Designing a Participatory and Interactive Opera

Opera as an art form should lend itself to participatory design, given its wide variety of theatrical and musical components. Opera, however, imposes its own constraints and challenges. The problem as laid out in the early stages of the project was to design a short one-act interactive opera that could be managed within a modest budget. The source material was a science fiction manuscript currently undergoing publication by a small independent publishing house. Our research and production team included a composer, several singers/musicians, an engineer, a designer, and a choreographer/dancer as well as the writer. Furthermore, several of these had done extensive work with interactive and immersive environments. In addition to the opera itself, which incorporated both live and virtual elements, we recycled the 3d virtual designs as the substratum for an online co-creation environment that could be used to elicit public participation in the future development of our operas. We discuss both the diverse challenges involved in creating the opera and the co-creation environment, and highlight projected future work

Materiality in the future of history: things, practices, and politics

Frank Trentmann is professor of history at Birkbeck College, University of London. From 2002 to 2007, he was director of the £5 million Cultures of Consumption research program, cofunded by the Arts and Humanities Research Council and the Economic and Social Research Council (ESRC). He is working on a book for Penguin, The Consuming Passion: How Things Came to Seduce, Enrich, and Define Our Lives, from the Seventeenth Century to the Twenty‐First. This article is one of a pair seeking to facilitate greater exchange between history and the social sciences. Its twin—“Crossing Divides: Globalization and Consumption in History” (forthcoming in the Handbook of Globalization Studies, ed. Bryan Turner)—shows what social scientists (and contemporary historians) might learn from earlier histories. The piece here follows the flow in the other direction. Many thanks to the ESRC for grant number RES‐052‐27‐002 and, for their comments, to Heather Chappells, Steve Pincus, Elizabeth Shove, and the editor and the reviewer

International Circumpolar Surveillance System for Invasive Pneumococcal Disease, 1999–2005

Disease rates are high among indigenous persons in Arctic countries, and PCV7 has resulted in decreased rates in North American children

Shiga Toxin and Lipopolysaccharide Induce Platelet-Leukocyte Aggregates and Tissue Factor Release, a Thrombotic Mechanism in Hemolytic Uremic Syndrome

BACKGROUND: Aggregates formed between leukocytes and platelets in the circulation lead to release of tissue factor (TF)-bearing microparticles contributing to a prothrombotic state. As enterohemorrhagic Escherichia coli (EHEC) may cause hemolytic uremic syndrome (HUS), in which microthrombi cause tissue damage, this study investigated whether the interaction between blood cells and EHEC virulence factors Shiga toxin (Stx) and lipopolysaccharide (LPS) led to release of TF. METHODOLOGY/PRINCIPAL FINDINGS: The interaction between Stx or LPS and blood cells induced platelet-leukocyte aggregate formation and tissue factor (TF) release, as detected by flow cytometry in whole blood. O157LPS was more potent than other LPS serotypes. Aggregates formed mainly between monocytes and platelets and less so between neutrophils and platelets. Stimulated blood cells in complex expressed activation markers, and microparticles were released. Microparticles originated mainly from platelets and monocytes and expressed TF. TF-expressing microparticles, and functional TF in plasma, increased when blood cells were simultaneously exposed to the EHEC virulence factors and high shear stress. Stx and LPS in combination had a more pronounced effect on platelet-monocyte aggregate formation, and TF expression on these aggregates, than each virulence factor alone. Whole blood and plasma from HUS patients (n = 4) were analyzed. All patients had an increase in leukocyte-platelet aggregates, mainly between monocytes and platelets, on which TF was expressed during the acute phase of disease. Patients also exhibited an increase in microparticles, mainly originating from platelets and monocytes, bearing surface-bound TF, and functional TF was detected in their plasma. Blood cell aggregates, microparticles, and TF decreased upon recovery. CONCLUSIONS/SIGNIFICANCE: By triggering TF release in the circulation, Stx and LPS can induce a prothrombotic state contributing to the pathogenesis of HUS

A Novel Escherichia coli O157:H7 Clone Causing a Major Hemolytic Uremic Syndrome Outbreak in China

An Escherichia coli O157:H7 outbreak in China in 1999 caused 177 deaths due to hemolytic uremic syndrome. Sixteen outbreak associated isolates were found to belong to a new clone, sequence type 96 (ST96), based on multilocus sequence typing of 15 housekeeping genes. Whole genome sequencing of an outbreak isolate, Xuzhou21, showed that the isolate is phylogenetically closely related to the Japan 1996 outbreak isolate Sakai, both of which share the most recent common ancestor with the US outbreak isolate EDL933. The levels of IL-6 and IL-8 of peripheral blood mononuclear cells induced by Xuzhou21 and Sakai were significantly higher than that induced by EDL933. Xuzhou21 also induced a significantly higher level of IL-8 than Sakai while both induced similar levels of IL-6. The expression level of Shiga toxin 2 in Xuzhou21 induced by mitomycin C was 68.6 times of that under non-inducing conditions, twice of that induced in Sakai (32.7 times) and 15 times higher than that induced in EDL933 (4.5 times). Our study shows that ST96 is a novel clone and provided significant new insights into the evolution of virulence of E. coli O157:H7

Les chantiers forestiers de la Rimouski : (1930-1940) : techniques traditionnelles et culture matérielle

Du début du siècle jusque dans les années 1950, le travail en forêt, au profit de grandes compagnies, est une activité importante pour les habitants du Bas-du-Fleuve. Durant cette période, l'emploi dans la région est peu diversifié et l'ampleur de l'activité forestière liée à sa non-mécanisation exige une main-d'oeuvre abondante. C'est du côté de ces emplois que doivent se tourner de nombreux journaliers en quête d'un gagne-pain et des agriculteurs à la recherche d'un revenu d'appoint. Le mémoire, basé en majeure partie sur le témoignage de ces forestiers, reconstitue l'espace d'une décennie, le réseau d'exploitation forestière organisé par la compagnie Price Brothers dans le bassin-versant de la Rimouski. Les informations sur l'organisation des opérations, sur les techniques et les outils utilisés, sur le rôle de l'entrepreneur et sur la vie quotidienne, resituées dans leur contexte physique, social et économique, portent la dimension du vécu ouvrier. Elles permettent de connaître l'importance de l'activité et de poser des hypothèses sur la provenance de la main-d'oeuvre et sur les causes de la syndicalisation tardive. On y relève également des pratiques qui font ressortir des traits sociaux et culturels engendrés par l'implantation de cette grande compagnie dans ce milieu