Kurunthogai Heroine- Cultural Records

Evidence for the Archaic Antiquity of the Tamil Language is Sangam literature. As explained in the Sangam literature, the Tamil word 'Pan' means merit. If 'padu' also means worldly morality then it can mean qualified worldly morality. Cultural levels are prevalent in Sangam literature. Domestic life is also defined as the specialty of living together even without a home. It can be realized that culture is seen in Sangam literature from the fact that the hero was very fond of the heroine and both the hero and heroine were very happy in their lives. The purpose of the article is that the culture of the poets of the Sangam period is manifested in that even though there are various emotions like hospitality, friendship, enmity, love, hatred and love. The poets of the Sangam period have chosen the high quality

DNA Cleavage Mechanism by Metal complexes of Cu(II), Zn(II), Mn(II) and Co(II) with a Schiff-base Ligand

Metal ions and metal complexes are important components of nucleic acid biochemistry, participating both in regulation of gene expression and as therapeutic agents. Four new transition  metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from a new Schiff base ligand derived from 4-bromo aniline, 2-hydroxy-1-naphthaldehyde. The ligand and its complexes have been characterized by spectral analysis. The in vitro antimicrobial activity of the investigated compounds was tested against the bacteria such as Bacillus subtilis, Escherichia coli and fungi Aspergillus flavus and Aspergillus niger. The data indicate that most of the metal complexes have higher antibacterial activity than the free ligand. DNA cleavage experiments performed on pBR322 DNA using metal complexes in the presence of H2O2 showed that all the complexes afford a pronounced DNA cleavage

THERMOSENSITIVE HYDROGELS–A POTENTIAL CARRIER FOR THE DELIVERY OF DRUGS AND MACROMOLECULES

In this review, the authors have discussed scientific advances in thermosensitive hydrogels over the past two decades. The ability of the thermo-sensitive hydrogel to undergo rapid changes with response to temperature makes it an attractive candidate for many biomedical applications such as targeted drug delivery, wound healing, soft contact lenses, sensors, tissue regeneration, gene, and protein delivery. This review aims to deliver a brief overview of gelation properties, merits, and demerits of various natural and synthetic thermo-sensitive polymers that have significant clinical relevance. The report emphasizes the importance of injectable thermosensitive hydrogels, as it can offer improved solubility of hydrophobic drugs and site-specificity, extended-release of drugs and macromolecules, improved safety, and local administration of drugs. The authors has also provided a commentary on the delivery of drugs or macromolecules from thermo-sensitive hydrogels through various approaches. This review highlights the current status of research in thermo-sensitive hydrogels and emphasizes the importance of developing nontoxic thermo-sensitive hydrogels, dual responsive, and multi-responsive hydrogel systems

An ε -Uniform Numerical Method for a System of Convection-Diffusion Equations with Discontinuous Convection Coefficients and Source Terms

In this paper, a parameter-uniform numerical method is suggested to solve a system of singularly perturbed convection-diffusion equations with discontinuous convection coefficients and source terms subject to the Dirichlet boundary condition. The second derivative of each equation is multiplied by a distinctly small parameter, which leads to an overlap and interacting interior layer. A numerical method based on a piecewise uniform Shishkin mesh is constructed. Numerical results are presented to support the theoretical results

Cent CORE: Centralized Cloud Oriented Requirement Engineering Strategy for Tracking and Elicitation of Dynamic Requirements

Requirement Engineering is one of the most important stages of Software Engineering. Eliciting requirements is highly critical and a complex process as the software end product totally depends on the quality of requirements that were collected. The property of the requirements is dynamic that keeps changing and constantly evolving. The Traditional Strategies for Requirement Engineering lacked organization and change management was entirely manual which consumed a lot of time and skilled labor. A centralized strategy for Elicitation of Dynamic Requirements using the concept of Requirement Cloud is proposed with high level of organization and structuring. A novel idea of using Cloud Storage Service for Requirement Engineering is implemented using a heuristics approach. Change management is incorporated and a few activities like requirements document generation is automated in this approach. Finally a survey between the Traditional Requirement Engineering and Proposed Cloud Methodology is conducted to prove the proposed methodology is better than the traditional strategies of Requirement Engineering

Punica Granatum L - A Nutraceutical functional food

Pomegranate is a widely used plant having medicinal properties. Pomegranates and their extracts may serve as natural alternatives due to their potency against a wide range of bacterial and viral pathogens. The synergistic action of the pomegranate constituents appears to be superior to that of single constituents.Pomegranate provides health benefits, that is, a nutraceutical food. It is used in dentistry as an active ingredient such as mouth rinse for plaque control, treatment of various oral lesions, storage media for avulsed teeth, wound healing. This paper describes the uses of pomegranate, its mechanism and various therapeutic and dental applications

Maturation-Dependent Licensing of Naive T Cells for Rapid TNF Production

The peripheral naïve T cell pool is comprised of a heterogeneous population of cells at various stages of development, which is a process that begins in the thymus and is completed after a post-thymic maturation phase in the periphery. One hallmark of naïve T cells in secondary lymphoid organs is their unique ability to produce TNF rapidly after activation and prior to acquiring other effector functions. To determine how maturation influences the licensing of naïve T cells to produce TNF, we compared cytokine profiles of CD4+ and CD8+ single positive (SP) thymocytes, recent thymic emigrants (RTEs) and mature-naïve (MN) T cells during TCR activation. SP thymocytes exhibited a poor ability to produce TNF when compared to splenic T cells despite expressing similar TCR levels and possessing comparable activation kinetics (upregulation of CD25 and CD69). Provision of optimal antigen presenting cells from the spleen did not fully enable SP thymocytes to produce TNF, suggesting an intrinsic defect in their ability to produce TNF efficiently. Using a thymocyte adoptive transfer model, we demonstrate that the ability of T cells to produce TNF increases progressively with time in the periphery as a function of their maturation state. RTEs that were identified in NG-BAC transgenic mice by the expression of GFP showed a significantly enhanced ability to express TNF relative to SP thymocytes but not to the extent of fully MN T cells. Together, these findings suggest that TNF expression by naïve T cells is regulated via a gradual licensing process that requires functional maturation in peripheral lymphoid organs

Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial

Background. Pediatric tuberculous meningitis (TBM) commonly causes death or disability. In adults, high-dose rifampicin may reduce mortality. The role of fluoroquinolones remains unclear. There have been no antimicrobial treatment trials for pediatric TBM. Methods. TBM-KIDS was a phase 2 open-label randomized trial among children with TBM in India and Malawi. Participants received isoniazid and pyrazinamide plus: (i) high-dose rifampicin (30 mg/kg) and ethambutol (R30HZE, arm 1); (ii) high-dose rifampicin and levofloxacin (R30HZL, arm 2); or (iii) standard-dose rifampicin and ethambutol (R15HZE, arm 3) for 8 weeks, followed by 10 months of standard treatment. Functional and neurocognitive outcomes were measured longitudinally using Modified Rankin Scale (MRS) and Mullen Scales of Early Learning (MSEL). Results. Of 2487 children prescreened, 79 were screened and 37 enrolled. Median age was 72 months; 49%, 43%, and 8% had stage I, II, and III disease, respectively. Grade 3 or higher adverse events occurred in 58%, 55%, and 36% of children in arms 1, 2, and 3, with 1 death (arm 1) and 6 early treatment discontinuations (4 in arm 1, 1 each in arms 2 and 3). By week 8, all children recovered to MRS score of 0 or 1. Average MSEL scores were significantly better in arm 1 than arm 3 in fine motor, receptive language, and expressive language domains (P < .01). Conclusions. In a pediatric TBM trial, functional outcomes were excellent overall. The trend toward higher frequency of adverse events but better neurocognitive outcomes in children receiving high-dose rifampicin requires confirmation in a larger trial. Clinical Trials Registration. NCT02958709