186 research outputs found
C-reaktive protein determined by highsensitivitz method and biomarkers in prediction of development and progression of peripheral arterial disease in patients with type 2 diabetes
Uvod: Predhodne studije su ukazale na visoko senzitivni C - reaktivni protein (hs-CRP) kao
faktor rizika za perifernu arterijsku bolest (PAB) u dijabetesu. Stidja je imala za cilj da se
proceni moguÄi prediktivni znaÄaj hs-CRP i lipidnih biomarkera (holesterol, LDL-holesterol,
HDL-holesterol, trigliceridi, Apo A1, Apo B i Lp (a)) u razvoju i progresiji PAD u pacijenata sa
tipom 2 dijabetesa (T2D).
Metode: U studiju je ukljuÄeno 80 pacijenata sa prethodnom dijagnozom T2D, starosti 45-70
godina, podeljenih u grupu A (T2D pacijenti sa PAB; n=38) i grupu B (T2D pacijenti bez PAB;
n=42). Posle 5 godina, pacijenti su podeljeni u podgrupe u zavisnosti od prisustva nove pojave
PAB ili progresije prethodno postojeÄe PAB. Pedo-brahijalni indeks (PBI) je koriÅ”Äen za
dijagnozu PAB a hs-CRP je odredjen nefelometrijski
Rezultati: NaÅ”li smo znaÄajno viÅ”i nivo hs-CRP u grupi A u odnosu na grupu B, ali samo na
poÄetku studije. U okviru grupe A, pacijenti sa kasnijom progresijom PAD (podgrupa A1) imali
su najviÅ”i nivo hs-CRP na poÄetku, mada bez znaÄajne razlike u odnosu na podgrupu A2.
Suprotno, nivo hs-CRP bio je znaÄajno viÅ”i u podgrupi B1 u poredjenju sa subgrupom B2 i na
poÄetku i na kraju ispitivanja. Od svih ispitivanih metaboliÄkih parametara-lipidnih biomarkera,
hs-CRP je bio jedini nezavisni prediktor progresije PAD (OR=0.456, 95%CI=0.267-0.7815,
p=0.004). Nivo hs-CRP od 2.5 mg/L je utvrdjen kao ācut-offā vrednost (specifiÄnost 75% i
senzitivnost 73.3%) sa relativnim rizikom za PAD od 2.93 (95% CI 1.351-6.3629).
ZakljuÄak: NaÅ”a studija je pokazala da se hs-CRP može koristiti kao pouzdan prediktor
progresije PAB u pacijenata sa T2D.Background: Previous studies indicated high sensitivity C-reactive protein (hs-CRP) as a risk
factor for the peripheral arterial disease (PAD) in diabetes. This study aimed to evaluate possible
predictive significance of hs-CRP and lipid biomarkers (total cholesterol, LDL-cholesterol,
HDL-cholesterol, triglycerides, Apo A1 and Apo B, Lp (a)) for development and progression of
PAD in patients with type 2 diabetes (T2D).
Methods: The study included 80 patients previously diagnosed with T2D, aged 45-70 years,
divided into group A (T2D patients with PAD; n=38) and group B (T2D patients without PAD;
n=42). After five years, all the patients were reexamined and divided into subgroups depending
on de novo development of PAD or progression of previously diagnosed PAD. Ankle-Brachial
Index (ABI) measurement was used for PAD diagnosis and hs-CRP was determined by
nephelometry.
Results: We found significantly higher hs-CRP level in group A compared to group B, but only
at baseline. Among patients in group A, those with later progression of PAD (subgroups A1) had
highest level of hs-CRP at baseline, although not significantly different compared to subgroup
A2. In contrast, hs-CRP level was significantly higher in subgroup B1 in comparison to subgroup
B2 at both first and second exam. Of all investigated metabolic parameters-lipid biomarkers, hs-
CRP was the only independent predictor of progression of PAD (OR=0.456, 95%CI=0.267-
0.7815, p=0.004). The cut-off point for hs-CRP was 2.5 mg/L (specificity 75% and sensitivity
73.3%) with the relative risk for PAD of 2.93 (95% CI 1.351-6.3629).
Conclusions: Our study implies that hs-CRP can be used as a reliable predictor for progression
of PAD in patients with T2D
Analyzing data from memory tasks - comparison of ANOVA, logistic regression and mixed logit model
We compared three statistical analyses over binary outcomes. As applying ANOVA over proportions violates at least two classical assumptions of linear models, two alternatives are described: the binary logistic regression and the mixed logit model. Firstly, we compared the effects obtained by the three methods over the same data from a previous memory research. All three methods gave similar results: the effects of the tasks and the number of sensory modalities were observed, but not their interaction. Secondly, by using the bootstrap estimates of the parameters, the efficacy of each method was explored. As predicted, the bootstrap parameter estimates of the ANOVA had large bias and standard errors, and consequently wide confidence intervals. On the other hand, the bootstrap parameter estimates of the binary logistic regression and the mixed logit models were similar - both had low bias and standard errors and narrow confidence intervals
Energy refurbishment of public buildings under cultural heritage protection in Serbia Constraints and Potentials
By harmonizing national legislation to European codes concerning energy efficiency in building sector, Serbia took commitment to improve energy efficiency of national government buildings. Following the Directive 2012/27/EU principles, refurbishment of this part of building stock is recognized as a leading example in long-therm process of applying energy efficiency regulations at national level. Initial steps in implementation of adopted energy efficiency principles were made in Serbia during 2015, when first energy certificates for three most valuable buildings of national authorities (Government building, The National Assembly, and the Palace of Serbia) were issued. This paper will present results obtained during energy-assessment and energy-certification process of this particular buildings, showing at the same time their specificity, that pretty much traces possible category and range of proposed energy refurbishment scenarios
Od crvenih do plavih beretŠŗi ā angažovanje ŠŗinesŠŗih vojnih snaga u mirovnim misijama Ujedinjenih nacija
This paper shall explore the reasons that triggered China to boost
its security and economic influence within the United Nations
Peacekeeping Operations (UNPKO) as a tool for embracing
international challenges. By doing so, China is not just sharing
the burden of providing international stability and achieving the
UN Sustainable Development Goals, but exerting its influence
in the process. Analysing the proposed subject, it will be
demonstrated that China faces numerous obstacles whilst trying
to insert the āChinese characteristicsā within the geopolitical
order, geo-economics distribution of wealth and international
security architecture. Instead of being perceived as a responsible
stakeholder, China`s ambitious initiatives can, additionally, stir
the China Threat Theory in the international community. This
paper shall be consisted of two parts. The first part will tackle
China`s growing footprint within the UNPKO from the end of
the Cold War onward. The second part will explore the reasons
that triggered China to swift its role within the UNPKO. Both
global and domestic reasons will be analysed tooRad se bavi razlozima jaÄanja kineskog uticaja u Mirovnim
misijama Ujedinjenih nacija. NR Šina se sve viÅ”e angažuje
u obezbjeÄivanju meÄunarodne stabilnosti i postizanju UN
ciljeva za održivi razvoj, paralelno jaÄajuÄi i svoj uticaj
u meÄunarodnim odnosima. U radu smo predstavili izazove
sa kojima se Šina suoÄava u nastojanju da uvede ākineske
karakteristikeā u geopolitiÄki poredak, geoekonomsku
raspodjelu dobara i meÄunarodnu bezbjedonosnu arhitekturu.
Percepcija Šine u meÄunarodnoj zajednici je sve loÅ”ija
i umjesto da se Šina posmatra kao odgovorni akter, njene
akcije dodatno nameÄu temu āŠine kao prijetnjeā. U prvom
dijelu rada smo obradili ulogu i aktivnosti Šine u okviru
Mirovnih misija Ujedinjenih nacija od kraja Hladnog
rata do danas. Drugi dio rada analizira razloge promjene
uloge kineske politike prema UN-u i konkrento Mirovnim
snagama Ujedinjenih nacija. U radu su analizirani i uzeti
u obzir i globalni razlozi kao i domaÄi koji su uticali na
promjenu kineske politike i veÄe angažovanje u okviru UN
misija. U zakljuÄku navodimo da i pored izazova, sumnji i
nedoreÄenosti vezanih za ovo pitanje, svjedoÄimo ānovoj
i globalnojā Šini koja je veÄ zauzela centralnu ulogu na
meÄunarodnoj sceni i da možemo raÄunati na Šinu i njen
doprinos u oÄuvanju globalnog mir
ASSESSMENT OF PREOPERATIVE RISK IN CHILDREN
Prijeoperacijska procjena zdravstvenog stanja bolesnika neizostavni je dio planiranja svakog zahvata pri kojemu se bolesnik podvrgava anesteziji. Klasifi kacija fizikalnog statusa bolesnika AmeriÄkog druÅ”tva anesteziologa (engl. The American Society of Anesthesiologists ā ASA) danas se rutinski rabi za procjenu rizika od anestezije i perioperacijske smrtnosti bolesnika neovisno o dobi. MeÄutim, kao Å”to se anestezija u djece razlikuje od anestezije u odraslih, nužno je i u prijeanestezijskoj procjeni rizika uzeti u obzir osobitosti djeÄje dobi. Radi kvalitetne procjene rizika od anestezije razvili su se novi sustavi procjene rizika i specifiÄne smjernice prijeanestezijske obrade u djece. Ukratko su prikazana dva nova alata za procjenu prijeanestezijskog rizika u djece: bodovni sustav PRAm (Pediatric Risk Assessment score) i sustav NARCO-SS (engl. neurological, airway, respiratory, cardiovascular, other-surgical severity). Cilj je rada kritiÄki osvrt na postojeÄe smjernice procjene prijeanestezijskog rizika u djece. Prijeoperacijskom procjenom
rizika i pripremom za anesteziju prilagoÄenom djeÄjoj dobi mogu se unaprijediti sigurnost i uspjeh anestezioloÅ”kog postupka u djece.The preoperative assessment of the patientās health status is an indispensable part of planning any procedure where the patient is undergoing anesthesia. The American Society of Anesthesiologistsā Physical Status (ASA PS) classification is routinely used today to assess the risks of anesthesia and perioperative mortality of patients undergoing surgery regardless of age. However, as anesthesia in children differs from anesthesia in adults, it is necessary to take into account the age-specific features of preoperative risk assessment in children.For better estimation of risks of anesthesia, new risk assessment systems and specific pre-anesthetic treatment guidelines for children have been developed. Two novel tools for assessing the preanesthetic risk in children are briefly presented: Pediatric Risk Assessment (PRAm) score and āNARCO-SSā (neurological, airway, respiratory, cardiovascular, other ā surgical severity) score. The aim of this paper is critical review of existing guidelines in assessing the preoperative risk in children. The preoperative risk assessment and the preparation for anesthesia adapted to the childās age can improve the safety and success of the anesthetic procedure
Environmental Governance as Opportunity for China and EU Cooperation
Climate changes, i.e. air pollution, water scarcity and soil contamination remain threats
and represent great challenge to Chinese efforts in making its development sustainable. Since
the very first developmental goals during the first decades of its policy of reforms and opening
did not follow high ecological standards, China became the worldās top emitter producing more
than a quarter of the worldās annual greenhouse emission. However, climate changes are not
only Chinese issues, their consequences are global in character. Thus, fighting climate changes
requires intercontinental and international cooperation. China pledged to cut emissions under
the Paris Agreement and is making great efforts by making environmental issue the priority in
the further developmental goals.
This paper analyses the Sino-EU relations and cooperation in creating āGreen
civilizationā and environmental global governance.
The first part of the paper tackles the development of the ecological state of mind in
China, particularly because China announced that it would become a climate neutral country.
In the same part of the paper, we are examining the development of the EU approach in
becoming the climate neutral space. The second part of the paper is focused on China`s
international cooperation in fighting climate changes, particularly the Sino-EU cooperation on
this particular issue, that is, making āGreen civilizationā.
We will examine whether this cooperation is opening new space for improving their
mutual cooperation and creating the harmonious atmosphere for a win-win cooperation of
further antagonizing currently disturbed relation
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