246 research outputs found
The future of recreational fisheries: Advances in science, monitoring, management, and practice
Recreational fisheries (RF) are complex social-ecological systems that play an important role in aquatic environments while generating significant social and economic benefits around the world. The nature of RF is diverse and rapidly evolving, including the participants, their priorities and behaviors, and the related ecological impacts and social and economic benefits. RF can lead to negative ecological impacts, particularly through overexploitation of fish populations and spread of non-native species and genotypes through stocking. Hence, careful management and monitoring of RF is essential to sustain these ecologically and socioeconomically important resources. This special issue on recreational fisheries contains diverse research, syntheses, and perspectives that highlight the advances being made in RF research, monitoring, management, and practice, which we summarize here. Co-management actions are rising, often involving diverse interest groups including government and non-government organizations; applying collaborative management practices can help balance social and economic benefits with conservation targets. Technological and methodological advances are improving the ability to monitor biological, social, and economic dynamics of RF, which underpin the ability to maximize RF benefits through management actions. To ensure RF sustainability, much research focuses on the ecological aspects of RF, as well as the development of management and angling practices that reduce negative impacts on fish populations. For example, angler behavior can be influenced to conform to conservation-minded angling practices through regulations, but is often best accomplished through growing bottom-up social change movements. Anglers can also play an important role in fisheries monitoring and conservation, including providing data on fish abundance and assemblages (i.e., citizen science). The increasing impacts that growing human populations are having on the global environment are threatening many of the natural resources and ecosystem services they provide, including valuable RF. However, with careful development of research initiatives, monitoring and management, sustainable RF can generate positive outcomes for both society and natural ecosystems and help solve allocation conflicts with commercial fisheries and conservation
The future of recreational fisheries: Advances in science, monitoring, management, and practice
Recreational fisheries (RF) are complex social-ecological systems that play an important role in aquatic environments while generating significant social and economic benefits around the world. The nature of RF is diverse and rapidly evolving, including the participants, their priorities and behaviors, and the related ecological impacts and social and economic benefits. RF can lead to negative ecological impacts, particularly through overexploitation of fish populations and spread of non-native species and genotypes through stocking. Hence, careful management and monitoring of RF is essential to sustain these ecologically and socioeconomically important resources. This special issue on recreational fisheries contains diverse research, syntheses, and perspectives that highlight the advances being made in RF research, monitoring, management, and practice, which we summarize here. Co-management actions are rising, often involving diverse interest groups including government and non-government organizations; applying collaborative management practices can help balance social and economic benefits with conservation targets. Technological and methodological advances are improving the ability to monitor biological, social, and economic dynamics of RF, which underpin the ability to maximize RF benefits through management actions. To ensure RF sustainability, much research focuses on the ecological aspects of RF, as well as the development of management and angling practices that reduce negative impacts on fish populations. For example, angler behavior can be influenced to conform to conservation-minded angling practices through regulations, but is often best accomplished through growing bottom-up social change movements. Anglers can also play an important role in fisheries monitoring and conservation, including providing data on fish abundance and assemblages (i.e., citizen science). The increasing impacts that growing human populations are having on the global environment are threatening many of the natural resources and ecosystem services they provide, including valuable RF. However, with careful development of research initiatives, monitoring and management, sustainable RF can generate positive outcomes for both society and natural ecosystems and help solve allocation conflicts with commercial fisheries and conservation
Sustainability appraisal: Jack of all trades, master of none?
Sustainable development is a commonly quoted goal for decision making and supports a large number of other discourses. Sustainability appraisal has a stated goal of supporting decision making for sustainable development. We suggest that the inherent flexibility of sustainability appraisal facilitates outcomes that often do not adhere to the three goals enshrined in most definitions of sustainable development: economic growth, environmental protection and enhancement, and the wellbeing of the human population. Current practice is for sustainable development to be disenfranchised through the interpretation of sustainability, whereby the best alternative is good enough even when unsustainable. Practitioners must carefully and transparently review the frameworks applied during sustainability appraisal to ensure that outcomes will meet the three goals, rather than focusing on a discourse that emphasises one or more goals at the expense of the other(s)
Therapeutic benefits of proning to improve pulmonary gas exchange in severe respiratory failure: Focus on fundamentals of physiology
NEW FINDINGS: What is the topic of this review? The use of proning for improving pulmonary gas exchange in critically ill patients. What advances does it highlight? Proning places the lung in its ‘natural’ posture, and thus optimises the ventilation‐perfusion distribution, which enables lung protective ventilation and the alleviation of potentially life‐threatening hypoxaemia in COVID‐19 and other types of critical illness with respiratory failure. ABSTRACT: The survival benefit of proning patients with acute respiratory distress syndrome (ARDS) is well established and has recently been found to improve pulmonary gas exchange in patients with COVID‐19‐associated ARDS (CARDS). This review outlines the physiological implications of transitioning from supine to prone on alveolar ventilation‐perfusion ([Formula: see text]) relationships during spontaneous breathing and during general anaesthesia in the healthy state, as well as during invasive mechanical ventilation in patients with ARDS and CARDS. Spontaneously breathing, awake healthy individuals maintain a small vertical (ventral‐to‐dorsal) [Formula: see text] ratio gradient in the supine position, which is largely neutralised in the prone position, mainly through redistribution of perfusion. In anaesthetised and mechanically ventilated healthy individuals, a vertical [Formula: see text] ratio gradient is present in both postures, but with better [Formula: see text] matching in the prone position. In ARDS and CARDS, the vertical [Formula: see text] ratio gradient in the supine position becomes larger, with intrapulmonary shunting in gravitationally dependent lung regions due to compression atelectasis of the dorsal lung. This is counteracted by proning, mainly through a more homogeneous distribution of ventilation combined with a largely unaffected high perfusion dorsally, and a consequent substantial improvement in arterial oxygenation. The data regarding proning as a therapy in patients with CARDS is still limited and whether the associated improvement in arterial oxygenation translates to a survival benefit remains unknown. Proning is nonetheless an attractive and lung protective manoeuvre with the potential benefit of improving life‐threatening hypoxaemia in patients with ARDS and CARDS
Early Agriculture in the Maya Lowlands
Wetland research in northern Belize provides the earliest evidence for development of agriculture in the Maya Lowlands. Pollen data confirm the introduction of maize and manioc before 3000 B.C. Dramatic deforestation, beginning ca. 2500 B.C. and intensifying in wetland environments ca. 1500-1300 B.C., marks an expansion of agriculture, which occurred in the context of a mixed foraging economy. By 1000 B.C. a rise in groundwater levels led farmers to construct drainage ditches coeval with the emergence of Maya complex society ca. 1000-400 B.C. Field manipulations often involved minor modifications of natural hummocks. Canal systems are not as extensive in northern Belize as previously reported, nor is there evidence of artificially raised planting platforms. By the Classic period, wetland fields were flooded and mostly abandoned
Designed artificial protein heterodimers with coupled functions constructed using bio-orthogonal chemistry
The formation of protein complexes is central to biology, with oligomeric proteins more prevalent than monomers. The coupling of functionally and even structurally distinct protein units can lead to new functional properties not accessible by monomeric proteins alone. While such complexes are driven by evolutionally needs in biology, the ability to link normally functionally and structurally disparate proteins can lead to new emergent properties for use in synthetic biology and the nanosciences. Here we demonstrate how two disparate proteins, the haem binding helical bundle protein cytochrome b562 and the β-barrel green fluorescent protein can be combined to form a heterodimer linked together by an unnatural triazole linkage. The complex was designed using computational docking approaches to predict compatible interfaces between the two proteins. Models of the complexes where then used to engineer residue coupling sites in each protein to link them together. Genetic code expansion was used to incorporate azide chemistry in cytochrome b562 and alkyne chemistry in GFP so that a permanent triazole covalent linkage can be made between the two proteins. Two linkage sites with respect to GFP were sampled. Spectral analysis of the new heterodimer revealed that haem binding and fluorescent protein chromophore properties were retained. Functional coupling was confirmed through changes in GFP absorbance and fluorescence, with linkage site determining the extent of communication between the two proteins. We have thus shown here that is possible to design and build heterodimeric proteins that couple structurally and functionally disparate proteins to form a new complex with new functional properties
A comment on the PCAST report:skip the “match”/“non-match” stage
This letter comments on the report “Forensic science in criminal courts: Ensuring scientific validity of feature-comparison methods” recently released by the President's Council of Advisors on Science and Technology (PCAST). The report advocates a procedure for evaluation of forensic evidence that is a two-stage procedure in which the first stage is “match”/“non-match” and the second stage is empirical assessment of sensitivity (correct acceptance) and false alarm (false acceptance) rates. Almost always, quantitative data from feature-comparison methods are continuously-valued and have within-source variability. We explain why a two-stage procedure is not appropriate for this type of data, and recommend use of statistical procedures which are appropriate
Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry
Construction of artificial higher order protein complexes allows sampling of structural architectures and functional features not accessible by classical monomeric proteins. Here, we combine in silico modelling with expanded genetic code facilitated strain promoted azide-alkyne cycloaddition to construct artificial complexes that are structurally integrated protein dimers and demonstrate functional synergy. Using fluorescent proteins sfGFP and Venus as models, homodimers and heterodimers are constructed that switched ON once assembled and display enhanced spectral properties. Symmetrical crosslinks are found to be important for functional enhancement. The determined molecular structure of one artificial dimer shows that a new long-range polar network comprised mostly of organised water molecules links the two chromophores leading to activation and functional enhancement. Single molecule analysis reveals the dimer is more resistant to photobleaching spending longer times in the ON state. Thus, genetically encoded bioorthogonal chemistry can be used to generate truly integrated artificial protein complexes that enhance function
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A systematic review of frameworks for the interrelationships of mental health evidence and policy in low- and middle-income countries
Background: The interrelationships between research evidence and policy-making are complex. Different theoretical frameworks exist to explain general evidence–policy interactions. One largely unexplored element of these interrelationships is how evidence interrelates with, and influences, policy/political agenda-setting. This review aims to identify the elements and processes of theories, frameworks and models on interrelationships of research evidence and health policy-making, with a focus on actionability and agenda-setting in the context of mental health in low- and middle-income countries (LMICs).
Methods: A systematic review of theories was conducted based on the BeHeMOTh search method, using a tested and refined search strategy. Nine electronic databases and other relevant sources were searched for peer-reviewed and grey literature. Two reviewers screened the abstracts, reviewed full-text articles, extracted data and performed quality assessments. Analysis was based on a thematic analysis. The included papers had to present an actionable theoretical framework/model on evidence and policy interrelationships, such as knowledge translation or evidence-based policy, specifically target the agenda-setting process, focus on mental health, be from LMICs and published in English.
Results: From 236 publications included in the full text analysis, no studies fully complied with our inclusion criteria. Widening the focus by leaving out ‘agenda-setting’, we included ten studies, four of which had unique conceptual frameworks focusing on mental health and LMICs but not agenda-setting. The four analysed frameworks confirmed research gaps from LMICs and mental health, and a lack of focus on agenda-setting. Frameworks and models from other health and policy areas provide interesting conceptual approaches and lessons with regards to agenda-setting.
Conclusion: Our systematic review identified frameworks on evidence and policy interrelations that differ in their elements and processes. No framework fulfilled all inclusion criteria. Four actionable frameworks are applicable to mental health and LMICs, but none specifically target agenda-setting. We have identified agenda-setting as a research theory gap in the context of mental health knowledge translation in LMICs. Frameworks from other health/policy areas could offer lessons on agenda-setting and new approaches for creating policy impact for mental health and to tackle the translational gap in LMICs
Author Correction:Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry (Communications Chemistry, (2019), 2, 1, (83), 10.1038/s42004-019-0185-5)
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