Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism

A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism. To test this hypothesis, we examined a group of recently detoxified alcoholics with high (n = 25) and low genetic loading for alcoholism (n = 28) and a group of healthy controls (n = 21). Clinical assessments were made using the SCID II interview for psychiatric disorders, the Family History Assessment Module and the Semi-Structural Assessment of Genetics in Alcoholism, a questionnaire especially designed for genetic studies. Platelet MAO activity with and without ethanol stimulation and the percentage of MAO activity with ethanol did not differ between groups. The only significant difference was a lower inhibition of MAO activity with ethanol in alcoholics both with and without a family history compared to controls. In patients with antisocial personality traits, platelet MAO activity was also not found to be different from other alcoholics. Our findings question the hypothesis of reduced platelet MAO activity to be a possible vulnerability marker for alcoholism. Copyright (C) 2000 S. Karger AG. Basel

Le démocracide furtif du Bénin - Comment la démocratie modèle de l'Afrique se tue peu à peu

ABSTRACT & RÉSUMÉ & ZUSAMMENFASSUNG : A 'democratic recession' is to be observed, which is not restricted to Sub-Sahara Africa but spreads worldwide since the beginning of the 21st century. Instead of concentrating on the outward appearance of a democratic form of government, greater attention should be paid to good governance and the stealthy erosion of democratic institutions, even in formerly shining examples and African 'model democracies' like Benin and Senegal. It went along with the rise of populist new nationalism and lack of regard of the concerned for the need to defend democracy actively. The lingering process of the decline of democratic institutions is driven by increasingly poor governance and disregard for the rule of law and transparency, which has been especially pronounced in African countries since the early 2000s. On the other hand, recent examples of African social movements that successfully campaigned for a democratic renaissance in Africa and elsewhere are promising indicators of progressive social forces that counteract global trends of the resurgence of right-wing nationalism and autocratic rule. ----------------------------------------------------------------------------------------------------------------------------------------------------------- RÉSUMÉ : On observe une « récession démocratique » qui ne se limite pas à l’Afrique subsaharienne mais s’étend à l’échelle mondiale depuis le début du XXIe siècle. Au lieu de se concentrer sur l’apparence extérieure d’une forme de gouvernement démocratique, il faudrait accorder une plus grande attention à la bonne gouvernance et à l’érosion furtive des institutions démocratiques, même dans les exemples jadis brillants et les « démocraties modèles » africaines comme le Bénin et le Sénégal. Cela a coïncidé avec la montée d'un nouveau nationalisme populiste et le manque de vigilance des personnes concernées quant à la nécessité de défendre activement la démocratie. Le processus persistant du déclin des institutions démocratiques s’explique par une gouvernance de plus en plus médiocre et un mépris de l’état de droit et de la transparence, qui se fait particulièrement sentir dans les pays africains depuis le début des années 2000. D'autre part, des exemples récents de mouvements sociaux africains qui ont mené avec succès une renaissance démocratique en Afrique et ailleurs sont des indicateurs prometteurs de forces sociales progressistes qui vont à l’encontre des tendances mondiales à la résurgence d’un nationalisme de droite et des régimes autocratiques. --------------------------------------------------------------------------------------------------------------------------------------------------------------------- ZUSAMMENFASSUNG : Es ist eine "demokratische Rezession" zu beobachten, die sich nicht nur auf Afrika südlich der Sahara beschränkt, sondern sich seit Beginn des 21. Jahrhunderts weltweit ausbreitet. Anstatt sich auf das äußere Erscheinungsbild einer demokratischen Regierungsform zu konzentrieren, sollte der verantwortungsvollen Regierungsführung und der heimlichen Erosion demokratischer Institutionen größere Aufmerksamkeit geschenkt werden, selbst in früheren Vorbildern und afrikanischen „Modelldemokratien“ wie Benin und Senegal. Dies geht einher mit dem Aufkommen eines populistischen neuen Nationalismus und dem mangelnden Augenmerk auf die Notwendigkeit, die Demokratie aktiv zu verteidigen. Der anhaltende Niedergang der demokratischen Institutionen ist auf eine zunehmend mangelhafte Regierungsführung und die Missachtung von Rechtsstaatlichkeit und Transparenz zurückzuführen, die in den afrikanischen Ländern seit Anfang der 2000er Jahre besonders ausgeprägt ist. Andererseits sind afrikanischer soziale Bewegungen, die sich erfolgreich für eine demokratische Renaissance in Afrika und anderswo einsetzen, vielversprechende Indikatoren für fortschrittliche soziale Kräfte, die globalen Trends des Wiederauflebens eines rechten Nationalismus und autokratischer Herrschaft entgegenwirken

Benin’s stealthy democracide : How Africa's model democracy kills itself bit by bit

A 'democratic recession' is to be observed, which is not restricted to Sub-Sahara Africa. It went along with the rise of populist new nationalism and lack of regard of the concerned for the need to defend democracy actively. On the other hand, recent examples of African social movements that successfully campaigned for a democratic renaissance in Africa and elsewhere are promising indicators of progressive social forces that counteract global trends of the resurgence of right-wing nationalism and autocratic rule

Vom Camarade zum Monsieur: Strukturanpassung und Demokratisierung in Benin

Der Prozess der politischen und wirtschaftlichen Liberalisierung in Benin gilt als Vorbild für das gesamte subsaharische Afrika. Benin schrieb Geschichte, indem er als erstes afrikanisches Land einen Militärdiktator mit demokratischen Mitteln stürzte. Der zivile Staatsstreich machte auch den Weg frei für eine wirtschaftliche Erholung. Die Stärkung der demokratischen Institutionen und der gute Wille der neuen Regierung des früheren hochrangigen Weltbankangestellten N. Soglo, den Empfehlungen des Strukturanpassungsprogramms zu folgen, wurden durch die Großzügigkeit der Geber gewürdigt. Die Erholung der Wirtschaft wurde jedoch durch die zugrunde liegende soziokulturelle Struktur von Klientelismus und Gönnerschaft behindert, die dazu führte, dass das laufende Strukturanpassungsprogramm hauptsächlich den Interessen der Staatsklasse und strategische Gruppen diente, die um die Beute der zunehmenden Entwicklungshilfe konkurrierten. Somit sind die sozioökonomischen Bedingungen für einen sich selbst tragenden Entwicklungsprozess und folglich eine verstärkte Entwicklungshilfe noch nicht erfüllt. Dennoch gibt es Möglichkeiten der Zusammenarbeit in den Bereichen Presse- und Meinungsfreiheit, Grundbedürfnisse und Selbsthilfeorganisationen.The process of political and economic liberalisation in Benin is regarded as a model for the whole of Sub-Saharan Africa. Benin made history by becoming the first African country to overthrow a military dictator by democratic means. The civilian coup d'état cleared the way for economic recovery, too. The strengthening of democratic institutions, and the good will of the new government of the former high ranking World Bank-employee Soglo, to follow the recommendations of the structural adjustment program have been honoured by the donors' generosity. The recovery of the economy, however, was hampered by the underlying fabric of the socio-cultural structure of clientelism and patronage, which resulted in a situation in which the on-going structural adjustment program mainly served the vested interests of the state class and rival strategic groups, bargaining for the booty of increasing development assistance. Thus, socio-economic conditions for a self-sustaining development process and, consequently, increased development assistance are not yet met. Nevertheless, areas of co-operation do exist in the fields of liberty of press and opinion, basic needs and self-help organizations.Le processus de libéralisation politique et économique au Bénin est considéré comme un modèle pour l'ensemble de l'Afrique subsaharienne. Le Bénin est entré dans l'histoire en étant le premier pays africain à renverser un dictateur militaire par des moyens démocratiques. Le coup d'État civil a également ouvert la voie au redressement économique. Le renforcement des institutions démocratiques et la bonne volonté du nouveau gouvernement de l'ancien haut fonctionnaire de la Banque mondiale, Nicephore Soglo, à suivre les recommandations du programme d'ajustement structurel, ont été honorés par la générosité des donateurs. Le redressement de l'économie a toutefois été entravé par le tissu sous-jacent de la structure socioculturelle du clientélisme et de la patronage, qui a abouti à une situation dans laquelle le programme d'ajustement structurel en cours servait principalement les intérêts de la classe étatique et des groupes stratégiques, négociation pour le butin de l'aide au développement croissante. Ainsi, les conditions socio-économiques d'un processus de développement autonome et, par conséquent, d'une aide au développement accrue ne sont pas encore réunies. Néanmoins, des domaines de coopération existent dans les domaines de la liberté de la presse et de l'opinion, des besoins fondamentaux et des organisations d'entraide

Benin’s stealthy democracide : How Africa's model democracy kills itself bit by bit

A 'democratic recession' is to be observed, which is not restricted to Sub-Sahara Africa. It went along with the rise of populist new nationalism and lack of regard of the concerned for the need to defend democracy actively. On the other hand, recent examples of African social movements that successfully campaigned for a democratic renaissance in Africa and elsewhere are promising indicators of progressive social forces that counteract global trends of the resurgence of right-wing nationalism and autocratic rule

The advantage of a toxicokinetic model of the honey bee colony in the context of the risk assessment of plant protection products

Within the current discussions about risk assessment of plant protection products regarding honey bees, one of the most important aspects is how to link pesticide exposure on field and landscape scale to potential effects within the colony. A dynamic toxicokinetic model may help to improve the evaluation of dose rates individuals are exposed to through various compartments of the colony, which may result from the application of plant protection products in the field. In addition, it may help to interpret the significance of ecotoxicological test results, especially from lower-tier studies, in the risk assessment and help to refine the exposure assessment and risk evaluation. Linking it to a realistic population model and a landscape-based foraging model would give an improved insight into the dynamics in a honey bee colony under exposure of plant protection productsKeywords: modelling, toxicokinetics, risk assessment, exposur

Urokinase-type plasminogen activator receptor (uPAR) on tumor-associated macrophages is a marker of poor prognosis in colorectal cancer

Patients were identified from a population-based prospective study of 4990 individuals with symptoms associated with colorectal cancer (CRC). A total of 244 CRC tissue samples were available for immunohistochemical staining of uPAR, semiquantitatively scored at the invasive front, and in the tumor core on cancer cells, macrophages, and myofibroblasts. In addition, the levels of the intact and cleaved uPAR-forms in blood from the same patients are evaluated in this study. In a univariate analysis, the number of uPAR-positive versus uPAR-negative macrophages (HR = 2.26, [95% CI: 1.39–3.66, P = 0.0009]) and cancer cells (HR=1.49, [95% CI: 1.01–2.20, P = 0.047]) located in the tumor core were significantly associated to overall survival. In a multivariate analysis, uPAR-positive versus uPAR-negative macrophages located in the tumor core showed the best separation of patients with positive score associated to poor prognosis (HR = 1.84 [95% CI: 1.12–3.04, P = 0.017]). In a multivariate analysis including clinical covariates and soluble uPAR(I), the latter was significantly associated to overall survival (HR = 2.68 [95% CI: 1.90–3.79, P < 0.0001]) and uPAR-positive macrophages in the tumor core remained significantly associated to overall survival (HR = 1.81 [95% CI: 1.08–3.01, P = 0.023]). Membrane-bound uPAR showed additive effects with the circulating uPAR(I) and stage, giving a hazard ratio of 12 between low and high scores. Thus, combining stage, uPAR(I) in blood and uPAR on macrophages in the tumor core increase the prognostic precision more than tenfold, as compared to stage alone

Completeness of tuberculosis case notifications in Germany in 2013–2017: first results of an inventory study

Background Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013–2017. Methods Acquisition of two pseudonymized case-based data sources (national TB notification data and antibiotic resistance surveillance data) was followed by two-source Capture-recapture (CRC) analysis, as case-based data from a third source was unavailable. Aggregated data on consumption of a key anti-TB drug (pyrazinamide [PZA]) was compared to an estimated need for PZA based on TB notification data to obtain an independent underreporting estimation. Additionally, notified TB incidence was compared to TB rate in an aggregated health insurance fund dataset. Results CRC and PZA-based approaches indicated that between 93 and 97% (CRC) and between 91 and 95% (PZA) of estimated cases were captured in the national TB notification data in the years 2013–2017. Insurance fund dataset did not indicate TB underreporting on the national level in 2017. Conclusions Our results suggest that more than 90% of estimated TB cases are captured within the German TB surveillance system, and accordingly the TB notification rate is likely a good proxy of the diagnosed TB incidence rate. An increase in underreporting and discrepancies however should be further investigated.Peer Reviewe

The Effect of Iron on Dislocation Evolution in Model and Commercial Zirconium Alloys

Although the evolution of irradiation-induced dislocation loops has been well correlated with irradiation-induced growth phenomena, the effect of alloying elements on this evolution remains elusive, especially at low fluences. To develop a more mechanistic understanding of the role iron has on loop formation, we used state-of-the-art techniques to study a proton-irradiated Zr-0.1Fe alloy and proton- and neutron-irradiated Zircaloy-2. The two alloys were irradiated with 2-MeV protons up to 7 dpa at 350\ub0C and Zircaloy-2 up to 14.7 7 1025n • m-2, approximately 24 dpa, in a boiling water reactor at approximately 300\ub0C. Baseline transmission electron microscopy showed that the Zr3Fe secondary-phase particles in the binary system were larger and fewer in number than the Zr (Fe, Cr)2and Zr2(Fe, Ni) particles in Zircaloy-2. An analysis of the irradiated binary alloy revealed only limited dissolution of Ze3Fe, suggesting little dispersion of iron into the matrix, while at the same time a higher 〈a〉-loop density was observed compared with Zircaloy-2 at equivalent proton dose levels. We also found that the redistribution of iron during irradiation led to the formation of iron nanoclusters. A delay in the onset of 〈c〉-loop nucleation in proton-irradiated Zircaloy-2 compared with the binary alloy was observed. The effect of iron redistributed from secondary-phase particles because of dissolution on the density and morphology of 〈a〉 and 〈c〉 loops is described. The implication this may have on irradiation-induced growth of zirconium fuel cladding is also discussed

Head and neck paragangliomas: clinical and molecular genetic classification

Head and neck paragangliomas are tumors arising from specialized neural crest cells. Prominent locations are the carotid body along with the vagal, jugular, and tympanic glomus. Head and neck paragangliomas are slowly growing tumors, with some carotid body tumors being reported to exist for many years as a painless lateral mass on the neck. Symptoms depend on the specific locations. In contrast to paraganglial tumors of the adrenals, abdomen and thorax, head and neck paragangliomas seldom release catecholamines and are hence rarely vasoactive. Petrous bone, jugular, and tympanic head and neck paragangliomas may cause hearing loss. The internationally accepted clinical classifications for carotid body tumors are based on the Shamblin Class I–III stages, which correspond to postoperative permanent side effects. For petrous-bone paragangliomas in the head and neck, the Fisch classification is used. Regarding the molecular genetics, head and neck paragangliomas have been associated with nine susceptibility genes: NF1, RET, VHL, SDHA, SDHB, SDHC, SDHD, SDHAF2 (SDH5), and TMEM127. Hereditary HNPs are mostly caused by mutations of the SDHD gene, but SDHB and SDHC mutations are not uncommon in such patients. Head and neck paragangliomas are rarely associated with mutations of VHL, RET, or NF1. The research on SDHA, SDHAF2 and TMEM127 is ongoing. Multiple head and neck paragangliomas are common in patients with SDHD mutations, while malignant head and neck paraganglioma is mostly seen in patients with SDHB mutations. The treatment of choice is surgical resection. Good postoperative results can be expected in carotid body tumors of Shamblin Class I and II, whereas operations on other carotid body tumors and other head and neck paragangliomas frequently result in deficits of the cranial nerves adjacent to the tumors. Slow growth and the tendency of hereditary head and neck paragangliomas to be multifocal may justify less aggressive treatment strategies