Evaluation of the syndrome of chronic fatigue in patients of the cardiological department

This study presents the structure of chronic fatigue syndrome in the cardiology department of City Clinical Hospital №7, Ekaterinburg. Leading patient complaints were noted and evaluated according to the Clinical Frailty scale.В настоящем исследовании представлена структура синдрома хронической усталости в кардиологическом отделении ГКБ №7, г.Екатеринбург. Отмечены ведущие жалобы пациентов и проведена оценка в соответствии со шкалой Clinical Frailty

Impact of inter-ventricular lead distance on cardiac resynchronization therapy outcomes

Cardiac resynchronization therapy (CRT) has been shown as an essential treatment of patients with heart failure, leading to improvements in symptoms, left ventricular (LV) function, and survival. However, up to 30% of appropriately selected patients remain non-responders to CRT. The aim of our study was to test a hypothesis on the impact of lead positioning in the ventricular walls on CRT response in patients with advanced chronic heart failure with and without pre-operative inter and intra-ventricular myocardial dyssynchrony. We examined 53 guideline-selected CRT candidates. Response to CRT was defined in 6 months after implantation of CRT devices. All patients underwent standard and Doppler echocardiography for assessment of LV function and mechanical dyssynchrony. Individual right ventricular (RV) and LV lead tip position, inter-lead distance, and the horizontal and vertical components were measured on the radiograph images with using an automated custom made software Our results showed that the RLV inter-lead distance is an essential parameter correlated with the CRT outcomes. A logistic model comprising the RLV inter-lead distance with parameters of dyssynchrony demonstrated a high predictive power for odds of CRT success. © 2017 IEEE Computer Society. All rights reserved.Research was supported by Act 211 Government of the Russian Federation, agreement № 02.A03.21.0006 and Program of the RAS Presidium #I.33П

Evaluation of the syndrome of chronic fatigue in patients of the cardiological department

This study presents the structure of chronic fatigue syndrome in the cardiology department of City Clinical Hospital №7, Ekaterinburg. Leading patient complaints were noted and evaluated according to the Clinical Frailty scale.В настоящем исследовании представлена структура синдрома хронической усталости в кардиологическом отделении ГКБ №7, г.Екатеринбург. Отмечены ведущие жалобы пациентов и проведена оценка в соответствии со шкалой Clinical Frailty

Mini-EUSO experiment to study UV emission of terrestrial and astrophysical origin onboard of the International Space Station

International audienceMini-EUSO will observe the Earth in the UV range (300 - 400 nm) offering the opportunity to study a variety of atmospheric events such as Transient LuminousEvents (TLEs), meteors and marine bioluminescence. Furthermore it aims to search for Ultra High Energy Cosmic Rays (UHECR) above $10^{21}$ eV and Strange Quark Matter (SQM).The detector is expected to be launched to the International Space Station in August 2019 and look at the Earth in nadir mode from the UV-transparent window of the Zvezda module of the International Space Station. The instrument comprises a compact telescope with a large field of view ($44^{\circ}$), based on an optical system employing two Fresnel lenses for lightcollection. The light is focused onto an array of 36 multi-anode photomultiplier tubes (MAPMT), for a total of 2304 pixels and the resulting signal is converted into digital, processed and stored viathe electronics subsystems on-board. In addition to the main detector, Mini-EUSO contains two ancillary cameras for complementary measurements in the near infrared (1500 - 1600 nm) and visible (400 - 780 nm) range and also a $8 \times 8$ SiPM imaging array

Pathogenetic Effects of Bacteria of the Genus <i>Desulfovibrio</i>. Experimental Study. Part One: Iron Metabolism

The aim of the work was to study specific systemic effect of sulfate-reducing bacteria of the genus Desulfovibrio on organism systems through creating an experimental model of intragastric bacterial invasion against the background of dysbiotic conditions of rodent gastrointestinal tract. Materials and methods. The experimental study was conducted on Wistar rats. Intestinal dysbiosis was modeled with the help of antibiotics, amoxicillin and metronidazole. Typical strain Desulfovibrio desulfuricans subsp. desulfuricans VKM B-1799T was used as an infectious agent. Results and discussion. As a result of the experiment performed, during the period of acute infection (on day 15 of the experiment), a direct correlation between the concentration of the injected D. desulfuricans VKM B-1799T bacteria suspension and the serum iron level was observed: the higher the infectious agent dose, the lower the serum iron concentration. During the phase of remote effects (day 38 of the experiment), the inverse correlation between the concentrations of D. desulfuricans VKM B-1799T in the intestines of rodents was revealed: when the concentration of the infecting agent increased from 103 CFU/g and higher, the iron level decreased from 43.5 μmol/l to 38.5 μmol/l. When comparing the level of transferrin and unsaturated iron binding capacity (UIBC), an increase in those parameters was observed in all groups of rats both during the period of acute infection and the period of long-term effects, and the percentage of transferrin iron saturation decreased, indicating the occurrence of iron deficiency against the background of exposure to the infectious agent. Intestinal dysbiosis promotes colonization by opportunistic flora, including Desulfovibrio sp. Changes in the iron metabolism markers in experimental animals against the background of D. desulfuricans VKM B-1799T infestation above 103 CFU/g and the ability of this microorganism to bind iron into an unavailable form suggest that the bacteria Desulfovibrio sp. are one of the key etiological factors of iron deficiency anemia