Exotic energy injection with ExoCLASS: Application to the Higgs portal model and evaporating black holes

We devise a new user-friendly tool interfaced with the Boltzmann code CLASS to deal with any kind of exotic electromagnetic energy injection in the universe and its impact on anisotropies of the Cosmic Microwave Background. It makes use of the results from standard electromagnetic cascade calculations develop in the context of WIMP annihilation, generalized to incorporate any injection history. We first validate it on a specific WIMP scenario, the Higgs Portal model, confirming that the standard effective on-the-spot treatment is accurate enough. We then analyze the more involved example of evaporating Primordial Black Holes (PBHs) with masses in the range $[3\times10^{13},5\times10^{16}]$g, for which the standard approximations break down. We derive robust CMB bounds on the relic density of evaporating PBHs, ruling out the possibility for PBHs with a monochromatic distribution of masses in the range $[3\times10^{13},2.5\times10^{16}]$g to represent all of the Dark Matter in our Universe. Remarkably, we confirm with an accurate study that the CMB bounds are several orders of magnitude stronger than those from the galactic gamma-ray background in the range $[3\times10^{13},3\times10^{14}]$g. A future CMB experiment like CORE+, or an experiment attempting at measuring the 21 cm signal from the Dark Ages could greatly improve the sensitivity to these models.Comment: 29 pages, 10 figures. Comments welcom

Excommunication : la puissance de la création langagière contemporaine

[À l'origine dans / Was originally part of : Thèses et mémoires - FAS - Département de littérature comparée]Cette thèse aborde la question de la valeur de la littérature contemporaine, en posant la question de la puissance de la création langagière. Dans la mesure où l’humanisme tombe en désuétude avec la fin de l’hégémonie médiatique de l’imprimerie, et où le capitalisme contemporain assigne à la culture un rôle économique et récréatif, la « littérature » se retrouve sans « critère final » pour penser sa puissance non économique. En d’autres termes, quels sont les effets intermédiaux de la création langagière livresque qui survivent à l’humanisme tout en résistant à la communication récréative? Il en va bien sûr de la nature même de la « création littéraire ». Le premier chapitre explore les liens entre l’humanisme et l’imprimerie à partir d’un concept de fongibilité, et introduit un ensemble de concepts clé. Le deuxième chapitre présente un autre ensemble de concepts (dont le geste vertical), cette fois pour penser le langage en termes de pouvoir et de puissance. Le troisième chapitre aborde le « capitalisme civilisationnel » en termes intermédiaux. On y réfléchit sur la saturation, la séparation et la fenestration, notamment à partir d’une éthique du jeu. Le quatrième chapitre traite de la question de la plasticité. Enfin, les cinquième et sixième chapitres forment deux exemples – des exemples de puissance – à partir des oeuvres de Valère Novarina (Lumières du corps) et de David Foster Wallace (Infinite Jest). Le corpus théorique se compose d’éléments puisés d’une part dans l’oeuvre de Walter Benjamin et de Giorgio Agamben, selon un matérialisme messianique, et d’autre part dans celle de Gilles Deleuze. Certaines considérations sont également tenues sous l’influence de Michel Foucault et de Ludwig Wittgenstein.This thesis broaches the value of contemporary literature as power (puissance) of language creation. Given that humanism becomes obsolete with the end of the printing press media dominance, and given that contemporary capitalism assigns an economical and recreational role to culture, “literature” is left without any “final criterion” to think its non-economical power. In other words, which intermedial effects of language creation through book form survives humanism while withstanding recreational communication? In the process, the practice of creative writing and its idea are set under a new paradigm. The first chapter explores the relationships between humanism and the printing press based on a concept of fungibility, and it introduces a set of key concepts. The second chapter presents another set of concepts (including vertical gesture), this time in order to think language in terms of ruling power (pouvoir) and virtual power (puissance). Chapter three broaches the idea of “civilizational capitalism” in intermedial terms. Saturation, separation and windowing are considered according to a game/play ethic. Chapter four is about plasticity. Finally, chapters five and six follow two examples—examples of virtual power, those of contemporary French writer Valère Novarina (Lumières du corps) and American novelist David Foster Wallace (Infinite Jest). The theoretical corpus is composed of elements taken, on the one hand, from Walter Benjamin’s and Giorgio Agamben’s works (regarding messianic materialism), and on the other hand, from Gilles Deleuze’s works. Some ideas are also influenced by Michel Foucault’s and Ludwig Wittgenstein’s works

Benthic diatom communities from two salt marshes of the St. Lawrence Estuary (Canada)

Microphytobenthic diatom communities were investigated in the high and low sections of two salt marshes of the Lower St. Lawrence Estuary (eastern Canada): one featuring a sandy low marsh zone (Pointe-aux-Épinettes; PE) and one with a muddy low marsh area (Pointe-au-Père; PP). Based on diatom composition and diversity, bacterial abundance, chlorophyll-a, phaeopigments and geochemical analyses (Corg, Ntot, granulometry, extracellular polymeric substances), the PP high marsh area appeared to be singular compared to the other sampling sites. Estimated surface biomass ranged from 11 to 71 g C•m-2 in the PE marsh and from 24 to 486 g C•m-2 in the PP marsh. A higher diversity of diatom species was observed in the PP high marsh area with a dominance of epipelic forms, in opposition to the dominant epipsammic forms at the other sites. Statistical analyses showed that diatom density was mainly affected by nutrient availability while the relative abundance of epipelic and epipsammic species was related to sediment grain size. This study provides original data on the composition of benthic diatoms in surface sediments in St. Lawrence saltmarshes during summer time that represent the first step to the determination of the DBI (Diatom biological index) of these northern environments.La composition des communautés de diatomées benthiques a été étudiée dans les zones supérieures et inférieures de deux marais côtiers de l’estuaire maritime du Saint-Laurent (Québec, Canada), l’un possédant un estran sableux (marais de Pointe-aux-Épinette; PE) et l’autre possédant un estran vaseux (marais de Pointe-au-Père; PP). En nous penchant sur l’abondance et la diversité des diatomées benthiques ainsi que sur les caractéristiques biogéochimiques du sédiment (abondance bactérienne totale, granulométrie, composition élémentaire, concentration de pigments, de polysaccharides), nous avons observé que la zone supérieure du marais PP constituait un milieu singulier. Une plus grande diversité de diatomées a été observée dans cette zone avec une dominance des formes épipéliques alors qu’aux autres sites, nous avons observé une prédominance des formes épipsammiques. Nos analyses statistiques ont montré que l’abondance totale de diatomées est corrélée à la disponibilité des nutriments, alors que l’abondance relative de cellules de types épipélique et épisammique est corrélée à la taille des particules de sédiment. Selon nos estimations, la biomasse associée aux diatomées variait de 11 à 71 g C•m-2 dans le marais PE et de 24 à 486 g C•m-2 dans le marais PP. Cette étude décrit pour la première fois la composition détaillée des communautés de diatomées établies dans les sédiments des marais côtiers nordiques en saison estivale et constitue un premier pas vers la détermination de l’indice biologique diatomique de ces environnements nordiques

Efficient Streaming of 3D Scenes with Complex Geometry and Complex Lighting

International audienceStreaming data to efficiently render complex 3D scenes in presence of global illumination is still a challenging task. In this paper, we introduce a new data structure based on a 3D grid of irradiance vectors to store the indirect illumination appearing on complex and detailed objects: the Irradiance Vector Grid (IVG). This representation is independent of the geometric complexity and is suitable for quantization to different quantization schemes. Moreover, its streaming over network involves only a small overhead compared to detailed geometry, and can be achieved independently of the geometry. Furthermore, it can be efficiently rendered using modern graphics hardware. We demonstrate our new data structure in a new remote 3D visualization system, that integrates indirect lighting streaming and progressive transmission of the geometry, and study the impact of different strategies on data transfer

Acute high altitude exposure, acclimatization and re-exposure on nocturnal breathing

Background: Effects of prolonged and repeated high-altitude exposure on oxygenation and control of breathing remain uncertain. We hypothesized that prolonged and repeated high-altitude exposure will improve altitude-induced deoxygenation and breathing instability. Methods: 21 healthy lowlanders, aged 18-30y, underwent two 7-day sojourns at a high-altitude station in Chile (4-8 hrs/day at 5,050 m, nights at 2,900 m), separated by a 1-week recovery period at 520 m. Respiratory sleep studies recording mean nocturnal pulse oximetry (SpO2), oxygen desaturation index (ODI, >3% dips in SpO2), breathing patterns and subjective sleep quality by visual analog scale (SQ-VAS, 0-100% with increasing quality), were evaluated at 520 m and during nights 1 and 6 at 2,900 m in the 1st and 2nd altitude sojourn. Results: At 520 m, mean ± SD nocturnal SpO2 was 94 ± 1%, ODI 2.2 ± 1.2/h, SQ-VAS 59 ± 20%. Corresponding values at 2,900 m, 1st sojourn, night 1 were: SpO2 86 ± 2%, ODI 23.4 ± 22.8/h, SQ-VAS 39 ± 23%; 1st sojourn, night 6: SpO2 90 ± 1%, ODI 7.3 ± 4.4/h, SQ-VAS 55 ± 20% (p < 0.05, all differences within corresponding variables). Mean differences (Δ, 95%CI) in acute effects (2,900 m, night 1, vs 520 m) between 2nd vs 1st altitude sojourn were: ΔSpO2 0% (-1 to 1), ΔODI -9.2/h (-18.0 to -0.5), ΔSQ-VAS 10% (-6 to 27); differences in acclimatization (changes night 6 vs 1), between 2nd vs 1st sojourn at 2,900 m were: ΔSpO2 -1% (-2 to 0), ΔODI 11.1/h (2.5 to 19.7), ΔSQ-VAS -15% (-31 to 1). Conclusion: Acute high-altitude exposure induced nocturnal hypoxemia, cyclic deoxygenations and impaired sleep quality. Acclimatization mitigated these effects. After recovery at 520 m, repeated exposure diminished high-altitude-induced deoxygenation and breathing instability, suggesting some retention of adaptation induced by the first altitude sojourn while subjective sleep quality remained similarly impaired. Keywords: altitude (MeSH); hypoxia; respiration - physiology; respiratory polygraphy; sleep-disordered breathing

Compact Structures for Interactive Global Illumination on Large Cultural Objects

International audienceCultural Heritage scenes usually consist of very large and detailed 3D objects with high geometric complexity. Even the raw visualization of such 3D objects already involves a large amount of memory and computation time. When trying to improve the sense of immersion and realism by using, global illumination techniques the demand on these resources becomes prohibitive Our approach uses regular grids combined with a vector-based representation to efficiently capture low-frequency indirect illumination. A fixed set of irradiance vectors is stored in 3D textures (for complex objects) and in 2D textures (for mostly planar objects). The vector-based representation offers additional robustness against local variations of the geometry. Consequently, the grid resolution can be set independently of geometric complexity, and the memory footprint can therefore be reduced. The irradiance vectors can be precomputed on a simplified geometry. For interactive rendering, we use an appearance preserving simplification of the geometry. The indirect illumination within a grid cell is interpolated from its associated irradiance vectors, resulting in an everywhere-smooth reconstruction

A prospective cohort study about the effect of repeated living high and working higher on cerebral autoregulation in unacclimatized lowlanders

Cerebral autoregulation (CA) is impaired during acute high-altitude (HA) exposure, however, effects of temporarily living high and working higher on CA require further investigation. In 18 healthy lowlanders (11 women), we hypothesized that the cerebral autoregulation index (ARI) assessed by the percentage change in middle cerebral artery peak blood velocity (Δ%MCAv)/percentage change in mean arterial blood pressure (Δ%MAP) induced by a sit-to-stand maneuver, is (i) reduced on Day1 at 5050 m compared to 520 m, (ii) is improved after 6 days at 5050 m, and (iii) is less impaired during re-exposure to 5050 m after 7 days at 520 m compared to Cycle1. Participants spent 4-8 h/day at 5050 m and slept at 2900 m similar to real-life working shifts. High/low ARI indicate impaired/intact CA, respectively. With the sit-to-stand at 520 m, mean (95% CI) in ΔMAP and ΔMCAv were − 26% (− 41 to − 10) and − 13% (− 19 to − 7), P < 0.001 both comparisons; mean ± SD in ARI was 0.58 ± 2.44Δ%/Δ%, respectively. On Day1 at 5050 m, ARI worsened compared to 520 m (3.29 ± 2.42Δ%/Δ%), P = 0.006 but improved with acclimatization (1.44 ± 2.43Δ%/Δ%, P = 0.039). ARI was less affected during re-exposure to 5050 m (1.22 ± 2.52Δ%/Δ%, P = 0.027 altitude-induced change between sojourns). This study showed that CA (i) is impaired during acute HA exposure, (ii) improves with living high, working higher and (iii) is ameliorated during re-exposure to HA

Formation of disclination lines near a free nematic interface

We have studied the nucleation and the physical properties of a -1/2 wedge disclination line near the free surface of a confined nematic liquid crystal. The position of the disclination line has been related to the material parameters (elastic constants, anchoring energy and favored anchoring angle of the molecules at the free surface). The use of a planar model for the structure of the director field (whose predictions have been contrasted to those of a fully three-dimensional model) has allowed us to relate the experimentally observed position of the disclination line to the relevant properties of the liquid crystals. In particular, we have been able to observe the collapse of the disclination line due to a temperature-induced anchoring angle transition, which has allowed us to rule out the presence of a real disclination line near the nematic/isotropic front in directional growth experiments. 61.30.Jf,61.30.G

Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36). It is a determinant in Wolf–Hirschhorn syndrome and is overexpressed in human multiple myeloma. Despite the relevance of NSD2 to cancer, there are no potent, selective inhibitors of this enzyme reported. Here, a combination of kinetic isotope effect measurements and quantum chemical modeling was used to provide subangstrom details of the transition state structure for NSD2 enzymatic activity. Kinetic isotope effects were measured for the methylation of isolated HeLa cell nucleosomes by NSD2. NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation. Primary Me-(14)C and (36)S and secondary Me-(3)H(3), Me-(2)H(3), 5′-(14)C, and 5′-(3)H(2) kinetic isotope effects were measured for the methylation of H3K36 using specifically labeled S-adenosyl-l-methionine. The intrinsic kinetic isotope effects were used as boundary constraints for quantum mechanical calculations for the NSD2 transition state. The experimental and calculated kinetic isotope effects are consistent with an S(N)2 chemical mechanism with methyl transfer as the first irreversible chemical step in the reaction mechanism. The transition state is a late, asymmetric nucleophilic displacement with bond separation from the leaving group at (2.53 Å) and bond making to the attacking nucleophile (2.10 Å) advanced at the transition state. The transition state structure can be represented in a molecular electrostatic potential map to guide the design of inhibitors that mimic the transition state geometry and charge