11 research outputs found
Pattern Recognition Software and Techniques for Biological Image Analysis
- Author
- A Ben-Hur
- A Kapelner
- AE Carpenter
- AL Tarca
- AN Basavanhally
- AR Gooding
- B Misselwitz
- BTM Roerdink
- C Ding
- CJ Fuller
- D. Mark Eckley
- DA Schiffmann
- E Meijering
- F Long
- Fran Lewitter
- G Cong
- G Holmes
- G Li
- H Peng
- H Peng
- H Peng
- H Peng
- H Peng
- H Peng
- I Mierswa
- IG Goldberg
- Ilya G. Goldberg
- J Johnston
- J Vromen
- J Zhou
- JB Tenenbaum
- JH Friedman
- John D. Delaney
- JP Carson
- JR Swedlow
- JR Swedlow
- K Huang
- K Kvilekval
- L Shamir
- L Shamir
- L Shamir
- L Vincent
- LH Loo
- Lior Shamir
- LP Coelho
- M Platani
- M Pool
- MJ Gardner
- MR Lamprecht
- MV Boland
- MV Boland
- MV Boland
- N Orlov
- Nikita Orlov
- PJ Phillips
- PK Sahoo
- Q Wang
- RE Fan
- S Knudsen
- ST Roweis
- T Joachims
- T Joachims
- T Lindeberg
- T Yoo
- TJ Macura
- TR Jones
- TR Jones
- TR Jones
- V Ljosa
- VN Vapnik
- W Schroeder
- Publication venue
- Public Library of Science
- Publication date
- 01/11/2010
- Field of study
The increasing prevalence of automated image acquisition systems is enabling new types of microscopy experiments that generate large image datasets. However, there is a perceived lack of robust image analysis systems required to process these diverse datasets. Most automated image analysis systems are tailored for specific types of microscopy, contrast methods, probes, and even cell types. This imposes significant constraints on experimental design, limiting their application to the narrow set of imaging methods for which they were designed. One of the approaches to address these limitations is pattern recognition, which was originally developed for remote sensing, and is increasingly being applied to the biology domain. This approach relies on training a computer to recognize patterns in images rather than developing algorithms or tuning parameters for specific image processing tasks. The generality of this approach promises to enable data mining in extensive image repositories, and provide objective and quantitative imaging assays for routine use. Here, we provide a brief overview of the technologies behind pattern recognition and its use in computer vision for biological and biomedical imaging. We list available software tools that can be used by biologists and suggest practical experimental considerations to make the best use of pattern recognition techniques for imaging assays
PLoS One
- Author
- Ajana Soufiane
- Arango-Gonzalez Blanca
- Arndt Verena
- Bartz-Schmidt Karl Ulrich
- Bhatia Vaibhav
- Bhattacharya Shomi S.
- Biarnes Marc
- Borrell Anna
- Buhren Sebastian
- Calado Sofia M.
- Codrea Marius
- Colijn Johanna M.
- Cougnard-Gregoire Audrey
- Dammeier Sascha
- de Jong Eiko
- de Jong Eiko K.
- De la Cerda Berta
- Delcourt Cecile
- den Hollander Anneke I.
- Diaz-Corrales F. J.
- Diether Sigrid
- Emri Eszter
- Endermann Tanja
- Fauser Sascha
- Ferraro Lucia
- Garcia Miriam
- Groenewoud Joannes M. M.
- Heesterbeek Thomas J.
- Honisch Sabina
- Hoyng Carel B.
- Iacone Roberto
- Kersten Eveline
- Kilger Ellen
- Klaver Caroline C. W.
- Klose Franziska
- Langen Hanno
- Lechanteur Yara T.
- Lengyel Imre
- Luthert Phil
- Maugeais Cyrille
- Meester-Smoor Magda
- Merle Benedicte
- Mones Jordi
- Nogoceke Everson
- Peto Tunde
- Pool Fran
- Rodriguez Eduardo
- Ueffing Marius
- van Leeuwen Elisabeth M.
- Verzijden Timo
- Zumbansen Markus
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2019
- Field of study
Age-related macular degeneration (AMD) is a common, progressive multifactorial vision-threatening disease and many genetic and environmental risk factors have been identified. The risk of AMD is influenced by lifestyle and diet, which may be reflected by an altered metabolic profile. Therefore, measurements of metabolites could identify biomarkers for AMD, and could aid in identifying high-risk individuals. Hypothesis-free technologies such as metabolomics have a great potential to uncover biomarkers or pathways that contribute to disease pathophysiology. To date, only a limited number of metabolomic studies have been performed in AMD. Here, we aim to contribute to the discovery of novel biomarkers and metabolic pathways for AMD using a targeted metabolomics approach of 188 metabolites. This study focuses on non-advanced AMD, since there is a need for biomarkers for the early stages of disease before severe visual loss has occurred. Targeted metabolomics was performed in 72 patients with early or intermediate AMD and 72 control individuals, and metabolites predictive for AMD were identified by a sparse partial least squares discriminant analysis. In our cohort, we identified four metabolite variables that were most predictive for early and intermediate stages of AMD. Increased glutamine and phosphatidylcholine diacyl C28:1 levels were detected in non-advanced AMD cases compared to controls, while the rate of glutaminolysis and the glutamine to glutamate ratio were reduced in non-advanced AMD. The association of glutamine with non-advanced AMD corroborates a recent report demonstrating an elevated glutamine level in early AMD using a different metabolomics technique. In conclusion, this study indicates that metabolomics is a suitable method for the discovery of biomarker candidates for AMD. In the future, larger metabolomics studies could add to the discovery of novel biomarkers in yet unknown AMD pathways and expand our insights in AMD pathophysiology
Language Policy and Innovation. An Evaluation of the Language Regime of the PCT System
- Author
- Anne-Claude Berthoud
- Anthony E Boardman
- De Rassenfosse
- De Rassenfosse
- Dietmar Harhoff
- Dominique Guellec
- Eugenio Archontopoulos
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Jonathan Pool
- Joseph Stiglitz
- J�r�me Danguy
- Linda Cardinal
- Marco Ceccagnoli
- Michele Gazzola
- Michele Gazzola
- Michele Gazzola
- Nelly Furman
- Philippe Van Parijs
- Richard E Just
- Roland Berger
- Siew Chua
- Sook Jung
- Van Pottelsberghe
- Van Zeebroeck
- Wipo
- Wipo
- Wipo
- Wipo
- Wipo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Multilingualism and the Decline of French in Quebec
- Author
- Ad Backus
- Alain B�langer
- Albert Breton
- Alex Arsenault Morin
- Barry Chiswick
- Barry Chiswick
- Barry Chiswick
- Beverly Irby
- Camille Bouchard-Coulombe
- Christian Dustmann
- Colin R Blyth
- Conseil Sup�rieur De La Langue Fran�aise
- David Albouy
- Deirdre Meintel
- Edward H Simpson
- Edward P Lazear
- Fran�ois Grin
- Fran�ois Vaillancourt
- Fran�ois Vaillancourt
- Fran�ois Vaillancourt
- Guy Bouthillier
- G�rald Bernier
- Hoyt Bleakley
- Hubert Charbonneau
- Jack Carr
- Jacques Henripin
- Jacques Henripin
- Jacques Ledent
- Jean Ferretti
- Jean-Pierre Corbeil
- Jean-Pierre Corbeil
- Jonathan Pool
- Julien Gagnon
- Julien Gagnon
- Kevin Lang
- Marc Levine
- Marc Termote
- Marcel Martel
- Marvin Mcinnis
- Michel Auger
- P Sabourin
- Patrick Sabourin
- Qu�bec Gouvernement Du
- Qu�bec Gouvernement Du
- R Landry
- Rachel Friedberg
- Ren� Houle
- Richard Y Bourhhis
- Richard Y Bourhis
- Richard Y Bourhis
- Richard Y Bourhis
- Simon Langlois
- Statistics Canada
- Steven Piantadosi
- Tasaku Tsunoda
- Victor Pich�
- Victor Pich�
- Victor Pich�
- Vincent Geloso
- Vincent Geloso
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Linguistic Justice: An Interdisciplinary Overview of the Literature
- Author
- Abel Montagut
- Aim�e Vega
- Alan Patten
- Alan Patten
- Alan Patten
- Alan Patten
- Alan Patten
- Albert Breton
- Albert W Musschenga
- Alexia Bos
- Ali Pourezzat
- Allan Jones
- Amos Tversky
- Amri Wandel
- Andrew Williams
- Anthony Pym
- Antonio Gramsci
- Ariel Rubinstein
- Axel Gosseries
- Barry Barry
- Barry R Chiswick
- Bastardas I Boada
- Bastardas I Boada
- Bastardas I Boada
- Bastardas I Boada
- Bengt-Arne Wickstr�m
- Bengt-Arne Wickstr�m
- Bengt-Arne Wickstr�m
- Bengt-Arne Wickstr�m
- Bengt-Arne Wickstr�m
- Bengt-Arne Wickstr�m
- Bengt-Arne Wickstr�m
- Bolduc
- Buchm�ller-Codoni
- Cestac
- Charles Taylor
- Chong-Yeong
- Christian Arnsperger
- Claude Piron
- Claude Piron
- Claude Piron
- D&apos
- Daniel M Weinstock
- Daniele Archibugi
- Daniele Archibugi
- Daniele Archibugi
- Dave Sinardet
- David Crystal
- David Crystal
- David D Laitin
- David D Laitin
- David D Laitin
- David D Laitin
- David D Laitin
- David D Laitin
- David D Laitin
- David D Laitin
- David K Harrison
- David Robichaud
- De Schutter
- De Schutter
- De Schutter
- De Swaan
- De Swaan
- Denise G R�aume
- Detlev Blanke
- Donald M Lamberton
- Edward P Lazear
- Farhad Pirmoradi
- Federico Gobbo
- Federico Gobbo
- Fernand De Varennes
- Francesco Palermo
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Grin
- Fran�ois Vaillancourt
- G P Meyjes
- George Steiner
- Gilles &
- Gilles Grenier
- Goro Kimura
- Hans
- Heinz Kloss
- Helmar Frank
- Hidenori Kadoja
- Humphrey Tonkin
- Humphrey Tonkin
- Humphrey Tonkin
- Humphrey Tonkin
- Idil Boran
- Inaz� Nitobe
- J Marschak
- J Tus�n
- Jacob T Levy
- Jacob T Levy
- Jacqueline Mowbray
- Jacqueline Mowbray
- James D Fearon
- Javier Alcalde
- Jean Laponce
- Jean-Claude Barbier
- Joanna Mcpake
- John Rawls
- Jonatan Casta�o
- Jonathan Pool
- Jonathan Pool
- Jonathan Pool
- Jonathan Pool
- Jonathan Pool
- Jordi Sol� I Camardons
- Joseph Lacey
- Joseph Lacey
- Joseph Poth
- Joshua A Fishman
- J�rgen Habermas
- J�rgen Trabant
- Keith Banting
- Keith Banting
- Klaus Schubert
- Kris Deschouwer
- Kris Deschouwer
- Kyotaro
- La Torre
- Leslie Green
- Louis-Jean Calvet
- Maria Junyent
- Maria Junyent
- Maria Junyent
- Marie De Saint Robert
- Marino
- Mark Fettes
- Mark Fettes
- Mark Fettes
- Mark Fettes
- Mark Fettes
- Mark Fleurbaey
- Meital Pinto
- Michael Blake
- Michael Boyden
- Michael Sandel
- Michael Schlo�macher
- Michele Gazzola
- Michele Gazzola
- Michele Gazzola
- Michele Gazzola
- Michele Gazzola
- Michele Gazzola
- Michele Gazzola
- Michele Gazzola
- Miquel Siguan
- Moreno Cabrera
- Nancy Fraser
- Nenad Stojanovic
- Nenad Stojanovic
- Nenad Stojanovic
- Nic Shuibhne
- Nicolas Baumard
- Nkonko M Kamwangamalu
- Olivier
- Pere Comellas
- Peter A Kraus
- Peter G Forster
- Peter Ives
- Peter Ives
- Philippe Van Parijs
- Philippe Van Parijs
- Philippe Van Parijs
- Philippe Van Parijs
- Philippe Van Parijs
- Philippe Van Parijs
- Philippe Van Parijs
- Philippe Van Parijs
- Philippe Van Parijs
- Pia Christiansen
- Probal Dasgupta
- Rainer Baub�ock
- Reinhard &
- Reinhard Selten
- Richard Bourhis
- Robert Phillipson
- Robert Phillipson
- Robert Phillipson
- Robert Phillipson
- Ruth Rubio-Marin
- Ruth Rubio-Marin
- Sabine Fiedler
- Sabine Fieldles
- Salvador Tordera
- Samuel Bowles
- Samuel Bowles
- Sarah C E Batterbury
- Stephen May
- Stephen May
- Sue Wright
- Sue Wright
- Sujata Gupta
- Susan M Ervin
- Syugo Hotta
- Thiong Ng?g? Wa
- Thomas Poggue
- Thomas Ricento
- Tove Skutnabb-Kangas
- Tove Skutnabb-Kangas
- Tove Skutnabb-Kangas
- Tove Skutnabb-Kangas
- Tsukasa ( Kobayashi
- Tsukasa Kobayashi
- Umberto Eco
- Van Bendegem
- Van Dyke
- Van Parijs
- Victor Ginsburgh
- Will Kymlicka
- Will Kymlicka
- Will Kymlicka
- Will Kymlicka
- William C Gay
- Xabier Arzoz
- Yahel Peled
- Yvo Peeters
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Putting Integrity into Finance: A Positive Approach (PDF of Keynote Slides)
- Author
- Adil Abdulali
- Agarwal
- Alexander Ljungqvist
- Amanda Cowen
- Amy Hutton
- Amy Hutton
- Amy Hutton
- Andriy Bodnaruk
- Bennett Stewart
- Brian Bushee
- C Hayn
- C Michael
- Carol Marquardt
- D Burgstahler
- Dawn A Matsumoto
- Eli Bartov
- Fran�ois Degeorge
- Harrison Hong
- Harvard Nom Working Paper
- Harvey &
- Hsiou-Wei Lin
- Hsiou-Wei Lin
- Hsiou-Wei Lin
- Hutton
- James N Myers
- John Jacob
- Joseph Fuller
- Mark T Bradshaw
- Masako Darrough
- Mathew L A Hayward
- Michael B Clement
- Michael C Jensen
- Michael C Jensen
- Michael C Jensen
- Michael C Jensen
- Michael C. Jensen
- Michael Some
- P M Healy
- Patricia C O&apos
- Patricia M Dechow
- Paul M Healy
- Paul M Healy
- R Michaely
- Raghuram Rajan
- Rajesh K Aggarwal
- S P Kothari
- S Rangan
- S Teoh
- Scott Richardson
- Veronika Pool
- � Michael
- � Michael
- � Michael
- � Michael
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway
- Author
- Ajana Soufiane
- Arango-Gonzalez Blanca
- Arndt Verena
- Bartz-Schmidt Karl Ulrich
- Bhatia Vaibhav
- Bhatta-Charya Shomi S.
- Biarnés Marc
- Borrell Anna
- Bühren Sebastian
- Calado Sofia M.
- Codrea Marius
- Colijn Johanna M.
- Cougnard-Grégoire Audrey
- Dammeier Sascha
- de Jong Eiko
- de Jong Eiko
- De la Cerda Berta
- Del-Court Cécile
- Delcourt Cécile
- Den Hollander Anneke I.
- Diaz-Corrales F. J.
- Diether Sigrid
- Emri Eszter
- Ender-Mann Tanja
- Fauser Sascha
- Ferraro Lucia
- Garcia Míriam
- Groenewoud Joannes M.M.
- Heesterbeek Thomas J.
- Honisch Sabina
- Hoyng Carel B.
- Iacone Roberto
- Kersten Eveline
- Kilger Ellen
- Klaver Caroline C.W.
- Klose Franziska
- Langen Hanno
- Lechanteur Yara T.
- Lengyel Imre
- Luthert Phil
- Maugeais Cyrille
- Meester-Smoor Magda
- Merle Benedicte
- Monés Jordi
- Nogoceke Everson
- Peto Tunde
- Pool Fran
- Rodríguez Eduardo
- Ueffing Marius
- Verzijden Timo
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/06/2019
- Field of study
Age-related macular degeneration (AMD) is a common, progressive multifactorial vision-threatening disease and many genetic and environmental risk factors have been identified. The risk of AMD is influenced by lifestyle and diet, which may be reflected by an altered metabolic profile. Therefore, measurements of metabolites could identify biomarkers for AMD, and could aid in identifying high-risk individuals. Hypothesis-free technologies such as metabolomics have a great potential to uncover biomarkers or pathways that contribute to disease pathophysiology. To date, only a limited number of metabolomic studies have been performed in AMD. Here, we aim to contribute to the discovery of novel biomarkers and metabolic pathways for AMD using a targeted metabolomics approach of 188 metabolites. This study focuses on non-advanced AMD, since there is a need for biomarkers for the early stages of disease before severe visual loss has occurred. Targeted metabolomics was performed in 72 patients with early or intermediate AMD and 72 control individuals, and metabolites predictive for AMD were identified by a sparse partial least squares discriminant analysis. In our cohort, we identified four metabolite variables that were most predictive for early and intermediate stages of AMD. Increased glutamine and phosphatidylcholine diacyl C28:1 levels were detected in non-advanced AMD cases compared to controls, while the rate of glutaminolysis and the glutamine to glutamate ratio were reduced in non-advanced AMD. The association of glutamine with non-advanced AMD corroborates a recent report demonstrating an elevated glutamine level in early AMD using a different metabolomics technique. In conclusion, this study indicates that metabolomics is a suitable method for the discovery of biomarker candidates for AMD. In the future, larger metabolomics studies could add to the discovery of novel biomarkers in yet unknown AMD pathways and expand our insights in AMD pathophysiology
Mortality after surgery in Europe: a 7 day cohort study.
- Author
- \u160akic K
- \u160aric JP
- \u160eric J
- \u160imic-Korac N
- \u160imurina T
- \u160ribar A
- \u17dilic A
- \u17dilinc\ue1rov\ue1 V
- \u17duni J
- \u17dupcic M
- \uc1lvaro JL
- \uc5lvarez JT
- \ucd\uf1igo JA
- Aakeroey K
- Acan I
- Adams D
- Adams T
- Adanic M
- Adolfsson A
- Afonso O
- Afshari A
- Agarwal B
- Agnic I
- Aguado DN
- Ahern R
- Ahonen T
- Aignatoaie M
- Akotia N
- Akouds E
- Al-Abdaly A
- Al-Subaie N
- Alagarsamy F
- Alameda LE
- Alasp\ue4\ue4 A
- Albalad DD
- Albaladejo P
- Albante A
- Alberdi F
- Albu C
- Alcaide CM
- Alcantud JF
- Aldecoa C
- Aldecoa C
- Alderson L
- Aleixandre IS
- Aleksic D
- Aleman M
- Alexander D
- Alexander P
- Algarra RR
- Ali ZS
- Aliste P
- Allu\ue9 RM
- Almeida E
- Almeida IM
- Almeras L
- Alonso AE
- Alonso E
- Alvarez AA
- Alvarez LR
- Amaniti E
- Amatya S
- Ampuero MS
- Anchuelo AH
- Andabaka T
- Andersen JD
- Anderson H
- Andresen B
- Angulo GO
- Anna US
- Anthopoulos G
- Antolinos MA
- Apsokardos A
- Aracil N
- Aranzubia M
- Arawwawala D
- Arcas JJ
- Arevalo J
- Argente GR
- Arif F
- Armaganidis A
- Armaganidis A
- Arnaoutoglou E
- Arnold G
- Arocas B
- Arpino I
- Arroyo MM
- Arteta DA
- Artigas A
- Artigas X
- Arvaniti K
- Arviza LP
- Asensio MA
- Assun\ue7\ue3o JP
- Aubrun F
- Auer P
- Austine P
- Aversano M
- Awlakpui E
- Axelsson P
- Ayman M
- B\ue1rtolo A
- B\ue9cl\ue8re A
- Baban O
- Bacak-Kocman I
- Bacci A
- Baciu M
- Baddeley S
- Bailey K
- Baker A
- Baker J
- Bakosova E
- Balaji P
- Balasa C
- Balciscueta G
- Balenovic I
- Ball C
- Ballington R
- Balust C
- Balust J
- Bandic D
- Baraldi S
- Baranovic S
- Barber R
- Barbes A
- Bari\u17eon M
- Baricocchi E
- Baroselli A
- Barr K
- Barrachima BB
- Barrasa H
- Barrios F
- Barrios J
- Barros F
- Barros N
- Barthel F
- Bartolom\ue9 MJ
- Bataillard A
- Batchelor N
- Bates D
- Batinica IM
- Battistella M
- Bauer P
- Bauer W
- Bauer Z\u160
- Baumgarten R
- Baxter I
- Bazin M
- Be\u161lic G
- Beach M
- Becanne X
- Beck O
- Beckingsale A
- Bekos V
- Belavic M
- Belcher A
- Belciu I
- Belenguer-Muncharaz A
- Belhaj A
- Belikova B
- Bellotti F
- Belvert BQ
- Benayoun L
- Bento HC
- Bento L
- Bergamini E
- Berger K
- Berger P
- Bergin A
- Bermejo FJ
- Bernal DG
- Bernat \uc1lvarez MJ
- Berneanu M
- Berntsen S
- Bestle M
- Betancor NO
- Bettelli G
- Bewley J
- Bhaskaran S
- Bianchin A
- Bicek V
- Bidd H
- Bierbaum K
- Bigeon JY
- Bignami E
- Bille AB
- Bingold F
- Bis B
- Biston P
- Bj\uf6rne H
- Bl\uf6ndal \uc1
- Bla\u17eanin B
- Black E
- Blaj M
- Blanco IA
- Bland M
- Blauwen Nd
- Blichfeldt L
- Bloos F
- Blunt M
- Bo\u161njak S
- Bo\u17eic A
- Bobinac M
- Bodega BM
- Boerma C
- Boerma C
- Bogdan P
- Boksasp OD
- Bolger C
- Bona F
- Bonet A
- Boninsegna D
- Bonnet A
- Bonnet F
- Bonnett A
- Bonnington S
- Bonnl\ue4nder G
- Borchers F
- Bordeianu C
- Borja MM
- Borovsak Z
- Borrat X
- Bosinceanu D
- Botas C
- Botelho MM
- Bottrill F
- Boufidis S
- Bougeard AM
- Bourdet B
- Bouw M
- Bowles T
- Bozilow D
- Bozovic MD
- Br\ue1z K
- Br\ufcnner H
- Brabcov\ue1 M
- Bratanic M
- Brattstr\uf6m O
- Braun R
- Braune A
- Brazzoni M
- Bredtmann RD
- Bresciani A
- Brestrich H
- Bright E
- Brko R
- Brod S
- Broderick A
- Brohan J
- Brotherston L
- Brouwer T
- Brown JD
- Brown L
- Brozovic G
- Bruce J
- Bruno G
- Brunori E
- Bucci B
- Buettner C
- Buhre W
- Bulasevic A
- Bullock L
- Bulnes ML
- Burcio SM
- Burgard G
- Burtenshaw A
- Burtin P
- Buss J
- Buttazzoni M
- Buttera S
- C\uedkov\ue1 A
- Caballero J
- Cabanes S
- Cacho E
- Cadrigati A
- Calder\uf3n R
- Calin M
- Callaghan M
- Calligaro P
- Calton E
- Calvo CP
- Camara M
- Campbell G
- Campos AG
- Canalechevarria AM
- Candi GM
- Cantarini E
- Capel YJ
- Capkov\ue1 J
- Capone M
- Capuzzo M
- Carballal FF
- Carballo CL
- Carbone L
- Carmino L
- Carrasco VG
- Carretero MJ
- Cartlidge D
- Carvalho A
- Carvalho M
- Carvalho P
- Casanova AC
- Cashman J
- Castellani G
- Casti\uf1eiras AP
- Castrill\uf3n S
- Castro Mde L
- Castro MR
- Castro NM
- Catal\ue1n M
- Cecconi M
- Centonze C
- Cerdeiri\uf1a AP
- Cerny V
- Cerutti E
- Cervantes AC
- Cervera-Montes M
- Chan P
- Chandan G
- Chang S
- Chantler J
- Chaudhry S
- Checa AA
- Cherfaoui S
- Chew M
- Chhatwal A
- Chiam P
- Chikungwa M
- Childs S
- Chohan H
- Choma R
- Choutas G
- Chovas A
- Christ S
- Christie I
- Christopoulos C
- Cimadevilla B
- Ciobanu A
- Cirillo V
- Ciubotaru R
- Clanchet M
- Clarke A
- Clausen NG
- Clauwaert C
- Claxton A
- Clouva-Molyvdas PM
- Cocu S
- Codreanu M
- Collantes E
- Collard E
- Collareta M
- Collates AF
- Collin V
- Collins D
- Collins H
- Collyer T
- Concostrina Mde L
- Conway D
- Copley E
- Copotoiu R
- Copotoiu SM
- Coppini R
- Corneci D
- Corner V
- Corradetti F
- Correia C
- Corsini LM
- Cort\ue9s AF
- Cortes JG
- Costagliola R
- Couper K
- Cowman S
- Craig J
- Craker L
- Crayford A
- Cremades M
- Crespo BI
- Crespo Mdel R
- Crespo P
- Cristina MV
- Crooks N
- Crowley S
- Cs\ufcll\uf6g E
- Csomos A
- Cuarental A
- Cubillos DN
- Cupitt J
- Currie V
- Cvachovec K
- Czeslick E
- D\uedaz JJ
- D\uedaz TD
- D\uedez EP
- Dabnell S
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- Gazibegovic N
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- Giasnetsova T
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- Gl\uf6ckner C
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- Golder K
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- Goranovic T
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- Grayling M
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- Samma C
- Sampedro MG
- Sances D
- Sanchez-Morcillo S
- Sander M
- Sandesc D
- Sandhar T
- Sandici Z
- Sandu M
- Sange M
- Saniova B
- Sanmiguel G
- Sanseverino M
- Saraiva JP
- Saran T
- Sarandan M
- Saravanmuthu R
- Sardo E
- Sari F
- Sarkar S
- Sartzi M
- Saunders D
- Savelsberg S
- Sbai H
- Scarth E
- Sch\ufcttler J
- Scheidemann M
- Schiere S
- Schmutzler M
- Schneider G
- Scholler A
- Scholz L
- Schoorl M
- Schr\uf6der S
- Schreiner F
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- Schwarzkopf K
- Seale T
- Secher EL
- Secker C
- Seeman-Lodding H
- Seeman-Lodding H
- Seisdedos \uc1A
- Sekulic A
- Sellden E
- Sep\ufalveda I
- Sepp\ue4nen H
- Serena G
- Sergejewa O
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- Serra AM
- Serra S
- Serrano LG
- Serrano MG
- Serrano PD
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- Sieiro JM
- Sigurbj\uf6rnsson FT
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- Sigurdsson G
- Sigurdsson GH
- Silva L
- Silvasti P
- Silvestre FP
- Silvius N
- Sime\uf3n RG
- Simkova A
- Simon M
- Simon V
- Simonsen M
- Singh N
- Singh R
- Sintes D
- Sipylaite J
- Sj\uf6vall S
- Smith A
- Smith A
- Smith N
- Smith R
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- Smoje M
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- Snaith C
- Snell J
- Snelson C
- Soar J
- Sobona V
- Sockalingam S
- Soldatou O
- Sole MJ
- Somaini M
- Soro M
- Soto CL
- Soto RA
- Soto TT
- Soultati I
- Soumpasis I
- Spagnesi L
- Spagnolo L
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- Spano G
- Spapen H
- Spena C
- Spielvogel C
- Spies C
- Spring A
- Sprunck A
- Spyropoulou E
- Spyropoulou-Pagdatoglou K
- Srecko M
- Stafylaraki M
- Stanzani MR
- Stathopoulos A
- Stecher A
- Stegmann N
- Steib A
- Steiner L
- Stelian DS
- Stendell L
- Stepanovs J
- Stephens R
- Stewart H
- Stier M
- Stilwell S
- Stivan F
- Stocker M
- Stone A
- Stourac P
- Strandvik G
- Streanga L
- Strietzel HF
- Struthers R
- Stuart-Smith K
- Su\uf1\ue9 AB
- Suba O
- Suita L
- Sulaj M
- Surbatovic M
- Susarla J
- Sweet K
- Sysimetsa A
- Szabo E
- Szakmany T
- Szarowar B
- Szederjesi I
- Szekeres G
- Szigeti J
- Szucs A
- Szyca R
- Szymkiewicz O
- Tachon G
- Talving J
- Tamm T
- Tamowicz B
- Tanfani A
- Tappata G
- Tasopoulos K
- Tassinati T
- Taylor A
- Templeton M
- Tena B
- Terol Ade L
- Theodorou V
- Thibaud A
- Thomas J
- Thomas J
- Thomas M
- Thomas R
- Thompson C
- Thorup L
- Thuet V
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- Tiainen P
- Tibblin AO
- Tikkerberi A
- Timms G
- Timoneda FL
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- Toft P
- Toha AC
- Toivonen J
- Toma\u161evic A
- Tomasevic B
- Tomescu D
- Tomkute G
- Tommasino C
- Tompsett L
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- Topic J
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- Toretti I
- Tormena M
- Toro JP
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- Torres BF
- Tosi M
- Tot OK
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- Trenkler S
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- Turcanu R
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- Turina M
- Turner A
- Tzani V
- Ubre M
- Ungureanu L
- Unterberg M
- Untergehrer G
- Unz\ufae CL
- Ursic T
- Ursu I
- Utrera FA
- V\ue4\ue4r\ue4niemi H
- Vaccarisi E
- Vainio K
- Vajter J
- Vakkala M
- Valc\ue1rcel IE
- Vallejo A
- Vallet B
- van Acker G
- van Bommel J
- van den Berg R
- van der A M
- van der Hoven B
- van Duijn D
- van Klei W
- Van Mossevelde V
- van Obbergh L
- Vanlinthout L
- Vaquer S
- Varela IP
- Vargas MJ
- Vasan R
- Vasanth S
- Vasian H
- Vega JL
- Velasco AR
- Veld B
- Velzeboer F
- Venema A
- Venkatesh S
- Venzera- Azenic D
- Verbeke A
- Vercauteren M
- Verdenelli P
- Verhamme B
- Vezzoli D
- Viarengo V
- Vicari L
- Vicente R
- Vidal FG
- Vidal SG
- Viitanen M
- Vijar K
- Vilardi A
- Villach IR
- Villagran J
- Villen LM
- Vincent JL
- Vincent JL
- Vingsnes SO
- Vinnal M
- Visentin R
- Visk E
- Viskovic N
- Vitor P
- Vizca\uedno M
- Vizcaychipi M
- Vojinovic R
- von Heymann C
- Voulas A
- Vrankovic S
- Vrbanovic V
- Vrettou E
- Vymazal T
- Wadams B
- Wagner B
- Wagner J
- Waife N
- Walder B
- Walker E
- Walker R
- Wallet F
- Walsh H
- Ward G
- Ward S
- Warde B
- Wasmund C
- Waton K
- Watters M
- Webb S
- Weber M
- Weda T
- Wepler U
- Wernerman J
- Wessels K
- Westbrook A
- Westbrook A
- Weyland A
- White N
- White S
- Wickboldt N
- Wiegand-L\uf6hnert C
- Wiese O
- Wigmore T
- Wilde J
- Willars C
- Williams C
- Williams M
- Wilson J
- Wilson R
- Wilson S
- Windsor D
- Winsser L
- Wintzheimer S
- Wittmann M
- Wollaston J
- Wong K
- Wong P
- Woolhead A
- Worton R
- Wright C
- Wright M
- Wyldbore M
- Yemnga B
- Yepes MJ
- Yeung J
- Ytrebo LM
- Zaballos J
- Zabarte M
- Zacharouli D
- Zacharovska A
- Zadrazilova K
- Zafiridis T
- Zahorec R
- Zahorec R
- Zaldibar E
- Zamora JF
- Zandvliet R
- Zantua K
- Zearo E
- Zeba S
- Ziekenhuis A
- Zittling R
- Zocca E
- Zoltowski MK
- Zompanti V
- Zsisku L
- Zunic F
- Zuzan O
- Publication venue
- Publication date
- 01/01/2012
- Field of study
The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
- Author
- Ab Majid Mohd Azuan
- Ab Rahman Ahmad Sufian
- Ab Rahman Rusnah
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abd Ghafar Fara Nur Idayu
- Abd Hadi Husni Zaeem
- Abdel Goad Ehab Helmy
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams David
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A.
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahamed khader null
- Ahmad Azam Ummi Azmira
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Anizi Mashel
- Al hussaini Sabah
- Al'Amri Khalid
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alberto Lisi Zaheer Moolla
- AlbertoVolta Carlo
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alit Mahaalit Aribawa
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Antonina Webombesa
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Arkalaki Eleni
- Arlo whitehouse null
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam F Noorbhai M.
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Bai Yun
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balaji Packianathaswamy
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Baroselli Antonio
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
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- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benedikt Preckel Osne Kirzner
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Bergin Colin
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
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- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais Matthieu
- Biccard B. M.
- Biccard Bruce
- Biccard Bruce M.
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- Blakemore Stephen P.
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- Bocchino Speranza
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- Bogner Gerhard
- Bokkel-Andela Janneke ten
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- Bouwman Arthur
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- Boyd Christine
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- Brown Caroline Wrey
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- Brown Jamie
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- Bua Emmanuel
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- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
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- Bunwarie Bimalshakth
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- Burton Megan
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- Cabral Raquel
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- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
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- Callaghan Mark
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- Campbell Douglas
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- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo' Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
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- CarmenVaida Laura Aflori
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- Carr Adrienne
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- Carroll Jo
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- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
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- Chan Alexander
- Chan Mathew
- Chan Matthew
- Chan Peter
- Chan Vincent
- Chan Wai Kit Jacky
- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cheng Zhonggui
- Cheong Edward
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R.
- Chew M. S.
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
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- Christiansen Ida Cecilie
- Christmas Natasha
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- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
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- Chu Susanna
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- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clarkson Rachel
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Hannah
- Collins Michelle
- Collins Nwokoro
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- Commey Thelma
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- Conde Carlos
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- Cook Tim
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- Cope Jennifer
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- Copotoiu Sanda Maria
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- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Correia da Silva Rui Freitas Mendonça
- Corti Daniele
- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
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- Cotterell Sharon
- Cotterill Donna
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- Craw Sarah
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- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- D'Andrea Rocco
- Dafnios Nikolaos
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- Dai Qingqing
- Dai Qinxue
- Dai Si Yuan
- Daikou Panagoula
- Dalamagka Maria
- Dalampini Eleftheria
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- Dalton Emma
- Damant Rose
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- Daniel Gayatri Daniel
- Daniel Harvey
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- De Andrés Ibanez José Antonio
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- de Beer Johan
- de Boer Hans Donald
- De Bruyne Ann
- de Fretes Jennifer
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- de Hert Stefan
- De Jongh Karen
- De Kegel Dirk
- De Meyer Jenine N.
- De Oliveira Mirella Cristine
- de Rudnicki Stéphane
- de Swardt Mathew
- de Vasconcellos Kim
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- de Wet Jacques
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- Del Valle Santiago Garcia
- Delgado García David R.
- Della Rocca Giorgio
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- Dobson Gary
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- Dominguez Saul Velaz
- Doncel Ma Sherezade Tovar
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- Doumos Rodamanthos
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- Dragnea Dragos
- Dragoescu Nicoleta Alice
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- Drummond Leanne
- Du Fang
- Du Xindan
- Duarte Célia
- Dube Nokukhanya Z.
- Duca Alejandro
- Dudgeon Lucy
- Dudson Rosie
- Duenser Martin
- Dumitrascu Clementina Oana
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- Dunk Nigel
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- Durst Alexander
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- Dylst Dimitri
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- Dzulkipli Norizawati
- Echem Richard
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- Eikman Johan
- Ekelund Kim
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- Ellis Kate
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- Ezike Humphrey
- Fagerlund Malin Jonsson
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- Farrow Mehreen
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- Feng Yunlin
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- Filippopoulos Andreas
- Finch Amanda
- Fiorentza Klara
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- Flatt Jim
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- Fleisher Lee
- Fleisher Lee A.
- Flores Armando Adolfo Alvarez
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- Zbitnew Geoff
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- Zerman Luiza
- Zettergren Jan
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- Zhang Shihai
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- Zhang Xiaoyan
- Zhang Xuekang
- Zhang Yan
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- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Lili
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Xiaoping
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Åkring Irene
- Ögren Katrin
- Publication venue
- Health Sciences Research Commons
- Publication date
- 30/10/2017
- Field of study
© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32–0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88–1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62–0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61–0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
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- Del Valle Santiago Garcia
- Delgado García David R
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- Gaitanakis Stylianos
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- Goebel Ulrich
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- Greaves Rosanna
- Green Garyth M
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- Haddow James
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- Hamzah Zulkarnain
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- Harrichandparsad R
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- Harris Benjamin
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- Hodgkiss Tracey
- Hodgson Richard E
- Hodzovic Emil
- Hoedt Marielle
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- Weatherill J
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- Zapata Darcy Danitza Mari
- Zbitnew Geoff
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- Zeidan Lisa
- Zeng Qiuting
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- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally