The effect of ball-handling on lower extremity mechanics in soccer

HRS Honors Research Thesis ScholarshipNearly 240,000 soccer injuries are estimated to have occurred in the United States in 2014 with a high number of them non-contact in nature and involving the lower extremities. These injuries result in time-loss from training or match play, potential psychological consequences, and financial burdens. Epidemiological research suggests that these non-contact injuries may occur more frequently while ball-handling compared to defending in soccer. However, no prior studies have investigated the biomechanical implications of controlling a soccer ball with the feet while running and cutting that may help explain this finding. The purpose of this study was to compare knee and ankle joint moments and angles implicated in non-contact soccer injury mechanisms demonstrated during run-to-cut maneuvers performed with and without dribbling a soccer ball. Our hypothesis was that the cutting maneuvers performed while dribbling a ball would have a detrimental effect on biomechanical parameters associated with non-contact ankle and knee injuries. Seventeen healthy male collegiate soccer players participated in the study. Subjects performed ball-handling and running maneuvers while running straight ahead and also at a 45° cutting angle. All data were collected using three-dimensional motion capture with force plates embedded in the floor. Ball-handling had a significant effect on peak ankle internal rotation angle (p=0.010) and knee abduction angle (p=0.024). Changes in other parameters of interest, including peak ankle inversion moment and peak knee abduction moment, did not reach significance (p>0.05). In conclusion, ball-handling in soccer can detrimentally alter lower extremity joint mechanics of dynamic movements. The results of this study support the need for coaches to consider the implications of an athlete’s sport-specific movements when creating training programs for teams and individuals.A three-year embargo was granted for this item.Academic Major: Biomedical Scienc

How to throw chocolate at students : a survey of extrinsic means for increased audience attention

This paper presents an overview of established and innovative means and teaching approaches that contribute to higher students' attention during lecture. The results are based on an international survey among lecturers from eleven universities. This survey was initiated by three lecturers from different countries who met at EDUCON 2016. The objective was to collect teaching experiences about playful means that motivate students to be attentive during a lecture. The proposed teaching approaches fall into three categories: established teaching methods, unconventional extrinsic methods, and tools. We focus on the extrinsic methods and discuss 14 illustrative examples of these approaches

The Effects of an Angiogenesis Inhibitor, ATN-224, on the Efficacy of Oncolytic Virus Therapy

Oncolytic viruses (OV) are genetically modified viruses specifically designed to lyse cancerous cells while leaving normal tissue intact. Within the tumor microenvironment, the angiogenic and inflammatory responses following OV inoculation have significantly limited the efficacy of oncolytic herpes simplex virus (oHSV) in clinical trials. Physiological levels of copper support angiogenesis and have been shown to inhibit the infection and replication of wild-type HSV. Here, we tested if OV replication and cytotoxicity are inhibited by copper and if this inhibition can be rescued by ATN-224, a second generation analog of ammonium tetrathiomolybdate (TM). TM is a copper-chelating agent that is FDA-approved for the treatment of Wilson’s disease and is currently under investigation as an anti-angiogenic and anti-neoplastic agent in clinical trials. Under serum concentration of copper, both OV replication and glioma cell killing were significantly inhibited (P<0.001). ATN-224 treatment rescued this copper-mediated inhibition of OV replication and glioma cell destruction in vitro (P<0.01). The anti-tumor efficacy of this combination therapy was evaluated in vivo using two xenograft glioma models. First, mice implanted with subcutaneous U251T3 gliomas were treated with PBS, ATN-224, OV, or OV+ATN224 (n=10). Results indicated that average tumor size in the OV+ATN224 group was significantly smaller compared to OV alone (21.51 vs. 153.93 mm3, P=0.0383). Next, mice implanted with intracranial U87ΔEGFR gliomas were treated as previously (n=8). Kaplan-Meier analysis revealed increased mean survivals for the OV+ATN224 group compared to OV alone (43.875 vs. 24.000 days). Testing for a biological explanation for this enhanced efficacy, we treated mice daily with ATN-224 or PBS via gavage. OV was administered intravenously, and blood was drawn to detect virus presence. Serum derived from ATN-224-treated mice revealed increased viral presence in vivo compared to PBS-treated mouse serum. Analysis of subcutaneous U251T3 tumors from mice receiving intratumoral OV treatment showed that ATN-224-treated tumors had significantly increased viral replication in vivo compared to PBS-treated tumors (P<0.05). Similarly, when OV was administered intravenously, ATN-224-treated tumors again displayed increased viral presence compared to PBS-treated tumors. Therefore, the reduced tumor growth and increased survival previously shown in vivo might be associated with enhanced viral replication. Collectively, our results strongly suggest that the co-treatment of ATN-224 with OV can significantly improve the poor efficacy profile of conventional clinical oncolytic virotherapy.Pelotonia Undergraduate Student Fellowship ProgramA five-year embargo was granted for this item

Respiratory failure and death in vulnerable premature children with lower respiratory tract illness

Background. Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal lower respiratory tract infection (LRTI) in premature children in developing countries are necessary to elaborate evidenced-based preventive interventions. We aim to characterize the burden of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) LRTI in premature children and determine risk factors for RF and fatal illness in a vulnerable population. Methods. This is a prospective, population-based, cross-sectional study. Subjects with severe LRTI were enrolled during respiratory season. Risk factors for RF and death in premature infants were investigated. Results. A total of 664 premature children participated. Infant's hospitalization rate due to LRTI was 82.6/1000 (95% confidence interval [CI], 68.6-96.7/1000). Infant's RSV and hMPV rates were 40.9/1000 (95% CI, 36.3-45.6/1000) and 6.6/1000 (95% CI, 3.9- 9.2/1000), respectively. The RF rate was 8.2/1000 (95% CI, 4.9-11.5/1000). The LRTI mortality was 2.2/1000 (95% CI, 0.7-3.7/1000); for RSV, the rate was 0.8/1000 (95% CI, 0-1.7/1000) with a case-fatality ratio of 1.8%. Never breastfeeding, malnutrition, younger than 6 months, congenital heart disease, and lower hematocrit were risk factors for RF. Experiencing pneumonia, pneumothorax, sepsis, or apnea were clinical determinants of poor outcomes. Conclusions. Premature children under 2 years old in vulnerable environments experience RF and death more often than term counterparts. Modifiable risk factors associated with poor outcomes should prompt evidence-based interventions.Fil: Ofman, Gaston. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Pradarelli, Brad. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Caballero, Mauricio Tomás. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bianchi, Alejandra. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Grimaldi, Luciano Alva. Gobierno de la Provincia de Buenos Aires. Hospital Zonal General de Agudos Doctor Lucio Melendez.; ArgentinaFil: Sancilio, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; ArgentinaFil: Duenas, Karina. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; ArgentinaFil: Rodriguez, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Provincial Evita Pueblo.; ArgentinaFil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Ferretti, Adrian. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Coviello, Silvina Andrea. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferolla, Fausto Martín. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Bergel, Eduardo. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Polack, Fernando Pedro. Fundacion de Endocrinologia Infantil.; Argentin

Integrated Circuits Testing: Remote Access to Test Equipment for Labs and Engineering

This paper concerns the local and remote use of an Integrated Circuits (IC) Automated Test Equipment (ATE) for both educational and engineering purposes. This experience was initiated in 1998 in the context of a French network (CNFM) in order to provide a distant control to industrial equipment for academic and industrial people. The actual shared resource is a Verigy V93K System on Chip (SoC) tester platform. The cost of such an equipment is close to 1Mâ?¬, without taking into account the maintenance and attached human resources expenses to make it work properly daily. Although the sharing of this equipment seems to be obvious for education, the French experience is quite a unique example in the world. Here, practical information regarding IC testing and network setup for remote access are detailed, together with the associated training program

Combo of innovative educational approaches to teach industrial test to undergraduate students

International audienceThis paper addresses a return of experience relative to the combination of several innovative educational approaches (classic lecture, per peers, and flipped classroom) to teach industrial test to undergraduate students from Polytech Montpellier engineering school. The objectives of the course were technical and educational: acquiring industrial test competencies in a way, students were the protagonists of their learning and for some topics they were the contributors of their peers'. At the end of the course, the teacher marked the students' skills and asked them to evaluate the course educational approaches completing a dedicated form created based on the F2A Louvain University one [1] to provide an objective and classifiable feedback. The paper presents the analysis of all results, states about this original experience and the future trends

Integrated Circuits Testing: Remote Access to Test Equipment for Labs and Engineering

International audienceThis paper concerns the local and remote use of an Integrated Circuits (IC) Automated Test Equipment (ATE) for both educational and engineering purposes. This experience was initiated in 1998 in the context of a French network (CNFM) in order to provide a distant control to industrial equipment for academic and industrial people. The actual shared resource is a Verigy V93K System on Chip (SoC) tester platform. The cost of such an equipment is close to 1M€, without taking into account the maintenance and attached human resources expenses to make it work properly daily. Although the sharing of this equipment seems to be obvious for education, the French experience is quite a unique example in the world. Here, practical information regarding IC testing and network setup for remote access are detailed, together with the associated training program

La formation tout au long de la vie en Microélectronique et en Nanotechnologies dans le cadre du réseau GIP-CNFM

National audienceCet article présente la mise en place d'un guichet (ou portail) national de formation continue en Microélectronique et en Nanotechnologies dans le cadre du réseau GIP-CNFM et l’offre qui est proposée aux acteurs académiques et industriels. Cette mise en place a correspondu à plusieurs actions et plusieurs étapes qui sont détaillées et qui ont permis de répondre à plusieurs types de besoins autant en contenu, qu’en niveau et durée

Asma infantile: dinamiche affettive e percezioni del sè.

Studied the effects of asthma on the personality of children suffering from the disease and on their relationships with their mothers, assessed the personality characteristics of Ss and their problems with regard to articulation of body scheme, and determined the degree of hyperprotectiveness of their mothers. Human Ss: 30 male and female Italian schoolage children (aged 7-10 yrs) (severe asthma). 30 male and female Italian schoolage children (aged 7-20 yrs) (mild asthma). 60 normal male and female Italian schoolage children (aged 7-20 yrs) (controls). 120 normal female Italian adults (mothers of the children). Ss completed the Body Scheme Test (C. Daurat-Hmeljak et al, 1978), and a Rorschach test interpreted according to the Roman School Rorschach method (C. Rizzo et al, 1980). The mothers completed a questionnaire on the psychological and physical development of their children and on their own psychological and physical states. The Parental Attitude Research Instrument (Schaefer and Bell, 1958) was also administered. (English abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved