23 research outputs found
Honey health benefits and uses in medicine
The generation of reactive oxygen species (ROS) and other free radicals during
metabolism is an essential and normal process that ideally is compensated through
the antioxidant system. However, due to many environmental, lifestyle, and pathological
situations, free radicals and oxidants can be produced in excess, resulting in
oxidative damage of biomolecules (e.g., lipids, proteins, and DNA). This plays a
major role in the development of chronic and degenerative illness such as cancer,
autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular, and
neurodegenerative diseases (Pham-Huy et al. 2008; Willcox et al. 2004). The human
body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally synthetized in situ, or externally supplied
through foods, and/or supplements (Pham-Huy et al. 2008).info:eu-repo/semantics/publishedVersio
Effect of Tinospora cordifolia
The safety of Tinospora cordifolia and its potential to protect against ultraviolet radiation-induced cytotoxicity and DNA damage in PC12 cells were investigated. To evaluate the safety of T. cordifolia, cell viability and agarose gel electrophoresis were carried out using PC12 cells treated with 0 to 100g mL(-1) of methanol extract of T. cordifolia. T. cordifolia extracts did not show cytotoxicity ranging 0 to 100g mL(-1). In addition, T. cordifolia extracts significantly increased cell viability at 1ng, 10ng and 1g mL(-1) concentrations in serum-deprived medium compared to control. To confirm the protective role against UV-induced damage, PC12 cells alone or in the presence of 10ng, 100ng, or 1g mL(-1) of T. cordifolia extract were exposed to 250, 270 and 290nm of UV radiation, which corresponded to doses of 120, 150 and 300 mJ cm(-2), respectively. Treatment with T. cordifolia extracts significantly increased the cell survival rate irradiated at 290nm. In addition, T. cordifolia extracts significantly reduced cyclobutane pyrimidine dimer formation induced by UV irradiation at all wavelengths. In conclusion, T. cordifolia is not toxic and safe for cells. Our findings can support its application as phototherapy in the medical sector
Targeting asymptomatic malaria infections: active surveillance in control and elimination.
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