Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

AIMS/HYPOTHESIS: This is an update of the results from the previous report of the CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). METHODS: The CORONADO initiative is a French nationwide multicentre study of patients with diabetes hospitalised for COVID-19 with a 28-day follow-up. The patients were screened after hospital admission from 10 March to 10 April 2020. We mainly focused on hospital discharge and death within 28 days. RESULTS: We included 2796 participants: 63.7% men, mean age 69.7 ± 13.2 years, median BMI (25th-75th percentile) 28.4 (25.0-32.4) kg/m(2). Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of participants, respectively. Within 28 days, 1404 (50.2%; 95% CI 48.3%, 52.1%) were discharged from hospital with a median duration of hospital stay of 9 (5-14) days, while 577 participants died (20.6%; 95% CI 19.2%, 22.2%). In multivariable models, younger age, routine metformin therapy and longer symptom duration on admission were positively associated with discharge. History of microvascular complications, anticoagulant routine therapy, dyspnoea on admission, and higher aspartate aminotransferase, white cell count and C-reactive protein levels were associated with a reduced chance of discharge. Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors. CONCLUSIONS/INTERPRETATION: In patients with diabetes hospitalised for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT04324736

Etude des deplacements domicile-travail. I: Methodologie et premiers resultats

SIGLECNRS-CDST / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Le tourisme urbain : les pratiques des francais

Available at INIST (FR), Document Supply Service, under shelf-number : 21083, issue : a.1996 n.208 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo

The tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), purified from bone marrow and constitutively synthesized in vivo, belongs to the family of negative regulators of hematopoiesis. It protects the stem cell compartment from the toxicity of anticancer drugs and irradiation and consequently contributes to a reduction in marrow failure. This current work provides experimental evidence for another novel biologic function of AcSDKP. We report that AcSDKP is a mediator of angiogenesis, as measured by its ability to modulate endothelial cell function in vitro and angiogenesis in vivo.AcSDKP at nanomolar concentrations stimulates in vitro endothelial cell migration and differentiation into capillary-like structures on Matrigel as well as enhances the secretion of an active form of matrix metalloproteinase-1 (MMP-1). In vivo, AcSDKP promotes a significant angiogenic response in the chicken embryo chorioallantoic membrane (CAM) and in the abdominal muscle of the rat. Moreover, it induces the formation of blood vessels in Matrigel plugs implanted subcutaneously in the rat. This is the first report demonstrating the ability of AcSDKP to interact directlywith endothelial cells and to elicit an angiogenic response in vitro and in vivo

Interactions between oceans and societies in 2030: challenges and issues for research

The perception of ocean areas by policy-makers or by people, living or not on the coast, has significantly varied over centuries. Due to its vastness and complexity, the sea has been studied within distinct academic disciplines. However, the current issues related to the sea, such as climate change, marine pollution or coastal tourism, require an integrated vision of the assets and drawbacks in order to meet the challenges arising from human activities both at sea and onshore. In this study, a group of foresight officers from the French network of public research institutes decided to cross-check and compare several science approaches (biology, sociology, economics, etc) about oceans. Thus, 11 sectors of maritime activity (transportation, fisheries, energy, etc.) were cross-tabulated with 9 basic social functions (providing food, housing, learning, etc.). In this matrix, the main challenges and issues projected for 2030 were sought, in the frame of a baseline scenario. Results were clustered through 4 criteria, leading to 9 major challenges, each of them broken down into two important issues for research. The outcomes were used to create a survey, allowing the ranking of the research priorities. Most of the 9 challenges tally with the research and development objectives of great maritime states, except for governance and monitoring, which remain underscored. As a result, maritime powers still show more interest on securing national resources rather than on promoting international cooperation for secure trade and sustainable exploitation of marine resources. But foresight in this field could help changing the mentalities notably because oceans show clearly now to be a vital common good for mankind

Evolution du tourisme etranger en France, du tourisme francais a l'etranger de 1982 a 1989

SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : 21083 A, issue : a.1992 n.17 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Les grandes manifestations : planification, gestion des mobilites et impacts

Available from INIST (FR), Document Supply Service, under shelf-number : RL 588 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Subjective cognitive decline and rates of incident Alzheimer's disease and non\u2013Alzheimer's disease dementia

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini\u2013Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E \u3b54 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts

Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

International audienceThe aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed