A CRITICAL REVIEW ON NUTRACEUTICALS IN MADHUMEHA (DIABETES)

Diabetes mellitus is a well-known clinical syndrome since antiquity. Ayurveda mainly focuses on the role of diet in Prameha and Madhumeha, which is akin to Diabetes. Nutraceuticals are food or food products that provide health and medical benefits, including the prevention and treatment of disease. Traditional Indian diets are functional and used both as food and medicine. Although in recent scientific studies these diets are evaluated for rich source of dietary fiber (whole grains and vegetables), antioxidants and other active principles suitable for diabetes. Primarily, they have been selected and used based on fundamental principles of Ayurveda, such as their Rasa, Guna, Virya, Vipaka, Prabhava, and so on. Reviewing the characteristic properties along with important antidiabetic properties of conventional system of medicine, accentuates the role of these diets in Diabetes. The correlation further emphasizes the way to include or to evaluate more Nutraceuticals for the benefit of Diabetic population. Diabetes is a complex disease with multiple variations. Nutraceuticals too have variant properties and belong to various dietetic groups, such as Kodrava (grain variety: Paspolum scrobiculatum Linn.), Adhaki (red gram: Cajamus indicus Spreng.), Yava (Barley: Hordeum vulgare Linn.), Mudga (green gram: Phaseolus radiatus Linn.), Kuluttha (horse gram: Dolichos biflorus Linn.), Amalaki (Indian goose berry: Emblica officinalis Gaertn.), Meti (fenugreek: Trigonella foenum-graecum Linn.), Karavellaka (bitter gourd: Momordica charantia Linn.), Jambu (java plum: Syzygium cumini (Linn.) Skeels.), Navapatola (young: Tricosanthes dioica Roxb.), Matsyakshi (Alternanthera sessiles Linn.) R. Br. etc

Gingival crevicularfluid osteoprotegerin levels in Indian population

Background: Initial research indicated that higher concentration of osteoprotegerin (OPG) is associated with healthy periodontium (protective) and its concentration decreases as the periodontal disease progresses. However, till date, there are no studies to investigate the levels of OPG in gingival crevicular fluid (GCF) after the treatment of periodontitis. Hence, the present study was carried out to assess its concentration in GCF to find out their association if any, and to explore its possible use as a 'novel bone marker' of the host modulation of periodontal disease. Materials and methods: Sixty-four subjects were divided into 4 groups (16 each), based on clinical attachment loss (CAL) and radiological parameters (bone loss); healthy (group I), gingivitis (group II), slight periodontitis (group III), and moderate-to-severe periodontitis (group IV). Moderate-to-severe periodontitis subjects, after nonsurgical periodontal treatment, (SRP) constituted group V. GCF samples were collected to estimate the levels of OPG using enzyme-linked immunosorbent assay (ELISA). The Kruskal-Wallis, Man-Whitney U test, and Wilcoxon signed-rank tests were carried out to compare OPG levels among groups. The Spearman rank correlation test was used to correlate OPG levels between the study groups and the clinical parameters; P < 0.05 was considered significant. Results: The highest mean OPG concentration in GCF was obtained for group I (162.47 ± 51.171 pg/ μL) and the least for group IV (10.92 ± 1.913 pg/μL), suggesting a negative correlation between OPG concentration and CAL. OPG concentrations in GCF after the treatment of group IV increased from 10.92 ± 1.913 pg/μL to 15.63 ± 4.679 pg/μL. Conclusion: OPG concentration in GCF was inversely proportional to CAL and not an active progression factor for periodontal disease. Further, after the treatment of moderate-to-severe periodontitis subjects (group IV), OPG concentrations increased. Hence, it can be concluded that OPG could be considered as a 'novel bone marker' the host modulation of periodontal disease

Gingival crevicularfluid osteoprotegerin levels in Indian population

Background: Initial research indicated that higher concentration of osteoprotegerin (OPG) is associated with healthy periodontium (protective) and its concentration decreases as the periodontal disease progresses. However, till date, there are no studies to investigate the levels of OPG in gingival crevicular fluid (GCF) after the treatment of periodontitis. Hence, the present study was carried out to assess its concentration in GCF to find out their association if any, and to explore its possible use as a 'novel bone marker' of the host modulation of periodontal disease. Materials and methods: Sixty-four subjects were divided into 4 groups (16 each), based on clinical attachment loss (CAL) and radiological parameters (bone loss); healthy (group I), gingivitis (group II), slight periodontitis (group III), and moderate-to-severe periodontitis (group IV). Moderate-to-severe periodontitis subjects, after nonsurgical periodontal treatment, (SRP) constituted group V. GCF samples were collected to estimate the levels of OPG using enzyme-linked immunosorbent assay (ELISA). The Kruskal-Wallis, Man-Whitney U test, and Wilcoxon signed-rank tests were carried out to compare OPG levels among groups. The Spearman rank correlation test was used to correlate OPG levels between the study groups and the clinical parameters; P < 0.05 was considered significant. Results: The highest mean OPG concentration in GCF was obtained for group I (162.47 ± 51.171 pg/ μL) and the least for group IV (10.92 ± 1.913 pg/μL), suggesting a negative correlation between OPG concentration and CAL. OPG concentrations in GCF after the treatment of group IV increased from 10.92 ± 1.913 pg/μL to 15.63 ± 4.679 pg/μL. Conclusion: OPG concentration in GCF was inversely proportional to CAL and not an active progression factor for periodontal disease. Further, after the treatment of moderate-to-severe periodontitis subjects (group IV), OPG concentrations increased. Hence, it can be concluded that OPG could be considered as a 'novel bone marker' the host modulation of periodontal disease

A Prospective Study on Parpati Kalpana w.s.r to Panchamrut Parpati

Rasa Shastra, one of the Pharmaco-therapeutic branches of Ayurveda, incorporates many of the inorganic, herbo-mineral and metallic pharmaceutical preparations namely Khalviya Rasayana, Parpati Rasayana, Pottali Rasayana and Kupipakwa RasayanaParpati Rasayanas are one among the Rasaoushidhis mentioned in the Ayurvedic classics and the therapeutically effective mineral &amp; metallic formulations. These are the most popular among the processing's of Mercury. Parpati Rasayana Kalpanas are the most popular among the processing's of Mercury and are widely used. These are therapeutically effective mineral and metallic formulations; including both Sagandha and Nirgandha Parada Yukta yogas. Parpati Kalpana (Flakes) is a well known and successfully used preparation for the management of Grahani. The name "Parpati" is given to this preparation because of its form and the method of preparation as it is made in the form of thin flakes.&nbsp; It is also said about it that because of its similarity of Papada, so it is called as Parpati. This process dates back to 11th century and is found widely in Ayurveda literature. Parpati Rasayanas have high therapeutic value, potent, less toxic and cost effective medicines. Panchamruta Parpati is one of the formulations used in Grahani (Malabsorption sprue syndrome). &nbsp;In this process, Parada is heated along with Gandhaka and other drugs. Here Parada gets a very intimate bondage with Gandhaka which helps to exhibit thousands of qualities compared to any other formulations. Agni plays an important role in altering the natural physico-chemical properties and the potency of the dravyas. A number of Parpatis are derived in subsequent periods such as &nbsp;Tamra parpati, Panchamruta parpati, Swarna parpati (Rasapaddhati), Loha parpati, Vijaya parpati&nbsp; etc. were developed by different scholars by adding one or the other ingredients