36 research outputs found
Public understanding of climate change-related sea-level rise.
Sea-level rise resulting from climate change is impacting coasts around the planet. There is strong scientific consensus about the amount of sea-level rise to 2050 (0.24-0.32 m) and a range of projections to 2100, which vary depending on the approach used and the mitigation measures taken to reduce carbon emissions. Despite this strong scientific consensus regarding the reality of climate change-related sea-level rise, and the associated need to engage publics in adaptation and mitigation efforts, there is a lack of empirical evidence regarding people's understanding of the issue. Here we investigate public understanding of the amount, rate and causes of sea-level rise. Data from a representative sample of New Zealand adults showed a suprising tendency for the public to overestimate the scientifically plausible amount of sea-level rise by 2100 and to identify melting sea ice as its primary causal mechanism. These findings will be valuable for scientists communicating about sea-level rise, communicators seeking to engage publics on the issue of sea-level rise, and media reporting on sea-level rise
The advent of the Anthropocene in Australasia.
As early as the late 19th Century, several scientists had suggested that humans were starting to influence the physical environment of planet Earth (e.g. Marsh, 1864; Stoppani, 1873; Arrhenius, 1896; Chamberlain, 1897). This idea was resurrected and expanded in 2000 by Paul Crutzen, a Nobel Prize-winning chemist, and the late Eugene Stoermer, a professor of biology specialising in diatoms, who suggested that we had left the Holocene and entered the âAnthropoceneâ (Crutzen and Stoermer, 2000). As summarised by Steffen et al. (2011) and Wolfe et al. (2013), these iconoclastic scientists were referring to the Anthropocene as the interval of demonstrable human alteration of global biogeochemical cycles, beginning subtly in the late 18th Century following James Wattâs invention of the coal-fired steam engine, and accelerating markedly in the mid-20th Century (termed âThe Great Accelerationâ). Thus Crutzen and Stoermer (2000) argued that the Anthropocene should be an epoch, and for a starting date at the beginning of the Industrial Revolution (Monastersky, 2015)
Editorial: Geoscience communication â planning to make it publishable
If you are a geoscientist doing work to achieve impact outside academia or engaging different audiences with the geosciences, are you planning to make this publishable? If so, then plan. Such investigations into how people (academics, practitioners, other publics) respond to geoscience can use pragmatic, simple research methodologies accessible to the non-specialist or be more complex. To employ a medical analogy, first aid is useful and the best option in some scenarios, but calling a medic (i.e. a collaborator with experience of geoscience communication or relevant research methods) provides the contextual knowledge to identify a condition and opens up a diverse, more powerful range of treatment options. Here, we expand upon the brief advice in the first editorial of Geoscience Communication (Illingworth et al., 2018), illustrating what constitutes robust and publishable work in this context, elucidating its key elements. Our aim is to help geoscience communicators plan a route to publication and to illustrate how good engagement work that is already being done might be developed into publishable research
The British Army, information management and the First World War revolution in military affairs
Information Management (IM) â the systematic ordering, processing and channelling of information within organisations â forms a critical component of modern military command and control systems. As a subject of scholarly enquiry, however, the history of military IM has been relatively poorly served. Employing new
and under-utilised archival sources, this article takes the British Expeditionary Force (BEF) of the First World War as its case study and assesses the extent to which its IM system contributed to the emergence of the modern battlefield in 1918. It argues that the
demands of fighting a modern war resulted in a general, but not universal, improvement in the BEFâs IM techniques, which in turn laid the groundwork, albeit in embryonic form, for the IM systems of modern armies.
KEY WORDS: British Army, Information Management, First World War, Revolution in Military Affairs, Adaptatio
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61â69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1â10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688â1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4â82·5) in the no ADT group and 80·4% (76·6â83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60â69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0â10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612â0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6â75·7) in the short-course ADT group and 78·1% (74·2â81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Nuclear New Zealand: New Zealand's nuclear and radiation history to 1987
New Zealand has a paradoxical relationship with nuclear science. We are as proud of Ernest Rutherford, known as the father of nuclear science, as of our nuclear-free status. Early enthusiasm for radium and X-rays in the first half of the twentieth century and euphoria in the 1950s about the discovery of uranium in a West Coast road cutting was countered by outrage at French nuclear testing in the Pacific and protests against visits from American nuclear-powered warships.
New Zealand today has a strong nuclear-free identity â a result of the New Zealand Nuclear Free Zone, Disarmament and Arms Control Act of 1987 that prohibited nuclear weapons and nuclear warships in the countryâs land, air and water â that can be traced back to the first protests against nuclear weapons in the 1940s. This thesis is based on the supposition that the ânuclear-free New Zealandâ narrative is so strong and such a part of the national identity that it has largely eclipsed another story, the pre-1980s story of ânuclear New Zealandâ. New Zealandâs early embracing of and enthusiasm for nuclear science and technology needs to be introduced into our national story. This thesis aims to discover and reveal that history: from the young New Zealand physicists seconded to work on the Manhattan Project; to the plans for a heavy water plant at Wairakei; prospecting for uranium on the West Coast of the South Island; plans for a nuclear power station on the Kaipara Harbour; and the thousands of scientists and medical professionals who have worked with nuclear technology. Put together, they provide a narrative history of nuclear New Zealand.
Between the âanti-nuclearâ voices, already well told in many histories of nuclear-free New Zealand, and the âpro-nuclearâ voices revealed in this thesis, options were considered and decisions made. This thesis shows that the people with decision-making power tended to make practical decisions based on economics and national interest when it came to deciding whether or not to adopt a certain piece of nuclear technology or whether or not to participate in projects or ventures with international agencies. This eventually led to a nuclear-free policy â focused on weapons, nuclear-powered ships and waste â that since the legislation was enacted in 1987 has been interpreted ever more widely by politicians and the public to include nuclear power, uranium prospecting and many other applications of nuclear technology