Size distribution, surface coverage, water, carbon, and metal storage of thermokarst lakes in the permafrost zone of the Western Siberia Lowland

Despite the importance of thermokarst (thaw) lakes of the subarctic zone in regulating greenhouse gas exchange with the atmosphere and the flux of metal pollutants and micro-nutrients to the ocean, the inventory of lake distribution and stock of solutes for the permafrost-affected zone are not available. We quantified the abundance of thermokarst lakes in the continuous, discontinuous, and sporadic permafrost zones of the western Siberian Lowland (WSL) using Landsat-8 scenes collected over the summers of 2013 and 2014. In a territory of 105 million ha, the total number of lakes >0.5 ha is 727,700, with a total surface area of 5.97 million ha, yielding an average lake coverage of 5.69% of the territory. Small lakes (0.5–1.0 ha) constitute about one third of the total number of lakes in the permafrost-bearing zone of WSL, yet their surface area does not exceed 2.9% of the total area of lakes in WSL. The latitudinal pattern of lake number and surface coverage follows the local topography and dominant landscape zones. The role of thermokarst lakes in dissolved organic carbon (DOC) and most trace element storage in the territory of WSL is non-negligible compared to that of rivers. The annual lake storage across the WSL of DOC, Cd, Pb, Cr, and Al constitutes 16%, 34%, 37%, 57%, and 73%, respectively, of their annual delivery by WSL rivers to the Arctic Ocean from the same territory. However, given that the concentrations of DOC and metals in the smallest lakes (<0.5 ha) are much higher than those in the medium and large lakes, the contribution of small lakes to the overall carbon and metal budget may be comparable to, or greater than, their contribution to the water storage. As such, observations at high spatial resolution (<0.5 ha) are needed to constrain the reservoirs and the mobility of carbon and metals in aquatic systems. To upscale the DOC and metal storage in lakes of the whole subarctic, the remote sensing should be coupled with hydrochemical measurements in aquatic systems of boreal plains

Size distribution, surface coverage, water, carbon, and metal storage of thermokarst lakes in the permafrost zone of the Western Siberia Lowland

Despite the importance of thermokarst (thaw) lakes of the subarctic zone in regulating greenhouse gas exchange with the atmosphere and the flux of metal pollutants and micro-nutrients to the ocean, the inventory of lake distribution and stock of solutes for the permafrost-affected zone are not available. We quantified the abundance of thermokarst lakes in the continuous, discontinuous, and sporadic permafrost zones of the western Siberian Lowland (WSL) using Landsat-8 scenes collected over the summers of 2013 and 2014. In a territory of 105 million ha, the total number of lakes >0.5 ha is 727,700, with a total surface area of 5.97 million ha, yielding an average lake coverage of 5.69% of the territory. Small lakes (0.5–1.0 ha) constitute about one third of the total number of lakes in the permafrost-bearing zone of WSL, yet their surface area does not exceed 2.9% of the total area of lakes in WSL. The latitudinal pattern of lake number and surface coverage follows the local topography and dominant landscape zones. The role of thermokarst lakes in dissolved organic carbon (DOC) and most trace element storage in the territory of WSL is non-negligible compared to that of rivers. The annual lake storage across the WSL of DOC, Cd, Pb, Cr, and Al constitutes 16%, 34%, 37%, 57%, and 73%, respectively, of their annual delivery by WSL rivers to the Arctic Ocean from the same territory. However, given that the concentrations of DOC and metals in the smallest lakes (<0.5 ha) are much higher than those in the medium and large lakes, the contribution of small lakes to the overall carbon and metal budget may be comparable to, or greater than, their contribution to the water storage. As such, observations at high spatial resolution (<0.5 ha) are needed to constrain the reservoirs and the mobility of carbon and metals in aquatic systems. To upscale the DOC and metal storage in lakes of the whole subarctic, the remote sensing should be coupled with hydrochemical measurements in aquatic systems of boreal plains

Design, Virtual Screening, and Synthesis of Antagonists of α_IIbβ₃ as Antiplatelet Agents

This article describes design, virtual screening, synthesis, and biological tests of novel α_IIbβ₃ antagonists, which inhibit platelet aggregation. Two types of α_IIbβ₃ antagonists were developed: those binding either closed or open form of the protein. At the first step, available experimental data were used to build QSAR models and ligand- and structure-based pharmacophore models and to select the most appropriate tool for ligand-to-protein docking. Virtual screening of publicly available databases (BioinfoDB, ZINC, Enamine data sets) with developed models resulted in no hits. Therefore, small focused libraries for two types of ligands were prepared on the basis of pharmacophore models. Their screening resulted in four potential ligands for open form of α_IIbβ₃ and four ligands for its closed form followed by their synthesis and <i>in vitro</i> tests. Experimental measurements of affinity for α_IIbβ₃ and ability to inhibit ADP-induced platelet aggregation (IC₅₀) showed that two designed ligands for the open form <b>4c</b> and <b>4d</b> (IC₅₀ = 6.2 nM and 25 nM, respectively) and one for the closed form <b>12b</b> (IC₅₀ = 11 nM) were more potent than commercial antithrombotic Tirofiban (IC₅₀ = 32 nM)

Jet-hadron correlations measured relative to the second order event plane in Pb–Pb collisions at √sNN = 2.76 TeV

The Quark Gluon Plasma (QGP) produced in ultra relativistic heavy-ion collisions at the Large Hadron Collider (LHC) can be studied by measuring the modifications of jets formed by hard scattered partons which interact with the medium. We studied these modifications via angular correlations of jets with charged hadrons for jets with momenta 20 < pjetT < 40 GeV/c as a function of the associated particle momentum. The reaction plane fit (RPF) method is used in this analysis to remove the flow modulated background. The analysis of angular correlations for different orientations of the jet relative to the second order event plane allows for the study of the path length dependence of medium modifications to jets. We present the dependence of azimuthal angular correlations of charged hadrons with respect to the angle of the axis of a reconstructed jet relative to the event plane in Pb-Pb collisions at sNN−−−√ = 2.76 TeV. The dependence of particle yields associated with jets on the angle of the jet with respect to the event plane is presented. Correlations at different angles relative to the event plane are compared through ratios and differences of the yield. No dependence of the results on the angle of the jet with respect to the event plane is observed within uncertainties, which is consistent with no significant path length dependence of the medium modifications for this observable

Higher harmonic non-linear flow modes of charged hadrons in Pb–Pb collisions at √sNN =5.02 TeV

Anisotropic flow coefficients, vn, non-linear flow mode coefficients, χn,mk, and correlations among different symmetry planes, ρn,mk are measured in Pb-Pb collisions at sNN−−−√=5.02 TeV. Results obtained with multi-particle correlations are reported for the transverse momentum interval 0.2<pT<5.0 GeV/c within the pseudorapidity interval 0.4<|η|<0.8 as a function of collision centrality. The vn coefficients and χn,mk and ρn,mk are presented up to the ninth and seventh harmonic order, respectively. Calculations suggest that the correlations measured in different symmetry planes and the non-linear flow mode coefficients are dependent on the shear and bulk viscosity to entropy ratios of the medium created in heavy-ion collisions. The comparison between these measurements and those at lower energies and calculations from hydrodynamic models places strong constraints on the initial conditions and transport properties of the system

Production of (anti-)3He and (anti-)3H in p–Pb collisions at √sNN = 5.02 TeV

The transverse momentum (pT) differential yields of (anti-)3He and (anti-)3H measured in p-Pb collisions at sNN−−−√ = 5.02 TeV with ALICE at the LHC are presented. The ratios of the pT-integrated yields of (anti-)3He and (anti-)3H to the proton yields are reported, as well as the pT dependence of the coalescence parameters B3 for (anti-)3He and (anti-)3H. For (anti-)3He, the results obtained in four classes of the mean charged-particle multiplicity density are also discussed. These results are compared to predictions from a canonical statistical hadronization model and coalescence approaches. An upper limit on the total yield of 4He¯ is determined

Measurement of spin-orbital angular momentum interactions in relativistic heavy-ion collisions

The first measurement of spin alignment of vector mesons (K∗0 and ϕ) in heavy-ion collisions at the Large Hadron Collider (LHC) is reported. The measurements are carried out as a function of transverse momentum (pT ) and collision centrality with the ALICE detector using the particles produced at midrapidity (|y|< 0.5) in Pb-Pb collisions at a center-of-mass energy (sNN−−−√) of 2.76 TeV. The second diagonal spin density matrix element (ρ00 ) is measured from the angular distribution of the decay daughters of the vector meson in the decay rest frame, with respect to the normal of both the event plane and the production plane. The ρ00 values are found to be less than 1/3 (= 1/3 implies no spin alignment) at low pT (< 2 GeV/c) for both vector mesons. The observed deviations from 1/3 are maximal for mid-central collisions at a level of 3σ for K∗0 and 2σ for ϕ mesons. As control measurements, the analysis is also performed using the K0S meson, which has zero spin, and for the vector mesons in pp collisions; in both cases no significant spin alignment is observed. The ρ00 values at low pT with respect to the production plane are closer to 1/3 than for the event plane; they are related to each other through correlations introduced by the elliptic flow in the system. The measured spin alignment is surprisingly large compared to the polarization measured for Λ hyperons, but qualitatively consistent with the expectation from models which attribute the spin alignment to a polarization of quarks in the presence of large initial angular momentum in non-central heavy-ion collisions and a subsequent hadronization by the process of recombination

Investigation of the p–Σ0 interaction via femtoscopy in pp collisions

This Letter presents the first direct investigation of the p-Σ0 interaction, using the femtoscopy technique in high-multiplicity pp collisions at s√ = 13 TeV measured by the ALICE detector. The Σ0 is reconstructed via the decay channel to Λγ, and the subsequent decay of Λ to pπ−. The photon is detected via the conversion in material to e+e− pairs exploiting the unique capability of the ALICE detector to measure electrons at low transverse momenta. The measured p-Σ0 correlation indicates a shallow strong interaction. The comparison of the data to several theoretical predictions obtained employing the Correlation Analysis Tool using the Schrödinger Equation (CATS) and the Lednický-Lyuboshits approach shows a reasonable agreement. The presented femtoscopic data cannot yet discriminate between different models, which is also the case for the available scattering and hypernuclei data. Nevertheless, the p-Σ0 correlation function is found to be sensitive to the strong interaction, and driven by the interplay of the different spin and isospin channels. This pioneering study demonstrates the feasibility of a femtoscopic measurement in the p-Σ0 channel and with the expected larger data samples in LHC Run 3 and Run 4, the p-Σ0 interaction will be constrained with high precision