On p-adic differential equations on semistable varieties II

This is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this record.This paper is a complement to the paper "On p-adic differential equations on semistable varieties" written by V. Di Proietto. Given an open variety over a DVR with semistable reduction, the author constructed in that paper a fully faithful algebraization functor from the category of certain log overconvergent isocrystals on the special fiber to the category of modules with regular integrable connection on the generic fiber. In this paper, we prove that, with convenable hypothesis, this functor is a tensor functor whose essential image is closed under extensions and subquotients. As a consequence, we can find suitable Tannakian subcategories of log overconvergent isocrystals and of modules with regular integrable connection on which the algebraization functor is an equivalence of Tannakian categories.The main part of this work was done when the first author was at the Graduate School of Mathematical Sciences of the University of Tokyo supported by a postdoctoral fellowship and kaken-hi (grant-in-aid) of the Japanese Society for the Promotion of Science (JSPS). She is now supported by a postdoctoral fellowship of Labex IRMIA.When the main part of this work was done, the second author was supported by JSPS Grant-in-Aid for Young Scientists (B) 21740003 and Grant-in-Aid for Scientific Research (B) 22340001. Currently he is supported by JSPS Grant-in-Aid for Scientific Research (C) 25400008 and Grant-in-Aid for Scientific Research (B) 23340001

On the homotopy exact sequence for log algebraic fundamental groups

This is the final published version.An earlier version of this paper appears in arXiv and is available in ORE at http://hdl.handle.net/10871/26921The final version is available from Documenta Mathematica via the DOI in this record.We construct a log algebraic version of the homotopy sequence for a quasi-projective normal crossing log variety over a log point of characteristic zero and prove some exactness properties of it. Our proofs are purely algebraic

Electrochemical remediation of phenol contaminated kaolin under low-strength electric fields

Soil degradation is a global concern. Electrochemical remediation (ER) technology is considered an appealing strategy for soil remediation because it is a low-cost, adaptable, and effective noninvasive in situ technology. Currently, the remediation of soil characterized by fine grains, low-hydraulic permeability, heterogeneous conditions, and mixtures of contaminants is still challenging since other conventional technologies are poorly effective. ER of soil is based on the application of low potentials between a couple of electrodes which induces an electric field (E) in the contaminated field. In this work, very low values of electric field (E ≤ 0.25 V cm−1) were used for the ER of contaminated kaolin. Phenol was selected as model hazardous organic compound and kaolin as model, reproducible and low buffering and low permeability clay. The effect of several factors, including the nature of the electrodes, treatment time, kind of current, the strength of the E and the nature of supporting electrolyte, on the performance of the process was investigated in detail and discussed in terms of the normalized phenol concentration and its total removal from the kaolin. Overall, the main finding is that the use of very low value of E (0.15 V cm−1) can allow to simultaneously desorb, mobilize and also in-situ degrade phenol. The highest removals of phenol up to approximately 80% and 90% from the kaolin under both direct and sinusoidal E, respectively, were reached using compact graphite as electrodes in presence of Na2SO4 into the kaolin

Electrochemical remediation of kaolin-soil contaminated by phenol: effect of several operative parameters

Electrochemical remediation technology is considered an appealing strategy for the remediation of fine- grained soils, characterized by a low hydraulic conductivity and large specific surface area, contaminated with inorganic, organic, and mixed pollutants. In both Electrokinetic (EK) and Electrochemical Geo-Oxidation (ECGO) technologies, an electric field is imposed on the contaminated soil to remove the pollutants by the combined mechanisms of electroosmosis, electromigration, and/or electrophoresis. Moreover, ECGO uses low voltage and both direct and alternating amperage (DC/AC) applied in a proprietary series to induce reduction-oxidation reactions on soil surfaces at the micro-scale. According to the literature, in this method, each soil particle acts as a micro-capacitor that charges and discharges in a cyclic fashion. The energy burst on discharge at the micro-scale is intense, theoretically allowing the conversion of most organic contaminants to carbon dioxide and water near the conducting particle surface [2-4]. However, the effectiveness of the technology strongly depends on the physical-chemical states of the soils and the contaminants, pH, sorption of contaminants on soil particle surfaces and different effects induced by the hydrogen ions and hydroxide ions generated at the electrodes. In this work, the effect of several factors, including the intensity and mode of the applied electric field, duration of treatment, nature of supporting electrolytes, on the electrochemical remediation of kaolin-soil contaminated by phenol (200 mgPhenol/kgsoil) was investigated. It was found that a proper selection of the operative parameters is the key- factor to improve the electrochemical remediation of the contaminated soil. High removal of phenol from the kaolin up to 88% was achieved after 93 hours of treatment using graphite electrodes and a gradient electric field of 0.15 V cm-1. [1] A. T. Yeung et al. J. Hazard. Mater. 2011, 195, 11 [2] D. Rahner et al. Electrochim. Acta 2002, 47, 1395 [3] J. Röhrs et al. Electrochim. Acta 2002, 47, 1405 [4] L.M. Zanko et al. Electrochim. Acta 2020, 354, 13669

Effect of the air pressure on electro-Fenton process

Electro-Fenton process is considered a very promising tool for the treatment of waste waters contaminated by organic pollutants refractant or toxic for microorganisms used in biological processes [1-6]. In these processes H2O2 is continuously supplied to an acidic aqueous solution contained in an electrolytic cell from the two-electron reduction of oxygen gas, directly injected as pure gas or bubbled air. Due to the poor solubility of O2 in aqueous solutions, two dimensional cheap graphite or carbon felt electrodes give quite slow generation of H2O2, thus resulting in a slow abatement of organics. In this context, we report here a series of studies [7-9] on the effect of air pressure on the electro-generation of H2O2 and the abatement of organic pollutants in water by electro-Fenton process. The effect of air pressure, current density, mixing and nature of the organic pollutant was evaluated. [1] E. Brillas, I. Sirés, M.A. Oturan, Chem. Rev., 109 (2009) 6570-6631. [2] C.A. Martínez-Huitle, M.A. Rodrigo, I. Sirés, O. Scialdone, Chem. Rev. 115 (2015) 13362–13407. [3] M. Panizza, G. Cerisola, Chem. Rev. 109 (2009) 6541–6569. [4] I. Sirés, E. Brillas, M.A. Oturan, M.A. Rodrigo, M. Panizza, Environ. Sci. Pollut. Res. 21 (2014) 8336–8367. [5] C.A. Martínez-Huitle, S. Ferro, Chem. Soc. Rev. 35 (2006) 1324–1340. [6] B.P.P. Chaplin, Environ. Sci. Process. Impacts. 16 (2014) 1182–1203. [7] O. Scialdone, A. Galia, C. Gattuso, S. Sabatino, B. Schiavo, Electrochim. Acta, 182 (2015) 775-780. [8] J.F. Pérez, A. Galia, M.A. Rodrigo, J. Llanos, S. Sabatino, C. Sáez, B. Schiavo, O. Scialdone, Electrochim. Acta, 248 (2017) 169-177. [9] A.H. Ltaïef, S. Sabatino, F. Proietto, A. Galia, O. Scialdone, O. 2018, Chemosphere, 202, 111-118

Elevated 8-isoprostane levels in basal cell carcinoma and in UVA irradiated skin.

Isoprostanes are prostaglandin isomers produced from the peroxidation of polyunsaturated fatty acids from the cellular membrane. They have been used as a specific index of cellular lipoperoxidation and as an indirect measure of oxidative stress. However, these molecules also present several biological activities. An oxidative environment measured as the presence of other indirect measurements of reactive oxygen species lipoperoxidation has recently been described in basal cell carcinoma, the most frequent type of non-melanoma skin cancer. This study aims to measure the levels of 8-isoprostaglandin F2α, an isoprostane widely studied in other models as a by-product of ROS-induced lipid peroxidation, in basal cell carcinoma and in UVA irradiated healthy skin. We found that 8-iso-PGF2α is present in higher levels in BCC specimens compared to healthy non sun-exposed skin, confirming previous studies on the production of lipoperoxidation in this tumor. Moreover, we demonstrated that topical pre-treatment with a compound containing vitamin E is capable of reducing 8-iso-PGF2α formation in UV irradiated skin suggesting a role for isoprostanes in UV induced inflammation and eventually carcinogenesis and confirming the function of vitamin E as an antioxidant in this model

Omalizumab decreases exacerbation frequency, oral intake of corticosteroids and peripheral blood eosinophils in atopic patients with uncontrolled asthma.

Omalizumab is a humanized monoclonal anti-IgE antibody approved in 2005 by the European Medicine Agency (EMA) for the treatment of severe persistent allergic asthma, which remains inadequately controlled despite optimal therapy with high doses of inhaled corticosteroids and long-acting β2-adrenergic agonists. Within this context, the present observational study refers to 16 patients currently treated with omalizumab at the Respiratory Unit of "Magna Græcia" University Hospital located in Catanzaro, Italy, whose anti- IgE therapy was started in the period included between March 2007 and February 2010, thus lasting at least 10 months. After 40 weeks of add-on treatment with omalizumab, very relevant decreases were detected, in comparison with pre-treatment mean (± standard deviation) values, in monthly exacerbation numbers (from 1.1 ± 0.6 to 0.2 ± 0.4; p < 0.01) and oral corticosteroid consumption (from 22.6 ± 5.0 to 1.2 ± 2.9 mg/day of prednisone; p < 0.01). These changes were associated with stable improvements in lung function, expressed as increases of both FEV1 (from 53.6 ± 14.6% to 77.0 ± 14.9% of predicted values; p < 0.01) and FEV1/FVC ratio (from 56.3 ± 9.5% to 65.8 ± 9.2%; p < 0.01). Moreover, in 5 patients who persistently had increased numbers of eosinophils (mean ± SD: 15.9 ± 8.0% of total WBC count; absolute number: 1,588.0 ± 956.9/μl) despite a long-lasting therapy with inhaled and systemic corticosteroids, the peripheral counts of these cells decreased down to near normal levels (mean ± SD: 6.3 ± 2.3% of total WBC count; absolute number: 462.0 ± 262.3/μl) after 16 weeks of treatment with omalizumab. Therefore, this descriptive evaluation confirms the efficacy of add-on omalizumab therapy in selected patients with exacerbation-prone, chronic allergic uncontrolled asthma, requiring a continuous intake of oral corticosteroids

Genetic variants in MUTYH are not associated with endometrial cancer risk

Hereditary non-polyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an autosomal dominant inherited predisposition to a number of epithelial cancers, most notably colorectal and endometrial cancer. Outside of the context of Lynch syndrome there is little evidence for an autosomal dominant or recessive condition that predisposes to endometrial cancer. Recently, genetic variants in MUTYH have been associated with a recessive form of colorectal cancer, known as MUTYH associated polyposis or MAP. MUTYH is involved in base excision repair of DNA lesions and as such a breakdown in the fidelity of this process would necessarily not be predicted to result in a specific disease. At present there is little information about the role of MUTYH in other types of cancer and only one report indicating a possible relationship with endometrial cancer

Detection of EGFR-Activating and T790M Mutations Using Liquid Biopsy in Patients With EGFR-Mutated Non–Small-Cell Lung Cancer Whose Disease Has Progressed During Treatment With First- and Second-Generation Tyrosine Kinase Inhibitors: A Multicenter Real-Life Retrospective Study

Epidermal growth factor receptor T790M detection using liquid biopsy was evaluated in a real-life setting in 120 advanced non–small-cell lung cancer patients whose disease had progressed during first- or second-generation tyrosine kinase inhibitors. The T790M detection rate was 25.8% using liquid biopsy and 49.2% after tissue rebiopsy. Liquid biopsies performed before disease progression according to Response Evaluation Criteria In Solid Tumors were all negative for T790M and T790M positivity was higher in cases of extrathoracic metastatic sites