Evaluating a Second Life PBL Demonstrator Project: What Can We Learn?

This article reports the findings of a demonstrator project to evaluate how effectively Immersive Virtual Worlds (IVWs) could support Problem-based Learning. The project designed, created and evaluated eight scenarios within Second Life (SL) for undergraduate courses in health care management and paramedic training. Evaluation was primarily qualitative, using illuminative evaluation which provided multiple perspectives through interviews, focus groups and questionnaires with designers, facilitators, learning technologists and students. Results showed that SL provided a rich, engaging environment which enhanced authenticity of the scenarios, though there were issues of access and usability. The article concludes by drawing together the lessons learned which will inform educators who seek to design and develop learning scenarios in this medium

Establishing a generalized polyepigenetic biomarker for tobacco smoking

Large-scale epigenome-wide association meta-analyses have identified multiple 'signatures'' of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking behavior and that can be utilized for multiple purposes in population health research. To validate the score, we use data from two birth cohort studies: The Dunedin Longitudinal Study, followed to age-38 years, and the Environmental Risk Study, followed to age-18 years. Longitudinal data show that changes in DNA methylation accumulate with increased exposure to tobacco smoking and attenuate with quitting. Data from twins discordant for smoking behavior show that smoking influences DNA methylation independently of genetic and environmental risk factors. Physiological data show that changes in DNA methylation track smoking-related changes in lung function and gum health over time. Moreover, DNA methylation changes predict corresponding changes in gene expression in pathways related to inflammation, immune response, and cellular trafficking. Finally, we present prospective data about the link between adverse childhood experiences (ACEs) and epigenetic modifications; these findings document the importance of controlling for smoking-related DNA methylation changes when studying biological embedding of stress in life-course research. We introduce the polyepigenetic DNA methylation score as a tool both for discovery and theory-guided research in epigenetic epidemiology.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.The Dunedin Longitudinal Study is funded by the New Zealand Health Research Council, the New Zealand Ministry of Business, Innovation, and Employment, the National Institute on Aging (AG032282), and the Medical Research Council (MR/P005918/1). The E-Risk Study is funded by the Medical Research Council (G1002190) and the National Institute of Child Health and Human Development (HD077482). Additional support was provided by a Distinguished Investigator Award from the American Asthma Foundation to Dr. Mill, and by the Jacobs Foundation and the Avielle Foundation. Dr. Arseneault is the Mental Health Leadership Fellow for the U.K. Economic and Social Research Council. Dr. Belsky is a Jacobs Foundation Fellow. This work used a high-performance computing facility partially supported by grant 2016-IDG-1013 (“HARDAC + : Reproducible HPC for Next-generation Genomics”) from the North Carolina Biotechnology Center. Illumina DNA methylation data are accessible from the Gene Expression Omnibus (accession code: GSE105018).pre-print, post-print, publisher's PD

Extensive Lower Cretaceous (Albian) methane seepage on Ellef Ringnes Island, Canadian High Arctic

During field mapping of Ellef Ringnes Island, Canadian Arctic Archipelago, 139 isolated Lower Cretaceous methane seep deposits were found from 75 field sites. Stable isotopes of the carbonates have values of δ13C= -47‰ to -35‰ and δ18O= -4.0‰ to +0.7‰. Isoprenoids in organics from one of the seeps are significantly depleted in 13C, with the most negative δ13C of = -118 ‰ and -113 ‰ for PMI and phytane/crocetane, respectively. These values indicate an origin through methane oxidation, consistent with biomarkers that are characteristic for anaerobic methanotrophic archaea within the seep deposits, accompanied by terminally-branched fatty acids sourced by sulphate-reducing bacteria, showing similar 13C values (-92‰). The seep deposits contain a moderate diversity macrofaunal assemblage containing ammonites, bivalves, gastropods, scaphopods, ‘vestimentiferan’ worm tubes and brachiopods. The assemblage is dominated numerically by species that probably had chemosymbionts. The seep deposits formed in the subsurface with strong redox zones, in an otherwise normal marine setting, characterised by oxic waters at high paleolatitudes. While geographically widespread, over an area of ~10,000 km2, seep deposits on Ellef Ringnes Island occur in a narrow stratigraphic horizon, suggesting a large release of biogenic methane occurred over a brief period of time. This gas release was coincident with a transition from a cold to warm climate during the latest Early Albian, and we hypothetize that this may relate to gas hydrate release

See Hear: Psychological Effects of Music and Music-Video During Treadmill Running

© 2014, The Society of Behavioral Medicine.Background: There is a paucity of work addressing the distractive, affect-enhancing, and motivational influences of music and video in combination during exercise. Purpose: We examined the effects of music and music-and-video on a range of psychological and psychophysical variables during treadmill running at intensities above and below ventilatory threshold (VT). Methods: Participants (N = 24) exercised at 10 % of maximal capacity below VT and 10 % above under music-only, music-and-video, and control conditions. Results: There was a condition × intensity × time interaction for perceived activation and state motivation, and an intensity × time interaction for state attention, perceived exertion (RPE), and affective valence. The music-and-video condition elicited the highest levels of dissociation, lowest RPE, and most positive affective responses regardless of exercise intensity. Conclusions: Attentional manipulations influence psychological and psychophysical variables at exercise intensities above and below VT, and this effect is enhanced by the combined presentation of auditory and visual stimuli

Getting Started with Second Life

This guide offers a basic overview of how to get started in Second Life with some tips on how to facilitate learning in this space. One of the difficulties with Second Life is that there is too much to learn by going through every menu or button systematically. It is better to pick up a few basics as outlined in this guide and experiment, rather than to get lost in the pursuit of mastering the detail of the environment

TAME - Training Against Medical Error

The TAME project (Training Against Medical Error) is an EC funded project. It aims to train students against medical error by using Virtual Patients (VPs) in an interactive Problem-Based Learning setting. Institutions from Kazakhstan, Ukraine and Vietnam have transformed their medical curricula to include these VP cases. Partners adapted six Paediatric medical error cases provided by St George’s University of London, into their own language, healthcare and cultural setting. They then created six new cases in their chosen subject area and delivered these to their students. Assessment and evaluation data was gathered and is being analysed. Past studies have shown learning through error is a powerful learning tool. <br