161 research outputs found
Study and analysis of an electric Z-shaped meta-atom
A printed Z-shaped electric meta-atom is presented as an alternative design to the conventional electric-LC (ELC) resonator. We propose to redesign the ELC resonator pattern to get a compact and a low cost electric resonator exhibiting a strong electric response. Our approach consists in redressing the resonator shape to accommodate higher inductance and therefore leading to a lower resonance frequency without being limited by fabrication tolerances. Simulation and measurement results show that the Z metaatom exhibits an electric response to normally incident radiation and can be used very effectively in producing materials with negative permittivity
Protocol for assessing bacterial wilt resistance in greenhouse and field conditions. International cooperatorsâ guide
This protocol is an updated version of âAssessing potato clone field resistance to bacterial wiltâ issued in The International Cooperatorsâ Guide (CIP 2007). The first edition of the protocol presented a standard procedure for field assessment of resistance to bacterial wilt for documenting levels of resistance of advanced potato germplasm. This second edition has included a standardized procedure for greenhouse screening of potato seedlings for bacterial wilt resistance useful for perform genetic studies, parental selection or identification of new sources of resistance in accessions of wild species propagated or maintained as true see
Nocturnal release of leukocyte-derived microparticles in males with obstructive sleep apnoea
Multiple pathophysiological mechanisms have been proposed to contribute to the increased cardiovascular morbidity in obstructive sleep apnoea (OSA), including autonomic dysfunction, inflammation, oxidative stress and endothelial dysfunction 1. Microparticles (MPs) are small membrane vesicles that are shed from circulating cells or from the components of the vessel wall in response to activation and apoptosis. There is growing evidence in support of a potential role of MPs in the field of cardiovascular diseases. Increased levels of MPs derived from various cell types are found in patients at risk of cardiovascular diseases 2. By modulating inflammation, coagulation, vasomotor reactivity and angiogenesis, MPs might directly contribute to cardiovascular diseases 2. Recent caseâcontrol studies suggest a potential involvement of MPs in OSA-associated cardiovascular morbidity 3â6. An increase in morning levels of MPs derived from activated leukocytes has been demonstrated in otherwise healthy male OSA patients with marked nocturnal desaturations 5. In vitro, nitric oxide (NO) production by endothelial cells incubated with MPs from OSA patients correlates negatively with circulating levels of activated leukocyte-derived MPs 5. Ex vivo, mice previously injected with MPs from OSA patients display endothelial dysfunction, reduced endothelial NO release and increased adhesion molecule expression 5
Study and analysis of an electric Z-shaped meta-atom
A printed Z-shaped electric meta-atom is presented as an alternative design to the conventional electric-LC (ELC) resonator. We propose to redesign the ELC resonator pattern to get a compact and a low cost electric resonator exhibiting a strong electric response. Our approach consists in redressing the resonator shape to accommodate higher inductance and therefore leading to a lower resonance frequency without being limited by fabrication tolerances. Simulation and measurement results show that the Z metaatom exhibits an electric response to normally incident radiation and can be used very effectively in producing materials with negative permittivity
Circulating microparticles from patients with obstructive sleep apnea enhance vascular contraction: mandatory role of the endothelium
Obstructive sleep apnea (OSA) is characterized by repetitive apnea-hypopnea cycles during sleep associated with oxygen desaturation and sleep disruption. We evaluated the role of circulating microparticles (MPs) from patients with OSA in the regulation of vascular function. MPs from whole blood from patients with OSA or control subjects were injected i.v. into mice. Injection of MPs from patients with OSA induced ex vivo vascular hyperreactivity in aortas with functional endothelium but, in contrast, hyporeactivity in vessels without functional endothelium. Vascular hyperreactivity was blunted in the presence of a nitric oxide synthase inhibitor alone or combined with the cyclooxygenase inhibitor indomethacin. MPs from patients with OSA reduced endothelial nitric oxide synthase activity and nitric oxide production, increased aortic cyclooxygenase-1 and cyclooxygenase-2 expression, and increased thromboxane A(2) and prostacyclin production. Blockade of thromboxane A(2) receptor did not affect the serotonin response in arteries from OSA MP-treated mice. A superoxide dismutase mimetic reduced the vascular hyperreactivity induced by MPs from patients with OSA but had no effect on contraction in vessels from control and non-OSA MP-treated mice. These data provide evidence that circulating MPs from patients with OSA induce ex vivo vascular hyperreactivity with the obligatory role of the endothelium and subtle interactions between the nitric oxide and cyclooxygenase pathways and metabolites. These results highlight the participation of MPs in vascular dysfunction associated with OSA
Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice
Peer reviewedPublisher PD
On micro-structural effects in dielectric mixtures
The paper presents numerical simulations performed on dielectric properties
of two-dimensional binary composites on eleven regular space filling
tessellations. First, significant contributions of different parameters, which
play an important role in the electrical properties of the composite, are
introduced both for designing and analyzing material mixtures. Later, influence
of structural differences and intrinsic electrical properties of constituents
on the composite's over all electrical properties are investigated. The
structural differences are resolved by the spectral density representation
approach. The numerical technique, without any {\em a-priori} assumptions, for
extracting the spectral density function is also presented.Comment: 24 pages, 8 figure and 7 tables. It is submitted to IEEE Transactions
on Dielectrics and Electrical Insulatio
Relativistic mechanics of neutron superfluid in (magneto) elastic star crust
At densities below the neutron drip threshold, a purely elastic solid model (including, if necessary, a frozen-in magnetic field) can provide an adequate description of a neutron star crust, but at higher densities it will be necessary to allow for the penetration of the solid lattice by an independently moving current of superfluid neutrons. In order to do this, the previously available category of relativistic elasticity models is combined here with a separately developed category of relativistic superfluidity models in a unified treatment based on the use of an appropriate Lagrangian master function. As well as models of the purely variational kind, in which the vortices flow freely with the fluid, such a master function also provides a corresponding category of non-dissipative models in which the vortices are pinned to the solid structure
Independent association between obstructive sleep apnea severity and glycated hemoglobin in adults without diabetes
OBJECTIVE: We tested the hypothesis of an independent cross-sectional association between obstructive sleep apnea (OSA) severity and glycated hemoglobin (HbA(1c)) in adults without known diabetes.
RESEARCH DESIGN AND METHODS: HbA(1c) was measured in whole-blood samples from 2,139 patients undergoing nocturnal recording for suspected OSA. Participants with self-reported diabetes, use of diabetes medication, or HbA(1c) value â„6.5% were excluded from this study. Our final sample size comprised 1,599 patients.
RESULTS: A dose-response relationship was observed between apnea-hypopnea index (AHI) and the percentage of patients with HbA(1c) >6.0%, ranging from 10.8% for AHI <5 to 34.2% for AHI â„50. After adjustment for age, sex, smoking habits, BMI, waist circumference, cardiovascular morbidity, daytime sleepiness, depression, insomnia, sleep duration, and study site, odds ratios (95% CIs) for HbA(1c) >6.0% were 1 (reference), 1.40 (0.84-2.32), 1.80 (1.19-2.72), 2.02 (1.31-3.14), and 2.96 (1.58-5.54) for AHI values <5, 5 to <15, 15 to <30, 30 to <50, and â„50, respectively. Increasing hypoxemia during sleep was also independently associated with the odds of HbA(1c) >6.0%.
CONCLUSIONS: Among adults without known diabetes, increasing OSA severity is independently associated with impaired glucose metabolism, as assessed by higher HbA(1c) values, which may expose them to higher risks of diabetes and cardiovascular disease
Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy?
Carcinomas of an unknown primary site (CUP) are heterogeneous tumours with a median survival of only 8 months. Tyrosine kinase inhibitors are promising new drugs. The aim of this study was to determine the expression of EGF-receptor, Her-2/neu, and c-Kit tyrosine kinases in CUP. Paraffin-embedded specimens were obtained from 54 patients with a CUP who were included in the GEFCAPI 01 randomised phase II trial. Immunohistochemistry was performed using the Dako autostainer with antibodies directed against HER-2/neu protein, EGFR protein, and c-Kit protein (CD117). EGFR expression was found in 36 out of 54 samples (66%). In contrast, Her-2/neu overexpression and c-Kit positivity were only detected in 4 and 10% of patients, respectively. No significant association was found between the expression of the tyrosine kinase receptors and prognosis. EGFR expression was significantly associated with response to cisplatin-based chemotherapy: the response rates were 50 and 22% in patients with EGFR-positive tumours and EGFR-negative tumours, respectively (P<0.05). This study shows that EGFR is frequently expressed in CUP. This finding may prompt clinical trials investigating EGFR inhibitors in this setting. In contrast, c-Kit expression and Her-2/neu overexpression occur infrequently in CUP. EGFR expression was correlated to tumour chemosensitivity
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