Just Security and the Crisis of Global Governance

Pursuing security and justice jointly in global governance will be vital to human progress in the twenty-first century. Humanity lives and operates simultaneously in three spaces critical to contemporary life and governance: public, transactional and ecological. Failures in one space can cascade into others. Managing them so as to avoid such failures is an essential function of global governance. Public space is the home of governance (formal and informal) and of rights-exercising groups and individuals enjoying areas maintained for common use. Civil society fully exercising its basic human rights is essential to a well-functioning state, and well-functioning states are critical supporting elements in the present architecture of global governance. Wherever states are fragile or torn by conflict, they become fracture points in that architecture. Transactional space – the realm of trade, finance, and other markets and networks, especially digital – has experienced explosive growth in the last two decades. The new global economy is marked by openness and low costs of communication and transport but also greater vulnerability to, and opportunity for, transnational crime. Both of these spaces depend, in turn, on ecological space, the planet-wide system of systems that influence one another and set the background conditions for human life and civilisation. In none of these spaces are current tools and institutions of global governance up to the challenges they face. Mass violence in fragile states, cross-border economic shocks and cyber attacks, and the threat of runaway climate change threaten the public, transactional and ecological spaces of human existence. Getting global-governance reform right, however, will require paying close attention to the provision not just of security, but also of justice – and seeing to it that the two are mutually reinforcing.Article / Letter to editorLeiden University College The Hagu

Deepening G20-UN system cooperation to foster socio-economic recovery from the pandemic and reduce inequality worldwide: towards a G20+

This policy brief recommends the introduction of a “G20+” to lead the way on a post-pandemic socio-economic recovery that is effective, sustainable, and equitable. The “G20+” would harness the group’s formidable economic and political clout, while addressing its current deficits as regards legitimacy, representativeness and connections to the wider multilateral system. The policy brief sets out specific priority actions for the “G20+” to pursue, both in the short and medium-term, and outlines which institutional innovations are needed to achieve these ends. Moreover, it sketches a strategy for launching the “G20+”, starting with Italy’s G20 Presidency in 2021.Global Challenges (FGGA

Effects of an intravaginal GnRH analogue administration on rabbit reproductive parameters and welfare

Abstract On commercial farms, rabbit does are subjected to a reproductive rhythm that does not account for their welfare or physiology, leading to reduced longevity and consequently high annual replacement. The European Food Safety Authority (EFSA) recommends limited and infrequent use of hormone treatments, and suggests replacement with alternative methods that do not threaten animal welfare when possible. In the present study, we aimed to determine whether the GnRH analogue lecirelin acetate could be administered by inclusion in the seminal dose during insemination. Twenty 9-month-old does (Grigio del Monferrato, autochthonous Italian breed),each having two previous deliveries, were individually housed and divided into two groups at artificial insemination. The control group received 0.2 mL of intramuscular lecirelin (Dalmarelin, Fatro®, Italy) prior to insemination. The intravaginal group was inseminated with a seminal dose that included 0.3 mL Dalmarelin. The experiment was performed for six consecutive reproductive cycles at 42-day intervals, and included a total of 120 inseminations. Prior to each insemination, the heterospermic pooled semen samples were assessed for sperm motility and morphology. Each ejaculate was divided into two samples, with and without lecirelin addition. Compared to the control group, the does with intravaginal Dalmarelin administration showed equal or greater sexual receptivity, which resulted in a higher fertility rate over increasing cycles. The seminal dose volume was very low, possibly explaining the better results in the intravaginal group, which received a similar amount of hormone (0.3 mL/doe) as the control group (0.2 mL/doe). The negative performance of the control group may have also been due to anti-GnRH formation, and the more stressful method of ovulation induction. The number of live-born kits did not significantly differ between groups. Progressive motility was significantly positively correlated with motility characteristics, including VAP, VSL, ALH, BCF, STR, and LIN. Overall, our present findings supported that the incorporation of GnRH in a seminal dose could be used for ovulation induction in rabbit does. Further studies should identify the optimal dose of GnRH for intravaginal administration, taking into account that the intravaginal absorption capacity is about 10 times smaller than the intramuscular absorption capacity

Probiotic activity of <i>Enterococcus faecalis</i> CECT7121: effects on mucosal immunity and intestinal epithelial cells

Aims: To analyse the effect of Enterococcus faecalis CECT7121 on intestinalepithelial cells (IECs) and its effects on the mucosal immune response. Methods and Results: Enterococcus faecalis CECT7121 showed a high adhesioncapacity to completely and heterogeneously differentiated human intestinalepithelial cell line (Caco-2 cells). In addition, the contact of this bacteriumwith Caco-2 cells did not induce inflammatory chemokines (IL-8 and CCL-20). The presence of IgA⁺ and IL-6⁺ cells in the small intestine, as well as theproduction of inflammatory cytokines (TNFa, IL-6 and IL-12) in the gut, wasdetermined after intragastric inoculation of Ent. faecalis CECT7121 in BALB/cmice. The administration of Ent. faecalis CECT7121 increased the number ofIgA⁺ cells in the intestinal lamina propria without modifying the percentage ofIL-6⁺ cells. No differences were observed in the cytokines measured in theintestinal extracts between probiotic-treated and control mice. Conclusions: Enterococcus faecalis CECT7121 stimulates local mucosalimmunity and adheres to IECs without inducing inflammatory signals. Significance and Impact of the Study: Our results indicate that, apart from itsalready reported systemic immune activity, Ent. faecalis CECT7121 has amodulatory effect at a local level.Centro Universitario de Estudios Microbiológicos y Parasitológico

Expression of the TGF-beta1 system in human testicular pathologies

In non-obstructive azoospermia, histological patterns of Sertoli cell-only Syndrome (SCO) and hypospermatogenesis (H) are commonly found. In these pathologies, Leydig cell hyperplasia (LCH) is detected in some patients. Since TGF-β1 is involved in cellular proliferation/development, the aim of this work was to analyze the expression of TGF-β1, its receptors TGFBRII, TGFBRI (ALK-1 and ALK-5), and the co-receptor endoglin in human biopsies from patients with idiopathic infertilityFil: Gonzalez, Candela Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Terradas, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos"Carlos G. Durand"; Argentina. Instituto Médico IPREFER; ArgentinaFil: Ponzio, Roberto . Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Puigdomenech, Elisa. Instituto Médico IPREFER;; ArgentinaFil: Levalle, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos"Carlos G. Durand"; ArgentinaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Gonzalez Calvar, Silvia Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentin

Rethinking global cooperation: three new frameworks for collective action in an age of uncertainty

In 2022, the growing impacts of climate change have been felt across the globe, from prolonged drought in the Middle East and North Africa, to erratic monsoons in South Asia and record-breaking heat waves in Europe and China. At the same time, the COVID-19 pandemic—which reached the tragic milestone of one million deaths within the first eight months of this year—and the ongoing war in Ukraine and other violent conflicts have impeded global progress toward the Sustainable Development Goals. To address these and other pressing global challenges, in his 2021 Out Common Agenda report, UN Secretary-General António Guterres called for a Summit of the Future to improve collective action worldwide. Among the summit’s anticipated outcomes are a Declaration on Future Generations, a Global Digital Compact, and a New Agenda for Peace. This report elaborates on the challenges, proposed major elements, and potential spoilers to be overcome by each of these global policy frameworks. It further argues that meaningful civil society engagement in the summit’s preparations can reassure all stakeholders that decisions taken in September 2023 are well-informed, enjoy broad social ownership, and generate a sense of co-responsibility in supporting their implementation.FdR – Publicaties niet-programma gebonde

Gas Analysis and Monitoring Systems for the RPC Detector of CMS at LHC

The Resistive Plate Chambers (RPC) detector of the CMS experiment at the LHC proton collider (CERN, Switzerland) will employ an online gas analysis and monitoring system of the freon-based gas mixture used. We give an overview of the CMS RPC gas system, describe the project parameters and first results on gas-chromatograph analysis. Finally, we report on preliminary results for a set of monitor RPC.Comment: 9 pages, 8 figures. Presented by Stefano Bianco (Laboratori Nazionali di Frascati dell'INFN) at the IEEE NSS, San Diego (USA), October 200

Road to 2023: our common agenda and the pact for the future

Fears of rising conflict, new COVID-19 variants, irreversible climate change, and eroding collaboration in the global economy threaten to undermine the 2030 Agenda for Sustainable Development and other efforts to advance human progress. Yet, a once-in-a-generation opportunity to review and dramatically improve global tools for managing such enormous challenges, a Summit of the Future, is under serious consideration for September 2023 by the United Nations’ 193 Member States. Informed by research and policy dialogues—initially undertaken for the Albright-Gambari Commission and its follow-through, and most recently to help flesh out key proposals in the Secretary-General’s seminal report, Our Common Agenda—this report’s twenty main recommendations are intended to encourage more ambitious, forward-looking thinking and deliberation on global governance renewal and innovation in the run-up to next year’s Summit.FdR – Publicaties niet-programma gebonde

The CMS RPC gas gain monitoring system: an overview and preliminary results

The status of the CMS RPC Gas Gain Monitoring (GGM) system developed at the Frascati Laboratory of INFN (Istituto Nazionale di Fisica Nucleare) is reported on. The GGM system is a cosmic ray telescope based on small RPC detectors operated with the same gas mixture used by the CMS RPC system. The GGM gain and efficiency are continuously monitored on-line, thus providing a fast and accurate determination of any shift in working point conditions. The construction details and the first result of GGM commissioning are described.Comment: 8 pages, 9 figures, uses lnfprepCMS.sty, presented by L. Benussi at RPC07, Mumbai, INDIA 200