Management of Hemangioma with Ksharasutra - A Case Study

It is benign vascular endothelial tumor, common in girls (3:1). In Ayurveda Hemangioma can be compared with Raktaja Granthi. The diagnosis is based on clinical examination and usually straight forward by visual inspection. The treatment of Hemangioma has to be done with endurance and careful selection of procedure according to the type and site of the disease; otherwise, it may lead to cosmetic derangement or recurrence of the ailment regarding the management of this disease, different types of treatment procedures are explained in contemporary science. In Ayurveda also, various treatment principles explained like administration of drugs internally, external application of drugs and parasurgical procedures [i.e., Raktamokshana (bloodletting), Ksharakarma (chemical cauterization), Ksharasutra (medicated thread ligation) and Agnikarma (thermal cauterization)]. These indigenous treatment methods are minimal invasive procedures which do not cause the scar formation, no recurrence and found to be more beneficial in the treatment of Hemangioma. This case study will reveal the management of hemangioma through Ksharasutra along with internal medications. A female patient of age 24-year complaints of small swelling on left breast. Patient was diagnosed case of hemangioma. After required investigations and local examination of swelling, patient was planned and treated with (Ksharasutra, Jatyadi Taila) Ayurvedic formulations as described in texts of Ayurveda

Prevalence of self-medication practices in the Maharashtra population: a cross-sectional study

Background: Self-medication is a significant issue in public health, with varying global prevalence. It is one of the major causes of the emergence of antibiotic resistance in India. The study's objective was to identify the pattern, cause, and adverse events of self-medication in Maharashtra's urban and rural areas. Methods: A cross-sectional survey was conducted using a pre-populated questionnaire; including information on age (18-85 years), non-prescription and prescription medication use. Age, gender, past medical and medication history, social history, and self-medication pattern, frequency, reason, source of information, and adverse events noticed as a result of self-medication are all sociodemographic questions on the questionnaire. A percentage analysis was used to examine the data. Results: Study states that out of 400 sample, 76% of the individuals self-medicate, with painkillers (49.4%), antacids (23.7%), antibiotics (15.3%), being the most often used drugs for ailments like headache, fever, bodily pain, and acidity. The top most medications taken for self-medication are paracetamol (53.1%), pantoprazole (30.43%), ondansetron (13.62%), and azithromycin (12.46%); 66.07% usage of prescription drugs as self-medication was found. The most frequent causes of self-medication were discovered to be mild illnesses, the easy accessibility of medications, and chemist recommendations, 8% of those surveyed had adverse events, and sources of information were chemists, past prescriptions, family members, and acquaintances. Conclusions: In Maharashtra, self-medication is a prevalent practice that primarily utilizes over-the-counter (OTC) drugs. As a result, consumers should be made aware of the hazards of antibiotic resistance and other pharmaceuticals

Management of Fistula In Ano with Ksharasutra - A Case Study

Fistula in ano is a disease known to the humanity since ancient times. For reasons that are unknown, non specific anal fistula are more common in men than women. The overall incidence is about nine cases per 100000 population per year in western Europe, and those in there third, fourth and fifth decades of life are most commonly affected. It is a chronic illness which is, though not fatal but quite discomfirting and troublesome to the patient and often puts deep impact on the quality of life of a patient. Despite many advances in medical field, it still poses big challenge to the surgeon as there is no suitable curative treatment available so far. For the same reason, Sushruta (500BC) has aptly described this disease as one of the Ashtamahagada. He was first person to describe, etiology, clinical feature and management of Bhagandara. He described Ksharasutra therapy in Bhagandara. A Female patient of age 65 years history of Ischiorectal abscess before 1month, she came on 10-7-2019 with the complaint of itching, pus discharge, mild pain in perianal region. Patient was a diagnosed case of Diabetes mellitus from 8years, Hypertension from 4 years, after investigations and local examination, patient was planned and treated with Ksharasutra

FORMULATION OPTIMIZATION AND EVALUATION OF FLURBIPROFEN EMULGEL

Objective: The objective of the present study was to formulate flurbiprofen (FLB) emulgel, evaluation of the formulations and the selection of an optimized formulation through in vitro drug release and drug content studies. Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) requiring frequent administration and its chronic intake can lead to systemic side effects like gastric irritation and GI bleeding. The development of a dermal drug delivery system can overcome these side effects. Methods: The emulgel formulations were produced using different combinations of oil and emulsifying agents. Carbopol 940 was used as a gelling agent. The prepared emulgels were evaluated for general appearance, pH, spreadability, extrudability, drug content, in vitro drug release, average globule size and viscosity. Results: Optimized formulation F7 showed a better in vitro drug release compared to the marketed gel preparation. The stability study for the optimized formulation was carried out at 25 °C/60 % RH for 3 mo and the emulgel was found to be stable concerning the physical appearance, pH and drug content. Conclusion: The study revolved around the formulation of emulgel containing Flurbiprofen for dermal delivery of the drug. Emulgel was formulated with the purpose to enhance the permeation of poorly water-soluble drug FLB. The study concluded that the optimized emulgel containing FLB exhibited better in vitro drug release profile compared to the marketed formulation

A CLINICAL STUDY TO EVALUATE THE EFFECT OF SARVANGA UDVARTANA FOLLOWED BY VIRECHANA KARMA AS ROOKSHA POORVAKA SHODHANA IN AMAVATA W.S.R TO RHEUMATOID ARTHRITIS

The change in the classification of Rheumatoid Arthritis under various headings over the past few decades gives an insight to the pathology that requires a deeper understanding.  Considering the role of immune mediating cells, progressive involvement of multiple joints & other systems, reduction in functional capacity, no other group of diseases is responsible for greater loss of earnings. The incidence of Rheumatoid Arthritis increases between 25 and 55years of age, after which it plateaus until the age of 75 and then decreases.Ayurveda understands this disease on the lines of Ama formation, Agni mandhya in rasa vaha srotas primarily, which over time dysfunctions all the 3 Agni (Jatharagni, Dhatwagni, Bhootagni) resulting in Sthabdham kurute gatram. The mainstay of treatment in Rheumatoid Arthritis comprises the early use of Disease Modifying Anti Rheumatic Drugs & Corticosteroids for induction of remission. As Amavata is an Abhishyandha pradhana vyadhi, adopting any snigdha modality of treatment will cause complications, hence identifying the degree of Sama - Nirama avastha in Amavata, Rookshana is to be done prior to any Snigdha chikitsa. Hence, the aim of this study was to evaluate the effect of Rookshana before Virechana Karma in the management of Amavata / Rheumatoid Arthritis. In this present clinical trial conducted in Varsha rtu, 10 diagnosed patients of Amavata / Rheumatoid Arthritis were selected. Statistical analysis showed highly significant improvement p <0.001 in almost all subjective & objective parameters of Amavata

Greenhouse Parameters Monitoring and Controlling System Using Arduino and Android

Greenhouse parameter monitoring and controlling system is basically designed to monitor and control various parameters of a greenhouse for efficient growth of plants. The system has been designed using Arduino, GSM, ZigBee and Sensors. The temperature, light and soil moisture sensors are used to measure the respective parameters of the greenhouse, further these measured values will be sent to Android app via GSM. As different plants require different moisture, by analyzing the values from the app the user can control the moisture by turning on the water pump via message to GSM. The objective of this project is to provide user full access to greenhouse on a single click through Android

Outlier Based Fraud Detection System

Data mining has the vital task of Outlier detection which aims to detect an outlier from given datasets. The analysis or detection of outlier data is referred to as Outlier Mining. In Data mining, outlier detection is the identification of unusual or distant data records that might be require further investigation or analysis. This paper provides the data driven methods for various fraud detection systems based on literature review, fraudulent activities or cases and comparative research. Outlier detection is the technique which discovers such type of data from the given data set. Several techniques of outlier detection have been introduced which requires input parameter from the user. The goal of this proposed work is to partition the input data set into the number of clusters using K-NN algorithm. Then the clusters are given as an input to the outlier detection methods namely cluster based outlier algorithm and Local Outlier Factor Algorithm. The Performance evaluation of this algorithm confirms that our approach of finding local outliers can be practically implemented

QuickNGS elevates Next-Generation Sequencing data analysis to a new level of automation

BACKGROUND: Next-Generation Sequencing (NGS) has emerged as a widely used tool in molecular biology. While time and cost for the sequencing itself are decreasing, the analysis of the massive amounts of data remains challenging. Since multiple algorithmic approaches for the basic data analysis have been developed, there is now an increasing need to efficiently use these tools to obtain results in reasonable time. RESULTS: We have developed QuickNGS, a new workflow system for laboratories with the need to analyze data from multiple NGS projects at a time. QuickNGS takes advantage of parallel computing resources, a comprehensive back-end database, and a careful selection of previously published algorithmic approaches to build fully automated data analysis workflows. We demonstrate the efficiency of our new software by a comprehensive analysis of 10 RNA-Seq samples which we can finish in only a few minutes of hands-on time. The approach we have taken is suitable to process even much larger numbers of samples and multiple projects at a time. CONCLUSION: Our approach considerably reduces the barriers that still limit the usability of the powerful NGS technology and finally decreases the time to be spent before proceeding to further downstream analysis and interpretation of the data. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1695-x) contains supplementary material, which is available to authorized users