Optimización de sistemas hidráulicos reversibles en mercados mayoristas de energía

El presente proyecto fin de carrera tiene como objetivo el estudio de la optimización de las ofertas de compra y venta de energía para una central hidroeléctrica reversible en los Mercados Mayoristas del Sistema Eléctrico Español. De esta forma podrá realizarse un control sobre los beneficios obtenidos con las transacciones de energía así como del riesgo inherente a estos mercados. En primer lugar, se realizará una descripción del Sistema Eléctrico español, en él se presentarán los diferentes mercados en los que es posible la venta y compra de energía actualmente para un agente generador. Así mismo se describirán los sistemas hidroeléctricos objeto del estudio y las principales metodologías de optimización de estos sistemas. Seguidamente, se presentarán los algoritmos desarrollados para la optimización de las ofertas. Para terminar se presentarán los resultados obtenidos en algunos escenarios concretos.The main purpose of this final project is the study of the optimization of the bids for a hydro power plant applied to the Spanish Electricity Power Market. In this way, the profit on this matter can be controlled taking into account the risk on the transactions. In the first chapter, a description of the Spanish Power System will be presented. Hydro-pump technologies participated on unit commitment and load following markets, achieving a high participation percentage in our country in the different seasons. In the second chapter, a brief description of technical hydro-pump generation systems characteristics is done as well as the state of the art of the bid optimization. For the optimization study, IBM CPLEX Optimization Studio is used as a computer tool for the algorithm design. One hundred scenarios are studied and global conclusions are included in final chapter.Ingeniería Industria

Propuesta de un modelo de negocio para el desarrollo de la empresa Midgard Graphics dentro del sector del videojuego

[ES] En el presente TFG se llevará a cabo la propuesta de un modelo de negocio para crear una empresa dentro del sector del videojuego. La empresa, denominada Midgard Graphics, parte de la idea de ayudar, tanto a jóvenes desarrolladores de videojuegos como a profesionales, a conseguir que sus trabajos/proyectos salgan al mercado con las máximas garantías posibles de convertirse en marcas reconocidas a nivel nacional o internacional. Para ello, Midgard Graphics proporcionará apoyo gráfico y empresarial a dichos desarrolladores en los distintos procesos de la creación de un videojuego (Alpha,Beta, etc.). En cuanto al TFG, partirá desde un estudio sobre la evolución de la cultura de los videojuegos a lo largo de su historia en el mundo, para posteriormente aplicar las herramientas para el desarrollo de modelos de negocio (Lean Canvas, Landing Page, Mínimo Producto Viable, etc.) que llevarán al planteamiento de la empresa.[EN] In the present TFG a proposal of a business model to create a company within the videogame sector will be carried out. The company, called Midgard Graphics, starts from the idea of helping both young videogame developers and professionals to get their work/projects to market with the maximum possible guarantees of becoming nationally or internationally recognized brands. To this end, Midgard Graphics will provide graphic and business support to these developers in the various processes of creating a video game (Alpha, Beta, etc.). As for the TFG, it will start from a study on the evolution of the video game culture throughout its history in the world, and then apply the tools for the development of business models (Lean Canvas, Landing Page, Minimum Viable Product, etc.) that will lead to the company's approach.Priego Vilaplana, P. (2018). Propuesta de un modelo de negocio para el desarrollo de la empresa Midgard Graphics dentro del sector del videojuego. http://hdl.handle.net/10251/107729TFG

Short-term results for laparoscopic repair of large paraesophageal hiatal hernias with Gore Bio A® mesh

AbstractBackgroundThe application of mesh-reinforced hiatal closure has resulted in a significant reduction in recurrence rates in comparison with primary suture repair. One of the most debated issues is the risk of complications related to the use of the prosthesis, such as esophageal erosion and postoperative dysphagia. The aim of this study is to present our short-terms results in the treatment of laparoscopic paraesophageal hiatal hernia (LPHH) with a synthetic polyglycolic acid:trimethylene carbonate mesh (Gore Bio A®).MethodsFrom January 2011 to December 2012, 10 patients with large paraesophageal hiatal hernias and hiatal defect over 5 cm were included. Primary simple suture of the crura and additional reinforcement with a Gore Bio A® mesh was performed. Hiatal hernia or gastroesophageal reflux disease (GERD) symptoms recurrence, dysphagia and mesh-related complications were investigated.ResultsOf the 10 patients undergoing mesh repair, there were 7 women and 3 men with a mean age of 65.5 years. All operations were completed laparoscopically. Median postoperative stay was 3 days. After a median follow-up of 20.3 months, one patient developed a recurrent hiatal hernia (10%). There were no mesh-related complications.ConclusionsThe use of Gore Bio A® mesh for the laparoscopic repair of large paraesophageal hiatal hernias is safe and with a reasonably low recurrence rate in this short-term study. Additional long-term studies with ample numbers carried out for years will be necessary to see if this synthetic mesh is not only safe but also successful in the prevention of recurrences

Arrested dynamics of the dipolar hard-sphere model

We report the combined results of molecular dynamics simulations and theoretical calculations concerning various dynamical arrest transitions in a model system representing a dipolar fluid, namely, N (softcore) rigid spheres interacting through a truncated dipole-dipole potential. By exploring different regimes of concentration and temperature, we find three distinct scenarios for the slowing down of the dynamics of the translational and orientational degrees of freedom: At low ({$\eta$} = 0.2) and intermediate (${\eta}$ = 0.4) volume fractions, both dynamics are strongly coupled and become simultaneously arrested upon cooling. At high concentrations ({$\eta$} $\lt$ 0.6), the translational dynamics shows the features of an ordinary glass transition, either by compressing or cooling down the system, but with the orientations remaining ergodic, thus indicating the existence of partially arrested states. In this density regime, but at lower temperatures, the relaxation of the orientational dynamics also freezes. The physical scenario provided by the simulations is discussed and compared against results obtained with the self-consistent generalized Langevin equation theory, and both provide a consistent description of the dynamical arrest transitions in the system. Our results are summarized in an arrested states diagram which qualitatively organizes the simulation data and provides a generic picture of the glass transitions of a dipolar fluid

Columnar spaces in Valencian Gothic Architecture. The cloister of the Carthusian Monastery of Porta Coeli

[EN] The Cartuja of Porta Coeli preserves a Gothic cloister which, despite its small size and apparent simplicity, stands out for its compositional beauty and sophisticated stonework. It is, moreover, a particularly singular work in the context of Valencian medieval architecture. The eremitic nature of the Carthusian order, far from any contact with the outside world, has kept this exquisite architectural example, where the tradition of stonework and structural masonry coexist, practically intact until the present day. This text shows the results of the graphic and documentary analysis carried out, restoring, by means of the survey, the compositional laws and the trace as a graphic design method. The article, therefore, presents an initial study of this architectural space, placing it in the context of Valencian stonemasonry, at the time of the great master stonemasons, and, furthermore, it aims to provide a well-founded approach to the discovery of its authorship.[ES] La Cartuja de Porta Coeli conserva un claustro gótico que, pese a sus reducidas dimensiones y aparente sencillez, destaca por su belleza compositiva y sofisticada manufactura de cantería. Es, además, una obra especialmente singular en el contexto de la arquitectura medieval valenciana. El carácter eremítico de la orden Cartujana alejada de todo contacto con el mundo exterior, ha mantenido prácticamente intacto hasta nuestros días este exquisito ejemplo arquitectónico donde conviven la tradición de la cantería con la albañilería estructural. El presente texto muestra los resultados del análisis gráfico y documental realizado, restituyendo por medio del levantamiento, las leyes compositivas y la traza como método gráfico de diseño. El artículo, pues, plantea un primer estudio sobre este espacio arquitectónico, situándolo en el contexto de la cantería valenciana, en el momento de los grandes maestros canteros, y, además, pretende realizar un acercamiento fundado al descubrimiento de su autoría.Navarro Camallonga, P.; Verdejo Gimeno, P.; Priego De Los Santos, JE.; López Patiño, MG. (2022). Espacios columnarios en la arquitectura gótica valenciana. El claustrillo de la Cartuja de Porta Coeli. EGA Expresión Gráfica Arquitectónica. 27(44):26-39. https://doi.org/10.4995/ega.2022.16721OJS2639274

Cultural Heritage Restoration of a Hemispherical Vault by 3D Modelling and Projection of Video Images with Unknown Parameters and from Unknown Locations

[EN] Reverse engineering applied to architectural restoration for the reconstruction of structural surfaces depends on metric precision. Sometimes there are elements on these surfaces whose value is even higher than the building itself. This is the case for many churches whose ceilings have pictorial works of art. Reconstruction requires the existence of some identifiable remainder and/or a surface geometry that enables mathematical development. In our case, the vault has an irregular hemispherical geometry (without possible mathematical development), and there are no significant remains of the painting (which was destroyed by a fire). Through the 3D modelling of the irregular vault and two historic frames with a camera of unknown geometry, an inverse methodology is designed to project the original painting without metric deformations. For this, a new methodology to locate the camera positions is developed. After, a 3D virtual mathematical model of the complete image on the vault is calculated, and from it, partial 3D virtual images are automatically calculated depending on the variable unknown positions of the video cannons (distributed along the upper corridor of the apse) that will project them (visually forming a perfect complete 3D image)Herráez Boquera, J.; Denia Rios, JL.; Priego De Los Santos, E.; Navarro Esteve, PJ.; Martín Sánchez, MT.; Rodríguez Pereña, J. (2021). Cultural Heritage Restoration of a Hemispherical Vault by 3D Modelling and Projection of Video Images with Unknown Parameters and from Unknown Locations. Applied Sciences. 11(12):1-12. https://doi.org/10.3390/app11125323112111

Study of IDO1 gene expression in histological variants of colorectal carcinoma.

pre-print477 K

Spontaneous functional recovery after focal damage in neuronal cultures

Damage in biological neuronal networks triggers a complex functional reorganization whose mechanisms are still poorly understood. To delineate this reorganization process, here we investigate the functional alterations of in vitro rat cortical circuits following localized laser ablation. The analysis of the functional network configuration before and after ablation allowed us to quantify the extent of functional alterations and the characteristic spatial and temporal scales along recovery. We observed that damage precipitated a fast rerouting of information flow that restored network's communicability in about 15 min. Functional restoration was led by the immediate neighbors around trauma but was orchestrated by the entire network. Our in vitro setup exposes the ability of neuronal circuits to articulate fast responses to acute damage, and may serve as a proxy to devise recovery strategies in actual brain circuits. Moreover, this biological setup can become a benchmark to empirically test network theories about the spontaneous recovery in dynamical networks

Metabolomics analysis of type 2 diabetes remission identifies 12 metabolites with predictive capacity: a CORDIOPREV clinical trial study.

Type 2 diabetes mellitus (T2DM) is one of the most widely spread diseases, affecting around 90% of the patients with diabetes. Metabolomics has proven useful in diabetes research discovering new biomarkers to assist in therapeutical studies and elucidating pathways of interest. However, this technique has not yet been applied to a cohort of patients that have remitted from T2DM. All patients with a newly diagnosed T2DM at baseline (n = 190) were included. An untargeted metabolomics approach was employed to identify metabolic differences between individuals who remitted (RE), and those who did not (non-RE) from T2DM, during a 5-year study of dietary intervention. The biostatistical pipeline consisted of an orthogonal projection on the latent structure discriminant analysis (O-PLS DA), a generalized linear model (GLM), a receiver operating characteristic (ROC), a DeLong test, a Cox regression, and pathway analyses. The model identified a significant increase in 12 metabolites in the non-RE group compared to the RE group. Cox proportional hazard models, calculated using these 12 metabolites, showed that patients in the high-score tercile had significantly (p-value < 0.001) higher remission probabilities (Hazard Ratio, HR, high versus low = 2.70) than those in the lowest tercile. The predictive power of these metabolites was further studied using GLMs and ROCs. The area under the curve (AUC) of the clinical variables alone is 0.61, but this increases up to 0.72 if the 12 metabolites are considered. A DeLong test shows that this difference is statistically significant (p-value = 0.01). Our study identified 12 endogenous metabolites with the potential to predict T2DM remission following a dietary intervention. These metabolites, combined with clinical variables, can be used to provide, in clinical practice, a more precise therapy. ClinicalTrials.gov, NCT00924937.The CORDIOPREV study is supported by the Ministerio de Economia y Competitividad, Spain, under the grants AGL2012/39615, PIE14/00005, and PIE14/00031 associated to J.L.-M.; AGL2015-67896-P to J.L.-M. and A.C.; CP14/00114 to A.C.; PI19/00299 to A.C.; DTS19/00007 to A.C.; FIS PI13/00023 to J.D.-L., PI16/01777 to F.P.-J. and P.P.-M.; Antonio Camargo is supported by an ISCIII research contract (Programa Miguel-Servet CPII19/00007); Marina Mora-Ortiz has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 847468; ‘Fundacion Patrimonio Comunal Olivarero’, Junta de Andalucía (Consejería de Salud, Consejeria de Agricultura y Pesca, Consejería de Innovacion, Ciencia y Empresa), ‘Diputaciones de Jaen y Cordoba’, ‘Centro de Excelencia en Investigación sobre Aceite de Oliva y Salud’ and ‘Ministerio de Medio Ambiente, Medio Rural y Marino’, Gobierno de España; ‘Consejeria de Innovación, Ciencia y Empresa, Proyectos de Investigación de Excelencia’, Junta de Andalucía under the grant CVI-7450 obtaiend by J.L.-M.; and we would also like to thank the ‘Fondo Europeo de Desarrollo Regional (FEDER)’.S

I.amAble: la ciencia (química) al alcance de toda la sociedad

En este proyecto de innovación, que nace con vocación de continuar en años sucesivos, se persigue mejorar la calidad de la formación de los estudiantes de la Facultad de Ciencias Químicas (F. CC.QQ.) en el ámbito de la docencia teórico-práctica y de la divulgación científica. El trabajo ha consistido en la preparación de unos experimentos prácticos para llevarlos a cabo en centros educativos no universitarios en los que se ha tenido en cuenta la participación conjunta de personas con y sin diversidad funcional, desde una perspectiva inclusiva colaborativa. Estas actividades las han realizado los estudiantes bajo la supervisión de profesores (PDI) y personal de administración y servicios (PAS). Los experimentos se han recogido en fichas didácticas para facilitar su desarrollo y aplicación por parte de otros usuarios. En estas fichas se explica detalladamente cómo realizar las experiencias en formato de taller. Las fichas de los talleres realizados están disponibles en una página web vinculada a la Universidad Complutense bajo el título I.amAble (iamable.ucm.es). Está página ha sido construida por un estudiante de la Facultad de Informática , bajo la supervisión de profesionales, tanto de esa facultad como del Instituto de Tecnología del Conocimiento, y está abierta a contribuciones similares de otras facultades y otras instituciones. La página web está diseñada de manera que resulte lo más intuitiva y accesible posible para todo tipo de público. Entre todos los experimentos se han elegido cuatro para llevarlos a la práctica en centros educativos como actividades inclusivas en las que han participado conjuntamente personas con y sin discapacidad. Con este proyecto se pretende mejorar la calidad docente al ofrecer a los estudiantes la posibilidad de aprender enseñando mediante una actividad semipresencial. El desarrollo por parte de los estudiantes de competencias transversales en educación y en divulgación de la ciencia facilitarán algunas salidas profesionales en el ámbito educativo formal (centros de enseñanza) o informal (museos, animación sociocultural). Otro aspecto importante a resaltar es la potenciación de la colaboración entre todos los miembros de la institución universitaria. Este proyecto pretende contribuir a la mejora de la cultura científica, así como al establecimiento de puentes entre la UCM y la sociedad a la que debe servir. Finalmente, es importante subrayar que incidirá en la inclusión de las personas con discapacidad como parte de la sociedad, a través del acercamiento compartido a la ciencia (Dimensiones de inclusión social y derechos de Schalock; NAVAS MACHO, P. y otros, 2012. Derechos de las personas con discapacidad intelectual: implicaciones de la Convención de Naciones Unidas. Siglo Cero. 43 (243): 7-28.)