4,263 research outputs found
Exciton-photon coupling in a ZnSe based microcavity fabricated using epitaxial liftoff
We report the observation of strong exciton-photon coupling in a ZnSe based
microcavity fabricated using epitaxial liftoff. Molecular beam epitaxial grown
ZnSe/ZnCdSe quantum wells with a one wavelength optical length
at the exciton emission were transferred to a SiO/TaO mirror with a
reflectance of 96% to form finesse matched microcavities. Analysis of our angle
resolved transmission spectra reveals key features of the strong coupling
regime: anticrossing with a normal mode splitting of at ;
composite evolution of the lower and upper polaritons; and narrowing of the
lower polariton linewidth near resonance. The heavy hole exciton oscillator
strength per quantum well is also deduced to be .Comment: 3 pages, 3 figure
Finding an Alternative to Formalin for Sterilization of Extracted Teeth for Teaching Purposes
FRI0592-HPR Work rehabilitation in inflammatory arthritis: A pilot randomised controlled trial
Background Work problems are common in people with inflammatory arthritis (IA): with 28-40% of people with rheumatoid arthritis (RA) stopping work in 5y of diagnosis. There is little research into effectiveness of job retention vocational rehabilitation (JRVR)for employed people with IA. Brief JR-VR led to significantly fewer job losses at 3.5 years in the USA (Allaire et al, 2003) and a
UK pilot trial demonstrated 6m improvements in work instability and work satisfaction (Macedo et al, 2009).
Objectives: To conduct a pilot randomised controlled trial (RCT) evaluating a JR-VR intervention with employed people with IA,to facilitate planning a full RCT.
Methods: Participants with IA were recruited from 6 Rheumatology departments and randomised to VR (delivered by
Rheumatology OTs with VR training) or a control group. Both groups received written self-help information about managing work problems. The VR group could receive up to 6h JR-VR, including a work visit. Presenteeism outcomes included: RA-Work Instability Scale (RAWIS:0-23), Work Limitations Questionnaire Productivity Loss (WLQPL: %), Work Activities Limitations Scale (WALS:0-33). Absenteeism was measured using monthly work diaries. Health outcomes included: SF12v2 Physical component(SF12-PC), pain, fatigue and perceived health status VAS (0-100). Mean (SD) change scores and effect sizes were calculated.
Results: 213 eligible employed patients with IA were identified, of whom 55 (26%) participated (34 with RA): 13M, 42F; aged 49y (SD 8.8); 7.9y (SD 8.9) disease duration; 33 worked full-time; job types were professional (27%), associated professional/skilled
(15%), partly skilled/admin/caring/retain (53%), unskilled (5%). Both groups were comparable at baseline (see Table). At 9m: effect sizes were moderate to large for changes in work and health outcomes in the JR-VR group and none to small in the control group; %working days lost due to sickness: JR-VR =9.6% (SD 13.6); control = 20% (SD 27.1). JR-VR lasted on average 3.08 (SD 1.8)hours and cost £74.98 (SD £46.80) per patient.
Conclusions: This pilot suggests brief JR-VR provided by Rheumatology OTs can improve presenteeism, absenteeism and health status, indicating a RCT is warranted. Recruitment was problematic, with many not consenting. Potential reasons include: fear about employers (in a recession) learning they have arthritis; concerns about time out of work attending VR; and not perceiving VR is needed as yet. JR-VR intends to prevent work problems. Support is needed to enable employed people with IA and work problems
to attend JR-VR
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Splanchnic metabolism of nutrients and hormones in steers fed alfalfa under conditions of increased absorption of ammonia and L-arginine supply across the portal-drained viscera
Effects of increased ammonia and/or arginine
absorption on net splanchnic (portal-drained viscera
[PDV] plus liver) metabolism of nonnitrogenous
nutrients and hormones in cattle were examined. Six
Hereford × Angus steers (501 ± 1 kg BW) prepared with
vascular catheters for measurements of net flux across
the splanchnic bed were fed a 75% alfalfa:25% (as-fed
basis) corn and soybean meal diet (0.523 MJ of ME/[kg
BW0.75.d]) every 2 h without (27.0 g of N/kg of DM) and
with 20 g of urea/kg of DM (35.7 g of N/kg of DM) in a
split-plot design. Net flux measurements were made
immediately before and after a 72-h mesenteric vein
infusion of L-arginine (15 mmol/h). There were no treatment
effects onPDVor hepaticO2 consumption. Dietary
urea had no effect on splanchnic metabolism of glucose
or L-lactate, but arginine infusion decreased net hepatic
removal of L-lactate when urea was fed (P < 0.01). Net PDV appearance of n-butyrate was increased by arginine
infusion (P < 0.07), and both dietary urea (P <
0.09) and arginine infusion (P < 0.05) increased net
hepatic removal of n-butyrate. Dietary urea also increased
total splanchnic acetate output (P < 0.06),
tended to increase arterial glucagon concentration (P
< 0.11), and decreased arterial ST concentration (P <
0.03). Arginine infusion increased arterial concentration
(P < 0.07) and net PDV release (P < 0.10) and
tended to increase hepatic removal (P < 0.11) of insulin,
as well as arterial concentration (P < 0.01) and total
splanchnic output (P < 0.01) of glucagon. Despite
changes in splanchnic N metabolism, increased ammonia
and arginine absorption had little measurable effect
on splanchnic metabolism of glucose and other nonnitrogenous
components of splanchnic energy metabolism
Quantum dynamics in photonic crystals
Employing a recently developed method that is numerically accurate within a
model space simulating the real-time dynamics of few-body systems interacting
with macroscopic environmental quantum fields, we analyze the full dynamics of
an atomic system coupled to a continuum light-field with a gapped spectral
density. This is a situation encountered, for example, in the radiation field
in a photonic crystal, whose analysis has been so far been confined to limiting
cases due to the lack of suitable numerical techniques. We show that both
atomic population and coherence dynamics can drastically deviate from the
results predicted when using the rotating wave approximation, particularly in
the strong coupling regime. Experimental conditions required to observe these
corrections are also discussed.Comment: 5 pages, 2 figures Updated with published versio
Non-invasive probing of random local potential fluctuations in ZnCdSe/ZnSe quantum wells
Temperature dependence and recombination behavior of trapped charge carriers
in ZnCdSe/ZnSe multiple quantum wells are investigated employing surface
acoustic waves. These weakly perturb the carrier system, but remain highly
sensitive even at small conductivities. Using this non-invasive probe we are
able to detect persistent photoconductivity minutes after optical excitation.
Measurement of exciting photon energies, the temperature dependence and ability
to quench the conductivity with energies lower than the bandgap, support the
notion of spatial separation of electrons and holes in the wells, due to random
local potential fluctuations possibly induced by compositional fluctuations
First communication on the efficacy of combined <sup>177</sup>Lutetium-PSMA with immunotherapy outside prostate cancer.
Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy is a validated treatment option for patients with advanced prostate cancer. Although PSMA expression is not limited to prostate tissue, little is known about its relevance to other types of cancer. Here, we present a case report of a patient with uterine leiomyosarcoma that is progressing while on immunotherapy and treated with <sup>177</sup> Lu-PSMA radionuclide therapy. We report for the first time that <sup>177</sup> Lu-PSMA radionuclide therapy combined with immunotherapy outside of prostate cancer. We did observe post-treatment reduction of tumor growth rate, although we did not notice disease response based on RECIST criteria. We suggest that <sup>177</sup> Lu-PSMA treatment especially combined with immunotherapy may be an option for patients with cancer without other therapeutic options. Insights: <sup>177</sup> Lu-PSMA radionuclide therapy should be considered for any tumor stained positive for PSMA
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