38 research outputs found
A Comprehensive Study on Metaheuristic Techniques Using Genetic Approach
Most real-life optimization problems involve multiple objective functions. Finding a solution that satisfies the decision-maker is very difficult owing to conflict between the objectives. Furthermore, the solution depends on the decision-maker’s preference. Metaheuristic solution methods have become common tools to solve these problems. The task of obtaining solutions that take account of a decision-maker’s preference is at the forefront of current research. It is also possible to have multiple decision-makers with different preferences and with different decision-making powers. It may not be easy to express a preference using crisp numbers. In this study, the preferences of multiple decision-makers were simulated and a solution based on a genetic algorithm was developed to solve multi-objective optimization problems. The preferences were collected as fuzzy conditional trade-offs and they were updated while running the algorithm interactively with the decision-makers. The proposed method was tested using well-known benchmark problems. The solutions were found to converge around the Pareto front of the problems
Exploration of Subjective Color Perceptual-Ability by EEG-Induced Type-2 Fuzzy Classifiers
Perceptual-ability informally refers to the ability of a person to recognize a stimulus. This paper deals with color perceptual-ability measurement of subjects using brain response to basic color (red, green and blue) stimuli. It also attempts to determine subjective ability to recognize the base colors in presence of noise tolerance of the base colors, referred to as recognition tolerance. Because of intra- and inter-session variations in subjective brain signal features for a given color stimulus, there exists uncertainty in perceptual-ability. In addition, small variations in the color stimulus result in wide variations in brain signal features, introducing uncertainty in perceptual-ability of the subject.
Type-2 fuzzy logic has been employed to handle the uncertainty in color perceptual-ability measurements due to a) variations in brain signal features for a given color, and b) the presence of colored noise on the base colors. Because of limited power of uncertainty management of interval type-2 fuzzy sets and high computational overhead of its general type-2 counterpart, we developed a semi-general type-2 fuzzy classifier to recognize the base color. It is important to note that the proposed technique transforms a vertical slice based general type-2 fuzzy set into an equivalent interval type-2 counterpart to reduce the computational overhead, without losing the contributions of the secondary memberships. The proposed semi-general type-2 fuzzy sets induced classifier yields superior performance in classification accuracy with respect to existing type-1, type-2 and other well-known classifiers. The brain-understanding of a perceived base or noisy base colors is also obtained by exact low resolution electromagnetic topographic analysis (e-LORETA) software. This is used as the reference for our experimental results of the semi-general type-2 classifier in color perceptual-ability detection. Statistical tests undertaken confirm the superiority of the proposed classifier over its competitors. The proposed technique is expected to have interesting applications in identifying people with excellent color perceptual-ability for chemical, pharmaceutical and textile industries
Hemodynamic Analysis for Olfactory Perceptual Degradation Assessment Using Generalized Type-2 Fuzzy Regression
Olfactory perceptual degradation refers to the inability of people to recognize the variation in concentration levels of olfactory stimuli. The paper attempts to assess the degree of olfactory perceptual degradation of subjects from their hemodynamic response to olfactory stimuli. This is done in 2 phases. In the first (training) phase, a regression model is developed to assess the degree of concentration levels of an olfactory stimulus by a subject from her hemodynamic response to the stimulus. In the second (test) phase, the model is employed to predict the possible concentration level experienced by the subject in [0, 100] scale. The difference between the model-predicted response and the oral response (the center value of the qualitative grades) of the subject about her perceived concentration level is regarded as the quantitative measure of the degree of subject's olfactory degradation. The novelty of the present research lies in the design of a General Type-2 fuzzy regression model, which is capable of handling uncertainty due to the presence of intra- and inter-session variations in the brain responses to olfactory stimuli. The attractive feature of the paper lies in adaptive tuning of secondary membership functions to reduce model prediction error in an evolutionary optimization setting. The effect of such adaptation in secondary measures is utilized to adjust the corresponding primary memberships in order to reduce the uncertainty involved in the regression process. The proposed regression model has good prediction accuracy and high time-efficiency as evident from average percentage success rate (PSR) and run-time complexity analysis respectively. The Friedman test undertaken also confirms the superior performance of the proposed technique with other competitive techniques at 95% confidence level
Mimicking Short-Term Memory in Shape-Reconstruction Task Using an EEG-Induced Type-2 Fuzzy Deep Brain Learning Network
The paper attempts to model short-term memory (STM) for shape-reconstruction tasks by employing a 4-stage deep brain leaning network (DBLN), where the first 2 stages are built with Hebbian learning and the last 2 stages with Type-2 Fuzzy logic. The model is trained stage-wise independently with visual stimulus of the object-geometry as the input of the first stage, EEG acquired from different cortical regions as input and output of respective intermediate stages, and recalled object-geometry as the output of the last stage. Two error feedback loops are employed to train the proposed DBLN. The inner loop adapts the weights of the STM based on a measure of error in model-predicted response with respect to the object-shape recalled by the subject. The outer loop adapts the weights of the iconic (visual) memory based on a measure of error of the model predicted response with respect to the desired object-shape. In the test phase, the DBLN model reproduces the recalled object shape from the given input object geometry.
The motivation of the paper is to test the consistency in STM encoding (in terms of similarity in network weights) for repeated visual stimulation with the same geometric object. Experiments undertaken on healthy subjects, yield high similarity in network weights, whereas patients with pre-frontal lobe Amnesia yield significant discrepancy in the trained weights for any two trials with the same training object. This justifies the importance of the proposed DBLN model in automated diagnosis of patients with learning difficulty. The novelty of the paper lies in the overall design of the DBLN model with special emphasis to the last 2 stages of the network, built with vertical slice based type-2 fuzzy logic, to handle uncertainty in function approximation (with noisy EEG data). The proposed technique outperforms the state-of-the-art functional mapping algorithms with respect to the (pre-defined outer loop) error metric, computational complexity and runtime
Hemodynamic Analysis for Cognitive Load Assessment and Classification in Motor Learning Tasks Using Type-2 Fuzzy Sets
The paper addresses a novel approach to assess and classify the cognitive load of subjects from their hemodynamic response while engaged in motor learning tasks, such as vehicle-driving. A set of complex motor-activity-learning stimuli for braking, steering-control and acceleration is prepared to experimentally measure and classify the cognitive load of the car-drivers in three distinct classes: High, Medium and Low. New models of General and Interval Type-2 Fuzzy classifiers are proposed to reduce the scope of uncertainty in cognitive load classification due to the fluctuation of the hemodynamic features within and across sessions. The proposed classifiers offer high classification accuracy over 96%, leaving behind the traditional type-1/type-2 fuzzy and other standard classifiers. Experiments undertaken also offer a deep biological insight concerning the shift of brain-activations from the orbito-frontal to the ventro-lateral prefrontal cortex during high-to-low transition in cognitive load. Further, the activation of the dorsolateral prefrontal cortex is also reduced during low cognitive load of subjects. The proposed research outcome may directly be utilized to identify driving learners with low cognitive load for difficult motor learning tasks, such as taking a U-turn in a narrow space and motion control on the top of a bridge to avoid possible collision with the car ahead
Intelligent Health Monitoring of Machine Bearings Based on Feature Extraction
This document is the Accepted Manuscript of the following article: Mohammed Chalouli, Nasr-eddine Berrached, and Mouloud Denai, ‘Intelligent Health Monitoring of Machine Bearings Based on Feature Extraction’, Journal of Failure Analysis and Prevention, Vol. 17 (5): 1053-1066, October 2017. Under embargo. Embargo end date: 31 August 2018. The final publication is available at Springer via DOI: https://doi.org/10.1007/s11668-017-0343-y.Finding reliable condition monitoring solutions for large-scale complex systems is currently a major challenge in industrial research. Since fault diagnosis is directly related to the features of a system, there have been many research studies aimed to develop methods for the selection of the relevant features. Moreover, there are no universal features for a particular application domain such as machine diagnosis. For example, in machine bearing fault diagnosis, these features are often selected by an expert or based on previous experience. Thus, for each bearing machine type, the relevant features must be selected. This paper attempts to solve the problem of relevant features identification by building an automatic fault diagnosis process based on relevant feature selection using a data-driven approach. The proposed approach starts with the extraction of the time-domain features from the input signals. Then, a feature reduction algorithm based on cross-correlation filter is applied to reduce the time and cost of the processing. Unsupervised learning mechanism using K-means++ selects the relevant fault features based on the squared Euclidian distance between different health states. Finally, the selected features are used as inputs to a self-organizing map producing our health indicator. The proposed method is tested on roller bearing benchmark datasets.Peer reviewe
Sec16 Defines Endoplasmic Reticulum Exit Sites and is Required for Secretory Cargo Export in Mammalian Cells
The selective export of proteins and lipids from the endoplasmic reticulum (ER) is mediated by the coat protein complex II (COPII) that assembles onto the ER membrane. In higher eukaryotes, COPII proteins assemble at discrete sites on the membrane known as ER exit sites (ERES). Here, we identify Sec16 as the protein that defines ERES in mammalian cells. Sec16 localizes to ERES independent of Sec23/24 and Sec13/31. Overexpression, and to a lesser extent, small interfering RNA depletion of Sec16, both inhibit ER-to-Golgi transport suggesting that Sec16 is required in stoichiometric amounts. Sar1 activity is required to maintain the localization of Sec16 at discrete locations on the ER membrane, probably through preventing its dissociation. Our data suggest that Sar1-GTP-dependent assembly of Sec16 on the ER membrane forms an organized scaffold defining an ERES
A Gammaherpesvirus Cooperates with Interferon-alpha/beta-Induced IRF2 to Halt Viral Replication, Control Reactivation, and Minimize Host Lethality
The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals. The precise immune mechanisms that prevent gammaherpesvirus reactivation and tumorigenesis are poorly defined. Murine gammaherpesvirus 68 (MHV68) is closely related to EBV and KSHV, and type I (alpha/beta) interferons (IFNαβ) regulate MHV68 reactivation from both B cells and macrophages by unknown mechanisms. Here we demonstrate that IFNβ is highly upregulated during latent infection, in the absence of detectable MHV68 replication. We identify an interferon-stimulated response element (ISRE) in the MHV68 M2 gene promoter that is bound by the IFNαβ-induced transcriptional repressor IRF2 during latency in vivo. The M2 protein regulates B cell signaling to promote establishment of latency and reactivation. Virus lacking the M2 ISRE (ISREΔ) overexpresses M2 mRNA and displays uncontrolled acute replication in vivo, higher latent viral load, and aberrantly high reactivation from latency. These phenotypes of the ISREΔ mutant are B-cell-specific, require IRF2, and correlate with a significant increase in virulence in a model of acute viral pneumonia. We therefore identify a mechanism by which a gammaherpesvirus subverts host IFNαβ signaling in a surprisingly cooperative manner, to directly repress viral replication and reactivation and enforce latency, thereby minimizing acute host disease. Since we find ISREs 5′ to the major lymphocyte latency genes of multiple rodent, primate, and human gammaherpesviruses, we propose that cooperative subversion of IFNαβ-induced IRFs to promote latent infection is an ancient strategy that ensures a stable, minimally-pathogenic virus-host relationship
Successful outcome of lamellar ichthyosis with oral retinoid therapy: A series of six cases
Lamellar ichthyosis (LI) is a rare skin disorder inherited as an autosomal recessive trait. Affected babies are born in a collodion membrane that sheds gradually revealing extensive scaling of the skin. The present communication is intended to provide the details of oral isotretinoin therapy in the management of LI in six children. The dose of oral isotretinoin which produced maximum clearing of the lesions with minimum side effects was found to vary from 0.6 mg/kg to 1 mg/kg body weight among these children and the duration of therapy lasted from 6 to 16 weeks. Therapeutic improvement varied from excellent in four and mild to satisfactory in two children and cheilitis of the lips was observed to be the main side effect