Evaluación de tres niveles de yeso como fuente de azufre inorgánico de la alimentación de cuyes de raza criolla (color negro) (cavia porcellus) en la etapa reproductiva, de 120 a 210 días en la Asociación APROCAAA, cantón Antonio Ante

Evaluar la influencia de tres niveles de yeso como fuente de azufre inorgánico en la alimentación de cuyes durante la etapa reproductiva (de 120 a 210 días).La investigación se la realizó en la Asociación APROCAAA en el Cantón Antonio Ante- Provincia de Imbabura. La investigación comprendió la crianza de cuyes criollos de color negro, durante un periodo de 90 días. Se plantearon los siguientes objetivos: Determinar la dosis óptima de yeso como fuente de azufre inorgánico durante la fase reproductiva del cuy. Evaluar la influencia del azufre inorgánico en el consumo de alimento en materia seca y determinar su conversión alimenticia. Establecer el efecto del yeso como fuente de azufre inorgánico mediante el análisis organoléptico de la carne, bajo un diseño completamente al azar (DCA) para la etapa reproductiva, se trabajó con 3 tratamientos: T4= (0,50 % de azufre); T3= (0,25% de azufre); T2= (0,10 % de azufre) para ser comparado con un tratamiento testigo (sin yeso). Los resultados registran diferencias significativas entre sus variables, al analizar el consumo final de alimento el T2 (45,77 g) mostrando el mejor resultado; El T3 (1363,00 g) mostró el mejor peso final en las madres, el T3 (1,85 g) mostró óptimos resultados para conversión alimenticia, el mayor número de crías por jaula resultaron con el T4 (12,33 crías), no hubo diferencias significativas en número de celos por jaula y en determinación de celo postparto, determinándose también que el yeso como fuente de azufre no influyo en el peso de crías al nacimiento, siendo el Testigo el que presentó mejores resultados, los resultados en el análisis organoléptico de la carne no tuvieron diferencias estadísticas, indicando que las dosis administradas no afectaron las características que se evaluaron al realizar la prueba de degustación de la carne de cuy (prueba de Friedman) , el T4 provocó los mejores resultados en la variable beneficio/costo, que indica que por cada dólar invertido ganamos 17 centavos de dólar. De la investigación se concluye que las dosis de azufre evaluadas (0,10 % de azufre), (0,25 % de azufre), (0,50% de azufre), causaron efectos positivos durante la etapa reproductiva del cuy, demostrado que los tratamientos que mostraron mejor resultado en la mayoría de las variables que se evaluaron fueron el T2 y T3. El mejor tratamiento en características reproductivas fue el T4. El (testigo) sin dosis de yeso, mostro mejores resultados para peso de crías al nacimiento. El análisis organoléptico no mostro diferencias, demostrando que las diferentes dosis evaluadas no influyen en las características tales como: color, sabor, textura, dureza, lípidos (grasocidad), aceptabilidad. El efecto positivo que provocaron las diferentes dosis de azufre, es de la mejorar las características reproductivas de los cuyes por lo cual se recomienda el uso de dosis mayores a 0,25 % de azufre, puesto que su administración aumento el número de crías, mejoró el peso en las madres y su conversión alimenticia, e influyo directamente en el beneficio económico.Ingenierí

Diseño e implementación de un sistema de información visual interactivo usando tecnología LED

Realizar el diseño, construcción e implementación de un sistema de información visual interactiva, usando tecnología led para la adecuada difusión de información en la carrera de Ingeniería en Mantenimiento Eléctrico.El propósito del presente trabajo es realizar un Sistema de Información Visual Interactivo, usando tecnología LED para la carrera de ingeniería en Mantenimiento Eléctrico de la Universidad Técnica del Norte, mediante un prototipo compuesto por LEDs, para lo cual se lleva a cabo una investigación de los diferentes tipos de pantallas interactivas y letreros de información que usan este tipo tecnología. El proyecto de investigación está elaborado en cinco capítulos, en los primeros se formula y delimita el problema de investigación, se plantea los diferentes objetivos; un general y cuatro específicos que son el trayecto para la investigación. A continuación se elabora el marco teórico con los temas y subtemas que más resaltan tales como; el led en sus principios, descripción de los principales fabricantes y en los diferentes campos las aplicaciones y comerciantes de esta tecnología. Además la investigación y el análisis de los controladores más usados y comunes para el manejo de mensajes y logotipos. Para el desarrollo se utilizó métodos inductivo - deductivo, tecnológico, técnicas e instrumentos. Sin embargo al estudiar los diferentes dispositivos se elige el adecuado, que se encargará de comandar y procesar la información que se desea mostrar como los mensajes hacia la pantalla compuesta por módulos LEDs; y para el desarrollo del programa se usa el software del controlador más indicado como el Arduino Mega que tiene su propia plataforma programable. La propuesta es el diseño e implementación de un sistema de información visual para la carrera de Ingeniería en Mantenimiento Eléctrico, con la prioridad de facilitar información fresca y actual, debido a que no satisfacen las necesidades tanto para docentes como estudiantes por la limitación de publicar información en hojas o pancartas y dicha información se pierde por no atraer su atención. El proyecto es factible ya que beneficia a los estudiantes y profesores al mostrar información congénita a la carrera, mediante el prototipo que usa una tecnología innovadora y eficiente.Ingenierí

El uso de monteas en los talleres catedralicios: el caso murciano

Es bien conocido el empleo de trazados a tamaño natural, denominados monteas, como paso previo a la ejecución de construcciones pétreas. Los autores argumentan que estas monteas aportan datos acerca de las técnicas de cantería que no facilitan ni las propias piezas, ni los tratados y manuscritos, incluso los más cercanos a la práctica constructiva. En concreto, examinan dos monteas renacentistas en la catedral de Murcia: una de ellas hallada en 1999 bajo el altar de la recapilla de Junterón y otra recientemente aparecida en los muros de la sacristía catedralicia al desmontar la cajonería quinientista. Tras comparar ambas monteas con las piezas de cantería correspondientes, los autores analizan en qué medida ambas monteas se separan de los métodos estereotómicos propuestos por la literatura hispánica de la cantería.The use of full-scale tracings as a preliminary step in stone construction is well known. The authors assert that those tracings furnish a number of valuable data about stonecutting techniques that cannot be obtained from actual members, treatises or manuscripts, even those closest to building practice. In particular, the article deals with two tracings in Murcia cathedral: the first one was found in 1999 under the altar of the inner chamber or recapilla of the funerary chapel of Gil Rodríguez de Junterón, while the second one has appeared recently behind the vestry drawers. The authors compare both tracings with the members built using them, explaining how the tracings depart from standard construction methods, in particular those described in Spanish stereotomic literature

Applying watershed algorithms to the segmentation of clustered nuclei

Cluster division is a critical issue in fluor escence micr oscopy-based analytical cytology when preparation protocols do not provide appropriate separation of objects. Overlooking cluster ed nuclei and analyzing only isolated nuclei may dramatically incr ease analysis time or af fect the statistical validation of the r esults. Automatic segmentation of cluster ed nuclei r equir es the implementation of specific image segmentation tools. Most algorithms are inspired by one of the two following strategies: 1) cluster division by the detection of inter nuclei gradients; or 2) division by definition of domains of influence (geometrical approach). Both strategies lead to completely different implementations, and usually algorithms based on a single view strategy fail to corr ectly segment most cluster ed nuclei, or per for m well just for a specific type of sample. An algorithm based on morphological watersheds has been implemented and tested on the segmentation of micr oscopic nuclei clusters. This algorithm pr ovides a tool that can be used for the implementation of both gradient- and domain-based algorithms, and, mor e importantly, for the implementation of mixed (gradient- and shape-based) algorithms. Using this algorithm, almost 90% of the test clusters wer e corr ectly segmented in peripheral blood and bone marr ow pr eparations. The algorithm was valid for both types of samples, using the appr opriate markers and transfor mations.Contract grant sponsor: ARCADIM Project; Contract grant number: CICYT TIC92-0922-C02-01 (Comisión Interministerial de Ciencia y Tecnología); Contract grant sponsor: European Concerted Action CA-AMCA; Contract grant number: BMH1-CT92-1307; Contract grant sponsor: Comunidad Autónoma de Madrid (CAM); Contract grant sponsor: Universidad Politécnica de Madrid (UPM).Publicad

The Burden of Hidradenitis Suppurativa Signs and Symptoms in Quality of Life: Systematic Review and Meta-Analysis

Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating inflammatory skin disease of the hair follicle that usually presents as painful, deep-seated inflamed lesions in the apocrine gland-bearing areas of the body. HS patients suffer from uncomfortable signs and symptoms, such as pain, pruritus, malodour and suppuration, which may impair patients’ quality of life (QoL). Although HS patients frequently experience these signs and symptoms, they are only occasionally assessed by clinicians and, unexpectedly, the scientific evidence available is limited and heterogeneous. The aim of this study is to summarize the evidence regarding the impact of HS signs and symptoms on QoL to serve as a basis for future research and help clinicians to consider them in the daily care of HS patients. A systematic review and meta-analysis were conducted following PRISMA Guidelines. The following search algorithm was used: (hidradenitis or “acne inversa”) and (pain or itch or odour or malodour or suppuration or oozing or drainage) and (“quality of life”). The literature search identified 836 references, 17 of them met the eligible criteria and were included for analysis, representing 4929 HS patients. Mean age of the participants was 36.28 years and there was a predominance of female sex among study participants. The BMI of the population was in the range of over-weight and about two out five patients were active smokers. Studies included patients with mild to moderate HS, with a mean disease duration of 13.69 years. The HS signs and symptoms assessed were pain, pruritus, malodour and suppuration. Overall, the higher intensity of a sign or symptom correlated with poorer general QoL or specific QoL dimensions including sexual distress, anxiety, depression and sleep. The most frequently employed tool to assess QoL was the Dermatology Life Quality Index (DLQI). DLQI was used in 52.9% of the studies (9/17) with a mean value of 10.70 (2.16 SD). The scores employed to assess signs and symptoms severity were subjective and varied between studies, being the numerical rating scale (NRS) for each of the most used symptoms. The mean NRS value for pain was 3.99 and the mean NRS for pruritus was 4.99. In conclusion, we have summarized, categorized and analyzed the scientific evidence regarding signs and symptoms in HS patients and their impairment in QoL. Their assessment should be thorough and included during routine evaluation of HS patients to motivate therapeutic modifications and increase patients’ health

Der p 1 based immunotoxin as potential tool for the treatment of dust mite respiratory allergy

Immunotoxins appear as promising therapeutic molecules, alternative to allergen-specifcimmunotherapy. In this work, we achieved the development of a protein chimera able to promote specifc cell death on efector cells involved in the allergic reaction. Der p 1 allergen was chosen as cell-targeting domain and the powerful ribotoxin α-sarcin as the toxic moiety. The resultant construction, named proDerp1αS, was produced and purifed from the yeast Pichia pastoris. Der p 1-protease activity and α-sarcin ribonucleolytic action were efectively conserved in proDerp1αS. Immunotoxin impact was assayed by using efector cells sensitized with house dust mite-allergic sera. Cell degranulation and death, triggered by proDerp1αS, was exclusively observed on Der p 1 sera sensitized-humRBL-2H3 cells, but not when treated with non-allergic sera. Most notably, equivalent IgE-binding and degranulation were observed with both proDerp1αS construct and native Der p 1 when using purifed basophils from sensitized patients. However, proDerp1αS did not cause any cytotoxic efect on these cells, apparently due to its lack of internalization after their surface IgEbinding, showing the complex in vivo panorama governing allergic reactions. In conclusion, herein we present proDerp1αS as a proof of concept for a potential and alternative new designs of therapeutic tools for allergies. Development of new, and more specifc, second-generation of immunotoxins following proDerp1αS, is further discussed

Free-form Fresnel RXI-RR Köhler design for high-concentration photovoltaics with spectrum-splitting

Development of a novel HCPV nonimaging concentrator with high concentration (>500x) and built-in spectrum splitting concept is presented. It uses the combination of a commercial concentration GaInP/GaInAs/Ge 3J cell and a concentration Back-Point-Contact (BPC) silicon cell for efficient spectral utilization, and external confinement techniques for recovering the 3J cell's reflection. The primary optical element (POE) is a flat Fresnel lens and the secondary optical element (SOE) is a free-form RXI-type concentrator with a band-pass filter embedded in it - Both the POE and SOE performing Köhler integration to produce light homogenization on the receiver. The band-pass filter transmits the IR photons in the 900-1200 nm band to the silicon cell. A design target of an "equivalent" cell efficiency ~46% is predicted using commercial 39% 3J and 26% Si cells. A projected CPV module efficiency of greater than 38% is achievable at a concentration level larger than 500X with a wide acceptance angle of ±1°. A first proof-of concept receiver prototype has been manufactured using a simpler optical architecture (with a lower concentration, ~100x and lower simulated added efficiency), and experimental measurements have shown up to 39.8% 4J receiver efficiency using a 3J cell with a peak efficiency of 36.9%

Freeform Fresnel RXI-RR Köhler design with spectrum-splitting for photovoltaics

The development of a novel optical design for the high concentration photovoltaics (HPCV) nonimaging concentrator (>500x) that utilizes a built-in spectrum splitting concept is presented. The primary optical element (POE) is a flat Fresnel lens and the secondary optical element (SOE) is a free-form RXI-type concentrator with a band-pass filter embedded in it. The POE and SOE perform Köhler integration to produce light homogenization on the receiver. The system uses a combination of a commercial concentration GaInP/GaInAs/Ge 3J cell and a concentration Back-PointContact (BPC) silicon cell for efficient spectral utilization, and an external confinement technique for recovering the 3J cell’s reflection. A design target of an “equivalent” cell efficiency ~46% is predicted using commercial 39% 3J and 26% Si cells. A projected CPV module efficiency of greater than 38% is achievable at a concentration level greater than 500X with a wide acceptance angle of ±1º. A first proof-of concept receiver prototype has been manufactured using a simpler optical architecture (with a lower concentration, ~100x and lower simulated added efficiency), and experimental measurements have shown up to 39.8% 4J receiver efficiency using a 3J cell with a peak efficiency of 36.9

Ultra-High Efficiency, High-Concentration PV System Based On Spectral Division Between GaInP/GaInAs/Ge And BPC Silicon Cells

A novel HCPV nonimaging concentrator concept with high concentration (>500×) is presented. It uses the combination of a commercial concentration GaInP∕GaInAs∕Ge 3J cell and a concentration Back‐Point‐Contact (BPC) concentration silicon cell for efficient spectral utilization, and external confinement techniques for recovering the 3J cell′s reflection. The primary optical element (POE) is a flat Fresnel lens and the secondary optical element (SOE) is a free‐form RXI‐type concentrator with a band‐pass filter embedded it, both POE and SOE performing Köhler integration to produce light homogenization. The band‐pass filter sends the IR photons in the 900–1200 nm band to the silicon cell. Computer simulations predict that four‐terminal terminal designs could achieve ∼46% added cell efficiencies using commercial 39% 3J and 26% Si cells. A first proof‐of concept receiver prototype has been manufactured using a simpler optical architecture (with a lower concentration, ∼ 100× and lower simulated added efficiency), and experimental measurements have shown up to 39.8% 4J receiver efficiency using a 3J with peak efficiency of 36.9