Blazar surveys with WMAP and Swift

We present the preliminary results from two new surveys of blazars that have direct implications on the GLAST detection of extragalactic sources from two different perspectives: microwave selection and a combined deep X-ray/radio selection. The first one is a 41 GHz flux-limited sample extracted from the WMAP 3-yr catalog of microwave point sources. This is a statistically well defined sample of about 200 blazars and radio galaxies, most of which are expected to be detected by GLAST. The second one is a new deep survey of Blazars selected among the radio sources that are spatially coincident with serendipitous sources detected in deep X-ray images (0.3-10 keV) centered on the Gamma Ray Bursts (GRB) discovered by the Swift satellite. This sample is particularly interesting from a statistical viewpoint since a) it is unbiased as GRBs explode at random positions in the sky, b) it is very deep in the X-ray band (\fx \simgt $10^{-15}$ \ergs) with a position accuracy of a few arc-seconds, c) it will cover a fairly large (20-30 square deg.) area of sky, d) it includes all blazars with radio flux (1.4 GHz) larger than 10 mJy, making it approximately two orders of magnitude deeper than the WMAP sample and about one order of magnitude deeper than the deepest existing complete samples of radio selected blazars, and e) it can be used to estimate the amount of unresolved GLAST high latitude gamma-ray background and its anisotropy spectrum.Comment: 3 pages, 3 figures, to appear in Proc. of the 1st GLAST Symposium, Feb 5-8, 2007, Stanford, AIP, Eds. S. Ritz, P. F. Michelson, and C. Meega

The multi-phase winds of Markarian 231: from the hot, nuclear, ultra-fast wind to the galaxy-scale, molecular outflow

We present the best sensitivity and angular resolution maps of the molecular disk and outflow of Mrk 231, as traced by CO observations obtained with IRAM/PdBI, and we analyze archival Chandra and NuSTAR observations. We constrain the physical properties of both the molecular disk and outflow, the presence of a highly-ionized ultra-fast nuclear wind, and their connection. The molecular outflow has a size of ~1 kpc, and extends in all directions around the nucleus, being more prominent along the south-west to north-east direction, suggesting a wide-angle biconical geometry. The maximum projected velocity of the outflow is nearly constant out to ~1 kpc, thus implying that the density of the outflowing material decreases from the nucleus outwards as $r^{-2}$. This suggests that either a large part of the gas leaves the flow during its expansion or that the bulk of the outflow has not yet reached out to ~1 kpc, thus implying a limit on its age of ~1 Myr. We find $\dot M_{OF}=[ 500-1000]~ M_{\odot}~yr^{-1}$ and $\dot E_{kin,OF}=[7-10]\times 10^{43}$ erg s$^{-1}$. Remarkably, our analysis of the X-ray data reveals a nuclear ultra-fast outflow (UFO) with velocity -20000 km s$^{-1}$, $\dot M_{UFO}=[0.3- 2.1] ~M_\odot yr^{-1}$, and momentum load $\dot P_{UFO}/\dot P_{rad}=[0.2-1.6]$.We find $\dot E_{kin,UFO}\sim \dot E_{kin,OF}$ as predicted for outflows undergoing an energy conserving expansion. This suggests that most of the UFO kinetic energy is transferred to mechanical energy of the kpc-scale outflow, strongly supporting that the energy released during accretion of matter onto super-massive black holes is the ultimate driver of giant massive outflows. We estimate a momentum boost $\dot P_{OF}/\dot P_{UFO}\approx [30-60]$. The ratios $\dot E_{kin, UFO}/L_{bol,AGN} =[ 1-5]\%$ and $\dot E_{kin,OF}/L_{bol,AGN} = [1-3]\%$ agree with the requirements of the most popular models of AGN feedback.Comment: 16 pages, 17 figures. Accepted for publication in A&

Long non-coding RNAs play a role in the pathogenesis of psoriatic arthritis by regulating microRNAs and genes involved in inflammation and metabolic syndrome

Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10-30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, driven by autoreactive T cells directed against autoantigens present in the skin and in the joints. However, an autoinflammatory origin has recently been proposed. Long noncoding RNAs (lncRNAs) are RNAs more than 200 nucleotides in length that do not encode proteins. LncRNAs play important roles in several biological processes, including chromatin remodeling, transcription control, and post-transcriptional processing. Several studies have shown that lncRNAs are expressed in a stage-specific or lineage-specific manner in immune cells that have a role in the development, activation, and effector functions of immune cells. LncRNAs are thought to play a role in several diseases, including autoimmune disorders. Indeed, a few lncRNAs have been identified in systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. Although several high-throughput studies have been performed to identify lncRNAs, their biological and pathological relevance are still unknown, and most transcriptome studies in autoimmune diseases have only assessed protein-coding transcripts. No data are currently available on lncRNAs in PsA. Therefore, by microarray analysis, we have investigated the expression profiles of more than 50,000 human lncRNAs in blood samples from PsA patients and healthy controls using Human Clariom D Affymetrix chips, suitable to detect rare and low-expressing transcripts otherwise unnoticed by common sequencing methodologies. Network analysis identified lncRNAs targeting highly connected genes in the PsA transcriptome. Such genes are involved in molecular pathways crucial for PsA pathogenesis, including immune response, glycolipid metabolism, bone remodeling, type 1 interferon, wingless related integration site, and tumor necrosis factor signaling. Selected lncRNAs were validated by RT-PCR in an expanded cohort of patients. Moreover, modulated genes belonging to meaningful pathways were validated by RT-PCR in PsA PBMCs and/or by ELISA in PsA sera. The findings indicate that lncRNAs are involved in PsA pathogenesis by regulating both microRNAs and genes and open new avenues for the identification of new biomarkers and therapeutical targets

Unveiling obscured accretion in the Chandra Deep Field South

A large population of heavily obscured, Compton Thick AGNs is predicted by models of galaxy formation, models of Cosmic X-ray Background and by the ``relic'' super-massive black-hole mass function measured from local bulges. However, so far only a handful of Compton thick AGNs have been possibly detected using even the deepest Chandra and XMM surveys. Compton-thick AGNs can be recovered thanks to the reprocessing of the AGN UV emission in the infrared by selecting sources with AGN luminosity's in the mid-infrared and faint near-infrared and optical emission. To this purpose, we make use of deep HST, VLT, Spitzer and Chandra data on the Chandra Deep Field South to constrain the number of Compton thick AGN in this field. We show that sources with high 24$\mu$m to optical flux ratios and red colors form a distinct source population, and that their infrared luminosity is dominated by AGN emission. Analysis of the X-ray properties of these extreme sources shows that most of them (80$\pm15$) are indeed likely to be highly obscured, Compton thick AGNs. The number of infrared selected, Compton thick AGNs with 5.8$\mu$m luminosity higher than $10^{44.2}$ erg s$^{-1}$ turns out to be similar to that of X-ray selected, unobscured and moderately obscured AGNs with 2-10 keV luminosity higher than $10^{43}$ erg s$^{-1}$ in the redshift bin 1.2-2.6. This ``factor of 2'' source population is exactly what it is needed to solve the discrepancies between model predictions and X-ray AGN selection.Comment: Revised version, to be published by The Astrophysical Journa

NuSTAR and multifrequency study of the two high-redshift blazars S5 0836+710 and PKS 2149-306

The most powerful blazars are the flat spectrum radio quasars whose emission is dominated by a Compton component peaking between a few hundred keV and a few hundred MeV. We selected two bright blazars, PKS 2149-306 at redshift z=2.345 and S5 0836+710 at z=2.172, in order to observe them in the hard X-ray band with the NuSTAR satellite. In this band the Compton component is rapidly rising almost up to the peak of the emission. Simultaneous soft-X-rays and UV-optical observations were performed with the Swift satellite, while near-infrared (NIR) data were obtained with the REM telescope. To study their variability, we repeated these observations for both sources on a timescale of a few months. While no fast variability was detected during a single observation, both sources were found to be variable in the X-ray band, up to 50%, between the two observations, with larger variability at higher energies. No variability was detected in the optical/NIR band. These data together with Fermi-LAT, WISE and other literature data are then used to study the overall spectral energy distributions (SEDs) of these blazars. Although the jet non-thermal emission dominates the SED, it leaves the UV band unhidden, allowing us to detect the thermal emission of the disc and to estimate the mass of the black hole. The non-thermal emission is well reproduced by a one-zone leptonic model. The non-thermal radiative processes are synchrotron, self-Compton and external Compton using seed photons from both the broad-line region (BLR) and the torus. We find that our data are better reproduced if we assume that the location of the dissipation region of the jet, R_diss, is in-between the torus, (at R_torus), and the BLR (R_torus>R_diss>R_BLR). The observed variability is explained by changing a minimum number of model parameters by a very small amount.Comment: 11 pages, 5 figures, accepted for publication in Ap

Broadband Observations of the Compton-thick Nucleus of NGC 3393

We present new NuSTAR and Chandra observations of NGC 3393, a galaxy reported to host the smallest separation dual AGN resolved in the X-rays. While past results suggested a 150 pc separation dual AGN, three times deeper Chandra imaging, combined with adaptive optics and radio imaging suggest a single, heavily obscured, radio-bright AGN. Using VLA and VLBA data, we find an AGN with a two-sided jet rather than a dual AGN and that the hard X-ray, UV, optical, NIR, and radio emission are all from a single point source with a radius <0.2". We find that the previously reported dual AGN is most likely a spurious detection resulting from the low number of X-ray counts (<160) at 6-7 keV and Gaussian smoothing of the data on scales much smaller than the PSF (0.25" vs. 0.80" FWHM). We show that statistical noise in a single Chandra PSF generates spurious dual peaks of the same separation (0.55$\pm$0.07" vs. 0.6") and flux ratio (39$\pm$9% vs. 32% of counts) as the purported dual AGN. With NuSTAR, we measure a Compton-thick source (NH=$2.2\pm0.4\times10^{24}$ cm$^{-2}$) with a large torus half-opening angle, {\theta}=79 which we postulate results from feedback from strong radio jets. This AGN shows a 2-10 keV intrinsic to observed flux ratio of 150. Using simulations, we find that even the deepest Chandra observations would severely underestimate the intrinsic luminosity of NGC 3393 above z>0.2, but would detect an unobscured AGN of this luminosity out to high redshift (z=5).Comment: Accepted for publication in ApJ. 15 Figures and 4 table

Detailed Shape and Evolutionary Behavior of the X-ray Luminosity Function of Active Galactic Nuclei

We construct the rest-frame 2--10 keV intrinsic X-ray luminosity function of Active Galactic Nuclei (AGNs) from a combination of X-ray surveys from the all-sky Swift BAT survey to the Chandra Deep Field-South. We use ~3200 AGNs in our analysis, which covers six orders of magnitude in flux. The inclusion of the XMM and Chandra COSMOS data has allowed us to investigate the detailed behavior of the XLF and evolution. In deriving our XLF, we take into account realistic AGN spectrum templates, absorption corrections, and probability density distributions in photometric redshift. We present an analytical expression for the overall behavior of the XLF in terms of the luminosity-dependent density evolution, smoothed two power-law expressions in 11 redshift shells, three-segment power-law expression of the number density evolution in four luminosity classes, and binned XLF. We observe a sudden flattening of the low luminosity end slope of the XLF slope at z>~0.6. Detailed structures of the AGN downsizing have been also revealed, where the number density curves have two clear breaks at all luminosity classes above log LX>43. The two break structure is suggestive of two-phase AGN evolution, consisting of major merger triggering and secular processes.Comment: 39 Pages, 9 figures. ApJ in pres

The 2-79 keV X-ray Spectrum of the Circinus Galaxy with NuSTAR, XMM-Newton and Chandra: a Fully Compton-Thick AGN

The Circinus galaxy is one of the nearest obscured AGN, making it an ideal target for detailed study. Combining archival Chandra and XMM-Newton data with new NuSTAR observations, we model the 2-79 keV spectrum to constrain the primary AGN continuum and to derive physical parameters for the obscuring material. Chandra's high angular resolution allows a separation of nuclear and off-nuclear galactic emission. In the off-nuclear diffuse emission we find signatures of strong cold reflection, including high equivalent-width neutral Fe lines. This Compton-scattered off-nuclear emission amounts to 18% of the nuclear flux in the Fe line region, but becomes comparable to the nuclear emission above 30 keV. The new analysis no longer supports a prominent transmitted AGN component in the observed band. We find that the nuclear spectrum is consistent with Compton-scattering by an optically-thick torus, where the intrinsic spectrum is a powerlaw of photon index $\Gamma = 2.2-2.4$, the torus has an equatorial column density of $N_{\rm H} = (6-10)\times10^{24}$cm$^{-2}$ and the intrinsic AGN $2-10$ keV luminosity is $(2.3-5.1)\times 10^{42}$ erg/s. These values place Circinus along the same relations as unobscured AGN in accretion rate-vs-$\Gamma$ and $L_X$-vs-$L_{IR}$ phase space. NuSTAR's high sensitivity and low background allow us to study the short time-scale variability of Circinus at X-ray energies above 10 keV for the first time. The lack of detected variability favors a Compton-thick absorber, in line with the the spectral fitting results.Comment: Accepted for publication in Ap