15 research outputs found

    Dans la forêt d'aménagement de l'Inera-Yangambi, la méthode d'échantillonnage par point (angle count method), donne pour l'estimation de la surface terrière, des résultats aussi précis que ceux de la méthode conventionnelle d'inventaire

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    Doctorat en sciences agronomiques et ingénierie biologiqueThèse annexe de :"Phytomasse et productivité de quelques peuplements forestiers des Alpes de Haute-Provence (France) et de Yangambi (Zaïre)"info:eu-repo/semantics/nonPublishe

    Phytomasse et productivité de quelques peuplements forestiers des Alpes de Haute-Provence (France) et de Yangambi (Zaïre)

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    Doctorat en sciences agronomiques et ingénierie biologiqueVol. 1 :Texte (TH-000158) ;Vol. 2 :Annexes (TH-000159)La thèse annexe a pour titre :"Dans la forêt d'aménagement de l'Inera-Yangambi, la méthode d'échantillonnage par point (angle count method), donne pour l'estimation de la surface terrière, des résultats aussi précis que ceux de la méthode conventionnelle d'inventaire"info:eu-repo/semantics/nonPublishe

    Nonconstant quality of auditory filters in the porpoises, Phocoena phocoena and Neophocaena phocaenoides (Cetacea, Phocoenidae)

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    Simultaneous tone-tone masking in conjunction with the envelope-following response (EFR) recording was used to obtain tuning curves in porpoises Phocoena phocoena and Neophocaena phocaenoides asiaeorientalis. The EFR was evoked by amplitude-modulated probes with a modulation rate of 1000 Hz and carrier frequencies from 22.5 to 140 kHz. Equivalent rectangular quality Q(ERB) of the obtained tuning curves varied from 8.3-8.6 at lower (22.5-32 kHz) probe frequencies to 44.8-47.4 at high (128-140 kHz) frequencies. The QERB dependence on probe frequency could be approximated by regression lines with a slope of 0.83 to 0.86 in log-log scale., which corresponded to almost frequency-proportional quality and almost constant bandwidth of 34 kHz. Thus, the frequency representation in the porpoise auditory system is much closer to a constant-bandwidth rather that to a constant-quality manner. (c) 2006 Acoustical Society of America.Simultaneous tone-tone masking in conjunction with the envelope-following response (EFR) recording was used to obtain tuning curves in porpoises Phocoena phocoena and Neophocaena phocaenoides asiaeorientalis. The EFR was evoked by amplitude-modulated probes with a modulation rate of 1000 Hz and carrier frequencies from 22.5 to 140 kHz. Equivalent rectangular quality Q(ERB) of the obtained tuning curves varied from 8.3-8.6 at lower (22.5-32 kHz) probe frequencies to 44.8-47.4 at high (128-140 kHz) frequencies. The QERB dependence on probe frequency could be approximated by regression lines with a slope of 0.83 to 0.86 in log-log scale., which corresponded to almost frequency-proportional quality and almost constant bandwidth of 34 kHz. Thus, the frequency representation in the porpoise auditory system is much closer to a constant-bandwidth rather that to a constant-quality manner. (c) 2006 Acoustical Society of America

    Evoked-potential audiogram of the Yangtze finless porpoise Neophocaena phocaenoides asiaeorientalis (L)

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    Evoked-potential audiograms were obtained in two (one male and one female) Yangtze finless porpoises, Neophocaena phocaenoides asiaseorientalis. Sinusoidal amplitude-modulated 20-ms tone bursts were used as probes with recording envelope-following evoked potentials. A frequency range of 8 to 152 kHz was investigated. The range of greatest sensitivity covered frequencies from 45 to 139 kHz, and the lowest thresholds of 47.2 and 48.5 dB re: 1 μ Pa were found at a frequency of 54 kHz in the two subjects, respectively. At lower frequencies, threshold increased with a rate of around 14 dB/octave, and threshold steeply increased at 152 kHz. © 2005 Acoustical Society of America.Evoked-potential audiograms were obtained in two (one male and one female) Yangtze finless porpoises, Neophocaena phocaenoides asiaseorientalis. Sinusoidal amplitude-modulated 20-ms tone bursts were used as probes with recording envelope-following evoked potentials. A frequency range of 8 to 152 kHz was investigated. The range of greatest sensitivity covered frequencies from 45 to 139 kHz, and the lowest thresholds of 47.2 and 48.5 dB re: 1 μ Pa were found at a frequency of 54 kHz in the two subjects, respectively. At lower frequencies, threshold increased with a rate of around 14 dB/octave, and threshold steeply increased at 152 kHz. © 2005 Acoustical Society of America

    Sulfiredoxin–Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling

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    Oxidative stress is known to cause tumorigenesis through induction of DNA and lipid damage. It also promotes cancer progression through a largely unknown mechanism. Sulfiredoxin (Srx) is a novel oxidative stress-induced antioxidant protein whose function in tumorigenesis and cancer progression has not been well studied. We report that Srx is highly expressed in human lung cancer. Knockdown of Srx reduces anchorage-independent colony formation, cell migration, and invasion of human lung cancer cells. Srx preferentially interacts with Peroxiredoxin (Prx) IV relative to other Prxs due to its intrinsic higher binding affinity. Knockdown of Prx IV recapitulates the phenotypic changes of depleting Srx. Disruption or enhancement of the Srx–Prx IV axis leads respectively to reduction or acceleration of tumor growth and metastasis formation in vivo. Through identification and validation of the downstream mediators we unraveled the Srx-mediated signaling network that traverses AP-1–activating and other phosphokinase signaling cascades. Our work reveals that the Srx–Prx IV axis is critical for lung cancer maintenance and metastasis, suggesting that targeting the Srx–Prx IV axis may provide unique effective strategies for cancer prevention and treatment

    Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies

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    Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study identifies Sulfiredoxin (Srx) as a unique target of activator protein-1 (AP-1) activation and TAM67 inhibition. Manipulation of Srx levels by ShRNA or over-expression demonstrates that Srx is critical for redox homeostasis through reducing hyperoxidized peroxiredoxins. In JB6 cells, knockdown of Srx abolishes tumor promoter-induced transformation and enhances cell sensitivity to oxidative stress. Knockdown of Srx also impairs c-Jun phosphorylation, implicating a role for Srx in the feedback regulation of AP-1 activity. Screening of patient tissues by tissue microarray reveals elevated Srx expression in several types of human skin cancers. Our study indicates that Srx is a functionally significant target of AP-1 blockade that may have value in cancer prevention or treatment
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