6000 bins in
W
,
Q
2
,
cos
(
θ
∗
)
, and
ϕ
∗
. Except at forward angles, very large target-spin asymmetries are observed over the entire
W
region. Reasonable agreement is found with phenomenological fits to previous data for
W
<
1.6
GeV, but very large differences are seen at higher values of
W
. A generalized parton distributions (GPD)-based model is in poor agreement with the data. When combined with cross-sectional measurements, the present results provide powerful constraints on nucleon resonance amplitudes at moderate and large values of
Q
2
, for resonances with masses as high as 2.4 GeV
Further evidence of Fukutin mutations as a cause of childhood onset limb-girdle muscular dystrophy without mental retardation
JLab Measurement of the He Charge Form Factor at Large Momentum Transfers
The charge form factor of ^4He has been extracted in the range 29 fm
fm from elastic electron scattering, detecting He
nuclei and electrons in coincidence with the High Resolution Spectrometers of
the Hall A Facility of Jefferson Lab. The results are in qualitative agreement
with realistic meson-nucleon theoretical calculations. The data have uncovered
a second diffraction minimum, which was predicted in the range of this
experiment, and rule out conclusively long-standing predictions of dimensional
scaling of high-energy amplitudes using quark counting.Comment: 4 pages, 2 figure
Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico = picolinate) (4), [(η 6-p-cym)RuCl(dap)] + (p-cym = p-cymene) (5), and [(η 6-p-cym)RuCl(imidazole-CO 2H)(PPh 3)] + (6), were synthesized by using a solid-phase approach. Conjugates 3-5 readily underwent hydrolysis and DNA binding, whereas conjugate 6 was inert to ligand substitution. NMR spectroscopy and molecular dynamics calculations showed that conjugate formation does not perturb the overall peptide structure. Only 6 exhibited antiproliferative activity in human tumor cells (IC 50 = 63 ± 2 μ in MCF-7 cells and IC 50 = 26 ± 3 μ in DU-145 cells) with active participation of somatostatin receptors in cellular uptake. Similar cytotoxic activity was found in a normal cell line (IC 50 = 45 ± 2.6 μ in CHO cells), which can be attributed to a similar level of expression of somatostatin subtype-2 receptor. These studies provide new insights into the effect of receptor-binding peptide conjugation on the activity of metal-based anticancer drugs, and demonstrate the potential of such hybrid compounds to target tumor cells specifically. © 2012 American Chemical Society
Polarization transfer in wide-angle Compton scattering and single-pion photoproduction from the proton
Wide-angle exclusive Compton scattering and single-pion photoproduction from the proton have been investigated via measurement of the polarization transfer from a circularly polarized photon beam to the recoil proton. The wide-angle Compton scattering polarization transfer was analyzed at an incident photon energy of 3.7 GeV at a proton scattering angle of θpcm=70°. The longitudinal transfer KLL, measured to be 0.645±0.059±0.048, where the first error is statistical and the second is systematic, has the same sign as predicted for the reaction mechanism in which the photon interacts with a single quark carrying the spin of the proton. However, the observed value is ∼3 times larger than predicted by the generalized-parton-distribution-based calculations, which indicates a significant unknown contribution to the scattering amplitude
Recoil Polarization Measurements of the Proton Electromagnetic Form Factor Ratio to Q^2 = 8.5 GeV^2
Among the most fundamental observables of nucleon structure, electromagnetic
form factors are a crucial benchmark for modern calculations describing the
strong interaction dynamics of the nucleon's quark constituents; indeed, recent
proton data have attracted intense theoretical interest. In this letter, we
report new measurements of the proton electromagnetic form factor ratio using
the recoil polarization method, at momentum transfers Q2=5.2, 6.7, and 8.5
GeV2. By extending the range of Q2 for which GEp is accurately determined by
more than 50%, these measurements will provide significant constraints on
models of nucleon structure in the non-perturbative regime
Measurement of Exclusive Electroproduction Structure Functions and their Relationship to Transversity GPDs
Exclusive electroproduction at a beam energy of 5.75 GeV has been
measured with the Jefferson Lab CLAS spectrometer. Differential cross sections
were measured at more than 1800 kinematic values in , , , and
, in the range from 1.0 to 4.6 GeV,\ up to 2 GeV,
and from 0.1 to 0.58. Structure functions and were extracted as functions of for each of
17 combinations of and . The data were compared directly with two
handbag-based calculations including both longitudinal and transversity GPDs.
Inclusion of only longitudinal GPDs very strongly underestimates and fails to account for and ,
while inclusion of transversity GPDs brings the calculations into substantially
better agreement with the data. There is very strong sensitivity to the
relative contributions of nucleon helicity flip and helicity non-flip
processes. The results confirm that exclusive electroproduction offers
direct experimental access to the transversity GPDs.Comment: 6 pages, 2 figure
A precise extraction of the induced polarization in the 4He(e,e'p)3H reaction
We measured with unprecedented precision the induced polarization Py in
4He(e,e'p)3H at Q^2 = 0.8 (GeV/c)^2 and 1.3 (GeV/c)^2. The induced polarization
is indicative of reaction-mechanism effects beyond the impulse approximation.
Our results are in agreement with a relativistic distorted-wave impulse
approximation calculation but are over-estimated by a calculation with strong
charge-exchange effects. Our data are used to constrain the strength of the
spin independent charge-exchange term in the latter calculation.Comment: submitted to Physical Review Letter
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