Food-drug Interactions in Patients with Cardiovascular Diseases

Cardiovascular diseases are one of the most common diseases in the world. Anticoagulants and other drugs are prescribed as treatment for these diseases however, polypharmacy may increase the risk of drug-drug or food-drug interatrions and decrease patient compliance. Food-drug interatrions may put the patient at risk for serious adverse effects and reduce safety and efficacy of treatment. Food‐drug interaction is a common problem that has occurred as a result of the concomitant use of multiple drugs with food. Food-drug interaction is the term used to describe how a food affects a medication in the body. Food can alter the effectiveness of medication, make unwanted side effects better or worse, or even bring on brand-new negative effects. Drugs may alter how the body processes food. Consumption of foods which contain vitamin K make anticoagulant therapy less effective. On the other hand, patients should be careful when consuming foods like: garlic, ginseng, ginger and ginkgo in order to avoid the undesirable effect of hemorrhage. Healthcare professionals should advice patients taking anticoagulants to be careful with the food they consume and clinicians should manage the time and dose variability of the medicine so a successful therapy can be achieved

An Answer to the Plant Variety Controversy in Chile

Chile has failed to ratify the 1991 International Convention for the Protection of New Varieties of Plants (UPOV) as stipulated in the free trade agreement (FTA) with the United States. Since Chile is amongst the US Priority Watch List countries, it is imperative for Chile to emanate a UPOV 1991-compliant law. The ratification of UPOV 1991, however, has encountered strong resistance within the country and it is not yet clear when and how Chile will adopt UPOV 1991 provisions. Through an analysis of legal and economic aspects of the domestic plant variety law, this paper explains that Chile should make better use of UPOV flexibilities and gives recommendations in order to accommodate the interests of all stakeholders

BOT Contract through the optics of Albanian legal provisions - Issues of the implementation and transfer framework

The last years have resulted in an increase of concession contracts in Albania, followed by a revised modern legal framework. Beside the debate on whether the government should perform most of the activities itself instead of giving them to the private sector through a concession contract, the concession contracts are nowadays a reality and as such they should be studied and analysed carefully. The scope of this article is limited to the provisions of the Albanian legislation and its approach to the international provisions regarding BOT (build – operate - transfer) concession contract. A detailed analyse will drive to the conclusionas to what extent the Albanian concession legislation does compile with the international accepted principles of Public Private Partnership concerning mainly implementation and transfer phase of a BOT contract. Albanian Public Private Partnershiplegislation has gone through many revisions and amendments during the last twenty years, resulting in a challenging situation for everybody that deals with any aspects of a concession. Having a detailed understanding of the legal provisions is indeed the core element toward a successful implementation process of any concession, resulting in the highest profitability for concession parties, the public entity and the private investor, and consequently culminating to the best interest of the population

Duplicate Defect Detection

Discovering and fixing faults is an unavoidable process in Software Engineering. It is always a good practice to document and organize fault reports. This facilitates the effectiveness of development and maintenance process. Bug Tracking Repositories, such as Bugzilla, are designed to provide fault reporting facilities for developers, testers and users of the system. Allowing anyone to contribute finding and reporting faults has an immediate impact on software quality. However, this benefit comes with one side-effect. Users often file reports that describe the same fault. This increases the triaging time spent by the maintainers. At the same time, important information required to fix the fault is likely to be distributed across different reports.;The objective of this thesis is twofold. First, we want to understand the dynamics of bug report filing for a large, long duration open source project, Firefox. Second, we present a new approach that can reduce the number of duplicate reports. The novel element in the proposed approach is the ability to concentrate the search for duplicates on specific portions of the bug repository. This improves the performance of Information Retrieval techniques and classification runtime of our algorithm. Our system can be deployed as a search tool to help reporters query the repository or it can be adopted to help maintainers detect duplicate reports. In both cases the performance is satisfactory. When tested as a search tool our system is able to detect up to 53% of duplicate reports. The approach adapted for maintainers has a maximum recall rate of 59%

Food-drug Interactions in Patients with Cardiovascular Diseases

Cardiovascular diseases are one of the most common diseases in the world. Anticoagulants and other drugs are prescribed as treatment for these diseases however, polypharmacy may increase the risk of drug-drug or food-drug interatrions and decrease patient compliance. Food-drug interatrions may put the patient at risk for serious adverse effects and reduce safety and efficacy of treatment. Food‐drug interaction is a common problem that has occurred as a result of the concomitant use of multiple drugs with food. Food-drug interaction is the term used to describe how a food affects a medication in the body. Food can alter the effectiveness of medication, make unwanted side effects better or worse, or even bring on brand-new negative effects. Drugs may alter how the body processes food. Consumption of foods which contain vitamin K make anticoagulant therapy less effective. On the other hand, patients should be careful when consuming foods like: garlic, ginseng, ginger and ginkgo in order to avoid the undesirable effect of hemorrhage. Healthcare professionals should advice patients taking anticoagulants to be careful with the food they consume and clinicians should manage the time and dose variability of the medicine so a successful therapy can be achieved

A multinomial logistic regression model for text in Albanian language

In this paper we present a multinomial logistic regression model for authorship identification in the Albanian language texts. In the model fitted the dependent variable is categorical which takes different values from 1 to 10 for each of the author and the independent variables are number of words, number of letters, number of vowels, number of consonants, number of punctuations and number of sentences for each text. The model was applied with success in the set of ten authors, each of them being represented by a set of one hundred texts they authored. As results first, second and the third authors have the higher correct predicted percentage and the highest overall correct predicted probability taken was 0.738. As conclusion adding in the model number of consonants, number of punctuations and number of sentences as independent variables the overall correct predicted percentage is increased