71 research outputs found
Staff Activities in the Texas House of Representatives
In this study multivariate analysis is applied to the allocation of staff time among members of the Texas House of Representatives. Ideology of the representative is found to be an important factor in explaining differences in staff behavior. Chief staffers serving liberal Democrats and Republicans report spending less time on constituency service, and more time on policy research, than do staffers serving conservative Democrats. There are differences between the parties, but not between the ideologies, on time spent with lobbyists. Other variables, such as urban population of the district, and the years a legislator has served in the House, show slight relationships with staff activities
Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors
Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflammatory agents. Recently, the structure of TLR4 bound to the inhibitor E5564 was solved, raising the possibility that novel TLR4 inhibitors that target the E5564-binding domain could be designed. We utilized a similarity search algorithm in conjunction with a limited screening approach of small molecule libraries to identify compounds that bind to the E5564 site and inhibit TLR4. Our lead compound, C34, is a 2-acetamidopyranoside (MW 389) with the formula C17H27NO9, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. Molecular docking of C34 to the hydrophobic internal pocket of the TLR4 co-receptor MD-2 demonstrated a tight fit, embedding the pyran ring deep inside the pocket. Strikingly, C34 inhibited LPS signaling ex-vivo in human ileum that was resected from infants with necrotizing enterocolitis. These findings identify C34 and the β-anomeric cyclohexyl analog C35 as novel leads for small molecule TLR4 inhibitors that have potential therapeutic benefit for TLR4-mediated inflammatory diseases. © 2013 Neal et al
Demonstration of the temporal matter-wave Talbot effect for trapped matter waves
We demonstrate the temporal Talbot effect for trapped matter waves using
ultracold atoms in an optical lattice. We investigate the phase evolution of an
array of essentially non-interacting matter waves and observe matter-wave
collapse and revival in the form of a Talbot interference pattern. By using
long expansion times, we image momentum space with sub-recoil resolution,
allowing us to observe fractional Talbot fringes up to 10th order.Comment: 17 pages, 7 figure
Pion, kaon, proton and anti-proton transverse momentum distributions from p+p and d+Au collisions at GeV
Identified mid-rapidity particle spectra of , , and
from 200 GeV p+p and d+Au collisions are reported. A
time-of-flight detector based on multi-gap resistive plate chamber technology
is used for particle identification. The particle-species dependence of the
Cronin effect is observed to be significantly smaller than that at lower
energies. The ratio of the nuclear modification factor () between
protons and charged hadrons () in the transverse momentum
range GeV/c is measured to be
(stat)(syst) in minimum-bias collisions and shows little
centrality dependence. The yield ratio of in minimum-bias d+Au
collisions is found to be a factor of 2 lower than that in Au+Au collisions,
indicating that the Cronin effect alone is not enough to account for the
relative baryon enhancement observed in heavy ion collisions at RHIC.Comment: 6 pages, 4 figures, 1 table. We extended the pion spectra from
transverse momentum 1.8 GeV/c to 3. GeV/
Azimuthal anisotropy at RHIC: the first and fourth harmonics
We report the first observations of the first harmonic (directed flow, v_1),
and the fourth harmonic (v_4), in the azimuthal distribution of particles with
respect to the reaction plane in Au+Au collisions at the Relativistic Heavy Ion
Collider (RHIC). Both measurements were done taking advantage of the large
elliptic flow (v_2) generated at RHIC. From the correlation of v_2 with v_1 it
is determined that v_2 is positive, or {\it in-plane}. The integrated v_4 is
about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8)
harmonics upper limits on the magnitudes are reported.Comment: 6 pages with 3 figures, as accepted for Phys. Rev. Letters The data
tables are at
http://www.star.bnl.gov/central/publications/pubDetail.php?id=3
Mid-rapidity anti-proton to proton ratio from Au+Au collisions at GeV
We report results on the ratio of mid-rapidity anti-proton to proton yields
in Au+Au collisions at \rts = 130 GeV per nucleon pair as measured by the
STAR experiment at RHIC. Within the rapidity and transverse momentum range of
and 0.4 1.0 GeV/, the ratio is essentially independent of
either transverse momentum or rapidity, with an average of for minimum bias collisions. Within errors, no
strong centrality dependence is observed. The results indicate that at this
RHIC energy, although the -\pb pair production becomes important at
mid-rapidity, a significant excess of baryons over anti-baryons is still
present.Comment: 5 pages, 3 figures, accepted by Phys. Rev. Let
Transverse-momentum correlations on from mean- fluctuations in Au-Au collisions at 200 GeV
We present first measurements of the pseudorapidity and azimuth
bin-size dependence of event-wise mean transverse momentum
fluctuations for Au-Au collisions at GeV. We invert that
dependence to obtain autocorrelations on differences
interpreted to represent velocity/temperature
distributions on (). The general form of the autocorrelations
suggests that the basic correlation mechanism is parton fragmentation. The
autocorrelations vary strongly with collision centrality, which suggests that
fragmentation is strongly modified by a dissipative medium in the more central
Au-Au collisions relative to peripheral or p-p collisions. \\Comment: 7 pages, 3 figure
Review of \u3ci\u3eThe Limits of Agrarian Radicalism: Western Populism and American Politics\u3c/i\u3e By Peter H. Argersinger
The book consists mainly of a collection of reworked articles that appeared in various journals from 1967 to 1992. At the level of analysis, the author\u27s meta-argument is that the Populists were ultimately unsuccessful because they failed politically. That is, they both failed to manage the ideological tensions within their movement, and failed to overcome various structural impediments placed in their path by the established parties. He elaborates this argument with a series of case studies, following in close detail a number of state conventions and elections. The documentation in these studies is impressive, and the studies themselves are convincingly argued
The Affective Labor and Performance of Live Streaming on Twitch.tv
This article explores affective and immaterial labor on the leading live-streaming platform, Twitch.tv, which boasts over one hundred million regular viewers and two million regular broadcasters. This labor involves digitally mediated outward countenance, including being friendly to viewers, soliciting donations, building parasocial intimacy with spectators, and engaging audiences through humor. We offer an examination of streamers broadcasting as a “character,” which we situate within the context of play becoming work, the labor of performance and acting, and the economic compulsions that shape cultural labor on Twitch. We draw on hundred interviews with professional and aspiring-professional game broadcasters conducted in 2016 and 2017 at gaming events across the United Kingdom, the United States, Germany, and Poland, alongside ethnographic research. This inquiry into the dynamics of digital games and labor underscores the importance of studying live streaming as part of a wider critical investigation of contemporary digital work
Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis
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