Information Content in Data Sets for a Nucleated-Polymerization Model

We illustrate the use of tools (asymptotic theories of standard error quantification using appropriate statistical models, bootstrapping, model comparison techniques) in addition to sensitivity that may be employed to determine the information content in data sets. We do this in the context of recent models [23] for nucleated polymerization in proteins, about which very little is known regarding the underlying mechanisms; thus the methodology we develop here may be of great help to experimentalists

Characterization and Modeling of DHBT in InP/GaAsSb Technology for the Design and Fabrication of a Ka Band MMIC Oscillator

This paper presents the design of an MMIC oscillator operating at a 38 GHz frequency. This circuit was fabricated by the III–V Lab with the new InP/GaAsSb Double Heterojunction Bipolar Transistor (DHBT) submicronic technology (We=700 nm). The transistor used in the circuit has a 15 μm long two-finger emitter. This paper describes the complete nonlinear modeling of this DHBT, including the cyclostationary modeling of its low frequency (LF) noise sources. The specific interest of the methodology used to design this oscillator resides in being able to choose a nonlinear operating condition of the transistor from an analysis in amplifier mode. The oscillator simulation and measurement results are compared. A 38 GHz oscillation frequency with 8.6 dBm output power and a phase noise of −80 dBc/Hz at 100 KHz offset from carrier have been measured

Extension of charge-state-distribution calculations for ion-solid collisions towards low velocities and many-electron ions

Knowledge of the detailed evolution of the whole charge-state distribution of projectile ions colliding with targets is required in several fields of research such as material science and atomic and nuclear physics but also in accelerator physics, and in particular in regard to the several foreseen large-scale facilities. However, there is a lack of data for collisions in the nonperturbative energy domain and that involve many-electron projectiles. Starting from the etacha model we developed [Rozet, Nucl. Instrum. Methods Phys. Res., Sect. B 107, 67 (1996)10.1016/0168-583X(95)00800-4], we present an extension of its validity domain towards lower velocities and larger distortions. Moreover, the system of rate equations is able to take into account ions with up to 60 orbital states of electrons. The computed data from the different new versions of the etacha code are compared to some test collision systems. The improvements made are clearly illustrated by 28.9MeVu-1Pb56+ ions, and laser-generated carbon ion beams of 0.045 to 0.5MeVu-1, passing through carbon or aluminum targets, respectively. Hence, those new developments can efficiently sustain the experimental programs that are currently in progress on the "next-generation" accelerators or laser facilities.Fil: Lamour, E.. Centre National de la Recherche Scientifique; Francia. Universite de Paris; FranciaFil: Fainstein, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Galassi, Mariel Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Prigent, C.. Centre National de la Recherche Scientifique; Francia. Universite de Paris; FranciaFil: Ramirez, C. A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Rozet, J. P.. Centre National de la Recherche Scientifique; Francia. Universite de Paris; FranciaFil: Trassinelli, M.. Centre National de la Recherche Scientifique; Francia. Universite de Paris; FranciaFil: Vernhet, D.. Centre National de la Recherche Scientifique; Francia. Universite de Paris; Franci

Modulating the phase transition temperature of giant magnetocaloric thin films by ion irradiation

Magnetic refrigeration based on the magnetocaloric effect at room temperature is one of the most attractive alternative to the current gas compression/expansion method routinely employed. Nevertheless, in giant magnetocaloric materials, optimal refrigeration is restricted to the narrow temperature window of the phase transition (Tc). In this work, we present the possibility of varying this transition temperature into a same giant magnetocaloric material by ion irradiation. We demonstrate that the transition temperature of iron rhodium thin films can be tuned by the bombardment of ions of Ne 5+ with varying fluences up to 10 14 ions cm --2 , leading to optimal refrigeration over a large 270--380 K temperature window. The Tc modification is found to be due to the ion-induced disorder and to the density of new point-like defects. The variation of the phase transition temperature with the number of incident ions opens new perspectives in the conception of devices using giant magnetocaloric materials

Editorial: Aurora Kinases: Classical Mitotic Roles, Non-Canonical Functions and Translational Views

Aurora kinases are key mitotic regulators that have also been associated with tumor development and progression. The interest on this highly conserved family of protein kinases has grown exponentially since they were discovered in the 1990s. Despite the steady increase in the number of laboratories involved and the consequent boost of the volume of research output during the last years, the study of Aurora kinases remains a very dynamic area in which new discoveries frequently keep coming to light. From a clinical perspective, the interest on Aurora kinase biology stems from their identification as targets for drug development; an increasing number of Aurora kinase inhibitors are being tested in preclinical projects and clinical trials. In this Frontiers Research Topic, we have aimed to not only review and revisit different aspects of the functions and regulation of Aurora kinases but also provide a forum for the publication of new developments in the field. We have been privileged to count on contributions from authors and reviewers that include some of the most experienced voices in our research area.Work in our laboratories is supported by grants from Ministerio de Economía, Industría y Competitividad (SAF SAF2016-76929-R), Ligue Nationale Contre le Cancer (LNCC, équipe labelisée 2014-2016), and Wellcome Trust (073915, 077707, and 092076).S

Suppression of the thermal hysteresis in magnetocaloric MnAs thin film by highly charged ion bombardment

We present the investigation on the modifications of structural and magnetic properties of MnAs thin film epitaxially grown on GaAs induced by slow highly charged ions bombardment under well-controlled conditions. The ion-induced defects facilitate the nucleation of one phase with respect to the other in the first-order magneto-structural MnAs transition with a consequent suppression of thermal hysteresis without any significant perturbation on the other structural and magnetic properties. In particular, the irradiated film keeps the giant magnetocaloric effect at room temperature opening new perspective on magnetic refrigeration technology for everyday use

Ground subsidence effects on simulating dynamic high-latitude surface inundation under permafrost thaw using CLM5

Simulating surface inundation is particularly challenging for the high-latitude permafrost regions. Ice-rich permafrost thaw can create expanding thermokarst lakes as well as shrinking large wetlands. Such processes can have major biogeochemical implications and feedbacks to the climate system by altering the pathways and rates of permafrost carbon release. However, the processes associated with it havenot yet been properly represented in Earth system models. We show a new model parameterization that allows direct representation of surface water dynamics in CLM (Community Land Model), the land surface model of several Earth System Models. Specifically, we coupled permafrost-thaw-induced ground subsidence and surface microtopography distribution to represent surface water dynamics in the high latitudes. Our results show increased surface water fractions around western Siberian plains and northeastern territories of Canada. Additionally, localized drainage events correspond well to severe ground subsidence events. Our parameterization is one of the first steps towards a process-oriented repre-sentation of surface hydrology, which is crucial to assess the biogeochemical feedbacks between land and the atmosphere under changing climat

Pattern fluctuations in transitional plane Couette flow

In wide enough systems, plane Couette flow, the flow established between two parallel plates translating in opposite directions, displays alternatively turbulent and laminar oblique bands in a given range of Reynolds numbers R. We show that in periodic domains that contain a few bands, for given values of R and size, the orientation and the wavelength of this pattern can fluctuate in time. A procedure is defined to detect well-oriented episodes and to determine the statistics of their lifetimes. The latter turn out to be distributed according to exponentially decreasing laws. This statistics is interpreted in terms of an activated process described by a Langevin equation whose deterministic part is a standard Landau model for two interacting complex amplitudes whereas the noise arises from the turbulent background.Comment: 13 pages, 11 figures. Accepted for publication in Journal of statistical physic