РЕЗУЛЬТАТИ ВПРОВАДЖЕННЯ ЄДИНОГО ДЕРЖАВНОГО КВАЛІФІКАЦІЙНОГО ІСПИТУ У СТУДЕНТІВ-ПРОВІЗОРІВ ДНІПРОПЕТРОВСЬКОЇ МЕДИЧНОЇ АКАДЕМІЇ

The article analyzes the results of the Unified State Qualification Examination (USQE) implementation in order to assess the pharmacy students’ education level during the Krok-1 licensed integrated examination and to compare these results with the national indicators. Considering that for the first time in 2019 a new qualitative assessment method of students’ knowledge has been introduced in Ukraine, both Ukrainian and foreign third year pharmacy students have had the USQ examination at Dnipropetrovsk Medical Academy (DMA), which included two components: Krok-1 licensed integrated examination and professional English. The analysis of the obtained results has revealed some shortcomings of the student training program and drawn an attention to the solution to these problematic issues. This comprehensive assessment of the pharmacy students’ profile knowledge allows us to identify the training programs’ shortcomings and provides an opportunity to increase the effectiveness of study at the academy in order to integrate Ukrainian specialists in the world medicine.У статті проведено аналіз результатів впровадження єдиного державного кваліфікаційного іспиту (ЄДКІ) для оцінки рівня знань у студентів-провізорів під час складання ліцензійного інтегрованого іспиту Крок-1 та порівняння цих результатів з національними показниками. Зважаючи на те, що у 2019 р. в Україні вперше було впроваджено якісно новий інструмент оцінювання знань студентів, в Дніпропетровській медичній академії студенти-провізори 3 курсу, як громадяни України, так і іноземці, складали ЄДКІ, який мав такі дві складові, як: ліцензійний інтегрований комплексний іспит Крок-1 та англійська мова професійного спрямування. Аналіз отриманих результатів дозволив виявити деякі недоліки при підготовці студентів в академії та привернути увагу до рішення цих проблемних питань. Таке комплексне оцінювання профільних знань студентів-провізорів дозволяє виявити слабкі сторони процесу навчання і надає можливість підвищити ефективність навчання в академії для інтегрування вітчизняних фахівців у світову медицину

A "former nobleman": survival in soviet realities

The issues addressed in the article are of particular relevance for the contemporary historiography due to the absence of systematic studies on the history of the "Soviet nobility" and their adaptation to the Soviet realities. An especially interesting aspect of this topic is the transformation of values and worldview of the nobility in the conditions of the dominant communist ideology. The article presents a comprehensive analysis of the nobility survival in the period of establishment of a totalitarian political regime and destruction of the traditional Russian system of values and religious traditions. The primary research method used to address the topic is the micro-historical analysis, which allowed the authors to obtain the following results: a typology of this social group was developed (involuntary or deported emigrants, open or hidden oppositionists, and those who were forced to adapt), based on characterization of beliefs, values and patterns of behaviour of individual representatives of the "former" nobility; oppressive measures used by the Soviet power against the "exploiters" were classified into several types: economic oppression, legal restrictions, ideological pressure and direct terror; and specific features of their adaptation to the Soviet realities, including its ethno-confessional aspect, were identified. The main conclusion drawn from the research is that the nobiliary culture and system of values proved extremely resistant to various challenges and threats of the Soviet epoch. Materials of this article have both theoretical and practical implications in the context of actualisation of the culture of mansions, nobiliary traditions and the cadet education in today´s Russia.Keywords: "Soviet nobility", system of values, emigration, opposition, terror, adaptatio

ІННОВАЦІЙНІ ТЕХНОЛОГІЇ В ПРОФЕСІЙНІЙ ОСВІТІ: СУЧАСНІ ТЕНДЕНЦІЇ ТА ПРАКТИКА ВПРОВАДЖЕННЯ

The aim of the work – to highlight the experience of applying distance learning, which works in the open and most popular world-wide platform – Moodle, to improve the quality of training of highly skilled pharmacists in the Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine. The main body. The article examines the introduction of the latest innovative teaching technologies used by teachers at the department of general and clinical pharmacy in the preparation of a specialist-observer. The features of distance learning system, its advantages are shown. The assessment of the effectiveness of the used innovative technologies is conducted throughout the entire period of study of a particular discipline, by testing and continuous monitoring and verification of the mastery of theoretical material and practical skills before the beginning of each practical or laboratory lesson. The efficiency of the use of distance learning system as a non-auditory form of organization of independent work of students is shown. Conclusions. In this way – innovative learning technologies contribute to the development of cognitive and cognitive abilities of students, namely – the ability to solve problems, collect, analyze and synthesize data, extract information from them, think independently, and have communicative skills. Educational technologies open new horizons of teaching, learning and evaluation of the acquired knowledge, allow to implement innovative, effective models of administration and management. To continuously monitor the acquisition of professional competencies, which allows for adjusting and individualizing the learning process in a short time. Distance learning systems provide opportunities for continuous education, providing a large range of people with the opportunity to receive postgraduate and additional education.Мета роботи – висвітлити досвід застосування дистанційної форми навчання, яка працює на відкритій і найбільш популярній у світі платформі – Moodle, для підвищення якості підготовки висококваліфікованих фахівців-провізорів у Дніпропетровській медичній академії. Основна частина. У статті розглянуто досвід впровадження новітніх інноваційних технологій навчання, які використовуються викладачами на кафедрі загальної та клінічної фармації при підготовці фахівця-провізора. Показано особливості дистанційної системи навчання, її переваги. Оцінка ефективності використаних інноваційних технологій проводиться протягом усього терміну навчання конкретної дисципліни, шляхом тестування та постійного контролю і перевірки опанування теоретичного матеріалу та практичних навичок перед початком кожного практичного чи лабораторного заняття. Показана ефективність використання дистанційної системи навчання як позааудиторної форми організації самостійної роботи студентів. Висновки. Інноваційні технології навчання сприяють розвитку пізнавальних і когнітивних здібностей студентів, а саме – вміння вирішувати поставлені завдання, займатися збором, аналізом і синтезом даних, витягувати з них інформацію, самостійно мислити, володіти комунікативними навичками. Освітні технології відкривають нові горизонти викладання, навчання й оцінки здобутих знань, дозволяють втілювати інноваційні, ефективні моделі адміністрування та управління. Здійснювати постійний моніторинг оволодіння професійними компетенціями, що дозволяє за короткий строк відкоректувати та індивідуалізувати процес навчання. Дистанційні системи навчання надають можливості безперервного навчання, забезпечуючи великому колу людей можливість отримання як післявузівської, так і додаткової освіти

Ethnicity-specific distribution of <em>TRPM8</em> gene variants in Eurasian populations: signs of selection

The TRPM8 gene encodes the ion channel, which is a cold receptor in afferent neurons of the mammalian somatosensory system. We studied the frequency of haplotype distribution from six SNPs in the TRPM8 gene in Eurasian human populations, including Russians, Kazakhs and Chukchi. Four of the six SNPs are located in exon 7 (rs13004520, rs28901637, rs11562975, rs17868387), rs7593557 is in exon 11. These exons encode parts of the N-terminus, which is necessary for channel functioning in the plasma membrane of neurons. The rs11563071 is in exon 23 encoding part of the C-terminus. The primary difference in population distribution of haplotypes determines the SNP from exon 11 which leads to Ser419Asn substitution in protein. The most pronounced dif­ferences in the patterns of diversity and frequencies of haplotypes were observed between Chukchi and Russians. The frequency of major H1 haplotype encompassing the 419Ser gene variant differs in examined populations; 0.738 (Russians), 0.507 (Kazakhs) and 0.337 (Chukchi), p &lt; 0.001. The TRPM8 gene variants encoding 419Asn and carrying the minor alleles of rs28901637 (P249P) and rs11562975 (L250L) in exon 7 are characteristic of Asian populations. The frequency of all 419Asn variants in Chukchi is comparable to that in Africans, however, the minor allele frequencies of rs28901637, rs11562975 in Africans is low. Apparently in the process of human colonization of Eurasia, minor alleles of these SNPs diverged depending on rs7593557 structure in exon 11. We analyzed sequences of five TRPM8 mRNA isoforms extracted by researchers from different tissues. Sequence analysis demonstrates that they are transcribed from major H1 variant of the TRPM8 gene but contain different translation start codons, which are generated by alternative splicing from pro-mRNA

Dynamics of cognitive functions in treatment of alcohol-dependent patients

The article describes the results of dynamics of impaired cognitive functions of patients with alcohol dependence who received treatment with antipsychotics. Cognitive functions improve significantly faster in patients of the main group whose treatment included Risperidone, an atypical antipsychotic. There is insignificant positive dynamics of impaired cognitive functions in the group of patients who received Haloperidol as antipsychotic. The patients who received Risperidone have shown improved compliance, lack of negative attitude to the therapy provided as compared with the control group patients. Risperidone's most significant effects include improvement of disorganized psychic activity, recovery of active attention, dynamic and tempo parameters of activity, recovery of the capacity for unconditioned regulation of thinking and behavior, critical assessment

Polymorphism in the TRP8 gene in Kyrgyz population: putative association with highland adaptation

The human TRPM8 gene encodes a receptor mediating cold sensitivity, and this fact points to its putative role in cold adaptation. The structural variability of the TRPM8 gene for five single-nucleotide polymorphisms (SNPs) has been studied in Kyrgyz population. The SNPs are located in coding regions of the gene, and three of them are confined to a segment of 20 bp in exon 7. The frequencies of minor SNP alleles are: rs13004520 G/C = 0.06; rs28901637 А/Т = 0.13; rs11562975 G/C = 0.27; rs7593557 G/A = 0.21; rs11563071 С/G = 0.12. The analyzed sample of Kyrgyz population includes 275 individuals living at different altitudes and under drastically different climatic conditions. The frequency of the minor rs11562975 allele in highlanders (living above 2 800 m A. S. L.) is one-third lower than in residents of lower regions (760–2 800 m A. S. L.; p &lt; 0.01). This result presumes a selective role of rs11562975 in cold adaptation. Comparison of haplotype frequencies in Kyrgyz people with Europeans, East Asians, and Africans shows a clear narrowing of genotype variation in Europeans in comparison to all others. Probably, this phenomenon is related to a population size decline (bottleneck effect) during the evolution. We consider the exon– intron structure of the TRPM8 gene. Epigenetic markers in the vicinity of the gene have been analyzed. Two strong binding sites for insulator ctcf proteins are present there. They are likely to be associated with chromatin conformation and alternative splicing regulation. A structure–functional characterization of genes for the TRP protein family is provided

The San Antonio River Mammoth Site: Archaeological Testing Investigations for the Interstate 37 Bridge at the San Antonio River Improvement Project, Bexar County, Texas

On behalf of the Texas Department of Transportation (TxDOT), SWCA Environmental Consultants (SWCA) conducted test excavations on the San Antonio River Mammoth site (41BX1239) and 41BX1240 and surveys in the area of potential effects (APE) of the Interstate Highway (IH) 37 bridge project at the San Antonio River in southeastern Bexar County, Texas. Work was initiated to address the requirements of Section 106 of the National Historic Preservation Act (1966) as Amended and the Antiquities Code of Texas. The purpose of the investigations was to identify, delineate, and evaluate the significance of all archaeological and historic properties potentially affected by the undertaking and, if warranted, recommend the scope of additional work. Of particular concern, site 41BX1239 contains the remains of at least two mammoths with possible evidence of cultural association based on the initial investigations by Texas A&M in 1997. However, subsequent faunal analysis, conducted by Olga Potapova and Larry D. Agenbroad of the Mammoth Site in Hot Springs, North Dakota, found inconclusive evidence for definite or valid cultural modification to the specimens studied. The testing investigations on the San Antonio River Mammoth site included the re-exposure of the original Texas A&M 1997 site trench; limited hand-excavated units to further assess the prior interpretations of the deposits and recover a sample of bone; and a detailed geomorphological assessment. The work identified a bone bed consisting of the remains of at least two mammoths. Flotation of recovered sediments from these hand excavations identified flakes of siliceous material that are consistent with micro-debitage produced by the use and retouch of stone tools. Although at the highest thresholds of certainty, the cumulative evidence is likely yet insufficient to conclusively prove human interaction with the mammoth remains, the additional data gathered herein lend some credence to the prior interpretation of the site as archaeological rather than strictly paleontological. Concurring with the previous determination, the site is considered eligible for inclusion to the National Register of Historic Places (NRHP) and for listing as a State Archeological Landmark (SAL). However, the investigations determined the site deposits are located outside the APE of the current undertaking, and therefore the project will not affect deposits associated with the San Antonio River Mammoth site. The investigations of 41BX1240 identified only a very sparse scatter of primarily surficial materials in a heavily disturbed context with no associated features or diagnostic materials. Accordingly, the site is not recommended as eligible for listing on the NRHP or for designation as a SAL. The survey identified no new archaeological sites. Based on the avoidance of 41BX1239, it is SWCA’s recommendation that no archaeological properties will be affected by the IH 37 bridge rehabilitation

НАНОЧАСТИЦЫ ГИДРОКСОКАРБОНАТА ЦЕРИЯ, ИНКРУСТИРОВАННЫЕ ПАЛЛАДИЕМ. СИНТЕЗ И ИССЛЕДОВАНИЕ

Cerium(III) nitrate and urea solution mixture were treated by hydrothermal and microwavehydrothermal methods, as a result cerium(III) carbonate hydroxide nanoparticles (22-37 nm) were obtained. Cerium(III) carbonate hydroxide nanoparticles, encrusted by palladium were obtained using palladium reduction process from cerium(III) carbonate hydroxide solution. It is shown, that palladium occurrence disturbs hard hydrogen bond system, leading to carbonate hydroxide nanoparticles structure disorder and also increases efficiency of catalytic reactivity process.Из смеси растворов нитрата церия(III) и мочевины с использованием различных методов и приемов выделены наночастицы (22-37 нм) гидроксокарбоната церия(III). Путем восстановления палладия в растворах в присутствии гидроксокарбоната церия(III) получены образцы наночастиц гидроксокарбоната церия(III) с поверхностью, инкрустированной палладием. Показано, что присутствие Pd нарушает жесткую систему водородных связей матрицы и приводит к разупорядочению строения наночастиц гидроксокарбоната. Подчеркивается перспективность использования указанных композитов в катализе

Simonsenia aveniformis sp nov (Bacillariophyceae), molecular phylogeny and systematics of the genus, and a new type of canal raphe system

The genus Simonsenia is reviewed and S. aveniformis described as new for science by light and electron microscopy. The new species originated from estuarine environments in southern Iberia (Atlantic coast) and was isolated into culture. In LM, Simonsenia resembles Nitzschia, with bridges (fibulae) beneath the raphe, which is marginal. It is only electron microscope (EM) examination that reveals the true structure of the raphe system, which consists of a raphe canal raised on a keel (wing), supported by rib like braces (fenestral bars) and tube-like portulae; between the portulae the keel is perforated by open windows (fenestrae). Based on the presence of portulae and a fenestrated keel, Simonsenia has been proposed to be intermediate between Bacillariaceae and Surirellaceae. However, an rbcL phylogeny revealed that Simonsenia belongs firmly in the Bacillariaceae, with which it shares a similar chloroplast arrangement, rather than in the Surirellaceae. Lack of homology between the surirelloid and simonsenioid keels is reflected in subtle differences in the morphology and ontogeny of the portulae and fenestrae. The diversity of Simonsenia has probably been underestimated, particularly in the marine environment.Polish National Science Centre in Cracow within the Maestro program [N 2012/04/A/ST10/00544]; Sciences and Technologies Foundation-FCT (Portugal) [SFRH/BD/62405/2009]info:eu-repo/semantics/publishedVersio