1,833 research outputs found
Optimization of the leak conductance in the squid giant axon
We report on a theoretical study showing that the leak conductance density,
\GL, in the squid giant axon appears to be optimal for the action potential
firing frequency. More precisely, the standard assumption that the leak current
is composed of chloride ions leads to the result that the experimental value
for \GL is very close to the optimal value in the Hodgkin-Huxley model which
minimizes the absolute refractory period of the action potential, thereby
maximizing the maximum firing frequency under stimulation by sharp, brief input
current spikes to one end of the axon. The measured value of \GL also appears
to be close to optimal for the frequency of repetitive firing caused by a
constant current input to one end of the axon, especially when temperature
variations are taken into account. If, by contrast, the leak current is assumed
to be composed of separate voltage-independent sodium and potassium currents,
then these optimizations are not observed.Comment: 9 pages; 9 figures; accepted for publication in Physical Review
From solid solution to cluster formation of Fe and Cr in -Zr
To understand the mechanisms by which Fe and Cr additions increase the
corrosion rate of irradiated Zr alloys, a combination of experimental (atom
probe tomography, x-ray diffraction and thermoelectric power measurements) and
modelling (density functional theory) techniques are employed to investigate
the non-equilibrium solubility and clustering of Fe and Cr in binary Zr alloys.
Cr occupies both interstitial and substitutional sites in the {\alpha}-Zr
lattice, Fe favours interstitial sites, and a low-symmetry site that was not
previously modelled is found to be the most favourable for Fe. Lattice
expansion as a function of alloying concentration (in the dilute regime) is
strongly anisotropic for Fe additions, expanding the -axis while contracting
the -axis. Defect clusters are observed at higher solution concentrations,
which induce a smaller amount of lattice strain compared to the dilute defects.
In the presence of a Zr vacancy, all two-atom clusters are more soluble than
individual point defects and as many as four Fe or three Cr atoms could be
accommodated in a single Zr vacancy. The Zr vacancy is critical for the
increased solubility of defect clusters, the implications for irradiation
induced microstructure changes in Zr alloys are discussed.Comment: 15 pages including figure, 9 figures, 2 tables. Submitted for
publication in Acta Mater, Journal of Nuclear Materials (2015
Relative Reactivity of the Metal-Amido versus Metal-Imido Bond in Linked Cp-Amido and Half-Sandwich Complexes of Vanadium
Treatment of (η5-C5H4C2H4NR)V(N-t-Bu)Me (R = Me, i-Pr) and CpV(N-p-Tol)(N-i-Pr2)Me (Cp = η5-C5H5) with B(C6F5)3 or [Ph3C][B(C6F5)4] results in formation of the corresponding cations, [(η5-C5H4C2H4NR)V(N-t-Bu)]+ and [CpV(N-p-Tol)(N-i-Pr2)]+. The latter could also be generated as its N,N-dimethylaniline adduct by treatment of the methyl complex with [PhNMe2H][BAr4] (Ar = Ph, C6F5). Instead, the analogous reaction with the linked Cp-amido precursor results in protonation of the imido-nitrogen atom. Sequential cyclometalation of the amide substituents gave cationic imine complexes [(η5-C5H4C2H4NCR'2)V(NH-t-Bu)]+ (R' = H, Me) and methane. Reaction of cationic [(η5-C5H4C2H4NR)V(N-t-Bu)]+ with olefins affords the corresponding olefin adducts, whereas treatment with 1 or 2 equiv of 2-butyne results in insertion of the alkyne into the vanadium-nitrogen single bond, affording the mono- and bis-insertion products [(η5-C5H4C2H4N(i-Pr)C2Me2)V(N-t-Bu)]+ and [(η5-C5H4C2H4N(i-Pr)C4Me4)V(N-t-Bu)]+. The same reaction with the half-sandwich compound [CpV(N-p-Tol)(N-i-Pr2)]+ results in a paramagnetic compound that, upon alcoholysis, affords sec-butylidene-p-tolylamine, suggesting an initial [2+2] cycloaddition reaction. The difference in reactivity between the V-N bond versus the V=N bond was further studied using computational methods. Results were compared to the isoelectronic titanium system CpTi(NH)(NH2). These studies indicate that the kinetic product in each system is derived from a [2+2] cycloaddition reaction. For titanium, this was found as the thermodynamic product as well, whereas the insertion reaction was found to be thermodynamically more favorable in the case of vanadium.
Creating an enduring developmental legacy from FIFA 2010: The Football Foundation of South Africa (FFSA)
Beyond prejudice: Are negative evaluations the problem and is getting us to like one another more the solution?
publication-status: Acceptedtypes: ArticleThis is a post print version of an article published in Behavioral and Brain Sciences, 2012, 35 (6), pp 438-439 DOI: http://dx.doi.org/10.1017/S0140525X12001252
Copyright © Cambridge University Press 2012For most of the history of prejudice research, negativity has been treated as its emotional and cognitive signature, a conception that continues to dominate work on the topic. By this definition, prejudice occurs when we dislike or derogate members of other groups. Recent research, however, has highlighted the need for a more nuanced and ‘inclusive’ (Eagly 2004) perspective on the role of intergroup emotions and beliefs in sustaining discrimination. On the one hand, several independent lines of research have shown that unequal intergroup relations are often marked by attitudinal complexity, with positive responses such as affection and admiration mingling with negative responses such as contempt and resentment. Simple antipathy is the exception rather than the rule. On the other hand, there is mounting evidence that nurturing bonds of affection between the advantaged and the disadvantaged sometimes entrenches rather than disrupts wider patterns of discrimination. Notably, prejudice reduction interventions may have ironic effects on the political attitudes of the historically disadvantaged, decreasing their perceptions of injustice and willingness to engage in collective action to transform social inequalities. These developments raise a number of important questions. Has the time come to challenge the assumption that negative evaluations are inevitably the cognitive and affective hallmarks of discrimination? Is the orthodox concept of prejudice in danger of side-tracking, if not obstructing, progress towards social justice in a fuller sense? What are the prospects for reconciling a prejudice reduction model of change, designed to get people to like one another more, with a collective action model of change, designed to ignite struggles to achieve intergroup equality
Consistent Application of Maximum Entropy to Quantum-Monte-Carlo Data
Bayesian statistics in the frame of the maximum entropy concept has widely
been used for inferential problems, particularly, to infer dynamic properties
of strongly correlated fermion systems from Quantum-Monte-Carlo (QMC) imaginary
time data. In current applications, however, a consistent treatment of the
error-covariance of the QMC data is missing. Here we present a closed Bayesian
approach to account consistently for the QMC-data.Comment: 13 pages, RevTeX, 2 uuencoded PostScript figure
Iron redistribution in a zirconium alloy after neutron and proton irradiation studied by energy-dispersive X-ray spectroscopy (EDX) using an aberration-corrected (scanning) transmission electron microscope
Cosmic Swarms: A search for Supermassive Black Holes in the LISA data stream with a Hybrid Evolutionary Algorithm
We describe a hybrid evolutionary algorithm that can simultaneously search
for multiple supermassive black hole binary (SMBHB) inspirals in LISA data. The
algorithm mixes evolutionary computation, Metropolis-Hastings methods and
Nested Sampling. The inspiral of SMBHBs presents an interesting problem for
gravitational wave data analysis since, due to the LISA response function, the
sources have a bi-modal sky solution. We show here that it is possible not only
to detect multiple SMBHBs in the data stream, but also to investigate
simultaneously all the various modes of the global solution. In all cases, the
algorithm returns parameter determinations within (as estimated from
the Fisher Matrix) of the true answer, for both the actual and antipodal sky
solutions.Comment: submitted to Classical & Quantum Gravity. 19 pages, 4 figure
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