A Data Structure for Spatio-Temporal Databases

The advantages and applications of spatial mechanisms are well documented; however, there are very few being designed. The principal hinderance to the design of spatial mechanisms is the great difficulty involved in specifying spatial problems and in interpreting spatial solutions. Similarly, the development of spatial codes to implement these techniques is held back by the lack of means to easily visualize and verify solutions, particularly in the realm of relational databases. If spatial mechanisms are to be successful, the designer must be able to synthesize, analyse and evaluate, as well as load and extract information, using a single code representing a spatial structure. This entails the implementation of spatial relationships involving spatial data structures. It is with this in mind that the Canadian Hydrographic Service database group embarked on the development of a new type of spatial database structure based on the quadtree concept

New hurdles for translational research

New guidelines for the collection and use of human tissues for research will impose new requirements on researchers to seek ethical approval and patient consent. This extends to the use of surplus tissue, such as breast cancer excision biopsies, which, until recently, have been regarded as having been 'abandoned' by the patient. This article argues that some of these new constraints provide hurdles to translational research that are unnecessary for patient protection. This is particularly significant when emerging technologies are expected to elicit major advances in clinical cancer research

Competing Strategies of FDI and Technology Transfer to China: American and Japanese Firms

This is a report based on four field site visits of Sino-foreign joint ventures in China. Two American and two Japanese joint ventures in electronics and auto parts were visited in the Shanghai area in December 1997. The joint ventures were Shanghai Raychem, Shanghai Fleetguard, Shanghai Mitsubishi Elevator, and Shanghai Koito. Although the sample size is extremely small, it does appear as if there are notable differences in how American and Japanese firms transfer technology to China and in their motivations for doing so. Further fieldwork-based research to capture and clarify these differences is recommended.http://deepblue.lib.umich.edu/bitstream/2027.42/39605/3/wp218.pd

Culture and collective action: Japan, Germany and the United States after 11 September 2001

In order to put a lens on the issue of international security cooperation after 11 September 2001, this article examines the question of how collective action in International Relations becomes possible. The author maintains that a fair amount of inter-state collective action can be understood, even explained, by analysing the culture of the international system. Using discourse analysis as a tool, the analysis addresses the underlying ideas, norms and identities that constitute the relationship between the United States and Japan, on the one hand, and Germany and the United States, on the other, as it has evolved since September 2001. The method exposes how some ideas are privileged over others, how norms are maintained, reformulated and abandoned, how identity is constructed and how power is legitimized in the 'war on terror'

Competing Strategies of FDI and Technology Transfer to China: American and Japanese Firms

This is a report based on four field site visits of Sino-foreign joint ventures in China. Two American and two Japanese joint ventures in electronics and auto parts were visited in the Shanghai area in December 1997. The joint ventures were Shanghai Raychem, Shanghai Fleetguard, Shanghai Mitsubishi Elevator, and Shanghai Koito. Although the sample size is extremely small, it does appear as if there are notable differences in how American and Japanese firms transfer technology to China and in their motivations for doing so. Further fieldwork-based research to capture and clarify these differences is recommended.

p53 gene aberrations in non-small-cell lung carcinomas from a smoking population.

We examined 46 non-small-cell lung carcinomas (NSCLCs) for the presence of p53 mutations in exons 4-9, positive p53 immunostaining and loss of heterozygosity (LOH) in the TP53 locus. p53 mutations were detected in 13 tumour samples (28.3%), whereas overexpression of the p53 protein was found in 30 of 45 (67%) samples. Allelic loss was found in 9 of 38 (23.6%) informative cases. The statistical analysis revealed no significant correlation between p53 mutations and clinicopathological data, although mutations appear to occur more frequently in squamous cell carcinomas (7 of 18) than in adenocarcinomas (2 of 15). All but three individuals in this study group smoked. In contrast to previous reports, we found a higher prevalence of GC-->AT transitions than of GC-->TA transversions, as expected in a smoking population. A trend was found between p53-positive immunostaining and a history of heavy smoking (76-126 pack-years) and was inversely correlated with allelic deletion (LOH) at the TP53 locus. Eight of the 12 NSCLCs containing p53 mutations also had concomitant p53 overexpression, and it is of specific note that three of the four tumours containing p53 'mutations' with no overexpression of the p53 protein had either insertions or deletions in the p53 gene. No correlation was found between p53 mutations and fractional allele loss or ras mutations. p53 mutations in this Merseyside population in the UK do not appear to be as common as in other reports for NSCLC and exhibit predominance of GC-->AT transitions preferentially at non-CpG sites, suggesting that other carcinogens in addition to those in tobacco smoke may be involved in NSCLC in the Merseyside area of the UK

Recruitment of ethnic minority patients to a cardiac rehabilitation trial: The Birmingham Rehabilitation Uptake Maximisation (BRUM) study [ISRCTN72884263]

Background: Concerns have been raised about low participation rates of people from minority ethnic groups in clinical trials. However, the evidence is unclear as many studies do not report the ethnicity of participants and there is insufficient information about the reasons for ineligibility by ethnic group. Where there are data, there remains the key question as to whether ethnic minorities more likely to be ineligible (e.g. due to language) or decline to participate. We have addressed these questions in relation to the Birmingham Rehabilitation Uptake Maximisation (BRUM) study, a randomized controlled trial (RCT) comparing a home-based with a hospital-based cardiac rehabilitation programme in a multi-ethnic population in the UK. Methods: Analysis of the ethnicity, age and sex of presenting and recruited subjects for a trial of cardiac rehabilitation in the West-Midlands, UK. Participants: 1997 patients presenting post-myocardial infarction, percutaneous transluminal coronary angioplasty or coronary artery bypass graft surgery. Data collected: exclusion rates, reasons for exclusion and reasons for declining to participate in the trial by ethnic group. Results: Significantly more patients of South Asian ethnicity were excluded (52% of 'South Asian' v 36% 'White European' and 36% 'Other', p < 0.001). This difference in eligibility was primarily due to exclusion on the basis of language (i.e. the inability to speak English or Punjabi). Of those eligible, similar proportions were recruited from the different ethnic groups (white, South Asian and other). There was a marked difference in eligibility between people of Indian, Pakistani or Bangladeshi origin