6 research outputs found
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
- Hong T
- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- Julião K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
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- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
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- Kim M
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- Kitchens D
- Klamm M
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- Klemsdal To
- Kleve R
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- Kodem Dr
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- Krupicka J
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- Kuruma T
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- Labovitz R
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- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
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- Macdonald J
- Macfadyen Jg
- Machova V
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- Majercak I
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- Makotoko E
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- Malik J
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- Mandic L
- Manenti E
- Manfreda S
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- Manning B
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- Manolis A
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- Manov E
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- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
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- Marshall L
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- Martinez J
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- Marziali A
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- Mavromatis K
- Maximov D
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- Mazutavicius R
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- Mckenzie A
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- Mckibbin A
- Mclaurin B
- Mclellan Ba
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- Mcneil D
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- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
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- Meijlis P
- Meissner A
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- Mellberg L
- Melliza T
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- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
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- Michalska A
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- Michel K
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- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
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- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
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- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Military Technologies, Nanotechnology and Law: Using Nano-Science Fiction as an Analytical Tool
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Recalibrating The Law of Humans with The Laws of Nature: Climate Change, Human Rights, and Intergenerational Justice
- Author
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- A David
- A David
- Alaska
- Alaska Amend Const
- Allan Kahner
- Annette Baier
- Axel Gosseries
- Ban Ki-Moon
- Barnes
- Brian Barry
- Brown Weiss
- Brown Weiss
- Brown Weiss
- Brown Weiss
- Brown Weiss
- Brown Weiss
- Burns H. Weston
- C A Ma
- C Civ
- C F R
- C F R
- Chapter
- Chapter
- Chapter
- Chapter
- Chapter
- Chi L Rev
- Civ
- Clark Wolf
- Conference On Environment
- Dante B Gatmaytan
- Div Affairs
- E G See
- Edith Brown Weiss
- Edith Brown Weiss
- Edward A Page
- Elisabeth Rosenthal
- Elise Boulding
- Emmanuel Agius
- Environment Ministry Of Justice
- F Reed
- Fair Deborah Groban Olson
- Fiordland
- Frank Ackerman &
- Gordon Smith
- Gro Harlem Brundtland
- Hans Jonas
- Hans Jonas
- Haw
- Heal
- Henry Shue
- Herman E See Also
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- J L Cornell
- James Hansen
- James Hansen
- James Norris
- James R May
- Jeffery Spear
- Joel Feinberg
- John Austin
- John L Horwich
- John Rawls
- John Rawls
- Jonathan C Carlson
- Joseph H See Also
- Jr Rodgers
- Juan Antonio Oposa
- Judith M Brawer
- Justin R Pidot
- J�rg
- Kentucky Util
- Kevin Harris
- Klass
- Kysar
- L Envtl
- L Rev
- L Richard
- Larry Nesper
- Lujan
- M Dutzer
- Mary C Wood
- Mary C Wood
- Mary F See Also
- Maureen Cropper &
- Minnesota Wisconsin
- Mont
- Ngai Tahu
- Nicholas Herbert Stern
- Norton
- Norton
- Norton
- Norton
- Norton
- Norton V
- O&apos
- Olson
- Oren Lyons
- P Daniel
- P Landais
- Partha Dasgupta
- Parthenia Blessing Evans
- Peter Barnes
- President John
- Price V U S Navy
- Rawls
- Reg
- Report_Full_En
- Revesz
- Richard L Revesz
- S Afr
- See Burns
- See Cass
- See Edith Brown
- See Gro Harlem Brundtland
- See Id
- See Mayo Found
- See Paul
- Shiro Kawashima
- Shlomo Shoham &
- Stern
- Supp Gaor
- Thomas L Friedman
- Thomas O Mcgarity
- Timothy J Brennan
- Tracy Bach
- Tremmel
- Tremmel
- U S
- U S C
- U S C
- U S C
- U S C
- U S C
- Usda Forest Service
- Wilfred Beckerman
- William A Nordhaus
- Wilson V Amoco Corp
- Working Weisbach &
- World Wildlife Fund
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2009
- Field of study
Florida’s Underwater Archaeological Preserves: Public Participation as an Approach to Submerged Heritage Management
- Author
- American Bureau of Shipping (ABS).
- American Shipmasters Association (ASA).
- Arenson S.
- Armstrong H. C.
- Baram U.
- Beeker C. D.
- Bowens A.
- Bradenton Herald.
- Bratten J. R.
- Conlin D. L.
- Crankshaw J.
- Florida Bureau of Archaeological Research (FBAR)
- Franklin H. Price
- Halsey J. R.
- Hanselmann F. H.
- Harris L.
- Jeffery B.
- Kaczor B.
- Lloyds
- Martin C.
- McGimsey C. R.
- Merriman N.
- Mueller E. A.
- Munroe R.
- New York Times (NYT).
- Nutley D. M.
- Pacacha F.
- Panama City News Herald (PCNH)
- Panama City News Herald (PCNH).
- Panama City News Herald (PCNH).
- Panama City Pilot (PCP)
- Ransley J.
- Reilly J. C.
- Silberman N.
- Smith R. C.
- Smith R. C.
- Smith S.
- The Tropical Sun.
- Tikkanen S.
- Tusa S.
- United Nations Educational Scientific, and Cultural Organization (UNESCO)
- United States Department of the Navy (USDN)
- United States Treasury Department (USTD).
- United States Treasury Department (USTD).
- Vrana K. J.
- Wagner K.
- Wentley S.
- Zarzynski J. W.
- Zmaić V.
- Publication venue
- 'Maney Publishing'
- Publication date
- Field of study
SURFACE ACTIVE AGENTS AND THEIR APPLICATION IN BACTERIOLOGY
- Author
- ABRL
- ADDISON C. C.
- ALEXANDER A. E.
- ALLEN T. H.
- ALLEN T. H.
- ANSON M. L.
- ANSON M. L.
- ARCHBALD R. M.
- ARMBRUSTER E. H.
- Ax M
- AYERS S. H.
- B.
- BAKER Z.
- BAKER Z.
- BAKER Z.
- BAWDEN F. C.
- BAWDEN F. C.
- BAWDEN F. C.
- BAWDEN F. C.
- BAYLISS M.
- BAYLISS M.
- BAYLISS M.
- BEGG A. M.
- BERNHEIMER A. W.
- BERNSTEIN H.
- BIE W. C.
- BIE W. C.
- BIRKELAND J. M.
- BODINE J. H.
- BODINE J. H.
- BOS R. J.
- BREWER C. M.
- BREWER C. M.
- BREWER C. M.
- BURNET F. M.
- CARYL C. R.
- COOKE B.
- D.
- D.
- DAVI
- DAVIS B. D.
- DAVIS B. D.
- DOMAGK G.
- DREGER E. E.
- DUNN C. G.
- EATON M. D.
- EI MAN
- EPSTEIN A. K.
- ERICKSON J. O.
- FA R G
- FINDLAY G. M.
- FISHER C. V.
- FOLEY G. E.
- FREEMAN S.
- FROBISHER M.
- GALE E. F.
- GERSHENFELD L.
- GERSHENFELD L.
- GERSHENFELD L.
- GERSHENFELD L.
- GERSHENFELD L.
- GERSHENPELD L.
- GIBB
- GIBBY I. W.
- GONICK E.
- GREEN T. W.
- GREEN T. W.
- HAGAN H. H.
- HARDING H. G.
- HARRIS A. H.
- HARTMNN M.
- HAUSER E. A.
- HAUSER E. A.
- HAUSER E. D.
- HE
- HEL ER
- HILL J. A.
- HN R.
- HOBER R.
- HOOGERHEIDE J. C.
- HUGHES D. L.
- HUYCK C. L.
- IB S R
- IS A. S.
- IS A. S.
- J.
- JACOBS W. A.
- JACOBS W. A.
- JACOBS W. A.
- JAFF
- JERCHEL D.
- JERCHEL D.
- JOHNS C. K.
- JOSLYN D. A.
- KALTER S. S.
- KENNER B. A.
- KLARMANN E. G.
- KLARMANN E. G.
- KLARMANN E. G.
- KLEIN M.
- KLEIN M.
- KLEIN M.
- KLIEWE H.
- KNIGHT C. A.
- KOLLOFF H. G.
- KOLMER J. A.
- KRAMER S. D.
- KROG A. J.
- KRUEGER A. P.
- KRUEGER A. P.
- KUHN E.
- KUHN R.
- KUHN R.
- KUHN R.
- KUHN R.
- KUHN R.
- KUHN R.
- LAMANNA C.
- LAMANNA C.
- LAR ON W
- LARSON W. P.
- LARSON W. P.
- LARSON W. P.
- LARSON W. P.
- LARSON W. P.
- LASSE R P
- LD Hi H
- LE
- LUNDGREN H. P.
- LUNDGREN H. P.
- MACFARLANE M. G.
- MACPHERSON R. M.
- MALLMANN W. L.
- MALLMANN W. L.
- MARRON T. U.
- MARSHALL M. S.
- MARTIN D. S.
- MCC LOCH
- MCCALLA T. M.
- MCCALLA T. M.
- MCCUTCHEON J. W.
- MCKINLEY J. C.
- MEEKIN T. L.
- MIDDLEBROOK G.
- MILLER B. F.
- MILLER G. L.
- MIRSKY A. E.
- MIRSKY A. E.
- MUELLER W. S.
- N'
- NAVY MED No.
- NETER E.
- NEURATH H.
- NEURATH H.
- NEY J.
- NUNGESTER W. J.
- OLITSKY P. K.
- ORDAL E. J.
- ORDAL E. J.
- ORDAL E. J.
- PALMER K. J.
- PANKHURST K. G.
- PAPPENHEIMER A. M.
- PECK R. L.
- PENNISTON V. J.
- PENNISTON V. J.
- PFANKUCH E.
- PHILLIPS M. A.
- PICE C.
- PIER E M
- PIK E A
- PILTAGR L.
- PONDER E.
- PRICE D.
- QUISNO R.
- QUISNO R.
- R.
- RAHN
- RALSTON A. W.
- RALSTON A. W.
- RAWLINS A. L.
- REDDISH G. F.
- REDDISH G. F.
- REDDISH G. F.
- ROBERTS M. H.
- ROUNTREE P. M.
- SCALES F. M.
- SCHMIDT S.
- SEEPARD E. R.
- SEVAG M. G.
- SHEDLOVSKY L.
- SHELTON R. S.
- SHELTON R. S.
- SHELTON R. S.
- SHIPPEN L. P.
- SHIROLKAR G. V.
- SMIM W.
- SREENIVASAYA M.
- STANLEY W. M.
- STANLEY W. M.
- STARK C. N.
- STEARN A. E.
- STEINHARDT J.
- STEINHARDT J.
- STOCK C. C.
- STOCK C. C.
- STOCK C. C.
- TARR H. L.
- TNA
- TNA
- TNAM F. W.
- TR
- VAGTBORG H.
- VALKO E. I.
- VALKO E. I.
- VENNESLAND K.
- VINCENT H.
- W.
- WELCH H.
- WELCH H.
- WELCH H.
- WESTPHAL O.
- WILBRANDT W.
- WILBRANDT W.
- WILKES B. G.
- WILLIAMS W. L.
- WITLIN B.
- WOLF C. G.
- WOLF P. A.
- WONG S. C.
- WRIGHT J. H.
- WRIGHT K. A.
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Antiinflammatory therapy with canakinumab for atherosclerotic disease
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- Abaci F.
- Abbate A.
- Abdullakutty J.
- Abhaichand R.
- Abhyankar A.
- Abib E.Jr.
- Aboufakher R.
- Abrantes J.
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- Abulencia K.
- Acampora D.
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- Accini Mendoza JL.
- Aceto L.
- Acevedo B.
- Acevedo L.
- Acheatel R.
- Actis M.V.
- Adams A.
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- Adjic N.C.
- Affaki G.S.
- Agafina A.
- Agarwal D.K.
- Aggarwal R.K.
- Agosta G.F.
- Aguilar M.
- Ahire N.
- Ahmad I.
- Ahmed S.H.
- Ahn Y.
- Aish B.
- Aiub F.
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- Ajax K.
- Ajioka M.
- Akai Y.
- Akatova E.
- Akrap B.
- Akyea-Djamson A.
- Al Joundi T.
- Al-Khalili F.
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- Alcalde J.M.
- Alcide P.
- Alfieri A.
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- Alllison D.C.
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- Amos A.
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- Angelova I.
- Angiolillo D.
- Anita S.
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- Anneveldt A.
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- Antolick A.
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- Aparicio C.V.
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- Apostolovic S.
- Ara M.
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- Arevalo S.
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- Field of study
BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P=0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P=0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P=0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P=0.31). CONCLUSIONS: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. Copyright © 2017 Massachusetts Medical Society