Sytuacja życiowa rodzeństwa osób z niepełnosprawnością intelektualną

Przedmiotem prezentowanych w niniejszym artykule badań było określenie sytuacji życiowej adolescentów i młodych dorosłych posiadających rodzeństwo z niepełnosprawnością intelektualną. W badaniach uwzględniono perspektywę zdrowych, młodych ludzi oraz ich rodziców. Zastosowano metodę wywiadu. Przebadano 25 osób (16 rodziców oraz 9 adolescentów) pochodzących z województwa łódzkiego. Rezultaty badawcze wyraźnie wskazują na istnienie zbliżonego obrazu życia rodzinnego u badanych adolescentów oraz młodych dorosłych i ich rodziców. Podejmowane próby zaprzeczania, umniejszania wpływu niepełnosprawności jednego z członków rodziny na cały system rodziny przy jednoczesnym idealizowaniu osoby niepełnosprawnego dziecka/rodzeństwa mogą świadczyć o przejawianiu przez badane rodziny mechanizmów obronnych.Udostępnienie publikacji Wydawnictwa Uniwersytetu Łódzkiego finansowane w ramach projektu „Doskonałość naukowa kluczem do doskonałości kształcenia”. Projekt realizowany jest ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Wiedza Edukacja Rozwój; nr umowy: POWER.03.05.00-00-Z092/17-00

Read-across of 90-Day Rat Oral Repeated-Dose Toxicity: A Case Study for Selected 2-Alkyl-1-alkanols

2-Alkyl-1-alkanols offer an example whereby the category approach to read-across can be used to predict repeated-dose toxicity for a variety of derivatives. Specifically, the NOAELs of 125 mg/kg bw/d for 2-ethyl-1-hexanol and 2-propyl-1-heptanol, the source substances, can be read across with confidence to untested 2-alkyl-1-alkanols in the C5 to C13 category based on a LOAEL of low systemic toxicity. These branched alcohols, while non-reactive and exhibiting unspecific, reversible simple anaesthesia or nonpolar narcosis mode of toxic action, have metabolic pathways that have significance to repeated-dose toxic potency. In this case study, the chemical category is limited to the readily bioavailable analogues. The read-across premise includes rapid absorption via the gastrointestinal tract, distribution in the circulatory system and first-pass metabolism in the liver via Phase 2 glucuronidation prior to urinary elimination. 2-Ethyl-1-hexanol and 2-propyl-1-heptanol, the source substances, have high quality 90-day oral repeated-dose toxicity studies (OECD TG 408) that exhibit qualitative and quantitative consistency. Findings include only mild changes consistent with low-grade effects including decreased body weight and slightly increased liver weight, which in some cases is accompanied by clinical chemical and haematological changes but generally without concurrent histopathological effects at the LOAEL. These findings are supported by results from the TG 408 assessment of a semi-defined mixture of isotridecanols. Chemical similarity between the analogues is readily defined and data uncertainty associated with toxicokinetic and toxicodynamics similarities are low. Uncertainty associated with mechanistic relevance and completeness of the read-across is reduced by the concordance of in vivo and in vitro results, as well as high throughput and in silico methods data. As shown in detail, the 90-day rat oral repeated-dose NOAEL values for the two source substances can be read across to fill the data gaps of the untested analogues in this category with uncertainty deemed equivalent to results from a TG 408 assessment

Read-Across for Rat Oral Gavage Repeated-Dose Toxicity for Short-Chain Mono-Alkylphenols: A Case Study

Short-chain mono-alkylphenols provide an example of where a category-approach to read-across may be used to estimate the repeated-dose endpoint for a number of derivatives. Specifically, the NOAELs of 50 mg/kg bw/d for mono-methylphenols based on a LOAEL of very low systemic toxicity can be read across with confidence to untested mono-alkylphenols in the category. These simple alkylphenols are non-reactive and exhibit an unspecific, reversible polar narcosis mode of toxic action. Briefly, polar narcotics act via unspecific, reversible interactions with biological membranes in a manner similar to cataleptic anaesthetics. The read-across premise includes rapid and complete absorption via the gastrointestinal tract, distribution in the circulatory system, first-pass Phase 2 metabolism in the liver, and elimination of sulphates and glucuronides in the urine. Thus, toxicokinetic parameters are considered to be similar and have the same toxicological significance. Five analogues have high quality experimental oral repeated-dose toxicity data (i.e., OECD TG 408 or OECD TG 422). These repeated-dose toxicity test results exhibit qualitative consistency in symptoms. Typical findings include decreased body weight and slightly increased liver and kidney weights which are generally without concurrent histopathological effects. The sub-chronic findings are quantitatively consistent with the No Observed Adverse Effect Level (NOAEL) of ≥ 50 mg/kg bw/d. Chemical similarity between the analogues is readily defined, and data uncertainty associated with the similarities in toxicokinetic properties, as well as toxicodynamic properties, are low. Uncertainty associated with mechanistic relevance and completeness of the read-across is low-to-moderate, largely because there is no adverse outcome pathway or intermediate event data. Uncertainty associated with mechanistic relevance and completeness of the read-across is reduced by the concordance of in vivo, in vitro, USEPA toxicity forecaster (ToxCast) results, as well as the in silico data. The rat oral repeated-dose NOAEL values for the source substances can be read across to fill the data gaps of the untested analogues in this category with uncertainty deemed equivalent to results from a TG 408 assessment

In Silico Prediction of Organ Level Toxicity: Linking Chemistry to Adverse Effects

In silico methods to predict toxicity include the use of (Quantitative) Structure-Activity Relationships ((Q)SARs as well as grouping (category formation) allowing for read-across. A challenging area for in silico modelling is the prediction of chronic toxicity and the No Observed (Adverse) Effect Level (NO(A)EL) in particular. A proposed solution to the prediction of chronic toxicity is to consider organ level effects, as opposed to modelling the NO(A)EL itself. This study has focussed on the use of structural alerts to identify potential liver toxicants. In silico profilers, or groups of structural alerts, were developed based on mechanisms of action and informed by current knowledge of Adverse Outcome Pathways. These profilers are robust and can be coded computationally to allow for prediction. However, they do not cover all mechanisms or modes of liver toxicity and recommendations for the improvement of these approaches are given

Air temperature in Novaya Zemlya Archipelago and Vaygach Island from 1832 to 1920 in the light of early instrumental data

In this article, the results of an investigation into the air temperature conditions in Novaya Zemlya Archipelago and Vaygach Island (NZR) from 1832 to 1920, on the basis of all available early instrumental data gathered during exploratory and scientific expeditions, are presented. Traditional analysis based on mean monthly data was supplemented by an approach less popular in the scientific literature, i.e. the additional use of daily data. Moreover, the daily data used were not limited only to mean daily air temperature, but include also maximum daily temperature, minimum daily temperature and diurnal temperature range. Such rich sets of data allowed for more comprehensive and precise recognition of air temperature conditions in the NZR. Based on these kinds of daily data, it was also possible to calculate the number of so-called ‘characteristic days’ (i.e. the number of days with temperatures exceeding specified thresholds) and day-to-day temperature variability and, for the first time, to determine different characteristics of thermal seasons (duration, onset and end dates) according to Baranowski's (1968) proposition. The results were compared with contemporary temperature conditions (1981–2010) to estimate the range of their changes between historical and present times. Analysis reveals that in 1832–1920, the NZR was markedly colder than today in all seasons. Coldest was autumn (on average by ca 5 °C), and least – summer (by 1.6 °C). Mean annual air temperature was colder than today by about 3 °C. The majority of mean monthly air temperatures in historical times lie within two standard deviations from the modern mean. This means that values of air temperature in historical times lie within the range of contemporary air temperature variability. Different air temperature characteristics calculated on the basis of daily data for the NZR for historical/contemporary periods also confirm the occurrence of climate warming between the studied periods

Air temperature conditions in northern Nordaustlandet (NE Svalbard) at the end of World War II

This article presents the results of an investigation into air temperature conditions in northern Nordaustlandet (NE Svalbard) based on meteorological observations made by German soldiers towards the end of World War II (1944/1945) and 4 months after its end. Traditional analysis using mean monthly data was supplemented by a detailed analysis based on daily data: maximum temperature, minimum temperature and diurnal temperature range. The latter kind of data made it possible to study such aspects of climate as the number of “characteristic days” (i.e., the number of days with temperatures exceeding specified thresholds), dayto-day temperature variability, and duration, onset and end dates of thermal seasons. The results from Nordaustlandet for the warmest period of the early 20th century warming period (ETCWP) were compared with temperature conditions both historical (the end part of the Little Ice Age) and contemporary (different sub-periods taken from the years 1981–2017) to estimate the range of warming during the ETCWP. Analysis reveals that the expedition year 1944/1945 in Nordaustlandet was, in the majority of months, the warmest of all analysed periods, that is, both historical and contemporary periods. The study period was markedly warmer than 1981–2010 (mean annual −6.5 vs. −8.4 °C) but colder than the periods 2011–2016 (−5.7 °C) and 2014–2017 (−5.8 °C). The majority of mean monthly air temperatures in the ETCWP lies within two standard deviations of the modern 2014–2017 mean. This means that values of air temperature in the study period lie within the range of recent temperature variability. All other thermal characteristics show changes in accordance with expectations associated with general warming of the Arctic (i.e., a decrease in diurnal temperature range and number of cold days, and an increase in number of warm days). The latter days were most common in the ETCWP

The influence of atmospheric circulation on the spatial diversity of air temperature in the area of Forlandsundet (NW Spitsbergen) during 2010–2013

The relationship between atmospheric circulation and climate in Svalbard has been described in dozens of studies. However, the data used for that purpose usually came from permanent stations on the coast. The influence of atmospheric circulation on topoclimatic diversity has not been explored so often, and hardly at all for other periods than the Arctic summer. In this article, the relationships between circulation and air temperature are described using daily data sourced from six sites located around Forlandsundet (NW Spitsbergen) during 2010–2013. The analysis was conducted independently for three seasons identified as: winter (Nov–Mar), spring/autumn (Apr–May and Sep–Oct) and summer (Jun–Aug) and also for three air temperature parameters: diurnal mean (Ti), maximum (Tmax) and minimum (Tmin) temperature. The atmospheric circulation in the studied area was described using Tadeusz Niedźwiedź’s classification of diurnal circulation types for Svalbard. The influence of atmospheric circulation on the spatial pattern of air temperature is not uniform across the Forlandsundet region; in particular, important differences were observed between coastal and inland parts of the study area. Thus, generalization of relationships between air temperature and atmospheric circulation for the entire area of Spitsbergen based on data only from coastal stations is not appropriate. The influence of atmospheric circulation on the spatial pattern of air temperature in the Forlandsundet region also changes through the year. In the cold season (Sep–May) it differs significantly from that observed in summer (Jun–Aug), and this feature is also seen in analyses of the 10% highest (≥ 90th percentile) and lowest (≤ 10th percentile) thermal differences. In summer, the influence of atmospheric circulation on air temperature in the topoclimatic scale is definitely less stable than in the cold season

Temporal and spatial variation of surface air temperature over the period of instrumental observations in the Arctic

A detailed analysis of the spatial and temporal changes in mean seasonal and annual surface air temperatures over the period of instrumental observations in the Arctic is presented. In addition, the role of atmospheric circulation in controlling the instrumental and decadal-scale changes of air temperature in the Arctic is investigated. Mean monthly temperature and temperature anomalies data from 37 Arctic, 7 sub-Arctic and 30 grid-boxes were used for analysis. The presented analysis shows that the observed variations in air temperature in the real Arctic (defined on the basis of climatic as opposed to other criteria, e.g. astronomical or botanical) are in many aspects not consistent with the projected climatic changes computed by climatic models for the enhanced greenhouse effect. The highest temperatures since the beginning of instrumental observation occurred clearly in the 1930s and can be attributed to changes in atmospheric circulation. The second phase of contemporary global warming (after 1975) is, at most, weakly marked in the Arctic. For example, the mean rate of warming for the period 1991–1995 was 2–3 times lower in the Arctic than the global average. Temperature levels observed in Greenland in the last 10–20 years are similar to those observed in the 19th century. Increases of temperature in the Arctic are more significant in the warm half-year than in the cold half-year. This seasonal pattern in temperature change confirms the view that positive feedback mechanisms (e.g. sea-ice–albedo– temperature) as yet play only a small role in enhancing temperature in the Arctic. Hypotheses are presented to explain the lack of warming in the Arctic after 1975. It is shown that in some parts of the Arctic atmospheric circulation changes, in particular in the cold half-year, can explain up to 10–50% of the temperature variance. For Arctic temperature, the most important factor is a change in the atmospheric circulation over the North Atlantic. The influence of atmospheric circulation change over the Pacific (both in the northern and in the tropical parts) is significantly lower