Transcriptome analysis of Dnmt3l knock-out mice derived multipotent mesenchymal stem/stromal cells during osteogenic differentiation

Multipotent mesenchymal stem/stromal cells (MSCs) exhibit great potential for cell-based therapy. Proper epigenomic signatures in MSCs are important for the maintenance and the subsequent differentiation potential. The DNA methyltransferase 3-like (DNMT3L) that was mainly expressed in the embryonic stem (ES) cells and the developing germ cells plays an important role in shaping the epigenetic landscape. Here, we report the reduced colony forming ability and impaire

Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice

We examined the molecular basis of virulence of pandemic H1N1/09 influenza viruses by reverse genetics based on two H1N1/09 virus isolates (A/California/04/2009 [CA04] and A/swine/Shandong/731/2009 [SD731]) with contrasting pathogenicities in mice. We found that four amino acid mutations (P224S in the PA protein [PA-P224S], PB2-T588I, NA-V106I, and NS1-I123V) contributed to the lethal phenotype of SD731. In particular, the PA-P224S mutation when combined with PA-A70V in CA04 drastically reduced the virus's 50% mouse lethal dose (LD50), by almost 1,000-fold

Search for C-parity violation in J/ψ→γγJ/ \psi \to \gamma\gamma and γϕ \gamma \phi

Using $1.06\times10^8$ $\psi(3686)$ events recorded in $e^{+}e^{-}$ collisions at $\sqrt{s}=$ 3.686 GeV with the BESIII at the BEPCII collider, we present searches for C-parity violation in $J/\psi \to \gamma\gamma$ and $\gamma \phi$ decays via $\psi(3686) \to J/\psi \pi^+\pi^-$. No significant signals are observed in either channel. Upper limits on the branching fractions are set to be $\mathcal{B}(J/\psi \to \gamma\gamma) < 2.7 \times 10^{-7}$ and $\mathcal{B}(J/\psi \to \gamma\phi) < 1.4 \times 10^{-6}$ at the 90\% confidence level. The former is one order of magnitude more stringent than the previous upper limit, and the latter represents the first limit on this decay channel.Comment: 7 pages, 2 figure

Measurement of the proton form factor by studying e+e−→ppˉe^{+} e^{-}\rightarrow p\bar{p}

Using data samples collected with the BESIII detector at the BEPCII collider, we measure the Born cross section of $e^{+}e^{-}\rightarrow p\bar{p}$ at 12 center-of-mass energies from 2232.4 to 3671.0 MeV. The corresponding effective electromagnetic form factor of the proton is deduced under the assumption that the electric and magnetic form factors are equal $(|G_{E}|= |G_{M}|)$. In addition, the ratio of electric to magnetic form factors, $|G_{E}/G_{M}|$, and $|G_{M}|$ are extracted by fitting the polar angle distribution of the proton for the data samples with larger statistics, namely at $\sqrt{s}=$ 2232.4 and 2400.0 MeV and a combined sample at $\sqrt{s}$ = 3050.0, 3060.0 and 3080.0 MeV, respectively. The measured cross sections are in agreement with recent results from BaBar, improving the overall uncertainty by about 30\%. The $|G_{E}/G_{M}|$ ratios are close to unity and consistent with BaBar results in the same $q^{2}$ region, which indicates the data are consistent with the assumption that $|G_{E}|=|G_{M}|$ within uncertainties.Comment: 13 pages, 24 figure

Observation of the ψ(13D2)\psi(1^3D_2) state in e+e−→π+π−γχc1e^+e^-\to\pi^+\pi^-\gamma\chi_{c1} at BESIII

We report the observation of the $X(3823)$ in the process $e^+e^-\to \pi^+\pi^-X(3823) \to \pi^+\pi^-\gamma\chi_{c1}$ with a statistical significance of $6.2\sigma$, in data samples at center-of-mass energies $\sqrt{s}=$4.230, 4.260, 4.360, 4.420 and 4.600~GeV collected with the BESIII detector at the BEPCII electron positron collider. The measured mass of the $X(3823)$ is $(3821.7\pm 1.3\pm 0.7)$~MeV/$c^2$, where the first error is statistical and the second systematic, and the width is less than $16$~MeV at the 90\% confidence level. The products of the Born cross sections for $e^+e^-\to \pi^+\pi^-X(3823)$ and the branching ratio $\mathcal{B}[X(3823)\to \gamma\chi_{c1,c2}]$ are also measured. These measurements are in good agreement with the assignment of the $X(3823)$ as the $\psi(1^3D_2)$ charmonium state.Comment: 7 pages, 3 figures, version to appear in Phys. Rev. Let

Precision measurement of the D∗0D^{*0} decay branching fractions

Using 482 pb$^{-1}$ of data taken at $\sqrt{s}=4.009$ GeV, we measure the branching fractions of the decays of $D^{*0}$ into $D^0\pi^0$ and $D^0\gamma$ to be \BR(D^{*0} \to D^0\pi^0)=(65.5\pm 0.8\pm 0.5)% and \BR(D^{*0} \to D^0\gamma)=(34.5\pm 0.8\pm 0.5)% respectively, by assuming that the $D^{*0}$ decays only into these two modes. The ratio of the two branching fractions is \BR(D^{*0} \to D^0\pi^0)/\BR(D^{*0} \to D^0\gamma) =1.90\pm 0.07\pm 0.05, which is independent of the assumption made above. The first uncertainties are statistical and the second ones systematic. The precision is improved by a factor of three compared to the present world average values

Observation of the Dalitz Decay η′→γe+e−\eta' \to \gamma e^+e^-

We report the first observation of the Dalitz decay $\eta' \to \gamma e^+e^-$, based on a data sample of 1.31 billion $J/\psi$ events collected with the BESIII detector. The $\eta'$ mesons are produced via the $J/\psi \to \gamma \eta'$ decay process. The ratio $\Gamma(\eta' \to \gamma e^+ e^-)/\Gamma(\eta'\to\gamma\gamma)$ is measured to be $(2.13\pm0.09(\text{stat.})\pm0.07(\text{sys.}))\times10^{-2}$. This corresponds to a branching fraction ${\cal B}(\eta' \to \gamma e^+e^-)= (4.69 \pm0.20(\text{stat.})\pm0.23(\text{sys.}))\times10^{-4}$. The transition form factor is extracted and different expressions are compared to the measured dependence on the $e^+e^-$ invariant mass. The results are consistent with the prediction of the Vector Meson Dominance model.Comment: 11 pages,7 figure

Measurement of yCPy_{CP} in D0−D‾0D^0-\overline{D}^0 oscillation using quantum correlations in e+e−→D0D‾0e^+e^-\to D^0\overline{D}^0 at s\sqrt{s} = 3.773\,GeV

We report a measurement of the parameter $y_{CP}$ in \ensuremath{D^0}\xspace-\ensuremath{\overline{D}^{0}}\xspace oscillations performed by taking advantage of quantum coherence between pairs of \ensuremath{D^0}\xspace \ensuremath{\overline{D}^{0}}\xspace mesons produced in $e^+e^-$ annihilations near threshold. In this work, doubly-tagged \ensuremath{D^0}\xspace \ensuremath{\overline{D}^{0}}\xspace events, where one $D$ decays to a $CP$ eigenstate and the other $D$ decays in a semileptonic mode, are reconstructed using a data sample of 2.92\,fb$^{-1}$ collected with the BESIII detector at the center-of-mass energy of $\sqrt{s}$ = 3.773\,GeV. We obtain $y_{CP} = (-2.0\pm1.3\pm0.7)\%$, where the first uncertainty is statistical and the second is systematic. This result is compatible with the current world average.Comment: 13 pages, 3 figure

Search for the isospin violating decay Y(4260)→J/ψηπ0Y(4260)\rightarrow J/\psi \eta \pi^{0}

Using data samples collected at center of mass energies of $\sqrt{s}$ = 4.009, 4.226, 4.257, 4.358, 4.416 and 4.599 GeV with the BESIII detector operating at the BEPCII storage ring, we search for the isospin violating decay $Y(4260)\rightarrow J/\psi \eta \pi^{0}$. No signal is observed, and upper limits on the cross section $\sigma(e^{+}e^{-}\rightarrow J/\psi \eta \pi^{0})$ at the 90\% confidence level are determined to be 3.6, 1.7, 2.4, 1.4, 0.9 and 1.9 pb, respectively.Comment: 7 pages, 2 figure