Control of Progressive Collapse of the Structure Using Shear Wall

The vulnerability of reinforced concrete (RC) building systems to progressive collapse has turned out to be a challenging trouble for professionalstructural engineers so as to prevent total failure on account of nearby damage. The goal of this paper is to enhance the knowledge of such buildings’behavior underneath several scenarios of misplaced columns at differentfloor stages, and their capacity for progressive collapse. The homes hadbeen analyzed following the guidelines for progressive collapse evaluation and design organized by means of the general services administrationguidelines (GSA). The progressive collapse of a ten story structure subjected to a simplest gravity load is taken into consideration and the columnhas been eliminated at one place and the spread damage is evaluated. Theprogressive collapse study has been carried out by way of removing thecolumn at a diagnosed crucial locations (at corner, middle and at interior) as in line with GSA guidelines. Static analysis is done using analysisprogram ETABS. For each case, the consequences were taken in terms ofdemand capacity ratio (DCR) at critical section, and as a result the structurehas been assessed for it’s susceptible to progressive collapse. The availability of shear wall is made on the component wherein collapse occurred andDCR values are mentioned. After imparting the shear wall to the structure,the progressive collapse of the structure because of accidental load maybe controlled in order that the GSA guidelines recommended DCR valuewould be within the range

Model equations from a chaotic time series

We present a method for obtaining a set of dynamical equations for a system that exhibits a chaotic time series. The time series data is first embedded in an appropriate phase space by using the improved time delay technique of Broomhead and King (1986). Next, assuming that the flow in this space is governed by a set of coupled first order nonlinear ordinary differential equations, a least squares fitting method is employed to derive values for the various unknown coefficients. The ability of the resulting model equations to reproduce global properties like the geometry of the attractor and Lyapunov exponents is demonstrated by treating the numerical solution of a single variable of the Lorenz and Rossler systems in the chaotic regime as the test time series. The equations are found to provide good short term prediction (a few cycle times) but display large errors over large prediction time. The source of this shortcoming and some possible improvements are discussed

Bdellovibrio bacteriovorus Inhibits Staphylococcus aureus Biofilm Formation and Invasion into Human Epithelial Cells

Bdellovibrio bacteriovorus HD100 is a predatory bacterium that attacks many Gram-negative human pathogens. A serious drawback of this strain, however, is its ineffectiveness against Gram-positive strains, such as the human pathogen Staphylococcus aureus. Here we demonstrate that the extracellular proteases produced by a host-independent B. bacteriovorus (HIB) effectively degrade/inhibit the formation of S. aureus biofilms and reduce its virulence. A 10% addition of HIB supernatant caused a 75% or greater reduction in S. aureus biofilm formation as well as 75% dispersal of pre-formed biofilms. LC-MS-MS analyses identified various B. bacteriovorus proteases within the supernatant, including the serine proteases Bd2269 and Bd2321. Tests with AEBSF confirmed that serine proteases were active in the supernatant and that they impacted S. aureus biofilm formation. The supernatant also possessed a slight DNAse activity. Furthermore, treatment of planktonic S. aureus with the supernatant diminished its ability to invade MCF-10a epithelial cells by 5-fold but did not affect the MCF-10a viability. In conclusion, this study illustrates the hitherto unknown ability of B. bacteriovorus to disperse Gram-positive pathogenic biofilms and mitigate their virulence.open6

A bibliography of parasites and diseases of marine and freshwater fishes of India

With the increasing demand for fish as human food, aquaculture both in freshwater and salt water is rapidly developing over the world. In the developing countries, fishes are being raised as food. In many countries fish farming is a very important economic activity. The most recent branch, mariculture, has shown advances in raising fishes in brackish, estuarine and bay waters, in which marine, anadromous and catadromous fishes have successfully been grown and maintained

Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide

Suicidal behaviors are frequent in mood disorders patients but only a subset of them ever complete suicide. Understanding predisposing factors for suicidal behaviors in high risk populations is of major importance for the prevention and treatment of suicidal behaviors. The objective of this project was to investigate gene expression changes associated with suicide in brains of mood disorder patients by microarrays (Affymetrix HG-U133 Plus2.0) in the dorsolateral prefrontal cortex (DLPFC: 6 Non-suicides, 15 suicides), the anterior cingulate cortex (ACC: 6NS, 9S) and the nucleus accumbens (NAcc: 8NS, 13S). ANCOVA was used to control for age, gender, pH and RNA degradation, with P≤0.01 and fold change±1.25 as criteria for significance. Pathway analysis revealed serotonergic signaling alterations in the DLPFC and glucocorticoid signaling alterations in the ACC and NAcc. The gene with the lowest p-value in the DLPFC was the 5-HT2A gene, previously associated both with suicide and mood disorders. In the ACC 6 metallothionein genes were down-regulated in suicide (MT1E, MT1F, MT1G, MT1H, MT1X, MT2A) and three were down-regulated in the NAcc (MT1F, MT1G, MT1H). Differential expression of selected genes was confirmed by qPCR, we confirmed the 5-HT2A alterations and the global down-regulation of members of the metallothionein subfamilies MT 1 and 2 in suicide completers. MTs 1 and 2 are neuro-protective following stress and glucocorticoid stimulations, suggesting that in suicide victims neuroprotective response to stress and cortisol may be diminished. Our results thus suggest that suicide-specific expression changes in mood disorders involve both glucocorticoids regulated metallothioneins and serotonergic signaling in different regions of the brain