The Remarkably Featureless High Resolution X-ray Spectrum of Mrk 478

An observation of Mrk 478 using the Chandra Low Energy Transmission Grating Spectrometer is presented. The source exhibited 30-40% flux variations on timescales of order 10000 s together with a slow decline in the spectral softness over the full 80 ks observation. The 0.15--3.0 keV spectrum is well fitted by a single power law with photon index of Gamma = 2.91 +/- 0.03. Combined with high energy data from BeppoSAX, the spectrum from 0.15 to 10 keV is well fit as the sum of two power laws with Gamma = 3.03 +/- 0.04, which dominates below 2 keV and 1.4 +/- 0.2, which dominates above 2 keV (quoting 90% confidence uncertainties). No significant emission or absorption features are detected in the high resolution spectrum, supporting our previous findings using the Extreme Ultraviolet Explorer but contradicting the claims of emission lines by Hwang & Bowyer (1997). There is no evidence of a warm absorber, as found in the high resolution spectra of many Sy 1 galaxies including others classified as narrow line Sy 1 galaxies such as Mrk 478. We suggest that the X-ray continuum may result from Comptonization of disk thermal emission in a hot corona through a range of optical depths.Comment: 21 pages, 7 figures; accepted for publication in the Astronomical Journa

Silent Springs: Why Are All the Frogs “Croaking”?

Amphibians are a fabulously successful group of animals; however, it is increasingly clear that they are experiencing extinction rates that far exceed those experienced by other classes of vertebrates. A new book examines the various reasons why amphibians are so threatened, and what can be done about it

Export-driven, extensive coastal aquaculture can benefit nutritionally vulnerable people

Export-orientated shrimp and prawn farming in coastal ghers has been associated with negative environmental, social, and nutritional impacts. This study challenges these perceptions based on field observations from four communities in South West Bangladesh. Most households observed (>60%) were either directly involved in seafood farming or engaged elsewhere in the seafood value chain. Our study set out to establish how the type and location of aquaculture impacted on access to and consumption of aquatic animals. Additionally, we assessed the effects of both household socioeconomic status and intra-household food allocation on individual diet and nutritional outcomes. We used a blended approach, including a 24-h consumption recall on two occasions, analysis of the proximate composition of aquatic animals and biomarkers from whole blood from a sample of the target population. The diverse polyculture systems generated broad social benefits, where “export-oriented” production actually supplied more food locally than to global markets. Key findings: (1) worse-off households achieved higher productivity of farmed aquatic animals on smaller landholding than better-off households with larger landholdings; (2) vegetable production on gher dikes was a significant source of nutrition and income in lower saline gradients; (3) more fish was eaten in lower saline gradients although fish consumption was highly variable within and between households; (4) intra-household allocation of specific foods within diets were similar across communities; (5) recommended nutrient intakes of protein and zinc exceeded daily requirements for adolescent females, but energy, calcium, and iron were below recommended intake levels; (6) n-3 LC-PUFA, expressed as percentage of total fatty acids, in whole blood samples of adolescent females declined with ambient salinity level regardless of household socioeconomic status; (7) analysis of aquatic animals consumed found that mangrove species and tilapia harvested from higher saline ghers contained high levels of desirable PUFAs. These findings suggest that export-driven, extensive coastal aquaculture can be nutrition sensitive when co-products are retained for local consumption

A novel retinoblastoma therapy from genomic and epigenetic analyses.

Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations that cooperate with RB1 loss, we performed whole-genome sequencing of retinoblastomas. The overall mutational rate was very low; RB1 was the only known cancer gene mutated. We then evaluated the role of RB1 in genome stability and considered non-genetic mechanisms of cancer pathway deregulation. For example, the proto-oncogene SYK is upregulated in retinoblastoma and is required for tumour cell survival. Targeting SYK with a small-molecule inhibitor induced retinoblastoma tumour cell death in vitro and in vivo. Thus, retinoblastomas may develop quickly as a result of the epigenetic deregulation of key cancer pathways as a direct or indirect result of RB1 loss

TRY plant trait database – enhanced coverage and open access

Plant traits - the morphological, anatomical, physiological, biochemical and phenological characteristics of plants - determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits - almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

A new quantitative approach to identify reworking in Eocene to Miocene pollen records from offshore Antarctica using red fluorescence and digital imaging

Antarctic palaeoclimate evolution and vegetation history after the formation of a continent-scale cryosphere at the Eocene-Oligocene boundary, 33.9 million years ago, has remained a matter of controversy. In particular, the reconstruction of terrestrial climate and vegetation has been strongly hampered by uncertainties in unambiguously identifying non-reworked as opposed to reworked sporomorphs that have been transported into Antarctic marine sedimentary records by waxing and waning ice sheets. Whereas reworked sporomorph grains over longer non-successive geological timescales are easily identifiable within younger sporomorph assemblages (e.g. Permian sporomorphs in Pliocene sediments), distinguishing non-reworked from reworked material in palynological assemblages over successive geological time periods (e.g. Eocene sporomorphs in Oligocene sediments) has remained problematic. This study presents a new quantitative approach to identifying non-reworked pollen assemblages in marine sediment cores from circum-Antarctic waters. We measured the fluorescence colour signature, including red, green, and blue fluorescence; brightness; intensity; and saturation values of selected pollen and spore taxa from Eocene, Oligocene, and Miocene sediments from the Wilkes Land margin Site U1356 (East Antarctica) recovered during Integrated Ocean Drilling Program (IODP) Expedition 318. Our study identified statistically significant differences in red-fluorescence values of non-reworked sporomorph taxa against age. We conclude that red fluorescence is a reliable parameter for identifying the presence of non-reworked pollen and spores in Antarctic marine sediment records from the circum-Antarctic realm that are influenced by glaciation and extensive reworking. Our study provides a new tool to accurately reconstruct Cenozoic terrestrial climate change on Antarctica using fossil pollen and spores.This study was funded by the Faculty of Engineering and Environment Research Studentship from Northumbria University. The samples used for this research were provided by the Integrated Ocean Drilling Program (IODP). Ulrich Salzmann acknowledges funding received from the Natural Environment Research Council (NERC grant NE/H000984/1). Francesca Sangiorgi thanks the Netherlands Organisation for Scientific Research (NWO) for NNPP Polar 866.10.110. Peter K. Bijl acknowledges the Dutch National Organisation for Scientific Research(NWO)for VENI grant no. 863.13.002. Carlota Escutia thanks the MINECO for scientific research grant CTM2014-60451-C2-1-P. Jörg Pross acknowledges support through the German Science Foundation (DFG; grant PR 651/10). We would finally like to thank the anonymous reviewer and Michael Hannah for their useful comments, which helped us to further improve this paper

An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and limited treatment options. Here we provide a comprehensive census of the bone marrow immune microenvironment in adult and pediatric patients with AML. We characterize unique inflammation signatures in a subset of AML patients, associated with inferior outcomes. We identify atypical B cells, a dysfunctional B-cell subtype enriched in patients with high-inflammation AML, as well as an increase in CD8+GZMK+ and regulatory T cells, accompanied by a reduction in T-cell clonal expansion. We derive an inflammation-associated gene score (iScore) that associates with poor survival outcomes in patients with AML. Addition of the iScore refines current risk stratifications for patients with AML and may enable identification of patients in need of more aggressive treatment. This work provides a framework for classifying patients with AML based on their immune microenvironment and a rationale for consideration of the inflammatory state in clinical settings.</p